LOCUS       NM_006098               1140 bp    mRNA    linear   PRI 13-MAR-2025
DEFINITION  Homo sapiens receptor for activated C kinase 1 (RACK1), mRNA.
ACCESSION   NM_006098
VERSION     NM_006098.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Zhao,L., Chen,Y., Li,H., Ding,X. and Li,J.
  TITLE     Deciphering the neuroprotective mechanisms of RACK1 in cerebral
            ischemia-reperfusion injury: Pioneering insights into mitochondrial
            autophagy and the PINK1/Parkin axis
  JOURNAL   CNS Neurosci Ther 30 (8), e14836 (2024)
   PUBMED   39097918
  REMARK    GeneRIF: Deciphering the neuroprotective mechanisms of RACK1 in
            cerebral ischemia-reperfusion injury: Pioneering insights into
            mitochondrial autophagy and the PINK1/Parkin axis.
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Wang,Y., Liu,Y., Chen,H., Xu,Z., Jiang,W., Xu,X., Shan,J.,
            Chang,J., Zhou,T., Wang,J., Chenyan,A., Fan,S., Tao,Z., Shao,K.,
            Li,X., Chen,X., Ji,G. and Wu,X.
  TITLE     PIN1 promotes the metastasis of cholangiocarcinoma cells by
            RACK1-mediated phosphorylation of ANXA2
  JOURNAL   Cell Oncol (Dordr) 47 (4), 1233-1252 (2024)
   PUBMED   38386231
  REMARK    GeneRIF: PIN1 promotes the metastasis of cholangiocarcinoma cells
            by RACK1-mediated phosphorylation of ANXA2.
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Peng,L., Wu,T., Liu,Y., Zhao,D., He,W. and Yuan,Y.
  TITLE     OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via
            its non-canonical ubiquitination
  JOURNAL   Cell Oncol (Dordr) 47 (3), 987-1004 (2024)
   PUBMED   38315284
  REMARK    GeneRIF: OTUB1 accelerates hepatocellular carcinoma by stabilizing
            RACK1 via its non-canonical ubiquitination.
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Yan,Y., Zhang,F., Zou,M., Chen,H., Xu,J., Lu,S. and Liu,H.
  TITLE     Identification of RACK1 as a novel regulator of non-structural
            protein 4 of chikungunya virus
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (10), 1425-1436 (2024)
   PUBMED   38813597
  REMARK    GeneRIF: Identification of RACK1 as a novel regulator of
            non-structural protein 4 of chikungunya virus.
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Yang,D., Lu,X., Zhang,X., Zhang,X., Zhu,L. and Liu,Q.
  TITLE     RACK1 promotes the occurrence and progression of cervical carcinoma
  JOURNAL   J Clin Lab Anal 38 (4), e25012 (2024)
   PUBMED   38305509
  REMARK    GeneRIF: RACK1 promotes the occurrence and progression of cervical
            carcinoma.
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Pumiglia,K.M., LeVine,H., Haske,T., Habib,T., Jove,R. and
            Decker,S.J.
  TITLE     A direct interaction between G-protein beta gamma subunits and the
            Raf-1 protein kinase
  JOURNAL   J Biol Chem 270 (24), 14251-14254 (1995)
   PUBMED   7782277
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Mochly-Rosen,D., Miller,K.G., Scheller,R.H., Khaner,H., Lopez,J.
            and Smith,B.L.
  TITLE     p65 fragments, homologous to the C2 region of protein kinase C,
            bind to the intracellular receptors for protein kinase C
  JOURNAL   Biochemistry 31 (35), 8120-8124 (1992)
   PUBMED   1326322
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Guillemot,F., Billault,A. and Auffray,C.
  TITLE     Physical linkage of a guanine nucleotide-binding protein-related
            gene to the chicken major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 86 (12), 4594-4598 (1989)
   PUBMED   2499885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK222488.1, M24194.1, BC029996.1 and AC008443.10.
            
            On May 17, 2019 this sequence version replaced NM_006098.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222488.1, SRR5189661.3171.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512805.6/ ENSP00000426909.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK222488.1         1-10
            11-89               M24194.1           1-79
            90-766              AK222488.1         90-766
            767-966             M24194.1           756-955
            967-1084            AK222488.1         967-1084
            1085-1109           BC029996.1         912-936
            1110-1140           AC008443.10        57436-57466         c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1140
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /note="receptor for activated C kinase 1"
                     /db_xref="GeneID:10399"
                     /db_xref="HGNC:HGNC:4399"
                     /db_xref="MIM:176981"
     exon            1..215
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1060
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /note="protein homologous to chicken B complex protein,
                     guanine nucleotide binding; guanine nucleotide-binding
                     protein subunit beta-2-like 1; lung cancer oncogene 7;
                     proliferation-inducing gene 21; human lung cancer oncogene
                     7 protein; receptor of activated protein kinase C 1; cell
                     proliferation-inducing gene 21 protein; receptor of
                     activated protein C kinase 1; guanine nucleotide-binding
                     protein subunit beta-like protein 12.3; guanine nucleotide
                     binding protein beta polypeptide 2-like 1; guanine
                     nucleotide binding protein (G protein), beta polypeptide
                     2-like 1"
                     /codon_start=1
                     /product="small ribosomal subunit protein RACK1"
                     /protein_id="NP_006089.1"
                     /db_xref="CCDS:CCDS34324.1"
                     /db_xref="GeneID:10399"
                     /db_xref="HGNC:HGNC:4399"
                     /db_xref="MIM:176981"
                     /translation="MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK
                     LTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
                     GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS
                     SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML
                     WDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIS
                     TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR"
     exon            216..387
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            388..535
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            536..631
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            632..742
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            743..883
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            884..994
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1140
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1083..1088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="RACK1"
                     /gene_synonym="Gnb2-rs1; GNB2L1; H12.3; HLC-7; PIG21"
                     /note="major polyA site"
ORIGIN      
        1 ctctctttca ctgcaaggcg gcggcaggag aggttgtggt gctagtttct ctaagccatc
       61 cagtgccatc ctcgtcgctg cagcgacaca cgctctcgcc gccgccatga ctgagcagat
      121 gacccttcgt ggcaccctca agggccacaa cggctgggta acccagatcg ctactacccc
      181 gcagttcccg gacatgatcc tctccgcctc tcgagataag accatcatca tgtggaaact
      241 gaccagggat gagaccaact atggaattcc acagcgtgct ctgcggggtc actcccactt
      301 tgttagtgat gtggttatct cctcagatgg ccagtttgcc ctctcaggct cctgggatgg
      361 aaccctgcgc ctctgggatc tcacaacggg caccaccacg aggcgatttg tgggccatac
      421 caaggatgtg ctgagtgtgg ccttctcctc tgacaaccgg cagattgtct ctggatctcg
      481 agataaaacc atcaagctat ggaataccct gggtgtgtgc aaatacactg tccaggatga
      541 gagccactca gagtgggtgt cttgtgtccg cttctcgccc aacagcagca accctatcat
      601 cgtctcctgt ggctgggaca agctggtcaa ggtatggaac ctggctaact gcaagctgaa
      661 gaccaaccac attggccaca caggctatct gaacacggtg actgtctctc cagatggatc
      721 cctctgtgct tctggaggca aggatggcca ggccatgtta tgggatctca acgaaggcaa
      781 acacctttac acgctagatg gtggggacat catcaacgcc ctgtgcttca gccctaaccg
      841 ctactggctg tgtgctgcca caggccccag catcaagatc tgggatttag agggaaagat
      901 cattgtagat gaactgaagc aagaagttat cagtaccagc agcaaggcag aaccacccca
      961 gtgcacctcc ctggcctggt ctgctgatgg ccagactctg tttgctggct acacggacaa
     1021 cctggtgcga gtgtggcagg tgaccattgg cacacgctag aagtttatgg cagagcttta
     1081 caaataaaaa aaaaactggc ttttctgact tttaggtttt tttttcttat atgcaaaaaa
//
