LOCUS       NM_002871               3119 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RAB interacting factor (RABIF), mRNA.
ACCESSION   NM_002871
VERSION     NM_002871.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Feng,N., Zhang,R., Wen,X., Wang,W., Zhang,N., Zheng,J., Zhang,L.
            and Liu,N.
  TITLE     RABIF promotes hepatocellular carcinoma progression through
            regulation of mitophagy and glycolysis
  JOURNAL   Commun Biol 7 (1), 1333 (2024)
   PUBMED   39414994
  REMARK    GeneRIF: RABIF promotes hepatocellular carcinoma progression
            through regulation of mitophagy and glycolysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Chen,Y., Li,Y. and Zhou,B.
  TITLE     Identification of the Roles of Coagulation-related Signature and
            its Key Factor RABIF in Hepatoma Cell Malignancy
  JOURNAL   Recent Pat Anticancer Drug Discov 19 (5), 695-710 (2024)
   PUBMED   37644748
  REMARK    GeneRIF: Identification of the Roles of Coagulation-related
            Signature and its Key Factor RABIF in Hepatoma Cell Malignancy.
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Wixler,V., Laplantine,E., Geerts,D., Sonnenberg,A., Petersohn,D.,
            Eckes,B., Paulsson,M. and Aumailley,M.
  TITLE     Identification of novel interaction partners for the conserved
            membrane proximal region of alpha-integrin cytoplasmic domains
  JOURNAL   FEBS Lett 445 (2-3), 351-355 (1999)
   PUBMED   10094488
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Muller-Pillasch,F., Zimmerhackl,F., Lacher,U., Schultz,N.,
            Hameister,H., Varga,G., Friess,H., Buchler,M., Adler,G. and
            Gress,T.M.
  TITLE     Cloning of novel transcripts of the human
            guanine-nucleotide-exchange factor Mss4: in situ chromosomal
            mapping and expression in pancreatic cancer
  JOURNAL   Genomics 46 (3), 389-396 (1997)
   PUBMED   9441742
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Burton,J.L., Slepnev,V. and De Camilli,P.V.
  TITLE     An evolutionarily conserved domain in a subfamily of Rabs is
            crucial for the interaction with the guanyl nucleotide exchange
            factor Mss4
  JOURNAL   J Biol Chem 272 (6), 3663-3668 (1997)
   PUBMED   9013620
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Yu,H. and Schreiber,S.L.
  TITLE     Structure of guanine-nucleotide-exchange factor human Mss4 and
            identification of its Rab-interacting surface
  JOURNAL   Nature 376 (6543), 788-791 (1995)
   PUBMED   7651540
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Yu,H. and Schreiber,S.L.
  TITLE     Cloning, Zn2+ binding, and structural characterization of the
            guanine nucleotide exchange factor human Mss4
  JOURNAL   Biochemistry 34 (28), 9103-9110 (1995)
   PUBMED   7619808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098934.3.
            
            On May 17, 2019 this sequence version replaced NM_002871.4.
            
            Summary: This gene encodes a member of the SCE4/YPT1/RAB family of
            small GTP-binding proteins that are involved in the regulation of
            intracellular vesicular transport. This protein stimulates GTP-GDP
            exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may
            play a general role in vesicular transport. [provided by RefSeq,
            Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.41507.1,
                                           SRR1803615.120745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMEA2152568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367262.4/ ENSP00000356231.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC098934.3         150143-150319       c
            178-3119            AC098934.3         139452-142393       c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3119
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /note="RAB interacting factor"
                     /db_xref="GeneID:5877"
                     /db_xref="HGNC:HGNC:9797"
                     /db_xref="MIM:603417"
     exon            1..177
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..423
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /note="Ras-specific guanine-releasing factor 3; mammalian
                     suppressor of SEC4; rab-interacting factor"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor MSS4"
                     /protein_id="NP_002862.2"
                     /db_xref="CCDS:CCDS1428.1"
                     /db_xref="GeneID:5877"
                     /db_xref="HGNC:HGNC:9797"
                     /db_xref="MIM:603417"
                     /translation="MEPAEQPSELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLF
                     LPSMRKKPALSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPI
                     GWHCLDDKNSFYVALERVSHE"
     exon            178..3119
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      944
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /note="hexamer: AACAAA"
     polyA_site      2234
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /note="hexamer: AATAAA"
     polyA_site      2444
                     /gene="RABIF"
                     /gene_synonym="MSS4; RASGFR3; RASGRF3"
                     /note="major polyA site"
ORIGIN      
        1 agagacagcg tctgcgcagc cgtggctgag gagcctgtgg cggcagcggc gatggaacca
       61 gcggagcagc cgagcgagtt agtgtcagcc gagggccgaa accggaaggc ggtgctgtgc
      121 cagcgttgcg gctcccgggt gctgcagcca gggaccgctc tcttctctcg ccgacagctt
      181 ttccttccct ccatgagaaa gaagccagct ctgtctgacg gcagcaatcc tgacggcgat
      241 ctcctccagg aacactggct ggttgaggac atgttcattt ttgagaatgt gggcttcacc
      301 aaggacgtgg gcaacatcaa gtttctggtc tgcgcagact gtgaaattgg accaattggc
      361 tggcattgcc tagatgacaa gaacagtttc tatgtggcct tggaacgagt ttcccatgag
      421 taactgaggg gaggggtact cagctccatc tccaaagata aacctactcc ccacaagaac
      481 tggcctttaa tgtggtataa ctgttccgct gccttcttgt ctgtgctaat ataaatactg
      541 agtaccagca tgtccatttg aacatgcaga gggttaatcc tgcttcctaa agcctcaagt
      601 acatgcctcc tgcttagttc actttgtatc acatttccta agctcccttt tcccccagtt
      661 ttgggacact gtgcttacct ccaaaaatct catctcttcc ctggcattct ccctaggctc
      721 tgttttgccc aggggctccc gctttttctt gctctagaag agcagtattc aaccttttag
      781 ctatgatgac acataacaaa agatgcttat gtactaatag ttgaaatctg cctttttctc
      841 attcaagaag gcatacaaat atctgagagt gactttgttg tatggctacc cttgtgatct
      901 acagtaattt attctttcta aaggtaaagc attttcaaaa ctcagtattt aaaccactaa
      961 ccagaaacat tactttggat gcatctctaa taccatgttt gagcacctct gctctaggtt
     1021 gagaatgaca ttttattgtg aagatgggtg tggtccctct tcccttgaaa tcttgtagtt
     1081 tctttttata ttagctcctc actgctacag cctagaaggt gagaagcaga ttttaacccc
     1141 atctggcagc cattcaagga aaacccagcc ctggctgttt actcaggctc tcttagaatg
     1201 agagtggagg gtgtaggata tgagggttag gcctttgcca cattatacaa aagtttataa
     1261 tttgccacat ctggacaagt aactttcttc ttttgttcat aggcaagact tctttaatgg
     1321 atagtatcat ttactgaacc tactgggcat ggtcctcatg gagttttggt tcaactggaa
     1381 tctctgtgcc aacccaggat acaaacttcc atccagatgc atggatacaa atttccatag
     1441 ctccggggct gctctaacag tttgatatca gcagacgtgt ttaagccttc aacttgattt
     1501 ccaattattc catcatttct attctgaaat gactcactgt cgtagaagga agtttattat
     1561 ataaccaagg tttcaggtat cctcctgtca ccacctctac tattcaggag gcctaaaatt
     1621 gaaataagta ctaaacagaa accttaccat ctgaagtccc ttccattgtt ttctagttgc
     1681 ttcctcattc ctttaccccc aaactttcta agggctcccc gactgcagtg caaggtggcc
     1741 ttgggcacag ttttgcaacc aacctactcc cctggaaaga tggcttcctt ctccaattag
     1801 cctgaatgag ctttagtaag caattgagag aactgtgttt ttccgacaaa cggtcacatg
     1861 tccatcgtta tggcatgtgc agaaaaacag agttatccac acaagtcagg agcaaaaccc
     1921 aagtagatgc ctctaggggc acatggcccc tcacatcaca agccagaacc taagctaagc
     1981 attttttaaa ttgagtttga gactagcctg ggcaacatag tgagacccca tctctattta
     2041 aaaaatgaac aaaattacct gggcatagtg gtgtatacct gtagtccctg ctacttggga
     2101 ggctcaggtg ggaggatcac ttgagcccca aagatggtgg ctgcagtaag ccaagatcac
     2161 accactggca ctccagcctg ggcaacagag tgagaccctg tctcaaacaa acaacaacag
     2221 taacaacaaa aaaatatata gcgacttgaa taggaaacca tagtatttca ttgttttaat
     2281 ttgcatttat tttatttcta gtgaaacttt tatatacgta tcggtcattt ctatttcctt
     2341 ttttgagaac tgccaaatgt tgccctagta gccaaaaata tcaggttgct attctgcctt
     2401 ttcagtttga tctgaaagaa ataaaggcat ttaagcaatg gaaattagat ttctgcatgt
     2461 ccttgggaag aatatataaa ttgaaaaaac aaaggagagc tgaaacctga accttggggt
     2521 ttagcttaag gtcaaccaac tgattatcta gtcagctata aaatgcaaac gtcatttctt
     2581 catttccctc acacctaata ggctctcagt acatacttgt gaatcagctg ctatttgctg
     2641 tgggtagata gaggcaacct gtgctttctg ctccgagtat agaaacttcc gttttctatt
     2701 ggggagagca gttgattttg tgaaagcctg attgtttcca cataattgtc tgttgtttta
     2761 caaaaacatg gaatcaaaga tgggcagtgg tgtactgaca tttcacaaat tgtcaccatg
     2821 ttgtatatga ggctacacat gtaactgagt aactatgagg acttctgctt ctgataatgg
     2881 tggataggtc ctttggacta cccagctcac tggttaacta gaaaggctgg acaaaatact
     2941 ttagaaatct gtgtgaacac accaagagag ccgacttgac tttgaagaat tgctaaacca
     3001 ggacagcaga ggagatggga accctgggag gtgggcttgg tgtgagggcc accgttctcc
     3061 tgggagcatt tgccaaactt ggaggtgatt cagaggctta gcagtgattt tagcagcct
//
