LOCUS       NM_173825               5605 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RAB, member of RAS oncogene family like 3 (RABL3),
            transcript variant 2, mRNA.
ACCESSION   NM_173825
VERSION     NM_173825.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5605)
  AUTHORS   Ma,Y., Ren,Y., Wen,H. and Cui,C.
  TITLE     circCOL1A1 Promotes the Progression of Gastric Cancer Cells through
            Sponging miR-145 to Enhance RABL3 Expression
  JOURNAL   J Immunol Res 2021, 6724854 (2021)
   PUBMED   34631898
  REMARK    GeneRIF: circCOL1A1 Promotes the Progression of Gastric Cancer
            Cells through Sponging miR-145 to Enhance RABL3 Expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5605)
  AUTHORS   Roberts,N.J., Grant,R.C., Gallinger,S. and Klein,A.P.
  CONSRTM   Familial Pancreatic Cancer Genome Sequencing Project
  TITLE     Germline sequence analysis of RABL3 in a large series of pancreatic
            ductal adenocarcinoma patients reveals no evidence of deleterious
            variants
  JOURNAL   Genes Chromosomes Cancer 60 (8), 559-564 (2021)
   PUBMED   33724601
  REMARK    GeneRIF: Germline sequence analysis of RABL3 in a large series of
            pancreatic ductal adenocarcinoma patients reveals no evidence of
            deleterious variants.
REFERENCE   3  (bases 1 to 5605)
  AUTHORS   Xu,Z., Li,H., Lin,C., Zeng,B., Chen,Y. and Luo,Y.
  TITLE     Knockdown of RABL3 suppresses the proliferation and invasion of
            oral squamous cell carcinoma through inactivating the FAK/AKT
            pathway
  JOURNAL   J Bioenerg Biomembr 53 (2), 203-211 (2021)
   PUBMED   33438143
  REMARK    GeneRIF: Knockdown of RABL3 suppresses the proliferation and
            invasion of oral squamous cell carcinoma through inactivating the
            FAK/AKT pathway.
REFERENCE   4  (bases 1 to 5605)
  AUTHORS   Puzzono,M., Crippa,S., Zuppardo,R.A., Zapparoli,E., Falconi,M. and
            Cavestro,G.M.
  TITLE     Low-frequency of RABL3 pathogenetic variants in hereditary and
            familial pancreatic cancer
  JOURNAL   Dig Liver Dis 53 (4), 519-521 (2021)
   PUBMED   33353859
  REMARK    GeneRIF: Low-frequency of RABL3 pathogenetic variants in hereditary
            and familial pancreatic cancer.
REFERENCE   5  (bases 1 to 5605)
  AUTHORS   Qi,W.Y., Mao,X.B., He,Y.B. and Xiao,C.H.
  TITLE     Long non-coding RNA LINC00858 promotes cells proliferation and
            invasion through the miR-153-3p/Rabl3 axis in hepatocellular
            carcinoma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (18), 9343-9352 (2020)
   PUBMED   33015775
  REMARK    GeneRIF: Long non-coding RNA LINC00858 promotes cells proliferation
            and invasion through the miR-153-3p/Rabl3 axis in hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 5605)
  AUTHORS   An,J., Liu,Z., Liang,Q., Pan,Y., Li,H., Wang,R. and Jin,Y.
  TITLE     Overexpression of Rabl3 and Cullin7 is associated with pathogenesis
            and poor prognosis in hepatocellular carcinoma
  JOURNAL   Hum Pathol 67, 146-151 (2017)
   PUBMED   28739496
  REMARK    GeneRIF: Hepatocellular carcinoma patients with positive expression
            for both Rabl3 and Cullin7 had a remarkably shorter survival time
            compared with patients with negative expression for both proteins.
REFERENCE   7  (bases 1 to 5605)
  AUTHORS   Pan,Y., Liu,Z., Feng,Z., Hui,D., Huang,X., Tong,D. and Jin,Y.
  TITLE     The overexpression of Rabl3 is associated with pathogenesis and
            clinicopathologic variables in hepatocellular carcinoma
  JOURNAL   Tumour Biol 39 (4), 1010428317696230 (2017)
   PUBMED   28443498
  REMARK    GeneRIF: Our studies suggest that the Rabl3 is a valuable marker of
            hepatocellular carcinoma progression and that the overexpression of
            Rabl3 plays an important role in the development and pathogenesis
            of hepatocellular carcinoma.
REFERENCE   8  (bases 1 to 5605)
  AUTHORS   Zhang,W., Sun,J. and Luo,J.
  TITLE     High Expression of Rab-like 3 (Rabl3) is Associated with Poor
            Survival of Patients with Non-Small Cell Lung Cancer via Repression
            of MAPK8/9/10-Mediated Autophagy
  JOURNAL   Med Sci Monit 22, 1582-1588 (2016)
   PUBMED   27164297
  REMARK    GeneRIF: We examine the correlation between the expression level of
            Rabl3 and survival of non-small cell lung cancer (NSCLC) patients
            in three independent cohorts containing 484 patients. We found high
            expression of Rabl3 might inhibit cell death in non-small cell lung
            cancer via repression of MAPK8/9/10-mediated autophagy
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5605)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   10 (bases 1 to 5605)
  AUTHORS   Li,Q., Wang,L., Zeng,L., Zhang,Y., Li,K., Jin,P., Su,B. and Wang,L.
  TITLE     Evaluation of the novel gene Rabl3 in the regulation of
            proliferation and motility in human cancer cells
  JOURNAL   Oncol Rep 24 (2), 433-440 (2010)
   PUBMED   20596630
  REMARK    GeneRIF: Rabl3 can be considered as a novel candidate in the
            control of tumorigenesis and as a new target for anticancer
            treatment.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647593.1 and AC133474.2.
            
            On Aug 29, 2019 this sequence version replaced NM_173825.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020832.1, SRR1803617.129596.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273375.8/ ENSP00000273375.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              BX647593.1         22-1320
            1300-5605           AC133474.2         21163-25468
FEATURES             Location/Qualifiers
     source          1..5605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..5605
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="RAB, member of RAS oncogene family like 3"
                     /db_xref="GeneID:285282"
                     /db_xref="HGNC:HGNC:18072"
                     /db_xref="MIM:618542"
     exon            1..55
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..720
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rab-like protein 3"
                     /codon_start=1
                     /product="rab-like protein 3 isoform 2"
                     /protein_id="NP_776186.2"
                     /db_xref="CCDS:CCDS3001.1"
                     /db_xref="GeneID:285282"
                     /db_xref="HGNC:HGNC:18072"
                     /db_xref="MIM:618542"
                     /translation="MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVD
                     VRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIIFVHDLTNKKS
                     SQNLRRWSLEALNRDLVPTGVLVTNGDYDQEQFADNQIPLLVIGTKLDQIHETKRHEV
                     LTRTAFLAEDFNPEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPG
                     FPDRKRFGAGTLKSLHYD"
     exon            56..147
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            148..277
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            278..392
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            393..543
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            544..615
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            616..654
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     exon            655..5605
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3290..3295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="hexamer: AATAAA"
     polyA_site      3316
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="major polyA site"
     regulatory      3836..3841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="hexamer: AATAAA"
     polyA_site      3862
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="major polyA site"
     regulatory      4770..4775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="hexamer: AATAAA"
     polyA_site      4794
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
     regulatory      4928..4933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="hexamer: ATTAAA"
     polyA_site      4970
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
     regulatory      5571..5576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
                     /note="hexamer: ATTAAA"
     polyA_site      5605
                     /gene="RABL3"
                     /gene_synonym="PNCA5"
ORIGIN      
        1 agtggcaaga tggcgtccct ggatcgggtg aaggtactgg tgttgggaga ctcaggtgtt
       61 gggaaatctt cgttagtcca tctcctatgc caaaatcaag tgctgggaaa tccatcatgg
      121 actgtgggct gctcagtgga tgtcagagtt catgattaca aagaaggaac cccagaagag
      181 aagacctact acatagaatt atgggatgtt ggaggctctg tgggcagtgc cagcagcgtg
      241 aaaagcacaa gagcagtatt ctacaactcc gtaaatggta ttattttcgt acacgactta
      301 acaaataaga agtcctccca aaacttgcgt cgttggtcat tggaagctct caacagggat
      361 ttggtgccaa ctggagtctt ggtgacaaat ggggattatg atcaagaaca gtttgctgat
      421 aaccaaatac cactgttggt aatagggact aaactggacc agattcatga aacaaagcgc
      481 catgaagttt taactaggac tgctttcctg gctgaggatt tcaatccaga agaaattaat
      541 ttggactgca caaatccacg gtacttagct gcaggttctt ccaatgctgt caagctcagt
      601 aggttttttg ataaggtcat agagaagaga tactttttaa gagaaggtaa tcagattcca
      661 ggctttcctg atcggaaaag atttggggca ggaacattaa agagccttca ttatgactga
      721 attacactca tcctttggaa gagtgagcaa gcagtggcag tttttcacag ctcatcttgc
      781 tgtgttcaat tattaccatc acagcctttt aacaaaatca tcttaaaatg ctacccttca
      841 gccttaccct ttaatggaaa aatgaaagga agtgacaata cgggaggtcc aaactttgtc
      901 cctgttctct gtgttcctta cctttctgtc cctgtgtata gattatgtaa aagccttgtg
      961 taaatatgag atgttgtcaa aatgatgcag taaatgagca atgacagtgt actgcagaga
     1021 aaatttactc ttgcctagaa ctggagggtt tttatgggtc tgtaattttc ccacactcat
     1081 tgctgaaagc ttaattaagt acttcaaaaa cgtatctcca ttgttttacc ttcttgaggg
     1141 gaacggtctt gttaaccagc cctgagttgt ctaccccaaa caatctctgt cattttcaaa
     1201 gatgcaaaat ggtgttattt aattgtctcc accattgtca cacacaggaa tgcctaataa
     1261 tagcaaccct tgtctccctc ttctctcctt tgcaaatggc tcagtgactg gaagaggcgg
     1321 actaatagcc agagttaaat ataaatacaa attaataata catagagaac agcaatacca
     1381 gaaaaaaaga attctggtaa aatgatgtga aaaattgaca gctccctcac tcttaaggtt
     1441 gctgctatat acagtctagg ttttctgttt ggaaataggt agggtaaaat ctaagacctg
     1501 cacaagggca gtgagagaca tttacagcct cctctctatt tgttttttta aggaaaagtc
     1561 aactcctgaa atgtccctta gctataatca gaaaactaag aatattattc tgtgtcaaca
     1621 atgtatttat ggagagaagt aaaaataagt tccacagcaa cacatttaca tgaattatga
     1681 actaggattc ttggatttca taatcactcc aaagcttttt ggggatggtg tgtgtgtgtg
     1741 tgtgtgtccg taattgttca tcattacttt ttttaaccta tctttttgct tgcttaatct
     1801 tctctgcccc agttcttcct gagtatatga atttgatttc taaaaacaat ttattcaaca
     1861 ctctatcacc cgtattctct ctctggctct gctgcaggtc tctgcactcc tgattttgct
     1921 ccatactttt aaataacaat aataaatata cagttttcat ttctcattta aaaaataggt
     1981 ggaaaacacc aaattcactt tctgttccat tttaattagg tttcagaagt atcttggaaa
     2041 tcaaggtatg ctgcaagagg atattaaaat aagaatgtta gagagtcctt ttagaaaggc
     2101 agtcttggga atttggaaaa ggatttttaa agcagctttc atcagctaga ctgttctcca
     2161 gcctttcttt acttcctctt tgaaaggaca tagccctggt ttctttttga cacaaaggaa
     2221 agctatgcaa atcatgatct gtatgtagaa ttggtcacaa gtatgttgtt gcataggctg
     2281 tacagttggg aagtagaaac caaatgctac ccagagacct aacccaatta agctctttgt
     2341 atttctcctt caagaaataa atcttccttc cttctttctt cctctttctt ttaattttaa
     2401 aaaaattcat cctgattttt ttattttcta tcttatttaa aaaataaaaa taggccaggc
     2461 gcggtggctc acacctttaa tcccaacact ttgggaggcg ggtcgatcac ttgatatcag
     2521 gagtttgaga ccagcctggc caacataggg aaaccctgtc tctactaaaa atacaaaaat
     2581 tagccaggcc tggtggcacg cgcctgtaat cccagctact tgggaggctg aggcaggaga
     2641 atcacttgaa cctgggaggt ggaggttgca gtgagtcaag atcgtgtcac tgcactccag
     2701 cctaggtgac agagtgagac tccaactaaa agaaaataaa taaataaata tataaatata
     2761 taaataaata ataaaagtaa actattgctg atgactccag ggtcaatctg gaaaaattaa
     2821 cagtattcct caactccatt actttctgca gccaagcttg attccttgaa ttatagtttt
     2881 ctaagaaaaa atagttttta ataatctaag gtaaatttgt tgcaattatt agcagcagca
     2941 taataaggct ttttgcgcaa atgaatgtta ttagctagag ttattcaaaa aagaatgaag
     3001 cacaattttt gctaggactt cttgagaact attcataaaa atgcttttag ataataaaca
     3061 agtataaatg tcaaaatatt tttttaaaag tataattggc caggtgctgg ctcacgccta
     3121 taatcccagc actctaggag actgaggcag gaggatcact tgagctcggg agtttgaggc
     3181 tgcagtgatt catgattgca ccactgcctt ccagcagcct gatgacagag tgggactcca
     3241 tctctttaca tatgtatatc ttactctctt gatgggacaa gttggtagaa ataaagattt
     3301 tttttttctg ttgtgatttc ggtgtctgac caattttctg actcattgtg aaggtgacca
     3361 gatatgaagg catatatatg actactcctc tgtcccttag gtgtataaga cttagctgga
     3421 atccaactaa agatttgggc tggtctctcc atcttaacgt tgatgggatt caggacacat
     3481 aaccccaaaa tattgcaccc tgttatttga gaaaactgca gaagcaaggt ttctcatacc
     3541 ttccccttac cccttctccc ctgaagcagg ccataaaccc taagtgactg ttccctgaag
     3601 tagatcataa aaccttcatt ccataggtac cctttatcct cacagataca gagacaccaa
     3661 gaagaatctg gacaaatagg acttgctaag ttctccacag tttattacca ttagattatg
     3721 tccttttgtc ctctgattat acttctgcat aagactgtac ataaaaatac acaagttttc
     3781 ctatttcttt tttgtcttca tttctgaaga ttcctgtcat gtaaaactta cagtaaataa
     3841 atgtgtgtgc ttttctcaat aatctgtctt tcgttatagg tgcctcattt gtgaacctag
     3901 tgatgggtga agaaagaaag ctcttctccg ctacagtgct ctaagaaaag ctattcccaa
     3961 aagagttgat ccatattagc tttagctcgg gttcttagaa ttcctcaaac ttgaggcatt
     4021 catgatataa tccaggtgcc ctgacacttg tttttctgtt cattctgaca tggacttcat
     4081 ggaaatgatg tgcagggaca tcagactgag gtgaagagct cctaattgct ccttgtaatc
     4141 agagtttctg agtcctcatt tcaatagttt gcagtagcac ccaccatagg taggaccttg
     4201 tatgggttac tagatggtgg cttaattgaa ttttttaaag cacaggtgac atcatatttt
     4261 aagaagttta aaggtctaac agggtgtctg cattggttta atatatgtta aaattcaaag
     4321 gaggagtctg ttttggggaa aggaggagaa ggaaattaga aattcatttc tccgcagtcc
     4381 caagactgag ctaaatcact gtggtgggag aggaagggtc gcaggaagtc taaccctgtg
     4441 tctcaaatat ttcacaacat gtttgcctac acaaaatatc tgatgttagg gtcagctggg
     4501 gctgctccat agcatagtaa aggaattgga catccagtta caattaatct gcacctccat
     4561 taaggactca catggagggc tttcaaactc tgaagtgtgt aagaatcccc tgaagtgctt
     4621 gctgaaaatg cagattccac gatttcctct ctcttccctt actctcccct ttctatatgt
     4681 ataggataag gccaggattt tgtattttta acagacaagc cagatttttc tcatgcagat
     4741 aagtcaggat ctagccttta agaaagacaa ataaactcat caaaaagtag ggaatataga
     4801 ttgtgaactc tgtactttat gagtgccatt atagcagaat tcatcaaagc gcatctttga
     4861 ctgcctcaac ctgatctcac cttaatgaac tgatccactc ctccccactc aaagctacat
     4921 atgccaaatt aaacatgaga tgattgtcat gtcttctgtt ggcaaaacaa gtatttgtct
     4981 ttcatgtatt gctatcattt ttattactgc cactgttttt cccctgggtt ctgtttttaa
     5041 tccaaatata tttatttcta accagtgcct tgccatctta cacacagccc cctctctagt
     5101 actgtgtttt ctcagctggc taatcactaa gctttaccga ggtcatcaat aactaatgac
     5161 aaagaatgga acccctaaac tccaaccaag gtgtaaaacc tcgctcagta ccatcaagta
     5221 tatcaggtaa tctctccgtt ccatcttttt ctcggagaca tctgtcctgg agtcctctga
     5281 tgcctaactc cgttttggag tgattactct gtagacctgt cacaccctgc ttcacattac
     5341 cttgtagcaa ttcctggatg taatgttttc cactttctat ccaactctta ctctatggga
     5401 cttggctcag acatagtctt ctctgggaag ccctccctgg ctctgctcgt ctgggctacg
     5461 tgcccactag tgcttcccct agatccctgg gctctttcct gtcagagcac ttacactatg
     5521 ttgtgatggt tttcaaaaat tgttaaataa atgaatgtat aattacatta attaaaatgg
     5581 aaagccatta gacatagaat cagaa
//
