LOCUS       NM_004582               1448 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Rab geranylgeranyltransferase subunit beta (RABGGTB),
            transcript variant 1, mRNA.
ACCESSION   NM_004582
VERSION     NM_004582.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Shirakawa,R., Goto-Ito,S., Goto,K., Wakayama,S., Kubo,H.,
            Sakata,N., Trinh,D.A., Yamagata,A., Sato,Y., Masumoto,H., Cheng,J.,
            Fujimoto,T., Fukai,S. and Horiuchi,H.
  TITLE     A SNARE geranylgeranyltransferase essential for the organization of
            the Golgi apparatus
  JOURNAL   EMBO J 39 (8), e104120 (2020)
   PUBMED   32128853
  REMARK    GeneRIF: A SNARE geranylgeranyltransferase essential for the
            organization of the Golgi apparatus.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Kuchay,S., Wang,H., Marzio,A., Jain,K., Homer,H., Fehrenbacher,N.,
            Philips,M.R., Zheng,N. and Pagano,M.
  TITLE     GGTase3 is a newly identified geranylgeranyltransferase targeting a
            ubiquitin ligase
  JOURNAL   Nat Struct Mol Biol 26 (7), 628-636 (2019)
   PUBMED   31209342
  REMARK    GeneRIF: This study reports the identification of a previously
            unknown human prenyltransferase complex consisting of an orphan
            prenyltransferase alpha subunit, PTAR1, and the catalytic
            beta-subunit of GGTase2, RabGGTB.
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Farnsworth,C.C., Seabra,M.C., Ericsson,L.H., Gelb,M.H. and
            Glomset,J.A.
  TITLE     Rab geranylgeranyl transferase catalyzes the geranylgeranylation of
            adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11963-11967 (1994)
   PUBMED   7991565
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Beranger,F., Cadwallader,K., Porfiri,E., Powers,S., Evans,T., de
            Gunzburg,J. and Hancock,J.F.
  TITLE     Determination of structural requirements for the interaction of
            Rab6 with RabGDI and Rab geranylgeranyltransferase
  JOURNAL   J Biol Chem 269 (18), 13637-13643 (1994)
   PUBMED   8175798
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Armstrong,S.A., Seabra,M.C., Sudhof,T.C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     cDNA cloning and expression of the alpha and beta subunits of rat
            Rab geranylgeranyl transferase
  JOURNAL   J Biol Chem 268 (16), 12221-12229 (1993)
   PUBMED   8505342
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Seabra,M.C., Brown,M.S. and Goldstein,J.L.
  TITLE     Retinal degeneration in choroideremia: deficiency of rab
            geranylgeranyl transferase
  JOURNAL   Science 259 (5093), 377-381 (1993)
   PUBMED   8380507
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   van den Hurk,J.A., van de Pol,T.J., Molloy,C.M., Brunsmann,F.,
            Ruther,K., Zrenner,E., Pinckers,A.J., Pawlowitzki,I.H.,
            Bleeker-Wagemakers,E.M., Wieringa,B. et al.
  TITLE     Detection and characterization of point mutations in the
            choroideremia candidate gene by PCR-SSCP analysis and direct DNA
            sequencing
  JOURNAL   Am J Hum Genet 50 (6), 1195-1202 (1992)
   PUBMED   1598901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020790.1, AL357314.11 and
            BQ773824.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004582.3.
            
            Summary: This gene encodes the beta-subunit of the enzyme Rab
            geranylgeranyl-transferase (RabGGTase), which belongs to the
            protein prenyltransferase family. RabGGTase catalyzes the
            post-translational addition of geranylgeranyl groups to C-terminal
            cysteine residues of Rab GTPases. Three small nucleolar RNA genes
            are present in the intronic regions of this gene. Alternately
            spliced transcript variants have been observed for this gene. A
            pseudogene associated with this gene is located on chromosome 3.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.140872.1,
                                           SRR5189661.109385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319942.8/ ENSP00000317473.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-621               BC020790.1         56-676
            622-622             AL357314.11        79291-79291
            623-1441            BC020790.1         678-1496
            1442-1448           BQ773824.1         22-28               c
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1448
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /note="Rab geranylgeranyltransferase subunit beta"
                     /db_xref="GeneID:5876"
                     /db_xref="HGNC:HGNC:9796"
                     /db_xref="MIM:179080"
     exon            1..19
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1012
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /EC_number="2.5.1.60"
                     /note="GGTase-II-beta; rab GGTase beta; rab GG transferase
                     beta; type II protein geranyl-geranyltransferase subunit
                     beta; Rab geranylgeranyltransferase beta subunit"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-2 subunit beta"
                     /protein_id="NP_004573.2"
                     /db_xref="CCDS:CCDS669.1"
                     /db_xref="GeneID:5876"
                     /db_xref="HGNC:HGNC:9796"
                     /db_xref="MIM:179080"
                     /translation="MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEY
                     LRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAV
                     QILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLD
                     AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWW
                     LCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG
                     GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS"
     exon            20..127
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            128..325
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            326..431
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            432..484
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            485..595
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            596..721
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            722..871
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1448
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /note="hexamer: AATAAA"
     polyA_site      1153
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /note="hexamer: ATTAAA"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
                     /note="major polyA site"
     polyA_site      1448
                     /gene="RABGGTB"
                     /gene_synonym="GGTB"
ORIGIN      
        1 cctttccctg ttagacatgg gcactccaca gaaggatgtt attatcaagt cagatgcacc
       61 ggacactttg ttattggaga aacatgcaga ttatatcgca tcctatggct caaagaaaga
      121 tgattatgaa tactgtatgt ctgagtattt gagaatgagt ggcatctatt ggggtctgac
      181 agtaatggat ctcatgggac aacttcatcg catgaataga gaagagattc tggcatttat
      241 taagtcttgc caacatgaat gtggtggaat aagtgctagt atcggacatg atcctcatct
      301 tttatacact cttagtgctg tccagattct tacgctgtat gacagtatta atgttattga
      361 cgtaaataaa gttgtggaat atgttaaagg tctacagaaa gaagatggtt cttttgctgg
      421 agatatttgg ggagaaattg acacaagatt ctctttttgt gcggtggcaa ctttggcttt
      481 gttggggaag cttgatgcta ttaatgtgga aaaggcaatc gaatttgttt tatcctgtat
      541 gaactttgac ggtggatttg gttgcagacc aggttctgaa tcccatgctg ggcagatcta
      601 ttgttgcaca ggatttctgg caattacaag tcagttgcat caagtaaatt ctgatttact
      661 tggctggtgg ctttgtgaac gacaattacc ctcaggcggg ctcaatggaa ggccggagaa
      721 gttaccagat gtatgctact catggtgggt cctggcttcc ctaaagataa ttggaagact
      781 tcattggatt gatagagaga aactgcgtaa tttcatttta gcatgtcaag atgaagaaac
      841 ggggggattt gcagacaggc caggagatat ggtggatcct tttcatacct tatttggaat
      901 tgctggattg tcacttttgg gagaagaaca gattaaacct gttaatcctg tcttttgcat
      961 gcctgaagaa gtgcttcaga gagtgaatgt tcagcctgag ctagtgagct agattcattg
     1021 aattgaaagt tgcatagtat agttttgcca ttttaacatt tctgtatttg aagtgcttat
     1081 cgaatctaaa agtgactact gttaatattt tgtatattgt gttaaattaa ttttaataaa
     1141 ttatataatt atacatattg taaaataaag accggtattt tattttctgc tttttattct
     1201 gaagtcctgt tattctgact acagttcttt gtgtatactt ctgtgtctgt tatgttcaat
     1261 aactgagcta acataaaata actctaggtt tctacttgat ttttccccca tgtatacctt
     1321 tcatctgttc tatagcaagt tgatgtaaat tggtttgtca acaagaatgt taactgatga
     1381 aagtggatag aacccataca tgaattaaat gatgcacaaa ataaatggct gttgaaattt
     1441 ggaaatga
//
