LOCUS       NM_024816               2307 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens rabaptin, RAB GTPase binding effector protein 2
            (RABEP2), mRNA.
ACCESSION   NM_024816 XM_937790
VERSION     NM_024816.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Lee,H.K., Kwon,D.H., Aylor,D.L. and Marchuk,D.A.
  TITLE     A cross-species approach using an in vivo evaluation platform in
            mice demonstrates that sequence variation in human RABEP2 modulates
            ischemic stroke outcomes
  JOURNAL   Am J Hum Genet 109 (10), 1814-1827 (2022)
   PUBMED   36167069
  REMARK    GeneRIF: A cross-species approach using an in vivo evaluation
            platform in mice demonstrates that sequence variation in human
            RABEP2 modulates ischemic stroke outcomes.
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Noto,J.M., Rose,K.L., Hachey,A.J., Delgado,A.G., Romero-Gallo,J.,
            Wroblewski,L.E., Schneider,B.G., Shah,S.C., Cover,T.L.,
            Wilson,K.T., Israel,D.A., Roa,J.C., Schey,K.L., Zavros,Y.,
            Piazuelo,M.B. and Peek,R.M. Jr.
  TITLE     Carcinogenic Helicobacter pylori Strains Selectively Dysregulate
            the In Vivo Gastric Proteome, Which May Be Associated with Stomach
            Cancer Progression
  JOURNAL   Mol Cell Proteomics 18 (2), 352-371 (2019)
   PUBMED   30455363
  REMARK    GeneRIF: Results found that H. pylori upregulates RABEP2 in human
            gastric epithelium. In addition, the level of RABEP2 expression
            increases with severity of gastric malignant lesions in vivo.
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Logie,L., Van Aalten,L., Knebel,A., Force,T., Hastie,C.J.,
            MacLauchlan,H., Campbell,D.G., Gourlay,R., Prescott,A.,
            Davidson,J., Fuller,W. and Sutherland,C.
  TITLE     Rab-GTPase binding effector protein 2 (RABEP2) is a primed
            substrate for Glycogen Synthase kinase-3 (GSK3)
  JOURNAL   Sci Rep 7 (1), 17682 (2017)
   PUBMED   29247183
  REMARK    GeneRIF: Phosphorylation regulates RABEP2 function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Airik,R., Schueler,M., Airik,M., Cho,J., Ulanowicz,K.A.,
            Porath,J.D., Hurd,T.W., Bekker-Jensen,S., Schroder,J.M.,
            Andersen,J.S. and Hildebrandt,F.
  TITLE     SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is
            Required for Hedgehog Signaling
  JOURNAL   PLoS One 11 (5), e0156081 (2016)
   PUBMED   27224062
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   7  (bases 1 to 2307)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   8  (bases 1 to 2307)
  AUTHORS   Schindler,E.M., Baumgartner,M., Gribben,E.M., Li,L. and Efimova,T.
  TITLE     The role of proline-rich protein tyrosine kinase 2 in
            differentiation-dependent signaling in human epidermal
            keratinocytes
  JOURNAL   J Invest Dermatol 127 (5), 1094-1106 (2007)
   PUBMED   17205062
  REMARK    GeneRIF: Pyk2 regulation is associated with increased expression of
            Fra-1 and JunD, activator protein-1 transcription factors known to
            be required for involucrin expression.
REFERENCE   9  (bases 1 to 2307)
  AUTHORS   Chiappetta,G., Ferraro,A., Botti,G., Monaco,M., Pasquinelli,R.,
            Vuttariello,E., Arnaldi,L., Di Bonito,M., D'Aiuto,G.,
            Pierantoni,G.M. and Fusco,A.
  TITLE     FRA-1 protein overexpression is a feature of hyperplastic and
            neoplastic breast disorders
  JOURNAL   BMC Cancer 7, 17 (2007)
   PUBMED   17254320
  REMARK    GeneRIF: FRA-1 expression, including its intracellular
            localization, may be considered a useful marker for hyperplastic
            and neoplastic proliferative breast disorders
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2307)
  AUTHORS   Gournier,H., Stenmark,H., Rybin,V., Lippe,R. and Zerial,M.
  TITLE     Two distinct effectors of the small GTPase Rab5 cooperate in
            endocytic membrane fusion
  JOURNAL   EMBO J 17 (7), 1930-1940 (1998)
   PUBMED   9524116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109460.3, AK026935.1 and BC046118.1.
            
            On Nov 24, 2018 this sequence version replaced NM_024816.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026935.1, AK092299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358201.9/ ENSP00000350934.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC109460.3         57765-57791         c
            28-33               AK026935.1         1-6
            34-2235             BC046118.1         1-2202
            2236-2307           AK026935.1         2208-2279
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2307
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /note="rabaptin, RAB GTPase binding effector protein 2"
                     /db_xref="GeneID:79874"
                     /db_xref="HGNC:HGNC:24817"
                     /db_xref="MIM:611869"
     exon            1..136
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1785
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /note="Rabaptin-5 beta; rabaptin-5beta"
                     /codon_start=1
                     /product="rab GTPase-binding effector protein 2"
                     /protein_id="NP_079092.2"
                     /db_xref="CCDS:CCDS42140.1"
                     /db_xref="GeneID:79874"
                     /db_xref="HGNC:HGNC:24817"
                     /db_xref="MIM:611869"
                     /translation="MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLR
                     AELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQIT
                     ALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME
                     KEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGG
                     PAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEG
                     IYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVL
                     LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQL
                     PSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLR
                     EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQR
                     AKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDI
                     KDT"
     exon            137..349
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            350..507
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            508..618
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            619..969
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1065
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1320
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1498
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1510
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1566
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1683
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..2307
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="RABEP2"
                     /gene_synonym="FRA"
                     /note="major polyA site"
ORIGIN      
        1 aaacagccga gaggacccgg aagcggtgcg ctccgtcacc agggagtgcg ggaatccgcc
       61 gtttgcgctg aggcaatggc ggcagctgcg ccggtggccg cggacgacga tgagcggcgg
      121 cggcggccgg gggctgcact ggaggactcc cggtcccagg aaggggcaaa tggtgaggcc
      181 gagtcaggtg agctcagccg gcttcgggct gagctggcag gcgccctggc agaaatggaa
      241 accatgaagg ctgtggcaga ggtgagcgag agcacgaagg ccgaggctgt ggctgcggtg
      301 cagcggcagt gccaagagga ggtggcctcg ctgcaggcca tcctgaaaga ctccatcagc
      361 agctatgaag cccagatcac cgccctgaag caggagcgac agcagcagca gcaggactgt
      421 gaggagaagg agcgggagct gggccgcctg aagcagctgc tgtcccgggc ctaccccctg
      481 gactccctgg agaagcagat ggaaaaggcc cacgaggact cggagaagct gcgggagatc
      541 gtactgccca tggaaaagga gatcgaggag ctgaaggcga agctgctgag ggccgaggag
      601 ctgattcagg agatccagag acgtccccgg catgcccctt ccctgcacgg ctccacggag
      661 ttgctgcccc tgtcccggga tccatcgccc ccgctggagc ctctggagga gctgagcgga
      721 gatgggggtc cagccgctga ggccttcgct cacaactgcg atgacagcgc ctccatctcc
      781 tccttctccc ttggcggtgg ggtcggcagc agctcctccc tgccccaaag ccgccagggc
      841 ctgagccctg aacaggaaga gacggcctcg ctggtgtcta cgggcaccct ggttcccgag
      901 ggcatctacc tgccccctcc tggctaccag ctcgtcccag acactcagtg ggagcagctg
      961 cagacagagg gccgacagct gcagaaggac ctggagagcg tcagtcgcga gcgggacgag
     1021 ctccaagagg gcctgagacg gagcaatgag gactgtgcca agcagatgca ggtgctcctg
     1081 gcccaggtcc agaactcaga gcagctgctg cggaccctgc aagggaccgt gagccaggcc
     1141 caggagcggg tgcagctgca gatggcggag ctggtcacca cccacaagtg cctgcaccat
     1201 gaggtaaagc ggttgaatga ggaaaaccaa gggctccggg ccgagcagct gccatcctca
     1261 gccccccagg gctcgcagca ggagcagggc gaggaggaat cactgcccag ctctgtgcca
     1321 gagctgcagc agctgctgtg ctgcacgcgg caagaggcga gggcccggct gcaggcccag
     1381 gagcacgggg ccgagcgcct gcggatcgag atcgtgacgc tgcgggaggc tctggaggag
     1441 gagacagtgg ccagggccag cctggagggg cagctgaggg tgcagcggga ggagacagag
     1501 gtgctggagg cctccctgtg cagcctgagg acagagatgg agcgggtgca gcaggaacag
     1561 agcaaggccc agctcccaga cctcctctca gaacagaggg ccaaggtgct gcggctgcag
     1621 gcagagctgg agaccagtga gcaggtgcag agggatttcg tgcgactgtc ccaggccctg
     1681 caggtgcgcc tagagcggat ccgccaggct gagaccctgg agcaagtgcg cagcatcatg
     1741 gatgaggcgc cactcacgga cgtcagggac atcaaggaca cctgaggggt caggatatcc
     1801 ccacccccac cctgggaaag acgcctttcc ccactcctga accatgaggc ctcgctctgg
     1861 ggtcttggat ggcttttcca ccgtccctga gactggggtt gaggggactg acgggggcca
     1921 ccaccgcccc gccctccagc gcctcctccc agggtggctg ggcctcctgt tctcagggat
     1981 cacacctggg tgaggggccc aagcccctcc cggaaccaaa ggtgcaggct caggcctgcg
     2041 gctttctggc tgctgtgctg cctcctgggc tccagccctc ccctgccccc agcccgtccc
     2101 ctgcccaggg cacagcggag ccatgggggc tgggagtccc catcagaggc agtgaggtgg
     2161 gccccggccc tgggacaggc agctgccttc tggtctgcat gacactaaga cgcttgtcca
     2221 cagcggcgac ccaggcctcc aagcttgcac agaggcaagg ccagactttt ccgtcgttta
     2281 ttttcaataa ataagcagct cagcgca
//
