LOCUS       NM_024718               3104 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB, member RAS oncogene family like 6 (RABL6),
            transcript variant 1, mRNA.
ACCESSION   NM_024718
VERSION     NM_024718.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3104)
  AUTHORS   Xu,P., Xu,X., Wu,X., Zhang,L., Meng,L., Chen,Z., Han,W., Yao,J. and
            Xu,A.
  TITLE     CircTMC5 promotes gastric cancer progression and metastasis by
            targeting miR-361-3p/RABL6
  JOURNAL   Gastric Cancer 25 (1), 64-82 (2022)
   PUBMED   34296378
  REMARK    GeneRIF: CircTMC5 promotes gastric cancer progression and
            metastasis by targeting miR-361-3p/RABL6.
REFERENCE   2  (bases 1 to 3104)
  AUTHORS   Kohlmeyer,J.L., Kaemmer,C.A., Umesalma,S., Gourronc,F.A.,
            Klingelhutz,A.J. and Quelle,D.E.
  TITLE     RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner
  JOURNAL   Int J Mol Sci 22 (10), 5367 (2021)
   PUBMED   34065204
  REMARK    GeneRIF: RABL6A Regulates Schwann Cell Senescence in an
            RB1-Dependent Manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3104)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3104)
  AUTHORS   Feng,Y., Yan,S., Huang,Y., Huang,Q., Wang,F. and Lei,Y.
  TITLE     High expression of RABL6 promotes cell proliferation and predicts
            poor prognosis in esophageal squamous cell carcinoma
  JOURNAL   BMC Cancer 20 (1), 602 (2020)
   PUBMED   32600359
  REMARK    GeneRIF: High expression of RABL6 promotes cell proliferation and
            predicts poor prognosis in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3104)
  AUTHORS   Lui,K., An,J., Montalbano,J., Shi,J., Corcoran,C., He,Q., Sun,H.,
            Sheikh,M.S. and Huang,Y.
  TITLE     Negative regulation of p53 by Ras superfamily protein RBEL1A
  JOURNAL   J Cell Sci 126 (Pt 11), 2436-2445 (2013)
   PUBMED   23572512
  REMARK    GeneRIF: RBEL1A appears to function as a novel p53 negative
            regulator that facilitates MDM2-dependent p53 ubiquitylation and
            degradation.
REFERENCE   6  (bases 1 to 3104)
  AUTHORS   Montalbano,J., Lui,K., Sheikh,M.S. and Huang,Y.
  TITLE     Identification and characterization of RBEL1 subfamily of GTPases
            in the Ras superfamily involved in cell growth regulation
  JOURNAL   J Biol Chem 284 (27), 18129-18142 (2009)
   PUBMED   19433581
  REMARK    GeneRIF: characterization of all four RBEL1 splice variants in
            terms of their GTPase activities, subcellular localizations,
            regulations & potential functions; results indicate RBEL1 proteins
            are linked to cell growth & survival & possess unique
            characteristics
REFERENCE   7  (bases 1 to 3104)
  AUTHORS   Montalbano,J., Jin,W., Sheikh,M.S. and Huang,Y.
  TITLE     RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras
            superfamily GTP-binding protein and is overexpressed in breast
            cancer
  JOURNAL   J Biol Chem 282 (52), 37640-37649 (2007)
   PUBMED   17962191
  REMARK    GeneRIF: RBEL1A and RBEL1B are novel Rab-like proteins that
            localize in the nucleus and cytosol and may play an important role
            in breast tumorigenesis
REFERENCE   8  (bases 1 to 3104)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   9  (bases 1 to 3104)
  AUTHORS   Cui,Y.P., Wang,J.B., Zhang,X.Y., Bi,M.X., Guo,L.P. and Lu,S.H.
  TITLE     Using yeast two-hybrid system to identify ECRG2 associated proteins
            and their possible interactions with ECRG2 gene
  JOURNAL   World J Gastroenterol 9 (9), 1892-1896 (2003)
   PUBMED   12970870
REFERENCE   10 (bases 1 to 3104)
  AUTHORS   Cui,Y., Wang,J., Zhang,X., Lang,R., Bi,M., Guo,L. and Lu,S.H.
  TITLE     ECRG2, a novel candidate of tumor suppressor gene in the esophageal
            carcinoma, interacts directly with metallothionein 2A and links to
            apoptosis
  JOURNAL   Biochem Biophys Res Commun 302 (4), 904-915 (2003)
   PUBMED   12646258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR989427.1, BC035786.1,
            BC002945.2 and BC021095.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024718.4.
            
            Summary: This gene encodes a member of the Ras superfamily of small
            GTPases. The encoded protein binds to both GTP and GDP and may play
            a role in cell growth and survival. Overexpression of this gene may
            play a role in breast cancer tumorigenesis, and pseudogenes of this
            gene are located on the long arm of chromosome 2 and the short arm
            of chromosome 18. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the coding region, compared to variant 3. The
            resulting isoform (1) lacks one internal residue, compared to
            isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021095.1, SRR1163655.182176.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311502.12/ ENSP00000311134.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CR989427.1         27-45
            20-773              BC035786.1         1-754
            774-1327            BC002945.2         563-1116
            1328-3104           BC021095.1         1058-2834
FEATURES             Location/Qualifiers
     source          1..3104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..3104
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /note="RAB, member RAS oncogene family like 6"
                     /db_xref="GeneID:55684"
                     /db_xref="HGNC:HGNC:24703"
                     /db_xref="MIM:610615"
     exon            1..379
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2439
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     partner of ARF; putative GTP-binding protein Parf;
                     Rab-like GTP-binding protein 1C; rab-like protein 6"
                     /codon_start=1
                     /product="rab-like protein 6 isoform 1"
                     /protein_id="NP_078994.3"
                     /db_xref="CCDS:CCDS48058.1"
                     /db_xref="GeneID:55684"
                     /db_xref="HGNC:HGNC:24703"
                     /db_xref="MIM:610615"
                     /translation="MFSALKKLVGSDQAPGRDKNIPAGLQSMNQALQRRFAKGVQYNM
                     KIVIRGDRNTGKTALWHRLQGRPFVEEYIPTQEIQVTSIHWSYKTTDDIVKVEVWDVV
                     DKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILR
                     ELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIDNLDRPPGSSYFRYAESSMKNSF
                     GLKYLHKFFNIPFLQLQRETLLRQLETNQLDMDATLEELSVQQETEDQNYGIFLEMME
                     ARSRGHASPLAANGQSPSPGSQSPVVPAGAVSTGSSSPGTPQPAPQLPLNAAPPSSVP
                     PVPPSEALPPPACPSAPAPRRSIISRLFGTSPATEAAPPPPEPVPAAEGPATVQSVED
                     FVPDDRLDRSFLEDTTPARDEKKVGAKAAQQDSDSDGEALGGNPMVAGFQDDVDLEDQ
                     PRGSPPLPAGPVPSQDITLSSEEEAEVAAPTKGPAPAPQQCSEPETKWSSIPASKPRR
                     GTAPTRTAAPPWPGGVSVRTGPEKRSSTRPPAEMEPGKGEQASSSESDPEGPIAAQML
                     SFVMDDPDFESEGSDTQRRADDFPVRDDPSDVTDEDEGPAEPPPPPKLPLPAFRLKND
                     SDLFGLGLEEAGPKESSEEGKEGKTPSKEKKKKKKKGKEEEEKAAKKKSKHKKSKDKE
                     EGKEERRRRQQRPPRSRERTAADELEAFLGGGAPGGRHPGGGDYEEL"
     exon            380..514
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..562
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..615
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..707
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..848
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..954
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1058
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1375
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1529
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1742
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2007
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2179
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2238
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3104
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3080..3085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /note="hexamer: CATAAA"
     polyA_site      3104
                     /gene="RABL6"
                     /gene_synonym="C9orf86; PARF; pp8875; RBEL1"
                     /note="major polyA site"
ORIGIN      
        1 agatggcggc gctgactcct ggagagcggt cgcgccggag gccgcggggg ccggagcgga
       61 gcagccgcgg ctgaggttcc cgagtcgccg ctcggggctg cgctccgccg ccgggacccc
      121 ggcctctggc cgcgccggct ccggcctccg ggggggccgg ggccgccggg acatggtgcc
      181 agtcgcaccc cttccccgcc gccgctgagc tcgccggccg cgcccgggct gggacgtccg
      241 agcgggaaga tgttttccgc cctgaagaag ctggtggggt cggaccaggc cccgggccgg
      301 gacaagaaca tccccgccgg gctgcagtcc atgaaccagg cgttgcagag gcgcttcgcc
      361 aagggggtgc agtacaacat gaagatagtg atccggggag acaggaacac gggcaagaca
      421 gcgctgtggc accgcctgca gggccggccg ttcgtggagg agtacatccc cacacaggag
      481 atccaggtca ccagcatcca ctggagctac aagaccacgg atgacatcgt gaaggttgaa
      541 gtctgggatg tagtagacaa aggaaaatgc aaaaagcgag gcgacggctt aaagatggag
      601 aacgaccccc aggaggcgga gtctgaaatg gccctggatg ctgagttcct ggacgtgtac
      661 aagaactgca acggggtggt catgatgttc gacattacca agcagtggac cttcaattac
      721 attctccggg agcttccaaa agtgcccacc cacgtgccag tgtgcgtgct gggaaactac
      781 cgggacatgg gcgagcaccg agtcatcctg ccggacgacg tgcgtgactt catcgacaac
      841 ctggacagac ctccaggttc ctcctacttc cgctatgctg agtcttccat gaagaacagc
      901 ttcggcctaa agtaccttca taagttcttc aatatcccat ttttgcagct tcagagggag
      961 acgctgttgc ggcagctgga gacgaaccag ctggacatgg acgccacgct ggaggagctg
     1021 tcggtgcagc aggagacgga ggaccagaac tacggcatct tcctggagat gatggaggct
     1081 cgcagccgtg gccatgcgtc cccactggcg gccaacgggc agagcccatc cccgggctcc
     1141 cagtcaccag tggtgcctgc aggcgctgtg tccacgggga gctccagccc cggcacaccc
     1201 cagcccgccc cacagctgcc cctcaatgcc gccccaccat cctctgtgcc ccctgtacca
     1261 ccctcagagg ccctgccccc acctgcgtgc ccctcagccc ccgccccacg gcgcagcatc
     1321 atctctaggc tgtttgggac gtcacctgcc accgaggcag cccctccacc tccagagcca
     1381 gtcccggccg cagagggccc agcaacggtc cagagtgtgg aggactttgt tcctgacgac
     1441 cgcctggacc gcagcttcct ggaagacaca acccccgcca gggacgagaa gaaggtgggg
     1501 gccaaggctg cccagcagga cagcgacagt gatggggagg ccctgggcgg caacccgatg
     1561 gtggcagggt tccaggacga tgtggacctc gaagaccagc cacgtgggag tcccccgctg
     1621 cctgcaggcc ccgtccccag tcaagacatc actctttcga gtgaggagga agcagaagtg
     1681 gcagctccca caaaaggccc tgccccagct ccccagcagt gctcagagcc agagaccaag
     1741 tggtcctcca taccagcttc gaagccacgg agggggacag ctcccacgag gaccgcagca
     1801 cccccctggc caggcggtgt ctctgttcgc acaggtccgg agaagcgcag cagcaccagg
     1861 ccccctgctg agatggagcc ggggaagggt gagcaggcct cctcgtcgga gagtgacccc
     1921 gagggaccca ttgctgcaca aatgctgtcc ttcgtcatgg atgaccccga ctttgagagc
     1981 gagggatcag acacacagcg cagggcggat gactttcccg tgcgagatga cccctccgat
     2041 gtgactgacg aggatgaggg ccctgccgag ccgcccccac cccccaagct ccctctcccc
     2101 gccttcagac tgaagaatga ctcggacctc ttcgggctgg ggctggagga ggccggaccc
     2161 aaggagagca gtgaggaagg taaggagggc aaaaccccct ctaaggagaa gaagaagaag
     2221 aagaaaaaag gcaaagagga agaagaaaaa gctgccaaga agaagagcaa acacaagaag
     2281 agcaaggaca aggaggaggg caaggaggag cggcgacggc ggcagcagcg gcccccgcgc
     2341 agcagggaga ggacggctgc cgatgagctg gaggctttcc tggggggcgg ggccccgggc
     2401 ggccgccacc ctgggggtgg cgactacgag gagctctagg ccggcgtggg cagtggccgc
     2461 cctggggcgg ggggcgtgcc tgtcactgcc tggggaggca tttgcctctg taccatcgcc
     2521 tttgccgctg ccccgtggct gccgtgtgcg cttctgagct ggaagaggcc gggcattggt
     2581 ggtccccagg ctgggccctg caggtgctgg gccttcaggc ccagtgtgag cctgctctgc
     2641 aagaagggag gggacagctg gcttcagcca ggctcggtgg acaccctggc cctctcgggg
     2701 cagagccgcc agtgtttctc agggatgtga ctgaggccca ggagggacct gtgagggtct
     2761 gtttacagag gctgggcagg ggccgcttgg ctgtggggtg tgcgctgccc cggcacctgc
     2821 ttgccctccg cgctcatctg gggccgcagc atgcctatgg ttccgcttcc ggccgggagc
     2881 cctgaacacg ggtgtgcaga ctcaccctaa agggcggccc aggccccacg ctagaaggct
     2941 ggcgagaccg aaggcagcat gtgaggcctc tcctgggagt gggggttgtg tttcccacag
     3001 tggcctcagc tgcgcccccg ctcaggtgag cccgaaggca ggagccggga ggcactcctc
     3061 ccaaacactc cactcagacc ataaagcact cctgtttcac tctg
//
