LOCUS       NM_001319999            3106 bp    mRNA    linear   PRI 19-JAN-2025
DEFINITION  Homo sapiens Rac GTPase activating protein 1 (RACGAP1), transcript
            variant 4, mRNA.
ACCESSION   NM_001319999 XM_005268812
VERSION     NM_001319999.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Xu,Q., Li,J., Zhuo,L., Gao,H., Yang,Y. and Li,W.
  TITLE     RACGAP1 is a pivotal gene in lung adenocarcinoma-associated
            membranous nephropathy: Based on comprehensive bioinformatics
            analysis and machine learning
  JOURNAL   Int Immunopharmacol 139, 112783 (2024)
   PUBMED   39068752
  REMARK    GeneRIF: RACGAP1 is a pivotal gene in lung
            adenocarcinoma-associated membranous nephropathy: Based on
            comprehensive bioinformatics analysis and machine learning.
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Xu,Z., Wu,S., Tu,J., Wang,M., Liang,W., Cheng,J., Guan,J. and Xu,J.
  TITLE     RACGAP1 promotes lung cancer cell proliferation through the
            PI3K/AKT signaling pathway
  JOURNAL   Sci Rep 14 (1), 8694 (2024)
   PUBMED   38622149
  REMARK    GeneRIF: RACGAP1 promotes lung cancer cell proliferation through
            the PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Yao,H., Li,J., Zhou,D., Pan,X., Chu,Y. and Yin,J.
  TITLE     FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT
            signaling pathway to promote the proliferation, migration, and
            invasion of cervical cancer cells
  JOURNAL   Int J Clin Oncol 29 (3), 333-344 (2024)
   PUBMED   38172354
  REMARK    GeneRIF: FOXM1 transcriptional regulation of RacGAP1 activates the
            PI3K/AKT signaling pathway to promote the proliferation, migration,
            and invasion of cervical cancer cells.
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Yan,T., Lu,G., Shang,R., Hu,J., Zhu,C. and Jin,L.
  TITLE     RACGAP1 drives proliferation, migration and invasion and suppresses
            autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2
  JOURNAL   Physiol Int 111 (1), 35-46 (2024)
   PUBMED   38261006
  REMARK    GeneRIF: RACGAP1 drives proliferation, migration and invasion and
            suppresses autophagy of gastric cancer cells via inhibiting
            SIRT1/Mfn2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Liu,Y., Han,T., Miao,R., Zhou,J., Guo,J., Xu,Z., Xing,Y., Bai,Y.,
            Wu,J. and Hu,D.
  TITLE     RACGAP1 promotes the progression and poor prognosis of lung
            adenocarcinoma through its effects on the cell cycle and tumor
            stemness
  JOURNAL   BMC Cancer 24 (1), 7 (2024)
   PUBMED   38167018
  REMARK    GeneRIF: RACGAP1 promotes the progression and poor prognosis of
            lung adenocarcinoma through its effects on the cell cycle and tumor
            stemness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   White,E.A. and Glotzer,M.
  TITLE     Centralspindlin: at the heart of cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (11), 882-892 (2012)
   PUBMED   22927365
  REMARK    Review article
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Das,B., Shu,X., Day,G.J., Han,J., Krishna,U.M., Falck,J.R. and
            Broek,D.
  TITLE     Control of intramolecular interactions between the pleckstrin
            homology and Dbl homology domains of Vav and Sos1 regulates Rac
            binding
  JOURNAL   J Biol Chem 275 (20), 15074-15081 (2000)
   PUBMED   10748082
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Zuber,J., Tchernitsa,O.I., Hinzmann,B., Schmitz,A.C., Grips,M.,
            Hellriegel,M., Sers,C., Rosenthal,A. and Schafer,R.
  TITLE     A genome-wide survey of RAS transformation targets
  JOURNAL   Nat Genet 24 (2), 144-152 (2000)
   PUBMED   10655059
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Abo,A., Qu,J., Cammarano,M.S., Dan,C., Fritsch,A., Baud,V.,
            Belisle,B. and Minden,A.
  TITLE     PAK4, a novel effector for Cdc42Hs, is implicated in the
            reorganization of the actin cytoskeleton and in the formation of
            filopodia
  JOURNAL   EMBO J 17 (22), 6527-6540 (1998)
   PUBMED   9822598
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Toure,A., Dorseuil,O., Morin,L., Timmons,P., Jegou,B., Reibel,L.
            and Gacon,G.
  TITLE     MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42
            similar to Drosophila rotundRacGAP gene product, is expressed in
            male germ cells
  JOURNAL   J Biol Chem 273 (11), 6019-6023 (1998)
   PUBMED   9497316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025154.31.
            
            On Nov 23, 2018 this sequence version replaced NM_001319999.1.
            
            Summary: This gene encodes a GTPase-activating protein (GAP) that
            is a compoment of the centralspindlin complex. This protein binds
            activated forms of Rho GTPases and stimulates GTP hydrolysis, which
            results in negative regulation of Rho-mediated signals. This
            protein plays a regulatory role in cytokinesis, cell growth, and
            differentiation. Alternatively spliced transcript variants have
            been found for this gene. There is a pseudogene for this gene on
            chromosome 12. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (4) lacks two exons in the 5' UTR
            compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032754.1, SRR12921934.3485916.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312377.10/ ENSP00000309871.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC025154.31        77788-77884         c
            98-186              AC025154.31        69021-69109         c
            187-389             AC025154.31        58824-59026         c
            390-526             AC025154.31        57646-57782         c
            527-596             AC025154.31        56625-56694         c
            597-650             AC025154.31        54637-54690         c
            651-731             AC025154.31        53562-53642         c
            732-849             AC025154.31        52006-52123         c
            850-980             AC025154.31        51531-51661         c
            981-1145            AC025154.31        49430-49594         c
            1146-1241           AC025154.31        46804-46899         c
            1242-1440           AC025154.31        46521-46719         c
            1441-1546           AC025154.31        44940-45045         c
            1547-1679           AC025154.31        44635-44767         c
            1680-1815           AC025154.31        44388-44523         c
            1816-1924           AC025154.31        43074-43182         c
            1925-3106           AC025154.31        41552-42733         c
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3106
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /note="Rac GTPase activating protein 1"
                     /db_xref="GeneID:29127"
                     /db_xref="HGNC:HGNC:9804"
                     /db_xref="MIM:604980"
     exon            1..97
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..186
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2000
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /note="isoform a is encoded by transcript variant 4; male
                     germ cell RacGap; protein CYK4 homolog"
                     /codon_start=1
                     /product="rac GTPase-activating protein 1 isoform a"
                     /protein_id="NP_001306928.1"
                     /db_xref="CCDS:CCDS8795.1"
                     /db_xref="GeneID:29127"
                     /db_xref="HGNC:HGNC:9804"
                     /db_xref="MIM:604980"
                     /translation="MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKW
                     QRTDHELGKYKDLLMKAETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQL
                     IREMLMCDTSGSIQLSEEQKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDK
                     TDESLDWDSSLVKTFKLKKREKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAK
                     TTVTVPNDGGPIEAVSTIETVPYWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVG
                     TPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLP
                     CIPTLIGTPVKIGEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRT
                     VKELKEKFLRVKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITD
                     EDNSIAAMYQAVGELPQANRDTLAFLMIHLQRVAQSPHTKMDVANLAKVFGPTIVAHA
                     VPNPDPVTMLQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENSNAFSTPQ
                     TPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRSTLTKNTPRFGSKSKSATNLGRQGN
                     FFASPMLK"
     exon            187..389
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..526
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..596
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..650
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..731
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..849
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..980
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1145
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1241
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1440
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1546
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1679
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1815
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1924
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..3106
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3083..3088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /note="hexamer: AGTAAA"
     polyA_site      3106
                     /gene="RACGAP1"
                     /gene_synonym="CDAN3B; CYK4; HsCYK-4; ID-GAP; MgcRacGAP;
                     RCGAP1"
                     /note="major polyA site"
ORIGIN      
        1 gttttcaaac cggagctgtg ggcgcggcgc tgctctgccg ttgggtgagg cgcggagcga
       61 agtgaagggt ggcccaggtg gggccaggct gactgaaaaa gatggatact atgatgctga
      121 atgtgcggaa tctgtttgag cagcttgtgc gccgggtgga gattctcagt gaaggaaatg
      181 aagtccaatt tatccagttg gcgaaggact ttgaggattt ccgtaaaaag tggcagagga
      241 ctgaccatga gctggggaaa tacaaggatc ttttgatgaa agcagagact gagcgaagtg
      301 ctctggatgt taagctgaag catgcacgta atcaggtgga tgtagagatc aaacggagac
      361 agagagctga ggctgactgc gaaaagctgg aacgacagat tcagctgatt cgagagatgc
      421 tcatgtgtga cacatctggc agcattcaac taagcgagga gcaaaaatca gctctggctt
      481 ttctcaacag aggccaacca tccagcagca atgctgggaa caaaagacta tcaaccattg
      541 atgaatctgg ttccatttta tcagatatca gctttgacaa gactgatgaa tcactggatt
      601 gggactcttc tttggtgaag actttcaaac tgaagaagag agaaaagagg cgctctacta
      661 gccgacagtt tgttgatggt ccccctggac ctgtaaagaa aactcgttcc attggctctg
      721 cagtagacca ggggaatgaa tccatagttg caaaaactac agtgactgtt cccaatgatg
      781 gcgggcccat cgaagctgtg tccactattg agactgtgcc atattggacc aggagccgaa
      841 ggaaaacagg tactttacaa ccttggaaca gtgactccac cctgaacagc aggcagctgg
      901 agccaagaac tgagacagac agtgtgggca cgccacagag taatggaggg atgcgcctgc
      961 atgactttgt ttctaagacg gttattaaac ctgaatcctg tgttccatgt ggaaagcgga
     1021 taaaatttgg caaattatct ctgaagtgtc gagactgtcg tgtggtctct catccagaat
     1081 gtcgggaccg ctgtcccctt ccctgcattc ctaccctgat aggaacacct gtcaagattg
     1141 gagagggaat gctggcagac tttgtgtccc agacttctcc aatgatcccc tccattgttg
     1201 tgcattgtgt aaatgagatt gagcaaagag gtctgactga gacaggcctg tataggatct
     1261 ctggctgtga ccgcacagta aaagagctga aagagaaatt cctcagagtg aaaactgtac
     1321 ccctcctcag caaagtggat gatatccatg ctatctgtag ccttctaaaa gactttcttc
     1381 gaaacctcaa agaacctctt ctgacctttc gccttaacag agcctttatg gaagcagcag
     1441 aaatcacaga tgaagacaac agcatagctg ccatgtacca agctgttggt gaactgcccc
     1501 aggccaacag ggacacatta gctttcctca tgattcactt gcagagagtg gctcagagtc
     1561 cacatactaa aatggatgtt gccaatctgg ctaaagtctt tggccctaca atagtggccc
     1621 atgctgtgcc caatccagac ccagtgacaa tgttacagga catcaagcgt caacccaagg
     1681 tggttgagcg cctgctttcc ttgcctctgg agtattggag tcagttcatg atggtggagc
     1741 aagagaacat tgacccccta catgtcattg aaaactcaaa tgccttttca acaccacaga
     1801 caccagatat taaagtgagt ttactgggac ctgtgaccac tcctgaacat cagcttctca
     1861 agactccttc atctagttcc ctgtcacaga gagtccgttc caccctcacc aagaacactc
     1921 ctagatttgg gagcaaaagc aagtctgcca ctaacctagg acgacaaggc aacttttttg
     1981 cttctccaat gctcaagtga agtcacatct gcctgttact tcccagcatt gactgactat
     2041 aagaaaggac acatctgtac tctgctctgc agcctcctgt actcattact acttttagca
     2101 ttctccaggc ttttactcaa gtttaattgt gcatgagggt tttattaaaa ctatatatat
     2161 ctccccttcc ttctcctcaa gtcacataat atcagcactt tgtgctggtc attgttggga
     2221 gcttttagat gagacatctt tccaggggta gaagggttag tatggaattg gttgtgattc
     2281 tttttgggga agggggttat tgttcctttg gcttaaagcc aaatgctgct catagaatga
     2341 tctttctcta gtttcattta gaactgattt ccgtgagaca atgacagaaa ccctacctat
     2401 ctgataagat tagcttgtct cagggtggga agtgggaggg cagggcaaag aaaggattag
     2461 accagaggat ttaggatgcc tccttctaag aaccagaagt tctcattccc cattatgaac
     2521 tgagctataa tatggagctt tcataaaaat gggatgcatt gaggacagaa ctagtgatgg
     2581 gagtatgcgt agctttgatt tggatgatta ggtctttaat agtgttgagt ggcacaacct
     2641 tgtaaatgtg aaagtacaac tcgtatttat ctctgatgtg ctgctggctg aactttgggt
     2701 tcatttgggg tcaaagccag tttttctttt aaaattgaat tcattctgat gcttggcccc
     2761 cataccccca accttgtcca gtggagccca acttctaaag gtcaatatat catcctttgg
     2821 catcccaact aacaataaag agtaggctat aagggaagat tgtcaatatt ttgtggtaag
     2881 aaaagctaca gtcatttttt ctttgcactt tggatgctga aatttttccc atggaacata
     2941 gccacatcta gatagatgtg agctttttct tctgttaaaa ttattcttaa tgtctgtaaa
     3001 aacgattttc ttctgtagaa tgtttgactt cgtattgacc cttatctgta aaacacctat
     3061 ttgggataat atttggaaaa aaagtaaata gctttttcaa aatgaa
//
