LOCUS       NP_004242                201 aa            linear   PRI 05-MAY-2025
DEFINITION  ras-related protein Rab-9A [Homo sapiens].
ACCESSION   NP_004242
VERSION     NP_004242.1
DBSOURCE    REFSEQ: accession NM_004251.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 201)
  AUTHORS   Cui,S., Faure,M. and Wei,Y.
  TITLE     CALCOCO2/NDP52 associates with RAB9 to initiate an antiviral
            response to hepatitis B virus infection through a lysosomal
            degradation pathway
  JOURNAL   Autophagy 20 (9), 2109-2111 (2024)
   PUBMED   38752371
  REMARK    GeneRIF: CALCOCO2/NDP52 associates with RAB9 to initiate an
            antiviral response to hepatitis B virus infection through a
            lysosomal degradation pathway.
REFERENCE   2  (residues 1 to 201)
  AUTHORS   Choi,J. and DiMaio,D.
  TITLE     Noncanonical Rab9a action supports retromer-mediated endosomal exit
            of human papillomavirus during virus entry
  JOURNAL   PLoS Pathog 19 (9), e1011648 (2023)
   PUBMED   37703297
  REMARK    GeneRIF: Noncanonical Rab9a action supports retromer-mediated
            endosomal exit of human papillomavirus during virus entry.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 201)
  AUTHORS   Mareninova,O.A., Dillon,D.L., Wightman,C.J.M., Yakubov,I.,
            Takahashi,T., Gaisano,H.Y., Munson,K., Ohmuraya,M., Dawson,D.,
            Gukovsky,I. and Gukovskaya,A.S.
  TITLE     Rab9 Mediates Pancreatic Autophagy Switch From Canonical to
            Noncanonical, Aggravating Experimental Pancreatitis
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (2), 599-622 (2022)
   PUBMED   34610499
  REMARK    GeneRIF: Rab9 Mediates Pancreatic Autophagy Switch From Canonical
            to Noncanonical, Aggravating Experimental Pancreatitis.
REFERENCE   4  (residues 1 to 201)
  AUTHORS   Ouyang,X., Yao,L., Liu,G., Liu,S., Gong,L. and Xiao,Y.
  TITLE     Loss of androgen receptor promotes HCC invasion and metastasis via
            activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia
  JOURNAL   Biochem Biophys Res Commun 557, 26-32 (2021)
   PUBMED   33862456
  REMARK    GeneRIF: Loss of androgen receptor promotes HCC invasion and
            metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under
            hypoxia.
REFERENCE   5  (residues 1 to 201)
  AUTHORS   Sun,P., Li,L. and Li,Z.
  TITLE     RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells
  JOURNAL   Biomed Res Int 2020, 5691671 (2020)
   PUBMED   32420351
  REMARK    GeneRIF: RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 201)
  AUTHORS   Diaz,E., Schimmoller,F. and Pfeffer,S.R.
  TITLE     A novel Rab9 effector required for endosome-to-TGN transport
  JOURNAL   J Cell Biol 138 (2), 283-290 (1997)
   PUBMED   9230071
REFERENCE   7  (residues 1 to 201)
  AUTHORS   Davies,J.P., Cotter,P.D. and Ioannou,Y.A.
  TITLE     Cloning and mapping of human Rab7 and Rab9 cDNA sequences and
            identification of a Rab9 pseudogene
  JOURNAL   Genomics 41 (1), 131-134 (1997)
   PUBMED   9126495
REFERENCE   8  (residues 1 to 201)
  AUTHORS   Shapiro,A.D. and Pfeffer,S.R.
  TITLE     Quantitative analysis of the interactions between prenyl Rab9, GDP
            dissociation inhibitor-alpha, and guanine nucleotides
  JOURNAL   J Biol Chem 270 (19), 11085-11090 (1995)
   PUBMED   7744738
REFERENCE   9  (residues 1 to 201)
  AUTHORS   Soldati,T., Shapiro,A.D., Svejstrup,A.B. and Pfeffer,S.R.
  TITLE     Membrane targeting of the small GTPase Rab9 is accompanied by
            nucleotide exchange
  JOURNAL   Nature 369 (6475), 76-78 (1994)
   PUBMED   8164745
REFERENCE   10 (residues 1 to 201)
  AUTHORS   Soldati,T., Riederer,M.A. and Pfeffer,S.R.
  TITLE     Rab GDI: a solubilizing and recycling factor for rab9 protein
  JOURNAL   Mol Biol Cell 4 (4), 425-434 (1993)
   PUBMED   8389620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA141710.1, BC017265.2, CF528703.1 and AC003037.1.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.687714.1,
                                           SRR5189652.54741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000464506.2/ ENSP00000420127.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     Protein         1..201
                     /product="ras-related protein Rab-9A"
                     /EC_number="3.6.5.2"
                     /note="RAB9, member RAS oncogene family"
                     /calculated_mol_wt=22707
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (P51151.1)"
     Region          3..172
                     /region_name="Rab9"
                     /note="Rab GTPase family 9 (Rab9); cd04116"
                     /db_xref="CDD:206697"
     Site            4..9
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206697"
     Site            14..21
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206697"
     Site            order(17..22,32..34,38..39,65,124..125,127,154..156)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206697"
     Site            order(22..33,35..38)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206697"
     Site            order(32,37..45)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206697"
     Region          36..44
                     /region_name="Effector region. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51151.1)"
     Site            order(37,41..48,55,57)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206697"
     Site            39
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206697"
     Site            order(40,42..44,59,61,68..69,72,76,78..81,172)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206697"
     Site            order(40..41,43,61..62,69,71,73..75)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206697"
     Site            40..44
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206697"
     Site            57..61
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206697"
     Site            62..65
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206697"
     Site            order(65,67..77)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206697"
     Site            68..73
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206697"
     Site            76..80
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206697"
     Site            85..90
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206697"
     Site            order(108..112,115..121)
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206697"
     Site            124..127
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206697"
     Site            154..156
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206697"
     Site            170..172
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206697"
     Site            179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983; propagated from
                     UniProtKB/Swiss-Prot (P51151.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P51151.1)"
     CDS             1..201
                     /gene="RAB9A"
                     /gene_synonym="RAB9"
                     /coded_by="NM_004251.5:277..882"
                     /db_xref="CCDS:CCDS14156.1"
                     /db_xref="GeneID:9367"
                     /db_xref="HGNC:HGNC:9792"
                     /db_xref="MIM:300284"
ORIGIN      
        1 magksslfkv illgdggvgk sslmnryvtn kfdtqlfhti gveflnkdle vdghfvtmqi
       61 wdtagqerfr slrtpfyrgs dcclltfsvd dsqsfqnlsn wkkefiyyad vkepesfpfv
      121 ilgnkidise rqvsteeaqa wcrdngdypy fetsakdatn vaaafeeavr rvlatedrsd
      181 hliqtdtvnl hrkpkpsssc c
//
