LOCUS       NM_006265               3660 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.
ACCESSION   NM_006265
VERSION     NM_006265.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Su,X.A., Stopsack,K.H., Schmidt,D.R., Ma,D., Li,Z., Scheet,P.A.,
            Penney,K.L., Lotan,T.L., Abida,W., DeArment,E.G., Lu,K., Janas,T.,
            Hu,S., Vander Heiden,M.G., Loda,M., Boselli,M., Amon,A. and
            Mucci,L.A.
  TITLE     RAD21 promotes oncogenesis and lethal progression of prostate
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 121 (36), e2405543121 (2024)
   PUBMED   39190349
  REMARK    GeneRIF: RAD21 promotes oncogenesis and lethal progression of
            prostate cancer.
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Xu,X., Wang,D., Xu,W., Li,H., Chen,N., Li,N., Yao,Q., Chen,W.,
            Zhong,J. and Mao,W.
  TITLE     NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway
            in non-small-cell lung cancer
  JOURNAL   Commun Biol 7 (1), 206 (2024)
   PUBMED   38378967
  REMARK    GeneRIF: NIPBL-mediated RAD21 facilitates tumorigenicity by the
            PI3K pathway in non-small-cell lung cancer.
            Erratum:[Commun Biol. 2024 Apr 1;7(1):397. doi:
            10.1038/s42003-024-06085-w.. PMID: 38561443]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Abarca-Barriga,H.H., Punil Luciano,R. and Vasquez Sotomayor,F.
  TITLE     Cornelia de Lange Syndrome Caused by an Intragenic Heterozygous
            Deletion in RAD21 Detected through Very-High-Resolution Chromosomal
            Microarray Analysis
  JOURNAL   Genes (Basel) 14 (12), 2212 (2023)
   PUBMED   38137034
  REMARK    GeneRIF: Cornelia de Lange Syndrome Caused by an Intragenic
            Heterozygous Deletion in RAD21 Detected through
            Very-High-Resolution Chromosomal Microarray Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3660)
  AUTHORS   Sadano,H., Sugimoto,H., Sakai,F., Nomura,N. and Osumi,T.
  TITLE     NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component
            of the nuclear matrix
  JOURNAL   Biochem Biophys Res Commun 267 (1), 418-422 (2000)
   PUBMED   10623634
REFERENCE   5  (bases 1 to 3660)
  AUTHORS   Parisi,S., McKay,M.J., Molnar,M., Thompson,M.A., van der Spek,P.J.,
            van Drunen-Schoenmaker,E., Kanaar,R., Lehmann,E., Hoeijmakers,J.H.
            and Kohli,J.
  TITLE     Rec8p, a meiotic recombination and sister chromatid cohesion
            phosphoprotein of the Rad21p family conserved from fission yeast to
            humans
  JOURNAL   Mol Cell Biol 19 (5), 3515-3528 (1999)
   PUBMED   10207075
REFERENCE   6  (bases 1 to 3660)
  AUTHORS   McKay,M.J., Troelstra,C., van der Spek,P., Kanaar,R., Smit,B.,
            Hagemeijer,A., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Sequence conservation of the rad21 Schizosaccharomyces pombe DNA
            double-strand break repair gene in human and mouse
  JOURNAL   Genomics 36 (2), 305-315 (1996)
   PUBMED   8812457
REFERENCE   7  (bases 1 to 3660)
  AUTHORS   Tuysuz,B., Gunes,N. and Alkaya,D.U.
  TITLE     Trichorhinophalangeal Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28426188
REFERENCE   8  (bases 1 to 3660)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   9  (bases 1 to 3660)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 3660)
  AUTHORS   Deardorff,M.A., Noon,S.E. and Krantz,I.D.
  TITLE     Cornelia de Lange Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA328186.1 and BC050381.1.
            
            On Aug 31, 2019 this sequence version replaced NM_006265.2.
            
            Summary: The protein encoded by this gene is highly similar to the
            gene product of Schizosaccharomyces pombe rad21, a gene involved in
            the repair of DNA double-strand breaks, as well as in chromatid
            cohesion during mitosis. This protein is a nuclear phospho-protein,
            which becomes hyperphosphorylated in cell cycle M phase. The highly
            regulated association of this protein with mitotic chromatin
            specifically at the centromere region suggests its role in sister
            chromatid cohesion in mitotic cells. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050381.1, D38551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297338.7/ ENSP00000297338.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DA328186.1         91-160
            71-3660             BC050381.1         1-3590
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.11"
     gene            1..3660
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /note="RAD21 cohesin complex component"
                     /db_xref="GeneID:5885"
                     /db_xref="HGNC:HGNC:9811"
                     /db_xref="MIM:606462"
     exon            1..166
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..342
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2094
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /note="protein involved in DNA double-strand break repair;
                     nuclear matrix protein 1; NXP-1; SCC1 homolog; sister
                     chromatid cohesion 1; RAD21 homolog; kleisin"
                     /codon_start=1
                     /product="double-strand-break repair protein rad21
                     homolog"
                     /protein_id="NP_006256.1"
                     /db_xref="CCDS:CCDS6321.1"
                     /db_xref="GeneID:5885"
                     /db_xref="HGNC:HGNC:9811"
                     /db_xref="MIM:606462"
                     /translation="MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESI
                     ISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENRE
                     AAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDF
                     GDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDD
                     NFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPD
                     SPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDS
                     KTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRC
                     LTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR
                     LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEE
                     PPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHG
                     LQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATP
                     GPRFHII"
     exon            343..472
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..572
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..679
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..886
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1012
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1135
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1359
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1519
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1668
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1818
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1902
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..3660
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="RAD21"
                     /gene_synonym="CDLS4; hHR21; HR21; HRAD21; MCD1; MGS;
                     NXP1; SCC1"
                     /note="major polyA site"
ORIGIN      
        1 atcttgtttg tttgagtgaa tcggaaagga ggcgccggct gtggcggcgg cgggagctgc
       61 tcggaagcta cacctcgcaa gggctccccc ctttccccac cccctccccc gacccttttc
      121 ccctccccgg gccacccagc ccgcccaact cccagcggag agcaaggttt tcttctgttt
      181 tcatagccag ccagaacaat gttctacgca cattttgttc tcagtaaaag agggcctctg
      241 gccaaaattt ggctagcggc ccattgggat aagaagctaa ccaaagccca tgtgttcgag
      301 tgtaatttag agagcagcgt ggagagtatc atctcaccaa aggtgaaaat ggcattacgg
      361 acatcaggac atctcttact gggagtagtt cgaatctatc acaggaaagc caaatacctt
      421 cttgcagact gtaatgaagc attcattaag ataaagatgg cttttcggcc aggtgtggtt
      481 gacctgcctg aggaaaatcg ggaagcagct tataatgcca ttactttacc tgaagaattt
      541 catgactttg atcagccact gcctgactta gatgacatcg atgtggccca gcagttcagc
      601 ttgaatcaga gtagagtgga agagataacc atgagagaag aagttgggaa catcagtatt
      661 ttacaagaaa atgattttgg tgattttgga atggatgatc gtgagataat gagagaaggc
      721 agtgcttttg aggatgacga catgttagta agcactacta cttctaacct cctattagag
      781 tctgaacaga gcaccagcaa tctgaatgag aaaattaacc atttagaata tgaagatcaa
      841 tataaggatg ataattttgg agaaggaaat gatggtggaa tattagatga caaacttatt
      901 agtaataatg atggcggtat ctttgatgat ccccctgccc tctctgaggc aggggtgatg
      961 ttgccagagc agcctgcaca tgacgatatg gatgaggatg ataatgtatc aatgggtggg
     1021 cctgatagtc ctgattcagt ggatcccgtt gaaccaatgc caaccatgac tgatcaaaca
     1081 acacttgttc caaatgagga agaagcattt gcattggagc ctattgatat aactgttaaa
     1141 gaaacaaaag ccaagaggaa gaggaagcta attgttgaca gtgtcaaaga gttggatagc
     1201 aagacaatta gagcccaact tagtgattat tcagatattg ttactacttt ggatctggca
     1261 ccgcccacca agaaattgat gatgtggaaa gagacaggag gagtagaaaa actgttttct
     1321 ttacctgctc agcctttgtg gaataacaga ctactgaagc tctttacacg ctgtcttaca
     1381 ccgcttgtac cagaagacct tagaaaaagg aggaaaggag gagaggcaga taatttggat
     1441 gaattcctca aagaatttga aaatccagag gttcctagag aggaccagca acagcagcat
     1501 cagcagcgtg atgttatcga tgagcccatt attgaagagc caagccgcct ccaggagtca
     1561 gtgatggagg ccagcagaac aaacatagat gagtcagcta tgcctccacc accacctcag
     1621 ggagttaagc gaaaagctgg acaaattgac ccagagcctg tgatgcctcc tcagcaggta
     1681 gagcagatgg aaataccacc tgtagagctt cccccagaag aacctccaaa tatctgtcag
     1741 ctaataccag agttagaact tctgccagaa aaagagaagg agaaagagaa ggaaaaagaa
     1801 gatgatgaag aggaagagga tgaagatgca tcagggggcg atcaagatca ggaagaaaga
     1861 agatggaaca aaaggactca gcagatgctt catggtcttc agcgtgctct tgctaaaact
     1921 ggagctgaat ctatcagttt gcttgagtta tgtcgaaata cgaacagaaa acaagctgcc
     1981 gcaaagttct acagcttctt ggttcttaaa aagcagcaag ctattgagct gacacaggaa
     2041 gaaccgtaca gtgacatcat cgcaacacct ggaccaaggt tccatattat ataaggagct
     2101 agaagcatta tagctagtgt ttgattcact agtgcttaca aattgccccc atgtgtaggg
     2161 gacacagaac cctttgagaa aacttagatt tttgtctgta caaagtcttt gcctttttcc
     2221 ttcttcattt ttttccagta cattaaattt gtcaatttca tctttgaggg aaactgatta
     2281 gatgggttgt gtttgtgttc tgatggagaa aacagcaccc caaggactca gaagatgatt
     2341 ttaacagttc agaacagatg tgtgcaatat tggtgcatgt aataatgttg agtggcagtc
     2401 aaaagtcatg atttttatct tagttcttca ttactgcatt gaaaaggaaa acctgtctga
     2461 gaaaatgcct gacagtttaa tttaaaacta tggtgtaagt ctttgacaag aaaaaaaaac
     2521 aaacaaacac ttctttccat cagtaacact ggcaatcttc ctgttaacca ctctccttag
     2581 ggatggtatc tgaaacaaca atggtcaccc tcttgagatt cgttttaagt gtaattccat
     2641 aatgagcaga ggtgtacgcg aaattgtgtt atgactgata gccttcagct acaaaaagat
     2701 aggactgacc tggtttaaag tgttctattt tgtaaatcat tccatttgag tctttctgat
     2761 gaacttggct atactgaaat ctgttatttt agtgaggctc caaaatgagc aaagctaggc
     2821 ctgattagag tagagtgact attaaaaaac ataactttct aggagctata aatcaaagtt
     2881 ttaaaaagat gtttggatat atttgagtat tccgatcatg aaaacagaaa ttgccctgcc
     2941 tactacaagg acagactgat gggaaattat gcacctggtc aacttagctt ttaagcagac
     3001 gatgctgtaa aaactaacgg cttctctgat atttattgta agttttagta ctgatctcct
     3061 tttccagtgc tgcacactcc tggtttggaa ctttaatagc gttgcaacga aatcctatat
     3121 ccagtttcct gtaatttaat tgaagaaaaa tacatccaaa taaagacttt attattaaca
     3181 gaccagatag catcagaaat catgtgactg ttatgattat cagaatgtct taacttttta
     3241 gggcaaagtt aacactgaaa gttctagctt aagtgttgaa acttttgtgg gaaaaaaaaa
     3301 tcacttttga aactcagact tcagtgtata cccaataatt taaaattatg tgaaatgttt
     3361 taaatttgtg aactcgtaat tactgtttta atgattcagt ttcttcagag tggtaattgt
     3421 ataaaattgc tattgcagct ttacattcaa tatgatgtgc ctgtaaacca aggagttttc
     3481 cccgtttgta aaaagacatt gtagataatt gaatgtttga ttttagaaag gtcattagtt
     3541 tcttgttaca cattttgtta gtctggtttt tgttgcttat cgggtttaat attgttcttg
     3601 aaaatagttg atgctatgtt atgtataact tttctaataa aagttgtgtt ataagctgta
//
