LOCUS       NM_006908               2309 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens Rac family small GTPase 1 (RAC1), transcript variant
            Rac1, mRNA.
ACCESSION   NM_006908
VERSION     NM_006908.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Zhao,H., Wu,G., Luo,Y., Xie,Y., Han,Y., Zhang,D., Han,Q., Zhao,X.,
            Qin,Y., Li,Q. and Wang,E.
  TITLE     WNT5B promotes the malignant phenotype of non-small cell lung
            cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway
  JOURNAL   Cell Signal 122, 111330 (2024)
   PUBMED   39094673
  REMARK    GeneRIF: WNT5B promotes the malignant phenotype of non-small cell
            lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Li,Y., Gu,A., Yang,L. and Wang,Q.
  TITLE     RAC1 serves as a prognostic factor and correlated with immune
            infiltration in liver hepatocellular carcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (9), 418 (2024)
   PUBMED   39264423
  REMARK    GeneRIF: RAC1 serves as a prognostic factor and correlated with
            immune infiltration in liver hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Zhao,P., Zhang,J., Song,W., Qi,D., Huang,Y., Su,Y., Wu,R., Zhang,L.
            and Zhang,S.
  TITLE     Incarvine C and its analogues inhibit the formation of cell
            cytoskeleton by targeting Rac1
  JOURNAL   Bioorg Chem 149, 107512 (2024)
   PUBMED   38833990
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Zhang,J., Fu,L., Wang,H., Yonemura,A., Semba,T.,
            Yasuda-Yoshihara,N., Nishimura,A., Tajiri,T., Tong,Y., Yasuda,T.,
            Uchihara,T., Yamazaki,M., Okamoto,Y., Yamasaki,J., Nagano,O.,
            Baba,H. and Ishimoto,T.
  TITLE     RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient
            gastric cancer cells promotes interactions with the stroma and
            peritoneal dissemination
  JOURNAL   Cancer Lett 591, 216901 (2024)
   PUBMED   38641311
  REMARK    GeneRIF: RAC1-mediated integrin alpha-6 expression in
            E-cadherin-deficient gastric cancer cells promotes interactions
            with the stroma and peritoneal dissemination.
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Ye,F., Xia,T., Zhao,M., Zhao,W., Min,P., Wang,Y., Wang,Q., Zhang,Y.
            and Du,J.
  TITLE     PlexinA1 promotes gastric cancer migration through preventing
            MICAL1 protein ubiquitin/proteasome-mediated degradation in a
            Rac1-dependent manner
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167124 (2024)
   PUBMED   38508474
  REMARK    GeneRIF: PlexinA1 promotes gastric cancer migration through
            preventing MICAL1 protein ubiquitin/proteasome-mediated degradation
            in a Rac1-dependent manner.
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   Burbelo,P.D., Drechsel,D. and Hall,A.
  TITLE     A conserved binding motif defines numerous candidate target
            proteins for both Cdc42 and Rac GTPases
  JOURNAL   J Biol Chem 270 (49), 29071-29074 (1995)
   PUBMED   7493928
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Ridley,A.J., Paterson,H.F., Johnston,C.L., Diekmann,D. and Hall,A.
  TITLE     The small GTP-binding protein rac regulates growth factor-induced
            membrane ruffling
  JOURNAL   Cell 70 (3), 401-410 (1992)
   PUBMED   1643658
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   Kinsella,B.T., Erdman,R.A. and Maltese,W.A.
  TITLE     Carboxyl-terminal isoprenylation of ras-related GTP-binding
            proteins encoded by rac1, rac2, and ralA
  JOURNAL   J Biol Chem 266 (15), 9786-9794 (1991)
   PUBMED   1903399
REFERENCE   9  (bases 1 to 2309)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
REFERENCE   10 (bases 1 to 2309)
  AUTHORS   Didsbury,J., Weber,R.F., Bokoch,G.M., Evans,T. and Snyderman,R.
  TITLE     rac, a novel ras-related family of proteins that are botulinum
            toxin substrates
  JOURNAL   J Biol Chem 264 (28), 16378-16382 (1989)
   PUBMED   2674130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009412.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006908.4.
            
            Summary: The protein encoded by this gene is a GTPase which belongs
            to the RAS superfamily of small GTP-binding proteins. Members of
            this superfamily appear to regulate a diverse array of cellular
            events, including the control of cell growth, cytoskeletal
            reorganization, and the activation of protein kinases. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (Rac1) has a 57 bp in-frame
            deletion of exon 3b in the coding region, as compared to the
            variant Rac1b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050687.1, AK054993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348035.9/ ENSP00000258737.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC009412.6         146697-146940
            245-316             AC009412.6         159382-159453
            317-434             AC009412.6         164094-164211
            435-497             AC009412.6         172296-172358
            498-657             AC009412.6         174038-174197
            658-2309            AC009412.6         174486-176137
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2309
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /note="Rac family small GTPase 1"
                     /db_xref="GeneID:5879"
                     /db_xref="HGNC:HGNC:9801"
                     /db_xref="MIM:602048"
     exon            1..244
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..788
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /EC_number="3.6.5.2"
                     /note="isoform Rac1 is encoded by transcript variant Rac1;
                     ras-like protein TC25; cell migration-inducing gene 5
                     protein; ras-related C3 botulinum toxin substrate 1 (rho
                     family, small GTP binding protein Rac1)"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 1
                     isoform Rac1"
                     /protein_id="NP_008839.2"
                     /db_xref="CCDS:CCDS5348.1"
                     /db_xref="GeneID:5879"
                     /db_xref="HGNC:HGNC:9801"
                     /db_xref="MIM:602048"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL"
     exon            245..316
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     exon            317..434
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     exon            435..497
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     exon            498..657
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     exon            658..2309
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /note="hexamer: AATAAA"
     polyA_site      2309
                     /gene="RAC1"
                     /gene_synonym="MIG5; MRD48; p21-Rac1; Rac-1; TC-25"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttctct gcagttttcc tcagctttgg gtggtggccg ctgccgggca tcggcttcca
       61 gtccgcggag ggcgaggcgg cgtggacagc ggccccggca cccagcgccc cgccgcccgc
      121 aagccgcgcg cccgtccgcc gcgccccgag cccgccgctt cctatctcag cgccctgccg
      181 ccgccgccgc ggcccagcga gcggccctga tgcaggccat caagtgtgtg gtggtgggag
      241 acggagctgt aggtaaaact tgcctactga tcagttacac aaccaatgca tttcctggag
      301 aatatatccc tactgtcttt gacaattatt ctgccaatgt tatggtagat ggaaaaccgg
      361 tgaatctggg cttatgggat acagctggac aagaagatta tgacagatta cgccccctat
      421 cctatccgca aacagatgtg ttcttaattt gcttttccct tgtgagtcct gcatcatttg
      481 aaaatgtccg tgcaaagtgg tatcctgagg tgcggcacca ctgtcccaac actcccatca
      541 tcctagtggg aactaaactt gatcttaggg atgataaaga cacgatcgag aaactgaagg
      601 agaagaagct gactcccatc acctatccgc agggtctagc catggctaag gagattggtg
      661 ctgtaaaata cctggagtgc tcggcgctca cacagcgagg cctcaagaca gtgtttgacg
      721 aagcgatccg agcagtcctc tgcccgcctc ccgtgaagaa gaggaagaga aaatgcctgc
      781 tgttgtaaat gtctcagccc ctcgttcttg gtcctgtccc ttggaacctt tgtacgcttt
      841 gctcaaaaaa aaacaaaaaa aaaaaacaaa aaaaaaaaac aacggtggag ccttcgcact
      901 caatgccaac tttttgttac agattaattt ttccataaaa ccattttttg aaccaatcag
      961 taattttaag gttttgtttg ttctaaatgt aagagttcag actcacattc tattaaaatt
     1021 tagccctaaa atgacaagcc ttcttaaagc cttatttttc aaaagcgccc cccccattct
     1081 tgttcagatt aagagttgcc aaaatacctt ctgaactaca ctgcattgtt gtgccgagaa
     1141 caccgagcac tgaactttgc aaagaccttc gtctttgaga agacggtagc ttctgcagtt
     1201 aggaggtgca gacacttgct ctcctatgta gttctcagat gcgtaaagca gaacagcctc
     1261 ccgaatgaag cgttgccatt gaactcacca gtgagttagc agcacgtgtt cccgacataa
     1321 cattgtactg taatggagtg agcgtagcag ctcagctctt tggatcagtc tttgtgattt
     1381 catagcgagt tttctgacca gcttttgcgg agattttgaa cagaactgct atttcctcta
     1441 atgaagaatt ctgtttagct gtgggtgtgc cgggtggggt gtgtgtgatc aaaggacaaa
     1501 gacagtattt tgacaaaata cgaagtggag atttacacta cattgtacaa ggaatgaaag
     1561 tgtcacgggt aaaaactcta aaaggttaat ttctgtcaaa tgcagtagat gatgaaagaa
     1621 aggttggtat tatcaggaaa tgttttctta agcttttcct ttctcttaca cctgccatgc
     1681 ctccccaaat tgggcattta attcatcttt aaactggttg ttctgttagt cgctaactta
     1741 gtaagtgctt ttcttataga accccttctg actgagcaat atgcctcctt gtattataaa
     1801 atctttctga taatgcatta gaaggttttt ttgtcgatta gtaaaagtgc tttccatgtt
     1861 actttattca gagctaataa gtgctttcct tagttttcta gtaactaggt gtaaaaatca
     1921 tgtgttgcag ctttatagtt tttaaaatat tttagataat tcttaaacta tgaaccttct
     1981 taacatcact gtcttgccag attaccgaca ctgtcacttg accaatactg accctcttta
     2041 cctcgcccac gcggacacac gcctcctgta gtcgctttgc ctattgatgt tcctttgggt
     2101 ctgtgaggtt ctgtaaactg tgctagtgct gacgatgttc tgtacaactt aactcactgg
     2161 cgagaataca gcgtgggacc cttcagccac tacaacagaa ttttttaaat tgacagttgc
     2221 agaattgtgg agtgttttta cattgatctt ttgctaatgc aattagcatt atgttttgca
     2281 tgtatgactt aataaatcct tgaatcata
//
