LOCUS       NM_006423                750 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rab acceptor 1 (RABAC1), mRNA.
ACCESSION   NM_006423
VERSION     NM_006423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 750)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 750)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 750)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 750)
  AUTHORS   Kim,J.T., Cho,H.J., Cho,M.Y., Lim,J., Park,E.S., Lim,J.S. and
            Lee,H.G.
  TITLE     Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein
            BCL2A1 and induces apoptosis
  JOURNAL   Biochem Biophys Res Commun 513 (4), 940-946 (2019)
   PUBMED   31003775
  REMARK    GeneRIF: RABAC1 caused caspase-3 activation and decreased cell
            proliferation, clonogenic cell survival, and cell migration and
            invasion.
REFERENCE   6  (bases 1 to 750)
  AUTHORS   Abdul-Ghani,M., Gougeon,P.Y., Prosser,D.C., Da-Silva,L.F. and
            Ngsee,J.K.
  TITLE     PRA isoforms are targeted to distinct membrane compartments
  JOURNAL   J Biol Chem 276 (9), 6225-6233 (2001)
   PUBMED   11096102
REFERENCE   7  (bases 1 to 750)
  AUTHORS   Hutt,D.M., Da-Silva,L.F., Chang,L.H., Prosser,D.C. and Ngsee,J.K.
  TITLE     PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1
  JOURNAL   J Biol Chem 275 (24), 18511-18519 (2000)
   PUBMED   10751420
REFERENCE   8  (bases 1 to 750)
  AUTHORS   Fenster,S.D., Chung,W.J., Zhai,R., Cases-Langhoff,C., Voss,B.,
            Garner,A.M., Kaempf,U., Kindler,S., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a presynaptic zinc finger protein structurally related to
            bassoon
  JOURNAL   Neuron 25 (1), 203-214 (2000)
   PUBMED   10707984
REFERENCE   9  (bases 1 to 750)
  AUTHORS   Bucci,C., Chiariello,M., Lattero,D., Maiorano,M. and Bruni,C.B.
  TITLE     Interaction cloning and characterization of the cDNA encoding the
            human prenylated rab acceptor (PRA1)
  JOURNAL   Biochem Biophys Res Commun 258 (3), 657-662 (1999)
   PUBMED   10329441
REFERENCE   10 (bases 1 to 750)
  AUTHORS   Martincic,I., Peralta,M.E. and Ngsee,J.K.
  TITLE     Isolation and characterization of a dual prenylated Rab and VAMP2
            receptor
  JOURNAL   J Biol Chem 272 (43), 26991-26998 (1997)
   PUBMED   9341137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB454056.1, CF242972.1 and AI376198.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006423.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.83507.1,
                                           SRR5189655.12603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222008.11/ ENSP00000222008.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DB454056.1         56-81
            27-701              CF242972.1         37-711
            702-750             AI376198.1         17-65               c
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..750
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /note="Rab acceptor 1"
                     /db_xref="GeneID:10567"
                     /db_xref="HGNC:HGNC:9794"
                     /db_xref="MIM:604925"
     exon            1..85
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..587
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /note="prenylated Rab acceptor 1; PRA1 domain family 1;
                     PRA1 family protein 1; Rab acceptor 1 (prenylated)"
                     /codon_start=1
                     /product="prenylated Rab acceptor protein 1"
                     /protein_id="NP_006414.2"
                     /db_xref="CCDS:CCDS12593.1"
                     /db_xref="GeneID:10567"
                     /db_xref="HGNC:HGNC:9794"
                     /db_xref="MIM:604925"
                     /translation="MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRP
                     WSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAV
                     FFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATL
                     VVIGSHAAFHQIEAVDGEELQMEPV"
     exon            86..298
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..396
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..498
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..750
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /note="hexamer: AATAAA"
     polyA_site      750
                     /gene="RABAC1"
                     /gene_synonym="PRA1; PRAF1; YIP3"
                     /note="major polyA site"
ORIGIN      
        1 acagcagctc tacccctcac gacgcagaca tggcagcgca gaaggaccag cagaaagatg
       61 ccgaggcgga agggctgagc ggcacgaccc tgctgccgaa gctgattccc tccggtgcag
      121 gccgggagtg gctggagcgg cgccgcgcga ccatccggcc ctggagcacc ttcgtggacc
      181 agcagcgctt ctcacggccc cgcaacctgg gagagctgtg ccagcgcctc gtacgcaacg
      241 tggagtacta ccagagcaac tatgtgttcg tgttcctggg cctcatcctg tactgtgtgg
      301 tgacgtcccc tatgttgctg gtggctctgg ctgtcttttt cggcgcctgt tacattctct
      361 atctgcgcac cttggagtcc aagcttgtgc tctttggccg agaggtgagc ccagcgcatc
      421 agtatgctct ggctggaggc atctccttcc ccttcttctg gctggctggt gcgggctcgg
      481 ccgtcttctg ggtgctggga gccaccctgg tggtcatcgg ctcccacgct gccttccacc
      541 agattgaggc tgtggacggg gaggagctgc agatggaacc cgtgtgaggt gtcttctggg
      601 acctgccggc ctcccgggcc agctgcccca cccctgccca tgcctgtcct gcacggctct
      661 gctgctcggg cccacagcgc cgtcccatca caagcccggg gagggatccc gcctttgaaa
      721 ataaagctgt tatgggtgtc attcaggaaa
//
