LOCUS       NM_012197               4986 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB GTPase activating protein 1 (RABGAP1), mRNA.
ACCESSION   NM_012197
VERSION     NM_012197.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Nagai,H., Yasuda,S., Ohba,Y., Fukuda,M. and Nakamura,T.
  TITLE     All members of the EPI64 subfamily of TBC/RabGAPs also have GAP
            activities towards Ras
  JOURNAL   J Biochem 153 (3), 283-288 (2013)
   PUBMED   23248241
  REMARK    GeneRIF: suggest that EPI64A and B, which are ubiquitously
            expressed members of the EPI64 subfamily, inactivate Ras and
            certain Rabs at the periphery of cells.
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Echard,A., Opdam,F.J., de Leeuw,H.J., Jollivet,F., Savelkoul,P.,
            Hendriks,W., Voorberg,J., Goud,B. and Fransen,J.A.
  TITLE     Alternative splicing of the human Rab6A gene generates two close
            but functionally different isoforms
  JOURNAL   Mol Biol Cell 11 (11), 3819-3833 (2000)
   PUBMED   11071909
REFERENCE   9  (bases 1 to 4986)
  AUTHORS   Opdam,F.J., Echard,A., Croes,H.J., van den Hurk,J.A., van de
            Vorstenbosch,R.A., Ginsel,L.A., Goud,B. and Fransen,J.A.
  TITLE     The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type
            specifically expressed and localised to the Golgi apparatus
  JOURNAL   J Cell Sci 113 (Pt 15), 2725-2735 (2000)
   PUBMED   10893188
REFERENCE   10 (bases 1 to 4986)
  AUTHORS   Cuif,M.H., Possmayer,F., Zander,H., Bordes,N., Jollivet,F.,
            Couedel-Courteille,A., Janoueix-Lerosey,I., Langsley,G., Bornens,M.
            and Goud,B.
  TITLE     Characterization of GAPCenA, a GTPase activating protein for Rab6,
            part of which associates with the centrosome
  JOURNAL   EMBO J 18 (7), 1772-1782 (1999)
   PUBMED   10202141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG622097.1, BC054492.1, AL365338.17 and AA948302.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012197.3.
            
            Sequence Note: The RefSeq transcript and protein was created from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011679.2, BC054492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373647.9/ ENSP00000362751.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BG622097.1         13-21
            10-3701             BC054492.1         1-3692
            3702-4537           AL365338.17        49088-49923
            4538-4986           AA948302.1         5-453               c
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2-q33.3"
     gene            1..4986
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="RAB GTPase activating protein 1"
                     /db_xref="GeneID:23637"
                     /db_xref="HGNC:HGNC:17155"
                     /db_xref="MIM:615882"
     exon            1..74
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            75..273
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3333
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="rab6 GTPase activating protein (GAP and
                     centrosome-associated); TBC1 domain family, member 11;
                     Rab6 GTPase activating protein, GAPCenA; GAP and
                     centrosome-associated protein; rab6 GTPase-activating
                     protein GAPCenA"
                     /codon_start=1
                     /product="rab GTPase-activating protein 1"
                     /protein_id="NP_036329.3"
                     /db_xref="CCDS:CCDS6848.2"
                     /db_xref="GeneID:23637"
                     /db_xref="HGNC:HGNC:17155"
                     /db_xref="MIM:615882"
                     /translation="MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDD
                     EKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSA
                     SSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNA
                     PRSEVEALRMMSILRSQCQISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFC
                     VRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPL
                     SATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQ
                     QTTNKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHF
                     QVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
                     NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPS
                     PPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNG
                     VPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTG
                     GDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRE
                     LFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYM
                     VFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAK
                     KLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQEN
                     DDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKE
                     MCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERC
                     REFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQD
                     LEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC"
     exon            274..508
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            509..713
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            714..888
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1046
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1157
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1224
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1327
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1497
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1672
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1766
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1917
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2031
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2106
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2232
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2376
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2418
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2547
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2640
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2751
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2856
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2940
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3012
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3210
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..4986
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4911..4916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="hexamer: AGTAAA"
     polyA_site      4922
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="major polyA site"
     regulatory      4963..4968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="hexamer: ATTAAA"
     polyA_site      4986
                     /gene="RABGAP1"
                     /gene_synonym="GAPCENA; TBC1D11"
                     /note="major polyA site"
ORIGIN      
        1 ggtttgggag gcccaggcgg cggagcctcc gggacggcga gcggcgggcg gcggaggagg
       61 agacggcagg tcgggcatta aaaaatattt aatcattcat gtgttgagac tcattcttga
      121 gttatggatg acaaggcttc tgttggaaaa atcagtgtct cttcagactc agtatctact
      181 cttaatagtg aagattttgt cttggtttcc aggcaaggag atgagacacc atctacaaat
      241 aatggaagtg atgatgagaa aacaggactc aagattgtag ggaatggaag tgaacagcag
      301 ctgcaaaaag agctagcaga tgtactgatg gatcctccaa tggacgacca gccaggggaa
      361 aaggagcttg tgaaaaggtc acaactggat ggtgaaggag atgggcctct ttctaatcag
      421 ctctccgctt catccaccat taaccctgtg ccattagtag ggctccaaaa accagagatg
      481 agcctaccag tgaaacctgg acaaggagat tctgaagctt caagtccttt cacaccagtg
      541 gccgatgagg acagcgtagt tttcagtaaa ctgacttact taggctgtgc ctcggtaaat
      601 gctcccagga gtgaagtgga agccttaagg atgatgtcca tcttaagaag ccagtgtcag
      661 atttcactag atgttaccct ttcagtgccg aatgtgtctg aaggaattgt gagactctta
      721 gatcctcaga caaacactga aatagcaaac taccctatct acaaaatcct cttctgtgtc
      781 agagggcatg atggaactcc tgagagtgac tgttttgctt tcactgaaag tcattacaat
      841 gcagagctct tcagaataca cgtcttccgg tgtgaaatac aagaagctgt aagccggata
      901 ctttacagtt ttgccactgc cttccgccgt tctgccaagc agaccccact ttcagccact
      961 gctgcacccc agactcctga cagtgacatc tttaccttct ctgtgtcttt agaaataaaa
     1021 gaagatgatg gtaaaggtta ttttagtgca gttcccaaag ataaggacag acagtgcttt
     1081 aaactacgcc aaggaattga taagaagatt gtcatctatg tgcagcaaac aactaataaa
     1141 gaacttgcca ttgaaaggtg ttttggtctt ctccttagtc caggaaaaga tgtacgaaat
     1201 agtgacatgc acttattaga tttggaatct atgggcaaaa gttcagatgg aaagtcgtat
     1261 gttattacgg ggagctggaa tccaaaatcc ccacattttc aagttgtaaa tgaagaaact
     1321 cctaaagata aagtcctgtt tatgaccaca gctgtagatt tggtaataac agaagtacag
     1381 gagcctgttc gatttctcct ggagacaaaa gtccgcgttt gctcacctaa tgaaagatta
     1441 ttctggccct tcagcaaacg tagtactact gaaaatttct ttttgaaact aaaacagata
     1501 aagcaaaggg agagaaagaa taatactgac actttatatg aagttgtatg cttggaaagt
     1561 gaatcagaaa gagagaggag gaaaactaca gccagtcctt cagttcgcct gccacagtct
     1621 ggatcgcaaa gttcagtgat accttctcct ccagaagatg atgaagagga agataatgat
     1681 gaacctctcc tgagtggatc tggtgatgta tccaaagaat gtgcagaaaa aattcttgaa
     1741 acatggggag aactgttgtc aaaatggcat ctcaacttga atgtgagacc gaagcagttg
     1801 tcatccttag taagaaacgg tgtccctgaa gctcttcgag gagaagtctg gcagctgcta
     1861 gcaggctgtc ataacaatga ccacctggta gagaaatacc gcattcttat cacaaaggag
     1921 tctccccagg acagtgctat cacccgggat attaaccgaa cattcccagc ccatgactac
     1981 tttaaggaca caggaggaga tggacaagat tccttatata aaatatgcaa ggcttattct
     2041 gtgtatgatg aagagattgg ttattgccag ggccagtcat ttcttgctgc tgtgctcctt
     2101 ctccatatgc ctgaagaaca ggcattcagt gttctggtca agatcatgtt tgactatggg
     2161 ctcagggaac ttttcaagca aaacttcgaa gatttgcatt gcaaatttta ccagttggag
     2221 cgcctcatgc aggaatacat tcctgacctg tacaaccact tcctggatat aagccttgaa
     2281 gcacacatgt atgcctccca gtggtttctt actcttttca ctgcaaaatt ccctctctac
     2341 atggtcttcc atatcatcga cctgctttta tgtgagggaa taagtgttat ttttaatgtc
     2401 gcccttggat tattaaagac ttcgaaagat gacctgctgt tgacagactt tgaaggtgcc
     2461 ttgaagttct ttagggttca gcttcctaag agataccgct cagaagaaaa tgcaaaaaaa
     2521 ctaatggaat tagcctgcaa catgaagatt agtcagaaga agttgaaaaa atacgagaaa
     2581 gaatatcaca ccatgaggga acagcaggcc cagcaagaag accccatcga gcgatttgag
     2641 cgggagaata ggcgtctaca agaagctaac atgaggttgg aacaggaaaa cgatgactta
     2701 gcccatgagc tggtgaccag caagattgca ctacggaagg acctggataa cgctgaggaa
     2761 aaggcagatg ctctgaataa ggagctgctg atgaccaaac agaagttgat tgatgcagaa
     2821 gaagagaaaa gacggctgga agaagagtct gctcagttaa aagaaatgtg ccgtcgggaa
     2881 ctcgacaagg cagaatctga gattaaaaaa aacagttcta tcattggtga ctataagcag
     2941 atttgttctc agttgagtga aagattggag aagcagcaga cagccaataa ggtggaaatt
     3001 gagaaaattc ggcaaaaagt ggatgactgt gagcggtgcc gggaattttt caacaaagaa
     3061 gggcgtgtaa aaggcataag ctcaaccaag gaggttttag atgaggacac ggatgaagag
     3121 aaagagacgc tcaagaacca gctgagagaa atggagctag aactggcaca gaccaaactc
     3181 cagctggtgg aggccgagtg taagatacag gacttggaac accatttagg gcttgccctc
     3241 aatgaggtgc aggcagccaa gaagacgtgg tttaaccgaa cactgagctc cataaagaca
     3301 gcaaccgggg ttcaagggaa agagacttgc tgagagcagc tgccgcctcc cgacaccttc
     3361 agaaaacacg acaccttttg ttgccttctt tggccagatg tgtgattctg tgacttgtcc
     3421 caggaccaga atgtacctaa gtcagatcca tagacgcatg ttggtaggtc actggaccag
     3481 agcttgtgaa gcaggcaacc tctggggtaa gactactgat actaacaggc ctgctagctc
     3541 agccgacgct ctggacactc tagaaatcac tcctcagtgt gacctcccag gcctcttccc
     3601 cgtgtacgtc aacacctcac ccagcctaaa ggctgagttt acatgatcag agttagggga
     3661 tccttcagtc tgttgatttt ttttctaaac cttttttttt taatatacat atatatatat
     3721 atatatatat atatatatat atatatatat atatatagtg ggggtggggc aagggatcag
     3781 aaattcaaat aattcttttc tgcttcaatg ccagcagaag gtcccccagg tagacatgga
     3841 gaagcacttt gttttaaata ggagggtttc atagttgcat ctgaagccac ctggttctgt
     3901 taaactgtat ggtgcaggtt ttgggtttgg cattattcat gtttctgatc aattctatgc
     3961 aactctcata gttcctgtta ctttttagca ttagctgcca aatgacttca aaaggctggg
     4021 gtgggtgact tgactgtgag actggattat aacatggaca aatcttattt tgcttaatgt
     4081 gtttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt atatatatat ataaatatct
     4141 ttcccaatat gccccgttga cagtgtttaa attccagact aggactgctg atctgcacaa
     4201 tttaattatg tggttattcg agcacttaat ttcactcaag gttcattggg ctctgctctc
     4261 ctccctgcca ttacgggagc tgtggacaga gctccctcac ttcaagattc ctagtgtttt
     4321 tgcacaacag gttgtccaag tgagaaagac tgagttgcgt gtctgtaaat gtctgcgcag
     4381 ggtgcacatg ctgcgaggtc tccatcctcc gggcctgtcc ctcccagatg ggctgggcct
     4441 ttgggccctc ctcagagtat gcctgggtac aaacctcact gttcagatgg gctgtaagtt
     4501 ctcacttcaa agctatggaa tggattttag cacctttaaa aaaaaaaaaa actttgactt
     4561 ttaatttata tagtgatatg ctgacaggct gacacgcaga tggttttgtc ctcttttctg
     4621 cgttcagtgt tgaggcggct gcttacaaga ggcactggtt ttgtatataa agacactcgg
     4681 gttgttttgt agctcttttt cttattggct gtactaacgc ttgctgaggt tatctgtaat
     4741 aagggaggta acaagtggca accccctccc caccaaccat cccctttgct gctttctgtg
     4801 tctttcttgt tcagttacca aaatagctgt aagcctatct aatgctaggt gtgtggacat
     4861 tgtgctaagg tagtttcagt gtgtcaactt tatgaattga aatataaacc agtaaaattg
     4921 tattactgtt tcttttgttg gttttatttt aacagcatat tgattaaata ttttggtaca
     4981 aacaaa
//
