LOCUS       NM_004703               5909 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens rabaptin, RAB GTPase binding effector protein 1
            (RABEP1), transcript variant 1, mRNA.
ACCESSION   NM_004703
VERSION     NM_004703.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5909)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5909)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5909)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5909)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5909)
  AUTHORS   Delacretaz,A., Zdralovic,A., Vandenberghe,F., Saigi-Morgui,N.,
            Glatard,A., Quteineh,L., Gholam-Rezaee,M., Raffoul,W.,
            Applegate,L.A., Jafari,P., Gamma,F., von Gunten,A., Conus,P. and
            Eap,C.B.
  TITLE     Association of variants in SH2B1 and RABEP1 with worsening of
            low-density lipoprotein and glucose parameters in patients treated
            with psychotropic drugs
  JOURNAL   Gene 628, 8-15 (2017)
   PUBMED   28694205
  REMARK    GeneRIF: SH2B1 and RABEP1 genetic variants are associated with
            worsening of LDL and glucose parameters in patients treated with
            psychotropic drugs
REFERENCE   6  (bases 1 to 5909)
  AUTHORS   Swanton,E., Bishop,N. and Woodman,P.
  TITLE     Human rabaptin-5 is selectively cleaved by caspase-3 during
            apoptosis
  JOURNAL   J Biol Chem 274 (53), 37583-37590 (1999)
   PUBMED   10608812
REFERENCE   7  (bases 1 to 5909)
  AUTHORS   Neve,R.L., Coopersmith,R., McPhie,D.L., Santeufemio,C., Pratt,K.G.,
            Murphy,C.J. and Lynn,S.D.
  TITLE     The neuronal growth-associated protein GAP-43 interacts with
            rabaptin-5 and participates in endocytosis
  JOURNAL   J Neurosci 18 (19), 7757-7767 (1998)
   PUBMED   9742146
REFERENCE   8  (bases 1 to 5909)
  AUTHORS   Vitale,G., Rybin,V., Christoforidis,S., Thornqvist,P.,
            McCaffrey,M., Stenmark,H. and Zerial,M.
  TITLE     Distinct Rab-binding domains mediate the interaction of Rabaptin-5
            with GTP-bound Rab4 and Rab5
  JOURNAL   EMBO J 17 (7), 1941-1951 (1998)
   PUBMED   9524117
REFERENCE   9  (bases 1 to 5909)
  AUTHORS   Xiao,G.H., Shoarinejad,F., Jin,F., Golemis,E.A. and Yeung,R.S.
  TITLE     The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5
            GTPase activating protein (GAP) in modulating endocytosis
  JOURNAL   J Biol Chem 272 (10), 6097-6100 (1997)
   PUBMED   9045618
REFERENCE   10 (bases 1 to 5909)
  AUTHORS   Stenmark,H., Vitale,G., Ullrich,O. and Zerial,M.
  TITLE     Rabaptin-5 is a direct effector of the small GTPase Rab5 in
            endocytic membrane fusion
  JOURNAL   Cell 83 (3), 423-432 (1995)
   PUBMED   8521472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB169027.1, BC041700.1, AK314183.1, AF098638.1, DB124187.1,
            AL157499.1, EB387308.1 and BM678290.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004703.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.122092.1,
                                           SRR1803616.41935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537505.6/ ENSP00000445408.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                DB169027.1         22-107
            87-2257             BC041700.1         74-2244
            2258-2587           AK314183.1         2270-2599
            2588-2792           AF098638.1         2286-2490
            2793-3310           DB124187.1         16-533
            3311-5381           AL157499.1         68-2138
            5382-5661           EB387308.1         1-280               c
            5662-5909           BM678290.1         16-263              c
FEATURES             Location/Qualifiers
     source          1..5909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..5909
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /note="rabaptin, RAB GTPase binding effector protein 1"
                     /db_xref="GeneID:9135"
                     /db_xref="HGNC:HGNC:17677"
                     /db_xref="MIM:603616"
     exon            1..237
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2792
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /note="isoform 1 is encoded by transcript variant 1; rab
                     GTPase-binding effector protein 1; rabaptin-5;
                     neurocrescin; rabaptin-4; rabaptin-5alpha; renal carcinoma
                     antigen NY-REN-17"
                     /codon_start=1
                     /product="rab GTPase-binding effector protein 1 isoform 1"
                     /protein_id="NP_004694.2"
                     /db_xref="CCDS:CCDS45592.1"
                     /db_xref="GeneID:9135"
                     /db_xref="HGNC:HGNC:17677"
                     /db_xref="MIM:603616"
                     /translation="MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRA
                     KFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA
                     IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRR
                     LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVK
                     ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQL
                     KHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKD
                     HKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSK
                     SDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSE
                     NFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR
                     LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQ
                     ANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDV
                     QEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL
                     KYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS
                     ISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMF
                     EEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDI
                     NQLPET"
     exon            238..366
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..570
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            571..731
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            732..851
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            852..987
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1166
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1298
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1766
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1871
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1988
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2087
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2228
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2418
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2474
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2573
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2690
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..5909
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5357..5362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /note="hexamer: ATTAAA"
     polyA_site      5379
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /note="major polyA site"
     regulatory      5875..5880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
                     /note="hexamer: AATAAA"
     polyA_site      5909
                     /gene="RABEP1"
                     /gene_synonym="RAB5EP; RABPT5"
ORIGIN      
        1 gtcaggatga ggaggcggag gtcggcggtc gggtccgtct ctgcccgcgg ctgtggcggc
       61 gccggcggat ccagccttag cggtttctct ctgggcggcg gcggcggcgg ctcggttgac
      121 gcctcctccg ccagctgagc ccgcgggagc ccaggacgcc gcttccccgc ccatccccgc
      181 tccccgaggc cggccgcctg gtcatggcgc agccgggccc ggcttcccag cctgacgttt
      241 ctcttcagca acgggtagca gaattggaaa aaattaatgc agaattttta cgtgcacaac
      301 agcagcttga acaagaattt aatcaaaaga gagcaaaatt taaggagtta tatttggcta
      361 aagaggagga tctgaagagg caaaatgcag tattacaagc tgcacaagat gatttgggac
      421 accttcgaac ccagctgtgg gaagctcaag cagagatgga gaatattaag gcgattgcca
      481 cagtctctga gaacaccaag caagaagcta tagatgaagt gaaaagacag tggagagaag
      541 aagttgcttc acttcaggct gttatgaaag aaacagttcg tgactatgag caccagttcc
      601 accttaggct ggagcaggag cgaacacagt gggcacagta tagagaatcc gcagagaggg
      661 aaatagctga tttaagaaga aggctgtctg aaggtcaaga ggaggaaaat ttagaaaatg
      721 aaatgaaaaa ggcccaagag gatgctgaga aacttcggtc cgttgtgatg ccaatggaaa
      781 aggaaattgc agctttgaag gataaactga cagaggctga agacaaaatt aaagagctgg
      841 aggcctcaaa ggttaaagaa ctgaatcatt atctggaagc tgagaaatct tgtaggactg
      901 atctagagat gtatgtagct gttttgaata ctcagaaatc tgttctacag gaagatgctg
      961 agaaactgcg gaaagaattg catgaagttt gccatctctt ggagcaagag cgacaacaac
     1021 acaaccagtt aaaacatacg tggcagaagg ccaatgacca gtttctggaa tctcagcgtt
     1081 tactgatgag agacatgcag cgaatggaga ttgtgctaac ttcagaacag ctccgacaag
     1141 ttgaagaact gaagaagaaa gatcaggagg atgatgaaca acaaagactc aataagagaa
     1201 aggatcacaa aaaagcagat gttgaggaag aaataaaaat accagtagtg tgtgctttaa
     1261 ctcaagaaga atcttcagcc cagttatcaa atgaagagga gcatttagac agcacccgtg
     1321 gctcagttca ttccttagat gcaggcttgc tgttgccatc tggagatcct ttcagtaaat
     1381 cggacaatga catgtttaaa gatggactca ggagagcaca gtctacagac agcttgggaa
     1441 cctcgggctc attgcaatcc aaagctttag gctataacta caaagcaaaa tctgctggaa
     1501 acctggacga gtcagatttt ggaccactgg taggagcaga ttcagtgtct gagaactttg
     1561 atactgcatc ccttgggtca ctccagatgc caagtgggtt tatgttaacc aaagatcagg
     1621 aaagagcaat caaggcgatg acaccagaac aagaagagac agcgtccctc ctctccagcg
     1681 ttacccaggg catggagagt gcctatgtgt cccctagtgg ttatcgttta gttagtgaaa
     1741 cagaatggaa tctcttgcag aaagaggtac ataatgctgg aaataaactt ggtagacgtt
     1801 gtgatatgtg ttccaattac gaaaaacagt tacaaggaat tcagattcag gaggctgaaa
     1861 cgagagacca ggtgaaaaaa ctacagctga tgctaaggca agctaatgac cagttagaga
     1921 agacaatgaa agataagcag gagctggaag acttcataaa gcaaagcagc gaagattcga
     1981 gtcaccagat ctctgcactc gtcctaagag cccaggcctc cgagatctta cttgaagagt
     2041 tacagcaggg gctttcccag gcaaagaggg atgttcagga acagatggcg gtgctgatgc
     2101 agtcacggga acaggtttca gaagagctgg tgaggttaca gaaagataat gacagtctcc
     2161 agggaaagca cagcctgcat gtgtcattac agcaagcaga agacttcatc ctcccagaca
     2221 ctacagaggc actgcgggag ttggtattaa aataccgtga ggacatcatt aatgtgcgga
     2281 cagcagcaga ccacgtagaa gaaaagctga aggctgagat acttttccta aaagagcaga
     2341 tccaagcaga acagtgttta aaagaaaatc ttgaagaaac tctgcaacta gaaatagaaa
     2401 actgcaagga ggaaatagct tctatttcta gcctaaaagc tgaattagaa agaataaaag
     2461 tggaaaaagg acagttggag tccacattaa gagagaagtc tcaacagctt gagagtcttc
     2521 aggaaataaa gatcagtttg gaagagcagt taaagaaaga gactgctgct aaggctaccg
     2581 ttgaacaact aatgtttgaa gagaagaata aagctcagag attacagaca gaattagatg
     2641 tcagtgagca agtccagagg gattttgtaa agctttcaca gacccttcag gtgcagttag
     2701 agcggatccg gcaagctgac tccttggaga gaatccgggc aattctgaat gatactaaac
     2761 tgacagacat taaccagctt cctgagacat gacaccctca tggcaggatt ctagcctgca
     2821 ctttgggttt ttaactcatc tttagagcaa cagtaattat tatttaactc ttaactgaag
     2881 aaagagaagt cacaacaaaa ggaagactgg agaaatgctt acttctagag ggagaagact
     2941 gtgcggcaca ggaaacagca aacagtgggg tgatctgcag cccagagacc ttcaaatgcg
     3001 aacactataa actccaggct tgattccaac aggcgtggga tcagatttgg tgatggaaaa
     3061 agcgctgttt ccttgcctgc tttctccaag acagattttc ggaacacatt tccctaccct
     3121 aaagcgacat cccagtagtg tttggaattt tctgttcata gatattggaa gagagaattt
     3181 gctttatctg ttgtctagag ctcatcagta acagtattca gttagcagac agaagtgtag
     3241 tatgctgtat gaatatttta tattaaaata tgaaggtttg agagcaggcc attggctact
     3301 gactgtattt tgttttcctt ttaccatttt atcttatctt gctttggagg accttaaatg
     3361 ctactgaaac ttacctgaga accataggac tgtggcaaac aaaaccaatt catgaagtga
     3421 attaatgatg aggatctgaa aacttggctg gggctatata tactggaagt tgaaggttaa
     3481 aggaaaagca caagaaactt tggaagcact ttttctgcat acttagatga tcttcatggg
     3541 cccacagggt accaggataa agccgaactg gtaccatcta ctcttttgaa gtgttttagt
     3601 ctagttattg gatcagtgaa aaacattagt atacgttttt aaataggcta atttttcaac
     3661 ttggatcatt aggcttacgt actacttgtt tcaaatgtgt caaatacaaa aatggtaact
     3721 aggttgacag atactttgta tttttctttt gaattcagac ctggaatgta agtaagtgac
     3781 aatgcttatg gaaagccagt tagttagaat tggaaatctg tcttgtcatt ttacaagcat
     3841 tagattcctt tcctgtgtga agaaagcctc agtgaaacag gtctttgcca taactttatg
     3901 aagtgctaca gaaagcacaa agaattgatt catgttcatc aatacctgct gagagtactg
     3961 tcccaggaat atccagtgga tggattcatc atccaggagg ttcaaaagta agatggtttt
     4021 caaatcattt ttgagactgg ttgcataaca gcagggtacc tgaaagagcc ttctgggagt
     4081 tagtgaacta ggtagattgt tttgttcaca taacgccacc atcaacttaa agtgaattgt
     4141 ctttgttata aatgaggtca ctatggactt accctaaaga tcttctgtac ttctgtcttc
     4201 cataggacaa atgataagta ctacatacct catctcttgg gttattattg tagtcttgca
     4261 ttcatggtta tgaatttaaa aataaatacc aattatggaa atagtactaa aggcttgccg
     4321 cacatgaaac attattttaa ttggtttaaa gtccctttat aaagagtgct acatggttta
     4381 gataaaggaa acatataact attgagttac aggggatttt attaattata aaatgcaatc
     4441 aatttaaatt acgtaggttt aagactagtc ccttggataa gccccaagcg aatttgtctt
     4501 cagattatta aaattagtgc tgtaaatcag ggtgggcaat tcacagcctt tctgaactga
     4561 ctgaactaga gcttgcagtg aagtgttctg ctgagactga gcaccttaca gatatttttc
     4621 tccagaagat ggtgctgggt aataaaatca tcacaattag ggaatggtta gtggtctcta
     4681 ctgtggcaaa tgccaactgt tggaattcac tttattgtag aaaaacccaa actgagactc
     4741 ttaagttttg tttagcaatg tgtttctggt atgaaacaaa ctactgtgtc actgtccagg
     4801 taggaaacaa ttctttcaac tgggttttca gcataaatgg gaactgatgt agaaggcagg
     4861 atttagccct tctaggcaaa agaaaagctc agttgggttt cacgagtgtt cctgtgctta
     4921 tattcagtct gtgcctacat gttctcatgc atgtctaacc tgatttacct cttacctgta
     4981 acctacctta tcatgtggct tttaattgac agtcactcag ccatttctaa gcagatatag
     5041 tagtaccttt cagaactcac attggcaagt gtaaaaagat gacttaaggt gaagtgagga
     5101 caaaatcaca ttctgcatac taacctattt ttttctccct ttaaggtgct aaacttgcac
     5161 ctcatgtcca ctcagtaaca agtattggga cgtagagcac agcctcactc agctctgaaa
     5221 ggtaatacag cttgtgagga agtgagccag cagtggcctt tgcaattgtg gatcttgagc
     5281 tctgctctca gcagatttca ggtgtaacca tttgttaact gtactgaagg tgtgtcctca
     5341 agaagaaagt gttcaaatta aaaaagctgc tgccaagtac actgtgtggt cttctccttt
     5401 gaatcctagg gttctatccc tcttcagagt catgtttctg gtgctgctac tttaaaacac
     5461 agctcacaag aataactaac ttgctcaaat atggagaaaa ctcaataggg ttcagggagg
     5521 ttctggcagt gtgcagtgtg aaataatcct gagtccttgc tgaacacaac tgtaggcttg
     5581 agttataaag cacattccaa attttaaata aaagcattta ctcaattatt ataaaacaac
     5641 atatttaaaa agatgaacca caccaaaggt catcaaaaca cctttttata aattagataa
     5701 ttctacctgt tttacaatat gggtttaagc cttcaatggt gttcagttca ggtgtgagtc
     5761 agctcctggt ggtgtcagaa gtttacatga ttgcggatat cattgatttg cttcaccatt
     5821 tcccttatat gttcacccct gtaaaattgt aaagtcactc acttttggaa ttataataaa
     5881 ccatttatat ggattcttaa gaatttaaa
//
