LOCUS       NM_005052               1038 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Rac family small GTPase 3 (RAC3), transcript variant
            1, mRNA.
ACCESSION   NM_005052
VERSION     NM_005052.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Song,L., Xu,Q., Chen,R., Sun,W. and Zhan,J.
  TITLE     KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and Enhance
            Cisplatin Resistance in Bladder Cancer Cells
  JOURNAL   Am J Mens Health 18 (5), 15579883241273305 (2024)
   PUBMED   39376007
  REMARK    GeneRIF: KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and
            Enhance Cisplatin Resistance in Bladder Cancer Cells.
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Li,H., Ma,H., Ma,J., Qin,F., Fan,S., Kong,S., Zhao,S. and Ma,J.
  TITLE     Unveiling the role of RAC3 in the growth and invasion of
            cisplatin-resistant bladder cancer cells
  JOURNAL   J Cell Mol Med 28 (11), e18473 (2024)
   PUBMED   38847477
  REMARK    GeneRIF: Unveiling the role of RAC3 in the growth and invasion of
            cisplatin-resistant bladder cancer cells.
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Chen,Y., Huang,M., Lu,J., Zhang,Q., Wu,J., Peng,S., Chen,S.,
            Zhang,Y., Cheng,L., Lin,T., Chen,X. and Huang,J.
  TITLE     Establishment of a prognostic model to predict chemotherapy
            response and identification of RAC3 as a chemotherapeutic target in
            bladder cancer
  JOURNAL   Environ Toxicol 39 (2), 509-528 (2024)
   PUBMED   37310098
  REMARK    GeneRIF: Establishment of a prognostic model to predict
            chemotherapy response and identification of RAC3 as a
            chemotherapeutic target in bladder cancer.
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Scala,M., Nishikawa,M., Ito,H., Tabata,H., Khan,T., Accogli,A.,
            Davids,L., Ruiz,A., Chiurazzi,P., Cericola,G., Schulte,B.,
            Monaghan,K.G., Begtrup,A., Torella,A., Pinelli,M.,
            Denomme-Pichon,A.S., Vitobello,A., Racine,C., Mancardi,M.M.,
            Kiss,C., Guerin,A., Wu,W., Gabau Vila,E., Mak,B.C.,
            Martinez-Agosto,J.A., Gorin,M.B., Duz,B., Bayram,Y.,
            Carvalho,C.M.B., Vengoechea,J.E., Chitayat,D., Tan,T.Y.,
            Callewaert,B., Kruse,B., Bird,L.M., Faivre,L., Zollino,M.,
            Biskup,S., Striano,P., Nigro,V., Severino,M., Capra,V., Costain,G.
            and Nagata,K.I.
  CONSRTM   Undiagnosed Diseases Network; Telethon Undiagnosed Diseases Program
  TITLE     Variant-specific changes in RAC3 function disrupt corticogenesis in
            neurodevelopmental phenotypes
  JOURNAL   Brain 145 (9), 3308-3327 (2022)
   PUBMED   35851598
  REMARK    GeneRIF: Variant-specific changes in RAC3 function disrupt
            corticogenesis in neurodevelopmental phenotypes.
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Meijuan,C., Fang,L., Min,F. and Qian,W.
  TITLE     Hypomethylated gene RAC3 induces cell proliferation and invasion by
            increasing FASN expression in endometrial cancer
  JOURNAL   Int J Biochem Cell Biol 150, 106274 (2022)
   PUBMED   35917927
  REMARK    GeneRIF: Hypomethylated gene RAC3 induces cell proliferation and
            invasion by increasing FASN expression in endometrial cancer.
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Mira,J.P., Benard,V., Groffen,J., Sanders,L.C. and Knaus,U.G.
  TITLE     Endogenous, hyperactive Rac3 controls proliferation of breast
            cancer cells by a p21-activated kinase-dependent pathway
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 185-189 (2000)
   PUBMED   10618392
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Morris,C.M., Haataja,L., McDonald,M., Gough,S., Markie,D.,
            Groffen,J. and Heisterkamp,N.
  TITLE     The small GTPase RAC3 gene is located within chromosome band
            17q25.3 outside and telomeric of a region commonly deleted in
            breast and ovarian tumours
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 18-23 (2000)
   PUBMED   10894930
REFERENCE   8  (bases 1 to 1038)
  AUTHORS   Courjal,F., Chuchana,P., Theillet,C. and Fort,P.
  TITLE     Structure and chromosomal assignment to 22q12 and 17qter of the
            ras-related Rac2 and Rac3 human genes
  JOURNAL   Genomics 44 (2), 242-246 (1997)
   PUBMED   9299243
REFERENCE   9  (bases 1 to 1038)
  AUTHORS   Haataja,L., Groffen,J. and Heisterkamp,N.
  TITLE     Characterization of RAC3, a novel member of the Rho family
  JOURNAL   J Biol Chem 272 (33), 20384-20388 (1997)
   PUBMED   9252344
REFERENCE   10 (bases 1 to 1038)
  AUTHORS   Didsbury,J., Weber,R.F., Bokoch,G.M., Evans,T. and Snyderman,R.
  TITLE     rac, a novel ras-related family of proteins that are botulinum
            toxin substrates
  JOURNAL   J Biol Chem 264 (28), 16378-16382 (1989)
   PUBMED   2674130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009605.1 and BU731383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005052.2.
            
            Summary: The protein encoded by this gene is a GTPase which belongs
            to the RAS superfamily of small GTP-binding proteins. Members of
            this superfamily appear to regulate a diverse array of cellular
            events, including the control of cell growth, cytoskeletal
            reorganization, and the activation of protein kinases. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.430169.1, BC009605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306897.9/ ENSP00000304283.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1028              BC009605.1         24-1051
            1029-1038           BU731383.1         18-27               c
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1038
                     /gene="RAC3"
                     /note="Rac family small GTPase 3"
                     /db_xref="GeneID:5881"
                     /db_xref="HGNC:HGNC:9803"
                     /db_xref="MIM:602050"
     exon            1..119
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..663
                     /gene="RAC3"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     family, small GTP binding protein Rac3; p21-Rac3;
                     ras-related C3 botulinum toxin substrate 3 (rho family,
                     small GTP binding protein Rac3)"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 3
                     isoform 1"
                     /protein_id="NP_005043.1"
                     /db_xref="CCDS:CCDS11798.1"
                     /db_xref="GeneID:5881"
                     /db_xref="HGNC:HGNC:9803"
                     /db_xref="MIM:602050"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF"
     exon            120..191
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..309
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            310..372
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..532
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1038
                     /gene="RAC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1018..1023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAC3"
                     /note="hexamer: AATAAA"
     polyA_site      1038
                     /gene="RAC3"
                     /note="major polyA site"
ORIGIN      
        1 gctcgggtcc gcggccgctg cggcgccggg catttctccg cagctcggct cgcggccgcg
       61 cccgccgccg cccggcccgc gcccatgcag gccatcaagt gcgtggtggt cggcgacggc
      121 gccgtgggga agacatgctt gctgatcagc tacacgacca acgccttccc cggagagtac
      181 atccccaccg tttttgacaa ctactctgcc aacgtgatgg tggacgggaa accagtcaac
      241 ttggggctgt gggacacagc gggtcaggag gactacgatc ggctgcggcc actctcctac
      301 ccccaaactg acgtctttct gatctgcttc tctctggtga gcccggcctc cttcgagaat
      361 gttcgtgcca agtggtaccc ggaggtgcgg caccactgcc cccacacgcc catcctcctg
      421 gtgggcacca agctggacct ccgcgacgac aaggacacca ttgagcggct gcgggacaag
      481 aagctggcac ccatcaccta cccacagggc ctggccatgg cccgggagat tggctctgtg
      541 aaatacctgg agtgctcagc cctgacccag cggggcctga agacagtgtt tgacgaggcg
      601 atccgcgcgg tgctctgccc gcccccagtg aagaagccgg ggaagaagtg caccgtcttc
      661 tagagccctg gcccacccga gcctgagggc tggcggggag cagccctgga cgtgtccgct
      721 gttgtgttga gacgtgtggt gtccctgagt cggctgtggg gagcggtggg ggtgggccgg
      781 ggggaagcat ggggatgagg ctgggtggca ggatcctgtc ctctctgccg cctcattctg
      841 gggtgtggct ccagccttcc ctggcccccg ccggaggccg ggagggagca gggtctccct
      901 cagggctgca ggggcaggtg cagggaagcc ccaggatggg cttccctgga gggggagggt
      961 gggggggagt tctgttcctt gtgccccgag gtggggcagc cccttctcat tttatacaat
     1021 aaacattctc cacctaca
//
