LOCUS       NM_016370               3772 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RAB9B, member RAS oncogene family (RAB9B), transcript
            variant 1, mRNA.
ACCESSION   NM_016370
VERSION     NM_016370.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Nottingham,R.M., Pusapati,G.V., Ganley,I.G., Barr,F.A.,
            Lambright,D.G. and Pfeffer,S.R.
  TITLE     RUTBC2 protein, a Rab9A effector and GTPase-activating protein for
            Rab36
  JOURNAL   J Biol Chem 287 (27), 22740-22748 (2012)
   PUBMED   22637480
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   4  (bases 1 to 3772)
  AUTHORS   Kloer,D.P., Rojas,R., Ivan,V., Moriyama,K., van Vlijmen,T.,
            Murthy,N., Ghirlando,R., van der Sluijs,P., Hurley,J.H. and
            Bonifacino,J.S.
  TITLE     Assembly of the biogenesis of lysosome-related organelles complex-3
            (BLOC-3) and its interaction with Rab9
  JOURNAL   J Biol Chem 285 (10), 7794-7804 (2010)
   PUBMED   20048159
REFERENCE   5  (bases 1 to 3772)
  AUTHORS   Espinosa,E.J., Calero,M., Sridevi,K. and Pfeffer,S.R.
  TITLE     RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi
            transport
  JOURNAL   Cell 137 (5), 938-948 (2009)
   PUBMED   19490898
REFERENCE   6  (bases 1 to 3772)
  AUTHORS   Yoon,S. and De Micheli,G.
  TITLE     Prediction of regulatory modules comprising microRNAs and target
            genes
  JOURNAL   Bioinformatics 21 Suppl 2, ii93-i100 (2005)
   PUBMED   16204133
REFERENCE   7  (bases 1 to 3772)
  AUTHORS   Zhao,H., Ettala,O. and Vaananen,H.K.
  TITLE     Intracellular membrane trafficking pathways in bone-resorbing
            osteoclasts revealed by cloning and subcellular localization
            studies of small GTP-binding rab proteins
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1060-1065 (2002)
   PUBMED   12051767
REFERENCE   8  (bases 1 to 3772)
  AUTHORS   Seki,N., Azuma,T., Yoshikawa,T., Masuho,Y., Muramatsu,M. and
            Saito,T.
  TITLE     cDNA cloning of a new member of the Ras superfamily, RAB9-like, on
            the human chromosome Xq22.1-q22.3 region
  JOURNAL   J Hum Genet 45 (5), 318-322 (2000)
   PUBMED   11043518
REFERENCE   9  (bases 1 to 3772)
  AUTHORS   Soldati,T., Shapiro,A.D., Svejstrup,A.B. and Pfeffer,S.R.
  TITLE     Membrane targeting of the small GTPase Rab9 is accompanied by
            nucleotide exchange
  JOURNAL   Nature 369 (6475), 76-78 (1994)
   PUBMED   8164745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA501604.1, AK313425.1 and
            FO393406.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016370.3.
            
            Summary: This gene encodes a member of a subfamily of RAS small
            guanosine triphosphate (GTP)-binding proteins that regulate
            membrane trafficking. The encoded protein may be involved in
            endosome-to-Golgi transport. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041336.1, SRR1803613.20022.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243298.3/ ENSP00000243298.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                DA501604.1         26-105
            81-920              AK313425.1         1-840
            921-3772            FO393406.1         9985-12836          c
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..3772
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /note="RAB9B, member RAS oncogene family"
                     /db_xref="GeneID:51209"
                     /db_xref="HGNC:HGNC:14090"
                     /db_xref="MIM:300285"
     exon            1..198
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /inference="alignment:Splign:2.1.0"
     exon            199..272
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /inference="alignment:Splign:2.1.0"
     exon            273..3772
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..920
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /note="Ras-associated protein RAB9-like; Ras-associated
                     protein 9B"
                     /codon_start=1
                     /product="ras-related protein Rab-9B"
                     /protein_id="NP_057454.1"
                     /db_xref="CCDS:CCDS14515.1"
                     /db_xref="GeneID:51209"
                     /db_xref="HGNC:HGNC:14090"
                     /db_xref="MIM:300285"
                     /translation="MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEF
                     LNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQ
                     KEFIYYADVKDPEHFPFVVLGNKVDKEDRQVTTEEAQTWCMENGDYPYLETSAKDDTN
                     VTVAFEEAVRQVLAVEEQLEHCMLGHTIDLNSGSKAGSSCC"
     regulatory      3744..3749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /note="hexamer: AATAAA"
     polyA_site      3772
                     /gene="RAB9B"
                     /gene_synonym="Rab-9L; RAB9L"
                     /note="major polyA site"
ORIGIN      
        1 gagacgctgc gcggcggcag cggcgggcgc gagcggcagc tgtcaggcca ccgaggtcca
       61 agccgcactt gctgccccat tgaggacgag gaggcagcag gagcagtgac ggtgactcta
      121 aggagccgga ttcccggcac gcagagctga cctgcctggc acccgcggcc ctctcctgtt
      181 tccttcccat tgtgttggca ccctaaaaag aaagaataaa acaacaacag gaaaaaaagg
      241 aaaatattta aattgtgaca aaaacccact gggttctctt ggttacaaac tccttccctt
      301 ctggtgctgc aaaaatgagt gggaaatccc tgctcttaaa ggtcattctc ttgggtgatg
      361 gtggagttgg gaaaagttcg cttatgaacc gttacgtaac caacaaattt gactcccagg
      421 cttttcacac cataggggta gagttcttaa atcgagatct ggaggtagat ggacgctttg
      481 taaccctcca gatctgggac actgcagggc aggaacgttt caagagcctt aggacaccct
      541 tctacagggg agcagactgc tgcctcttga ccttcagcgt ggatgatcgg cagagcttcg
      601 agaatcttgg taactggcag aaagaattta tttactatgc ggatgtgaag gaccctgagc
      661 atttcccctt tgtagttctg ggtaacaagg tagacaaaga ggataggcaa gtgactactg
      721 aggaggcaca aacctggtgc atggagaatg gggattaccc ttatttagaa actagtgcca
      781 aagatgatac taatgtgaca gtggcctttg aagaagctgt caggcaggtg ctggctgtag
      841 aggaacagct ggagcattgc atgttgggtc acaccattga cttgaacagt ggctccaaag
      901 cagggtcttc gtgctgttaa agatagggag ccttttaaaa atgtgcccca aattgatcag
      961 tcagtagtgt aagaataact gtgcccctct aagagtgcac acacacgcac acaagagggt
     1021 aagagacaag gttctgattg tgaaacagag cctttcaaat tgaagtgtag attgatttaa
     1081 aaaaattaaa aattaaaaaa aatgaagctc tatcaagcca agtgtatttt gcgtgatttc
     1141 tgctatttcc ccttcttgtg tgtctcagga catatcagaa aattttagtc ctgagacagt
     1201 taaatatttt ttaaatcaca gtttaaacct agaacccagc tgcatgaagg agttaaagag
     1261 ctacaactat ttcttaaagt gttccattaa tcaactaaca aatgtcacta tcagactctt
     1321 gccaagcagt ttctgacatt tctgccaaag gggaaaaaaa tcagactttg agctgtatta
     1381 caataaaaat aataatgcaa ataaggattc ctaggcttga attaaagaag ttgtaatgat
     1441 taggagtgca aaagtataat gatatacact gacttgttta aatccttatg tatggttcgc
     1501 tcccatctga gcttttcaaa aaatcccatc tcaataagag atactctaat gacactggca
     1561 attgattata cttcttgtgt ttgaagtcat aggatactag tgaatggatt atgcttaaat
     1621 atgccaacca cctttgcaaa taaatggttg gtctgctttt aattcctaag tctacttttg
     1681 ctgcatagag atgttgcttc tctgacaacc tcttaccaat ttagcaatgc tgcttagtat
     1741 atgaatttgg atgcagtgct ctctgctcat catttagatg gtcctttgat ccaacatgct
     1801 gggctcatgg agaaggcttc ataaaagatt gggggataat gaacttttct cacaaggctc
     1861 cttaactcaa atatttattg cagaagaagg aactggtttc ttatatgttg cactgtatgt
     1921 tcaactagcc taattaggac attgaaagtg acagaagagc agatcttaac ccagtgttag
     1981 aatgaatttc ccataaacag agttgtccaa cagtggaatg gactgcctta atagtgagct
     2041 ccctgcctct gaaaatattc actggatgac catctgttag aataccataa aaagattttc
     2101 tgtgctggct acatgttcaa tataaagtcc tttctggctc taagttctat gaatatataa
     2161 actacatcag tgccatgctg tggttagatt tatctgatga taacagctaa gactatggag
     2221 agggacttta aaaattctca aaccattctg tgatcaatct ttaacagcaa ctacatagct
     2281 cttccttttg cttttgcact gtggcaggaa aaattcttga gctctgagta atctttatgt
     2341 gactgataaa aaacatctta aagctcccat gttaaaatat aaaaatggtt tgacaatttt
     2401 tgattaccat gactgtcagt tatatactat attatgaata tgcagtgtgg ttcttgttgg
     2461 ttgatctgtt taccctgcat agattttaat ctgtacttta aaacatctat gataaaaata
     2521 gtgacagaca gaaattaccc caaaaagaga cctaggccag gaagggggtg ggagctttca
     2581 taggaataca gcctagaact ctccattgta gccacgtatg gaatcagcct tacttacatg
     2641 taggaccttt gtgctttaag agctctggga catattggcc aaatagaaaa gaagaggaca
     2701 gtatttcaac tcagtcatac tcaatatttc caattaagat ataatcctga caccattgtt
     2761 caattaactt tgacgccaga agtcaaagcc agaactggga ccccacagct cttaagtact
     2821 ggtccctatc ctgcctatgc ctatagccag ccacactggt ttccaagttc tgtgatcatt
     2881 ttgctacaat catgttaggg tgaaaatctg tacgtcagaa ctgttaaatg ctaattattt
     2941 ttaagtgcat gagacctggg gccttctctt tctacttgca ctctgcttat actagtttct
     3001 atttgtagat ctcaggcctt catcataaag acctctatca actcacaaaa gtatttgtct
     3061 ctattagagt ggcatgtggt catttgagta aaaaaaaaaa aattacatgg gtatcggatt
     3121 cataggcatc ctgtccatct aagacaagtg ttaattttat tggcccatca gctggagccc
     3181 ctttcctctt agccatacca ttgttttcta ccaaattacc actcaatatc ttaatgaaag
     3241 cactcaacat taagtgacat aaacagtggc atttgggtaa gcaacactca gtggggtgct
     3301 gacatacagt ttgggtaaga ttaaaaaaca ccaaaggctg aaatctgtga gtaccaagaa
     3361 ctgtgcatat aggtttagaa attgactgtg taccctagaa tgtgcagtgt aatattttca
     3421 ataggtgttt ttttaaagaa cactagattt ttggaataat atatttctaa ttaggactat
     3481 actgtttttc aatggtctgt taaaacatca tacagaatat ttatttagtt tattgtcatg
     3541 tattggctaa ctttcagggg cctcagattc catatgtctt cagtggattg atgaatatca
     3601 ggttaatttg tgcctgcccc agccatctct actttattct gaggtattcc acaatcctct
     3661 tgttgcaggt gctgctaaaa aaaactcaaa attgtgtatc aaatattttc tttcaactgt
     3721 aaaaaatcat ctgtgttaaa gtgaataaaa agtgcatttt gaataaccag ca
//
