LOCUS       NM_182836               1946 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Rab geranylgeranyltransferase subunit alpha (RABGGTA),
            transcript variant 1, mRNA.
ACCESSION   NM_182836
VERSION     NM_182836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Esposito,G., De Falco,F., Tinto,N., Testa,F., Vitagliano,L.,
            Tandurella,I.C., Iannone,L., Rossi,S., Rinaldi,E., Simonelli,F.,
            Zagari,A. and Salvatore,F.
  TITLE     Comprehensive mutation analysis (20 families) of the choroideremia
            gene reveals a missense variant that prevents the binding of REP1
            with Rab geranylgeranyl transferase
  JOURNAL   Hum Mutat 32 (12), 1460-1469 (2011)
   PUBMED   21905166
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   van Bokhoven,H., Rawson,R.B., Merkx,G.F., Cremers,F.P. and
            Seabra,M.C.
  TITLE     cDNA cloning and chromosomal localization of the genes encoding the
            alpha- and beta-subunits of human Rab geranylgeranyl transferase:
            the 3' end of the alpha-subunit gene overlaps with the
            transglutaminase 1 gene promoter
  JOURNAL   Genomics 38 (2), 133-140 (1996)
   PUBMED   8954794
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Farnsworth,C.C., Seabra,M.C., Ericsson,L.H., Gelb,M.H. and
            Glomset,J.A.
  TITLE     Rab geranylgeranyl transferase catalyzes the geranylgeranylation of
            adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11963-11967 (1994)
   PUBMED   7991565
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Armstrong,S.A., Seabra,M.C., Sudhof,T.C., Goldstein,J.L. and
            Brown,M.S.
  TITLE     cDNA cloning and expression of the alpha and beta subunits of rat
            Rab geranylgeranyl transferase
  JOURNAL   J Biol Chem 268 (16), 12221-12229 (1993)
   PUBMED   8505342
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Seabra,M.C., Brown,M.S. and Goldstein,J.L.
  TITLE     Retinal degeneration in choroideremia: deficiency of rab
            geranylgeranyl transferase
  JOURNAL   Science 259 (5093), 377-381 (1993)
   PUBMED   8380507
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Seabra,M.C., Reiss,Y., Casey,P.J., Brown,M.S. and Goldstein,J.L.
  TITLE     Protein farnesyltransferase and geranylgeranyltransferase share a
            common alpha subunit
  JOURNAL   Cell 65 (3), 429-434 (1991)
   PUBMED   2018975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA379718.1 and BC003093.1.
            
            On Aug 14, 2020 this sequence version replaced NM_182836.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003093.1, SRR14038195.2593315.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216840.11/ ENSP00000216840.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA379718.1         31-62
            33-1946             BC003093.1         1-1914
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1946
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /note="Rab geranylgeranyltransferase subunit alpha"
                     /db_xref="GeneID:5875"
                     /db_xref="HGNC:HGNC:9795"
                     /db_xref="MIM:601905"
     exon            1..111
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            112..168
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1869
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /EC_number="2.5.1.60"
                     /note="protein prenyltransferase alpha subunit repeat
                     containing 3; geranylgeranyl transferase type II subunit
                     alpha; Rab GGTase alpha; Rab GG transferase alpha; rab
                     geranyl-geranyltransferase subunit alpha; Rab
                     geranylgeranyltransferase alpha subunit"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-2 subunit alpha"
                     /protein_id="NP_878256.1"
                     /db_xref="CCDS:CCDS45088.1"
                     /db_xref="GeneID:5875"
                     /db_xref="HGNC:HGNC:9795"
                     /db_xref="MIM:601905"
                     /translation="MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGEL
                     DESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRV
                     NPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPP
                     AEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNA
                     FFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLL
                     MVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLL
                     KGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLM
                     RALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAH
                     KDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLP
                     RLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVL
                     T"
     exon            169..279
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            280..404
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            405..592
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..796
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..880
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            881..963
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1065
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1171
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1223
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1312
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1401
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1518
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1632
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1720
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1946
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="RABGGTA"
                     /gene_synonym="PTAR3"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtgcg ctgcgtttcg atgagccggg acgtggcgcc gctctagcca gcgcctgggc
       61 tctgtggcgg gcgccgcagc tccgcgtccc ccgcgcctcc tcccagcgca gacttcaagg
      121 gctaccactg gacccttccc ctgtcttgaa ccctgagccg gcaccatgca cggacgcctg
      181 aaggtgaaga cgtcagaaga gcaggcggag gccaaaaggc tagagcgaga gcagaagctg
      241 aagctatacc agtcagccac ccaggccgta ttccagaagc gccaggctgg tgagctggat
      301 gagtccgtgc tggaactgac aagccagatt ctgggagcca accctgattt tgccaccctc
      361 tggaactgcc gacgagaggt gctccagcag ctggagactc agaagtctcc tgaagagttg
      421 gctgctctgg tgaaggcaga actgggcttc ctggagagct gcctgcgggt gaaccccaag
      481 tcttatggta cctggcacca ccgatgctgg ctgctaggcc gcctgcctga gcccaactgg
      541 acccgagagc tggagctctg tgcccgtttc ctggaggtgg atgagcggaa ctttcactgc
      601 tgggactatc ggcggtttgt ggccacacag gcagccgtgc cccctgcaga agagctagcc
      661 ttcactgaca gcctcatcac ccgaaacttc tccaactact cttcctggca ttaccgctcc
      721 tgtctcttgc cccagctgca cccccagccg gattctggac cacaggggcg cctccctgag
      781 gatgtgctgc tcaaagagct ggagctggtg cagaatgcct tcttcactga ccccaatgac
      841 cagagtgcct ggttttatca ccgttggctc ctaggccgag ctgaccccca ggatgcactg
      901 cgctgcctgc atgtgagccg ggacgaggcc tgtctgactg tctccttctc tcggcccctc
      961 ttagtgggct ccaggatgga gatcttgctg ctcatggttg atgattctcc cctgattgtg
     1021 gagtggagga ccccagatgg caggaaccgg cccagccatg tctggctctg tgacctgcct
     1081 gctgcctccc tcaacgacca gttgccccaa catacatttc gcgtcatttg gacagcaggc
     1141 gatgtccaga aagaatgcgt gcttttaaaa ggccgccagg agggctggtg ccgggactcc
     1201 acgacagacg agcagctatt caggtgtgag ctgtcagtgg agaagtccac agtgctgcag
     1261 tctgagctgg aatcctgtaa ggagctgcag gagctggagc ctgagaataa atggtgcctg
     1321 cttaccatca tcctgctgat gcgggcactg gaccccctgc tgtatgagaa ggagaccctg
     1381 cagtacttcc agaccctcaa ggccgtggac cccatgcggg caacgtatct ggatgacctg
     1441 cgcagcaagt tcttgctgga gaatagcgtg ctcaagatgg agtatgccga ggtgcgtgtg
     1501 ctgcacctgg ctcacaagga tctgacagtg ctctgccatc tggaacagct gctcttggtc
     1561 acccatcttg acttgtcaca caatcgcctc cgaaccctgc cacctgcact ggctgccctg
     1621 cgctgccttg aggtgctgca ggccagtgat aatgccatag agtccctgga cggcgtcacc
     1681 aacctacccc ggctgcagga gctgctactg tgcaacaacc gcctccagca gcctgcagtg
     1741 ctccagcctc ttgcctcctg ccccaggctg gtcctcctca acctgcaggg taacccgctg
     1801 tgccaagcgg tgggcatctt ggagcaactg gctgaactgc tgccttcagt tagcagcgtc
     1861 ctcacctaag aggccctgcc ccctaccctt gccctttaac ttattgggac tgaataaaga
     1921 atggagaggc cctctcaggc taccaa
//
