LOCUS       NM_004251               2034 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RAB9A, member RAS oncogene family (RAB9A), transcript
            variant 1, mRNA.
ACCESSION   NM_004251
VERSION     NM_004251.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2034)
  AUTHORS   Cui,S., Faure,M. and Wei,Y.
  TITLE     CALCOCO2/NDP52 associates with RAB9 to initiate an antiviral
            response to hepatitis B virus infection through a lysosomal
            degradation pathway
  JOURNAL   Autophagy 20 (9), 2109-2111 (2024)
   PUBMED   38752371
  REMARK    GeneRIF: CALCOCO2/NDP52 associates with RAB9 to initiate an
            antiviral response to hepatitis B virus infection through a
            lysosomal degradation pathway.
REFERENCE   2  (bases 1 to 2034)
  AUTHORS   Choi,J. and DiMaio,D.
  TITLE     Noncanonical Rab9a action supports retromer-mediated endosomal exit
            of human papillomavirus during virus entry
  JOURNAL   PLoS Pathog 19 (9), e1011648 (2023)
   PUBMED   37703297
  REMARK    GeneRIF: Noncanonical Rab9a action supports retromer-mediated
            endosomal exit of human papillomavirus during virus entry.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2034)
  AUTHORS   Mareninova,O.A., Dillon,D.L., Wightman,C.J.M., Yakubov,I.,
            Takahashi,T., Gaisano,H.Y., Munson,K., Ohmuraya,M., Dawson,D.,
            Gukovsky,I. and Gukovskaya,A.S.
  TITLE     Rab9 Mediates Pancreatic Autophagy Switch From Canonical to
            Noncanonical, Aggravating Experimental Pancreatitis
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (2), 599-622 (2022)
   PUBMED   34610499
  REMARK    GeneRIF: Rab9 Mediates Pancreatic Autophagy Switch From Canonical
            to Noncanonical, Aggravating Experimental Pancreatitis.
REFERENCE   4  (bases 1 to 2034)
  AUTHORS   Ouyang,X., Yao,L., Liu,G., Liu,S., Gong,L. and Xiao,Y.
  TITLE     Loss of androgen receptor promotes HCC invasion and metastasis via
            activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia
  JOURNAL   Biochem Biophys Res Commun 557, 26-32 (2021)
   PUBMED   33862456
  REMARK    GeneRIF: Loss of androgen receptor promotes HCC invasion and
            metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under
            hypoxia.
REFERENCE   5  (bases 1 to 2034)
  AUTHORS   Sun,P., Li,L. and Li,Z.
  TITLE     RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells
  JOURNAL   Biomed Res Int 2020, 5691671 (2020)
   PUBMED   32420351
  REMARK    GeneRIF: RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2034)
  AUTHORS   Diaz,E., Schimmoller,F. and Pfeffer,S.R.
  TITLE     A novel Rab9 effector required for endosome-to-TGN transport
  JOURNAL   J Cell Biol 138 (2), 283-290 (1997)
   PUBMED   9230071
REFERENCE   7  (bases 1 to 2034)
  AUTHORS   Davies,J.P., Cotter,P.D. and Ioannou,Y.A.
  TITLE     Cloning and mapping of human Rab7 and Rab9 cDNA sequences and
            identification of a Rab9 pseudogene
  JOURNAL   Genomics 41 (1), 131-134 (1997)
   PUBMED   9126495
REFERENCE   8  (bases 1 to 2034)
  AUTHORS   Shapiro,A.D. and Pfeffer,S.R.
  TITLE     Quantitative analysis of the interactions between prenyl Rab9, GDP
            dissociation inhibitor-alpha, and guanine nucleotides
  JOURNAL   J Biol Chem 270 (19), 11085-11090 (1995)
   PUBMED   7744738
REFERENCE   9  (bases 1 to 2034)
  AUTHORS   Soldati,T., Shapiro,A.D., Svejstrup,A.B. and Pfeffer,S.R.
  TITLE     Membrane targeting of the small GTPase Rab9 is accompanied by
            nucleotide exchange
  JOURNAL   Nature 369 (6475), 76-78 (1994)
   PUBMED   8164745
REFERENCE   10 (bases 1 to 2034)
  AUTHORS   Soldati,T., Riederer,M.A. and Pfeffer,S.R.
  TITLE     Rab GDI: a solubilizing and recycling factor for rab9 protein
  JOURNAL   Mol Biol Cell 4 (4), 425-434 (1993)
   PUBMED   8389620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA141710.1, BC017265.2, CF528703.1 and AC003037.1.
            
            On May 17, 2019 this sequence version replaced NM_004251.4.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.687714.1,
                                           SRR5189652.54741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000464506.2/ ENSP00000420127.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               DA141710.1         33-557
            526-1175            BC017265.2         432-1081
            1176-1355           CF528703.1         16-195              c
            1356-2034           AC003037.1         13000-13678
FEATURES             Location/Qualifiers
     source          1..2034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2034
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="RAB9A, member RAS oncogene family"
                     /db_xref="GeneID:9367"
                     /db_xref="HGNC:HGNC:9792"
                     /db_xref="MIM:300284"
     exon            1..161
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /inference="alignment:Splign:2.1.0"
     exon            162..250
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /inference="alignment:Splign:2.1.0"
     exon            251..2034
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..882
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="RAB9, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-9A"
                     /protein_id="NP_004242.1"
                     /db_xref="CCDS:CCDS14156.1"
                     /db_xref="GeneID:9367"
                     /db_xref="HGNC:HGNC:9792"
                     /db_xref="MIM:300284"
                     /translation="MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEF
                     LNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWK
                     KEFIYYADVKEPESFPFVILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSAKDATN
                     VAAAFEEAVRRVLATEDRSDHLIQTDTVNLHRKPKPSSSCC"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="hexamer: AATAAA"
     polyA_site      1201
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="major polyA site"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="hexamer: ATTAAA"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="hexamer: ATTAAA"
     polyA_site      1348
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="major polyA site"
     polyA_site      1355
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="major polyA site"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="hexamer: ATTACA"
     polyA_site      1740
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /note="hexamer: GATAAA"
     polyA_site      2034
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
ORIGIN      
        1 atgttgttcc ctccgcgctg gacgggagca gctggagcgg gagcctggct gcgctaccgc
       61 ggctgcctcc tgctgtgcag gtccccgacc ctctctctgt cctcattgcg cccagacggg
      121 ccggcccaga gctcccgggt cgtctttcgt gtggccgcga gacactcttg cactcctgta
      181 atgagcctgg cactgtgatg aaacactttt cccgtgtcgt ttgagtgcat cttctcaaca
      241 accctaggag ggttcttgaa gcttttgaga ttaacaatgg caggaaaatc atcacttttt
      301 aaagtaattc tccttggaga tggtggagtt gggaagagtt cacttatgaa cagatatgta
      361 actaataagt ttgataccca gctcttccat acaataggtg tggaattttt aaataaagat
      421 ttggaagtgg atggacattt tgttaccatg cagatttggg acacggcagg tcaggagcga
      481 ttccgaagcc tgaggacacc attttacaga ggttctgact gctgcctgct tacttttagt
      541 gtcgatgatt cacaaagctt ccagaactta agtaactgga agaaagaatt catatattat
      601 gcagatgtga aagagcctga gagctttcct tttgtgattc tgggtaacaa gattgacata
      661 agcgaacggc aggtgtctac agaagaagcc caagcttggt gcagggacaa cggcgactat
      721 ccttattttg aaacaagtgc aaaagatgcc acaaatgtgg cagcagcctt tgaggaagcg
      781 gttcgaagag ttcttgctac cgaggatagg tcagatcatt tgattcagac agacacagtc
      841 aatcttcacc gaaagcccaa gcctagctca tcttgctgtt gattgttaga ttgttgatgc
      901 attctaacca actcacacat atacacaaaa tcaacatggg gatggagaag agaattagcg
      961 tttgcagcag tgtatcatct actaataaaa ttaaactaat gttgctgctt cattagttgg
     1021 tgggagaagg gacacatcca ctcttggagg aatatattta ctcaataatg gcaccttaca
     1081 tttataaatt gtaacagttg tctaataacg tttctttaat ttaaatatgt aagttgcaga
     1141 gctaataaat gaaatgacca agactttaat tataataaaa ataagaaact tgactattct
     1201 agaagttata cttggatttt ttcctgggaa aatggagaac tactttttat atgtgtatgt
     1261 ttttatgcaa ttagcattgt attcttggtt cagggaaata ctttcctaaa gcaataatgt
     1321 tagatattaa agattaaaat ctaatgtatt tgcaatgcat tgttaattta cttcttcatt
     1381 ctcttcaaaa tgatttaacc attcctgttt tcattctaca tactagaatt actctcacta
     1441 gtaattactc atcatttgtg tgccattcat gcacccccac ccccataaat catgttccac
     1501 agtctcaggc ggagggtggg cccccagtgg tacaagagtt gcttcataca gtctgtaata
     1561 catccagcta aattcaagtt gtctatgaat ggaaagcctt tccatagata gagttcagtt
     1621 ttaagaaaaa ggctaactac tgaacttgga gaacagacaa atgtgcattt gataactgat
     1681 gtaataatta caatgtactg tgtggaagat acaaaattac aattcgatta atggactaaa
     1741 tatttttgtt actttcttga cccttgggga aagtttctta attgaagtta aaacattcct
     1801 ttataacaca agacacaagc tgactttatc actctcagaa gaaatactaa gaaggattgt
     1861 actttgtgag agggtaaacg aagacatctt tattcggcaa tgtatttact tagtgtcttc
     1921 tctattactg aacatttagt gatttgctct caaggagatt ttttgttaga aaaagacttg
     1981 ttgcagtgat cagacttgat aaagcaaatt gtggtctttt gtggatgaag ttca
//
