LOCUS       NM_001366446            8634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB GTPase activating protein 1 like (RABGAP1L),
            transcript variant 9, mRNA.
ACCESSION   NM_001366446 XM_005245680
VERSION     NM_001366446.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8634)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8634)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8634)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8634)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   5  (bases 1 to 8634)
  AUTHORS   Kim,J.H., Jung,S.H., Bae,J.S., Lee,H.S., Yim,S.H., Park,S.Y.,
            Bang,S.Y., Hu,H.J., Shin,H.D., Bae,S.C. and Chung,Y.J.
  TITLE     Deletion variants of RABGAP1L, 10q21.3, and C4 are associated with
            the risk of systemic lupus erythematosus in Korean women
  JOURNAL   Arthritis Rheum 65 (4), 1055-1063 (2013)
   PUBMED   23335107
  REMARK    GeneRIF: Deletion variants of RABGAP1L were found to be
            significantly associated with SLE in Korean women.
REFERENCE   6  (bases 1 to 8634)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8634)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   8  (bases 1 to 8634)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8634)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031286.2, AL022400.8, AL022171.1, AL591108.18, AL136377.15,
            AL161671.25 and Z99127.2.
            
            On Oct 5, 2018 this sequence version replaced XM_005245680.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.117518.1,
                                           SRR1803613.260197.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681986.1/ ENSP00000507884.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL031286.2         7479-7616
            139-309             AL031286.2         67084-67254
            310-502             AL022400.8         261-453
            503-713             AL022400.8         10434-10644
            714-888             AL022400.8         20772-20946
            889-1046            AL022400.8         29764-29921
            1047-1157           AL022400.8         31769-31879
            1158-1224           AL022400.8         51703-51769
            1225-1327           AL022400.8         55122-55224
            1328-1494           AL022400.8         57902-58068
            1495-1636           AL022400.8         84275-84416
            1637-1730           AL022171.1         2038-2131
            1731-1881           AL022171.1         25054-25204
            1882-1995           AL591108.18        38737-38850
            1996-2070           AL136377.15        44725-44799
            2071-2196           AL136377.15        60728-60853
            2197-2340           AL136377.15        63316-63459
            2341-2382           AL136377.15        113516-113557
            2383-2511           AL161671.25        59224-59352
            2512-2604           Z99127.2           67934-68026
            2605-2715           Z99127.2           79754-79864
            2716-2820           Z99127.2           86555-86659
            2821-2904           Z99127.2           89284-89367
            2905-2976           Z99127.2           93311-93382
            2977-3174           Z99127.2           99118-99315
            3175-8634           Z99127.2           100326-105785
FEATURES             Location/Qualifiers
     source          1..8634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..8634
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /note="RAB GTPase activating protein 1 like"
                     /db_xref="GeneID:9910"
                     /db_xref="HGNC:HGNC:24663"
                     /db_xref="MIM:609238"
     exon            1..138
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            139..309
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..3327
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /note="isoform G is encoded by transcript variant 9; TBC1
                     domain family, member 18; expressed in hematopoietic
                     cells, heart, liver (HLL); rab GTPase-activating protein
                     1-like"
                     /codon_start=1
                     /product="rab GTPase-activating protein 1-like isoform G"
                     /protein_id="NP_001353375.1"
                     /db_xref="CCDS:CCDS91111.1"
                     /db_xref="GeneID:9910"
                     /db_xref="HGNC:HGNC:24663"
                     /db_xref="MIM:609238"
                     /translation="MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQ
                     LKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQ
                     LILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKS
                     SSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFT
                     ESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTF
                     SVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGML
                     LSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMT
                     VAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNA
                     GDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEK
                     ILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRI
                     LITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQS
                     FLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLH
                     SHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSK
                     EDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRE
                     SQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVL
                     NKELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICS
                     QLSTRLEKQQAASKEELEVVKGKMMACKHCSDIFSKEGALKLAATGREDQGIETDDEK
                     DSLKKQLREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIK
                     TATGTQPLQPAPVTQPPKEST"
     exon            310..502
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            503..713
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            714..888
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1046
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1157
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1224
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1327
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1494
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1636
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1730
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1881
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1995
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2070
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2196
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2340
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2382
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2511
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2604
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2715
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2820
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2904
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2976
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3174
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..8634
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8611..8616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /note="hexamer: AATAAA"
     polyA_site      8634
                     /gene="RABGAP1L"
                     /gene_synonym="HHL; TBC1D18"
                     /note="major polyA site"
ORIGIN      
        1 agttccctcc gccctcctcg ggctccagcg gtggcggagc gaacgggacc ggcccggctt
       61 cagagcgcga ggtggagggt ggaacgcggg cgcctgaagg agttgttgtc tcggcagcgc
      121 ccgcggagac gtgaagaggt ggttgtggga agagaagttt gcagaactga aatggaggtc
      181 agagcttcat tacagaaggt tagtggatca tctgattctg tggctacaat gaacagtgaa
      241 gaatttgttt tggttcctca gtatgcagat gataattcta caaaacatga agaaaaacct
      301 caactgaaga tagtttctaa tggtgatgaa caattggaaa aagccatgga agagattttg
      361 agagattccg agaaaaggcc aagcagtctt cttgttgatt gtcaaagttc cagtgagatt
      421 tcagaccatt cgtttggaga tattccagcc agccaaacaa ataagccatc tcttcagtta
      481 attttggatc cgtctaacac agaaatttct acacccagac catcttctcc aggtggacta
      541 cctgaagaag atagtgtttt atttaataaa ctgacctact taggatgtat gaaggtttct
      601 tccccacgta atgaagtaga ggctttacgg gcaatggcaa ccatgaaatc ttccagtcaa
      661 tacccctttc ctgttaccct gtatgtacca aatgttccag aaggttctgt gagaattata
      721 gaccaatcca gcaatgtgga gatagcatct tttccaatct ataaggtgtt attctgtgca
      781 cgtggacatg acggaacaac agagagcaat tgctttgcat ttacagagag ttcccatggt
      841 tcggaagaat ttcagataca tgttttctcc tgtgaaatta aagaggcagt aagcagaatt
      901 ttgtacagtt tctgtacagc attcaaacgt tcttccagac aagtgtctga tgttaaagac
      961 tcagttattc ctacccccga cagtgatgtg tttaccttca gtgtctcctt ggaggtaaaa
     1021 gaagacgatg gaaaaggaaa ctttagccct gtgcctaagg atagagataa attttatttc
     1081 aaattaaagc aaggaataga gaagaaggtt gtgattacag tgcagcaact ttctaacaaa
     1141 gaattagcta ttgaaagatg ttttggaatg ttattaagcc caggtcgaaa cgtgaagaac
     1201 agtgacatgc atttactgga tatggaatcc atgggaaaga gctatgatgg gagagcttat
     1261 gtcatcactg gcatgtggaa ccccaatgca ccagtatttc tggcacttaa cgaggaaacc
     1321 ccaaaagata agcaagtata catgactgtg gcagtggata tggtagtcac agaggtggtg
     1381 gagcctgttc gctttctcct ggagacagta gtccgtgtgt accctgcaaa tgagcgattt
     1441 tggtatttca gcagaaagac tttcacagag actttcttca tgagattgaa acagtctgag
     1501 ggaaaaggcc ataccaatgc tggagatgca atatatgagg tggtgagtct acagcgagag
     1561 tctgacaagg aggaaccagt cactcctact agtggagggg gtccaatgtc accccaggat
     1621 gatgaagcag aagaggagag tgataatgaa ctctcaagtg gaacaggtga tgtgtctaag
     1681 gattgtcctg agaagatcct gtattcttgg ggagagttgc taggaaaatg gcacagtaac
     1741 cttggtgcac gaccgaaagg gctgtctact ctggtgaaga gtggtgtccc tgaagcattg
     1801 agggcagagg tatggcagtt attggcaggc tgccatgaca accaggcaat gctggataga
     1861 taccgaattc ttatcacaaa ggactcagcc caggagagtg ttattactcg agatattcat
     1921 cgtacatttc ccgcacatga ttactttaaa gatactggag gagatggtca agaatcgctc
     1981 tataagatct gcaaggccta ctctgtgtat gatgaagaca ttgggtactg tcaagggcag
     2041 tcttttcttg ctgctgtatt actgctgcat atgccagagg aacaagcatt ctgtgttttg
     2101 gtgaaaatca tgtacgacta tggtttgaga gacctctaca gaaacaactt cgaagatctt
     2161 cattgcaaat tctaccagtt ggagagacta atgcaggaac agctaccgga cctgcatagc
     2221 catttttctg atctgaacct ggaagctcat atgtatgcat cccagtggtt tctcactctt
     2281 tttactgcca agttcccact ctgcatggtg ttccacatca ttgacttact gctttgtgag
     2341 ggtttgaaca taatctttca tgtagctttg gctctcctaa agacctcaaa ggaagacctt
     2401 ctgcaggctg attttgaagg tgctttaaag ttctttagag ttcagcttcc aaagagatac
     2461 agggcagagg aaaatgcaag aagactgatg gagcaggctt gcaatattaa agtaccaacc
     2521 aagaagctga agaaatatga gaaagaatat cagacaatgc gagagagtca gctgcaacag
     2581 gaagacccaa tggatagata caagagggag aaccgaagat tacaggaggc cagcatgagg
     2641 ttggaacaag agaatgatga ccttgcccat gaactagtaa caagcaaaat tgctctacgg
     2701 aatgacttgg atcaggcaga agacaaggca gatgtgttga ataaagagct ccttttgacc
     2761 aaacagaggc tggtggagac tgaagaggag aagaggaagc aagaggaaga gactgcccag
     2821 ctaaaagaag tcttcaggaa acagctagag aaggcagaat atgaaataaa gaagactaca
     2881 gctatcattg ctgagtataa acagatctgt tcgcagttga gtaccaggct ggagaaacag
     2941 caagcagcca gcaaggagga gctggaagtg gtaaagggta agatgatggc atgcaaacac
     3001 tgcagtgaca ttttcagcaa ggagggtgct ttgaaactag cagccacagg cagagaggac
     3061 cagggaattg aaacagatga tgagaaggac tcacttaaga agcagctgag agagatggaa
     3121 ctggaactgg cacaaaccaa actgcagttg gtggaggcca agtgtaaaat tcaggaactt
     3181 gaacatcaga gaggagccct tatgaatgaa atccaagctg cgaaaaactc ttggtttagc
     3241 aaaaccctga actctatcaa aacggccacg ggcacccagc cattgcagcc agcaccggtc
     3301 acccagccac ccaaggagag cacatagttc cagccttacc caagcacaag agcacaatgt
     3361 tcaaaccaat ggaaatctgg gaggattctt cctggtgtcc ctttgaagga aagtcaagga
     3421 ggccagaaaa caagccagaa tttttcagta gctctcactc tttcttgtat gacacttttc
     3481 aaagggatgc tatttaaact gacctgttct atgttgaata cctattttcc agcttctgga
     3541 aggccatgtt cagatccatc atagtattac acattatttt gtttgcctga tgtttagttg
     3601 gaaataagta attcagaact aaatgctttt ttatttagaa ttattcataa ttatttttat
     3661 cttacataaa aatggagaca tctgttattc caaggttgaa gtgataagaa gatctttgtc
     3721 acaggaaaaa aaaaattgaa acctaaacat cttaagtttt caggatttat tcagataaag
     3781 cacactgtgg ggccaggcat gaccactctc aggtttcctc ctgagcctga ttcccaggga
     3841 agtgttaatc ctgtccaaag gaaagaacca atcagcgatc attggtttac tttcattttc
     3901 tgttcggtac atctggaaat gaagtgccag gaatagacgg gctgttcaga ttatacgcta
     3961 ggtaaaagga actgaaattt taataagtgt aggtcaggat catttgggct gtggtattct
     4021 aacagatcct tttaagaatg ccacatagga cttgtgagtt cctaagtaca ccaaagtatg
     4081 gacacagatg tgacttctgg caattataaa gttaaaggtg gatattgcac cttacagact
     4141 tagggagcct ttaccagaga cgcctaaaaa gccccaggtt cagccattgt gctgaataga
     4201 gtggaatata gaaccaggga cagagtattt catttaacgt tgatatatac ttgctaagga
     4261 aacactaaca atactgtaac tttgttaaag gacatagtat tgaaatggga aatagaggtc
     4321 aggctcacat catcttagtt taatgctggg caactttttc tgatttctgt agttccctga
     4381 aaatgtgtcc ttcgtaccca taaagagata caaatgcatt tgtaacattt ttgattgaat
     4441 ataaaacctt tacagaaata cttatctcat ggaaaggtaa agctattgtt taaaaattag
     4501 tggaaatatt ttttcaatta tatttaacat gcctataaaa atagtccttg caggaaatta
     4561 tttgataaga gcaaaactat ttttatttta taaactattt tggaggcctc tgatcctttc
     4621 aaaccaacca aactactatt agatatgtac aataacattt gttgatatta atcattggcc
     4681 tcattgttga acatattatt tgcaaagaat cttaaactct gtagtgccag aatgattctc
     4741 atctgtgcca tattttgcaa ttaaaagtaa cacaccctta gaagaatcaa ataagagcca
     4801 tctacatccc aggaggatgc accaagttgc tcacagtgga tcttttcctc taaaatgatc
     4861 ttttatgttc taaaaagtga aatccccttt atctgtgttt atattctcta cagcccataa
     4921 aactgatgtg attgttatgt tatactcatc agataatact tttcttacat aaatctttca
     4981 ttgttgttct gacatctttc attacaaaat ttattttctt aacaaaaagg aacataaccc
     5041 agcattccaa gtgtctgtgt tggctttaac attctctaca tggtggtcta gataagctaa
     5101 tttttttttt tttttttttg taaaatgtaa tagctagaaa atgttatctt ggcgcttgtt
     5161 tttgtaaatc atttagtata ggctgttagc tttactggta ctttacgctt tgattccaag
     5221 aagccttgtg cagttgcctt atcaaatggc cagctaaatt aaagatgctc ttttgtgttg
     5281 tgaatttcat agttctgtac agagcttgtt tcaatttaca aaaataagta cattccacag
     5341 aatgcctaaa gtgtgtaatt ttctttaaat aatagtaggt gagggagaaa cataatggct
     5401 ctaggtcaat cccttatcta aagaccttgt tcaacttcat agtccctttc cttttaaaga
     5461 ggagaagaga aaaatccccc ctggccaggc atggtggctc acatctgtaa tcccagcact
     5521 ttgggaggct gaggtgggtg gatcacctaa ggtcaggagt ttgagaccag cctggccaac
     5581 atggtgaaac cctatctcta ctgcaaaata caaaaattag ccgggcttgg tggcgggtgc
     5641 ctgtaatccc agctactcgg gaggttgagg caggagaatc acttgaaccc aggaggcaga
     5701 ggttgcagtg ggccaagatt acggcattac attccatcca gcctgggcga caagagcaaa
     5761 attccgtctc gaaaaatcac caggtacata cctctcaagt ttgataagtc catcttttga
     5821 gttttctttt agctctttca aaagattacg agggcaatac atattttttt tttttttatt
     5881 ctccagcccc atatcatact tgggtatgcc tgttggtacc ataagcctaa actctccttc
     5941 actgcaatgc ctttgagtca gtagcaatag taaagactag aaacaaagaa aattcagaat
     6001 ttggtatgtg atatgattgt tcatacaata tgttataata gcaatattcc aaacaatatg
     6061 tccttcactg tctattgttg gaaaactcat gcatcccagc atgaagtaac tcctagtttt
     6121 aattttagtt attttgagat atatttgaga attgcatctc ttctcttgaa tttcacttag
     6181 aagagattaa ccagccaaat atccaggaaa gtttcaaaac attctagtgt ttttcatcct
     6241 ttgctaggat gcactctgta caaaacattc ctctgaaaat ctaatatttg cagtatctaa
     6301 gaattgatca tttctatttt cattaaattc tgtggaaaaa attaaatgaa tgaaattcaa
     6361 cttcataatt cagttcatca gcttttgtat cttgagaatc taaacacgtc tttaaatctg
     6421 aaagaaacca agctggattt tgcagtgcat atgtttgcta gcttcccaca tcctgaacca
     6481 tgtcaaaatt tggttttatt tagttacata taatttaatg caaagaaatt ctgttactta
     6541 atgttctgtt tatttatgag tgcctatcag gaacactaat aggaatgcca ttcaaccagt
     6601 gtcttctgcc cctctcccag ctgttaaatt agtacttctt cattggcttt ctgaaatgtc
     6661 ctgagtaaag tagaaaagca acctttgtat ggatgtgggg atatttaata gtatgtatct
     6721 tgtttcattt ttttcctatg atgtattaat atttattttt ctccaacccc tgctccattt
     6781 tcttaaaata ttttccagtt aataactagt tgctttattt cctagctgaa gtgagaaaac
     6841 caacggaaaa caatacagat ttgggcagag gagatagagt tacatcttta aaggagtgag
     6901 ccagtcaccc aggagaatca catgtgtaac tgatgtaggg gtttaagtct tcatactttc
     6961 actaaaatct gtctactaac tctcccacca acctttgcat caaacactta ggtacctgcc
     7021 tgattagggg ggccccttta agggaaaaaa cttttaaaaa attaaatgcc ttggttttgt
     7081 tttatcttct gggaaagaac acttttactt gattagcaag atgattatat tatataactt
     7141 gcccttaaaa acactccaaa atactgactc cttttctcca attacaaatg agtgtgaaga
     7201 aattctgttg tatgatttga acactattag gtttgtatgt gtgtttaatt ggaagaattt
     7261 tatatagagt atctctgctg cttttgttta cctgggtacc acacaaccaa atacacattg
     7321 agatttcaag aaatgatgat gaaagccaga aggccagacc acagctctgc agcctgtttc
     7381 ctacaaccag atataaaact ctttctcgtc gccatgctga tagtcacact gaactagaac
     7441 tgtcccaaca cattcttcct ctctcataat ggcttccatt taatacaggc aaagcccttt
     7501 accttagcaa attctttatc tttcaaaagt gaccaaaatg aggacttcaa ccttggctgc
     7561 acctcaatag gagatgctga tcttgagttg taatgagaaa agtgggcata taggagattt
     7621 tagtgactgc agtcagctgt ctggcattcc tttctcagtt tgcatctaaa agactacata
     7681 tgtcaagctt atctccacct gaatttgctg cctgctataa aaacatttca ttaatatatc
     7741 ccattcttcc tacctccatc tctggtttgt cattagtggt attctgaaaa gcttaagaaa
     7801 aaagaatcat tgagtagaaa gtgaacattt taagttattt tcctttttca ttggcaatta
     7861 gttaacatgt aaaatctttt ccattaaact gtataacttt taataactat atattatata
     7921 tgggataaaa tatatggact gaattgtgag aatataaatg catcgaaaga ctctggtgtc
     7981 atgaaagcac aagaataagg ctggagatgg tcccagatcc aagatgtccc aaaagccttt
     8041 tgtatcagtt tctctatttt tggtattttg cataatgcat ggatccttag ttcaaatgag
     8101 ggacaaagtt tctcagtcag ccccacttcc tttctttcta actcctacct ttcccttgca
     8161 gaggaggtag tagagattct ggaattgtct atttttatga attccattat tttgtccatg
     8221 gcatctctaa tgaaaacagg ttctagaata aaggagttga ttagtctgaa cagtactaat
     8281 taactacaaa ataaacgtta gtgatcagcc tcttcctcta taaacaatga ccaattagac
     8341 gtttccgtaa ttccatgtat tatgtatagt acactctata aatgtaaatg taatgcttgt
     8401 ctaaaaagtg caatttattg tacattgtcc caacaaatgt ttacttttat aatcgttatg
     8461 aacttgaatt ggattagtat cttgttttta tgtgtgaatg aagccttgtg aaataaacaa
     8521 atgcaactga gaaggtaaca aggtgactgt ttttgtgagc cagtgatgtt ttcaatgctt
     8581 tgtgttgccc ctttggcccc attaagcagt aataaacatt tgttctgaag tcca
//
