LOCUS       NM_016530               4800 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB8B, member RAS oncogene family (RAB8B), mRNA.
ACCESSION   NM_016530
VERSION     NM_016530.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4800)
  AUTHORS   Lucken-Ardjomande Hasler,S., Vallis,Y., Pasche,M. and McMahon,H.T.
  TITLE     GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of
            E-cadherin, MMP14, and CFTR DeltaF508
  JOURNAL   J Cell Biol 219 (5) (2020)
   PUBMED   32344433
REFERENCE   2  (bases 1 to 4800)
  AUTHORS   Chen,B., Huang,S., Pisanic Ii,T.R., Stark,A., Tao,Y., Cheng,B.,
            Li,Y., Wei,Y., Zhao,W., Wang,T.H. and Wu,J.
  TITLE     Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and
            progression by directly modulating its surface expression in human
            non-small cell lung cancer
  JOURNAL   EBioMedicine 49, 118-132 (2019)
   PUBMED   31707148
  REMARK    GeneRIF: Rab8 GTPase can regulate Klotho-mediated inhibition of Wnt
            signaling activity by modulating translocation of Klotho onto the
            cell surface.
REFERENCE   3  (bases 1 to 4800)
  AUTHORS   Johari,A.H., Nejad,F.R., Mansoori,N., Vafaei,F., Salehi,S.,
            Alehabib,E., Alinaghi,S., Chapi,M., Jamali,F., Darvish,H. and
            Ghaedi,H.
  TITLE     The rs1986112 Variant is Associated with Increased RAB8B Gene
            Expression in Schizophrenic Patients
  JOURNAL   Clin Lab 65 (4) (2019)
   PUBMED   30969072
  REMARK    GeneRIF: there is significant upregulation of RAB8B in patients
            with rs1986112 GG and AG genotype compared to AA genotype,
            suggesting a role in schizophrenia development
REFERENCE   4  (bases 1 to 4800)
  AUTHORS   Lai,Y.C., Kondapalli,C., Lehneck,R., Procter,J.B., Dill,B.D.,
            Woodroof,H.I., Gourlay,R., Peggie,M., Macartney,T.J., Corti,O.,
            Corvol,J.C., Campbell,D.G., Itzen,A., Trost,M. and Muqit,M.M.
  TITLE     Phosphoproteomic screening identifies Rab GTPases as novel
            downstream targets of PINK1
  JOURNAL   EMBO J 34 (22), 2840-2861 (2015)
   PUBMED   26471730
  REMARK    GeneRIF: Rab8A GTPase Ser(111) phosphorylation is not directly
            regulated by PINK1 in vitro and demonstrate in cells the time
            course of Ser(111) phosphorylation of Rab8A, 8B and 13 is markedly
            delayed compared to phosphorylation of Parkin at Ser(65).
REFERENCE   5  (bases 1 to 4800)
  AUTHORS   St Pourcain,B., Skuse,D.H., Mandy,W.P., Wang,K., Hakonarson,H.,
            Timpson,N.J., Evans,D.M., Kemp,J.P., Ring,S.M., McArdle,W.L.,
            Golding,J. and Smith,G.D.
  TITLE     Variability in the common genetic architecture of
            social-communication spectrum phenotypes during childhood and
            adolescence
  JOURNAL   Mol Autism 5 (1), 18 (2014)
   PUBMED   24564958
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4800)
  AUTHORS   Lau,A.S. and Mruk,D.D.
  TITLE     Rab8B GTPase and junction dynamics in the testis
  JOURNAL   Endocrinology 144 (4), 1549-1563 (2003)
   PUBMED   12639940
REFERENCE   7  (bases 1 to 4800)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   8  (bases 1 to 4800)
  AUTHORS   de Bruyn,K.M., de Rooij,J., Wolthuis,R.M., Rehmann,H.,
            Wesenbeek,J., Cool,R.H., Wittinghofer,A.H. and Bos,J.L.
  TITLE     RalGEF2, a pleckstrin homology domain containing guanine nucleotide
            exchange factor for Ral
  JOURNAL   J Biol Chem 275 (38), 29761-29766 (2000)
   PUBMED   10889189
REFERENCE   9  (bases 1 to 4800)
  AUTHORS   Chen,D., Guo,J. and Gahl,W.A.
  TITLE     RAB GTPases expressed in human melanoma cells
  JOURNAL   Biochim Biophys Acta 1355 (1), 1-6 (1997)
   PUBMED   9030196
REFERENCE   10 (bases 1 to 4800)
  AUTHORS   Armstrong,J., Thompson,N., Squire,J.H., Smith,J., Hayes,B. and
            Solari,R.
  TITLE     Identification of a novel member of the Rab8 family from the rat
            basophilic leukaemia cell line, RBL.2H3
  JOURNAL   J Cell Sci 109 (Pt 6), 1265-1274 (1996)
   PUBMED   8799816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG721755.1, AB038995.1 and AC016207.9.
            
            On Nov 23, 2018 this sequence version replaced NM_016530.2.
            
            Summary: RAB proteins, like RAB8B, are low molecular mass monomeric
            GTPases that localize on the cytoplasmic surfaces of distinct
            membrane-bound organelles. RAB proteins function in intracellular
            vesicle transport by aiding in the docking and/or fusion of
            vesicles with their target membranes (summary by Chen et al., 1997
            [PubMed 9030196]).[supplied by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.183400.1,
                                           SRR1660803.106208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321437.9/ ENSP00000312734.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               BG721755.1         141-295
            156-1176            AB038995.1         228-1248
            1177-4800           AC016207.9         54855-58478         c
FEATURES             Location/Qualifiers
     source          1..4800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..4800
                     /gene="RAB8B"
                     /note="RAB8B, member RAS oncogene family"
                     /db_xref="GeneID:51762"
                     /db_xref="HGNC:HGNC:30273"
                     /db_xref="MIM:613532"
     exon            1..143
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..643
                     /gene="RAB8B"
                     /note="RAB-8b protein"
                     /codon_start=1
                     /product="ras-related protein Rab-8B"
                     /protein_id="NP_057614.1"
                     /db_xref="CCDS:CCDS10183.1"
                     /db_xref="GeneID:51762"
                     /db_xref="HGNC:HGNC:30273"
                     /db_xref="MIM:613532"
                     /translation="MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGID
                     FKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNW
                     IRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSANVEE
                     AFFTLARDIMTKLNRKMNDSNSAGAGGPVKITENRSKKTSFFRCSLL"
     exon            144..204
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            205..265
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            266..343
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            344..433
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            434..499
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            500..550
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     exon            551..4800
                     /gene="RAB8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4773..4778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB8B"
                     /note="hexamer: AATAAA"
     polyA_site      4800
                     /gene="RAB8B"
                     /note="major polyA site"
ORIGIN      
        1 agagggccgg agcgagaaga tggcgaagac gtacgattat ctcttcaagc tcctgctgat
       61 cggcgactcg ggggtaggca agacctgcct cctgttccgc ttctcagagg acgccttcaa
      121 caccaccttc atctccacca tcggaattga ttttaaaatt agaacgatag aactagatgg
      181 aaagaaaatt aagcttcaga tatgggacac agcgggtcag gaaagattcc gaacaatcac
      241 gacagcgtac tacagaggag ccatgggcat tatgctggtc tatgacatca caaatgaaaa
      301 atcctttgac aatattaaaa attggatcag aaacattgaa gagcatgcct cttccgatgt
      361 cgaaagaatg atcctgggta acaaatgtga tatgaatgac aaaagacaag tgtcaaaaga
      421 aagaggggag aagctagcaa ttgactatgg gattaaattc ttggagacaa gcgcaaaatc
      481 cagtgcaaat gtagaagagg cattttttac acttgcacga gatataatga caaaactcaa
      541 cagaaaaatg aatgacagca attcagcagg agcaggtgga ccagtgaaaa taacagaaaa
      601 ccgatcaaag aagaccagtt tctttcgttg ctcgctactt tgatgaactc tttctgagag
      661 actgcagcac acctagaggg ccctttcctg cttctctgaa agcacaggtc acccagcctc
      721 agaatcacac ctcccggctg ctgctgagag caccactgaa cttagacctc tcaacacagt
      781 atgccaagtg gattccagcc tcatggccta gcaaaagaac agactccctt tttcaaacat
      841 ggaagcaatg aagtggagac acatgcagga cctaactcgt tttttccttg ttttattacc
      901 tgttgcagaa gcggttatct ttctttttta ctttgcacat cagtgttagc ctttccctat
      961 ttcagcacaa tcttagactc atatttgcac acttttgtgt cgtgaagttc tagacaaatt
     1021 tgtacatgtg gcaatgttaa aagagcattt acagcagagg ttaatatact aaaattaaag
     1081 ggtatttggt ctggttcata tggtcaaata ttactgcctt ggtagcattt atttaagggc
     1141 tttttcttaa ataagaatca ttaaagtcat taaaaaaatt tactgaaatg cccatcttgt
     1201 catcaaaggc cacaatttct ttatttcttc agattaagag ctttgcctca tccccgacct
     1261 gttttccaga gtctgggtag ctgaatgaat cactttaaaa tgattacctc tgcctaatct
     1321 atagaaactg catttggaaa tcaccataat ctcatttttc cctggggttt gtatttgcta
     1381 ttctttccca tgtttgactt aagtgtaatc actcttaagt aatatttgaa cattattatc
     1441 tgtttctatt tgtgaacttc ttgagctgaa attttacgtg ggctgagaga tataccattt
     1501 agggttttag tgcagcatct aactgtgatt ctgtcaataa ggatatgtaa tatatttttt
     1561 cttaggttca ctccttagct ggctggttta gttgtaatac caaattccta ccataatccc
     1621 tgtctacaaa agttaggttt agattttagt ttgcggaaac cttccctata tagagacaga
     1681 ttaacttgtt gatataaatt taatagagct agctcttggt aatggtgaaa ataatgagtt
     1741 ttggttggtt ttatttggca gatgttttta gaaataaaag tacttagacc tagtgcagcc
     1801 tctaggaaaa gtcttgcctt ttcattagag aaaacaggac caaggtttca gttttcaaac
     1861 agctgttgtt gattgtgtag aacccagttc catctgtttt ggttcattgt tacagaactt
     1921 agtccagtca tttgggctaa agccaaccaa aagcttagtt gcctttctca acaaacactg
     1981 gtactggtat acttttgtag atgaaaccat cacaaggtat ttagtgttaa cttgtgtgcc
     2041 aaattcagat cactatgtcg ttgttgctct agccttcagt gtcataacac aggggggata
     2101 aaacagaggg gatgagggaa atgaattctg ttaataatta ttcttcctgg tatgcctgtt
     2161 ttgcttcaca aaggctacta tcatgctgga tagataagaa caggagatgg cagtggaaag
     2221 ggattgcttg ttaccacaga gaattctctt caaattaaga tatgtcatta gaatgcttgg
     2281 accagtcaat cttttgtact tatttgaaaa tataggaaca atttagcagc tgcaaatatg
     2341 cccaagctat ttttaataga tatactaaac ttattgttga caaatttcag cctccttaat
     2401 tttttttttt ttggtaatta cctataggct taaaagtcat tcgttgctgt tctagtataa
     2461 ttagtagttc cgtgattgaa agtttattgt aattctacta tcttcaaatt agatacattt
     2521 tcaaaaggaa aagataattt tttagaaaca tcttaatatt cactatttcc tgaaaaaatc
     2581 caagcagtta acgctttctg gatggtaaca aagtaccttc taaaagataa gtgctatgac
     2641 accatgtatg aatgtaattc tcttagtaat ttacctctga ctatttggtg tcttaacgct
     2701 ttggtttata taatctcagg ggttgtctgc aaaccaaaac tgacatattc tgtggttagc
     2761 ttttattact ttttttttta acagaatgct ttgctttggt tatatttctt ctttcttctt
     2821 ttgtcttata tggattaata actagtctcc atgaacttca cttgaaagag cctgtaaaag
     2881 ttagatgagt ctaaaagtgc tctttgaagt agcagcaaat tgggagtata tgctctgtta
     2941 tatagaaata aattgtcctt gctattttct tacatttagc tttgctagat tgtatataca
     3001 ttgagctaag accttaggaa attcactttc tgcatgataa aatgacccaa taaatattcc
     3061 actttgctta ataatgtaca tacagtgcat tattttttct atttgtagat gaatttaatg
     3121 acagataatt gtctgttccc cgctgaaact gaagaaatct agtttttttg tgaacatttt
     3181 tgtggtctta tggataaggt acatgaagat ttttgcagca gtattagtgg ttcagtggct
     3241 gcactttatt aatcagtgtg ttaatttttg acagtgattg gactagacct tttcaaatag
     3301 agtctgaggg tatcagacag tgaaaatgtg ctgtaactaa gtagcatgta aatcagttga
     3361 ttgtaaaacg tttcgctggg aacttatttt agctatattt tacttcagac agattatgat
     3421 acaataatct acctgtgcat cagttagtag gtgctgcagg gtttcttact atttacagaa
     3481 acattttgtg cagtctttgt tataaatttt cagaagacta tactctttac tttgaaggtc
     3541 tattttttaa ttatacctca tttagctaac tagtattcta atacctggta gaaaaacagt
     3601 gagccagcct ttaagcatct aacaaaattt agactctttg ttttgttttg aactgaagac
     3661 atcattggga aaggtaggaa atattagttt aggatagagc atacatgtca tatccagtag
     3721 cataaaaaaa gtattatctc cctgtctcca ttaataaatt tagctgtgca atataggtgc
     3781 gtttttgcag aagtttctag taagagatta taactccatt ttacaggttc tgaatgctca
     3841 gagtctatat taaggcttat aaagtttttc ctgtgatcag taagtgacac atttaagcag
     3901 acattctttt caagttcatg acttagattc ctttacaaat ttagttctca atctttaaaa
     3961 accacatttc attatgttgg ttaattatta taaattttaa gcactcattt ctgcaatcag
     4021 gtttctcaga attttttttt tttaaacaga agagacattc ctttttcctt gttacatcca
     4081 aggggggcac aggggtgggt ggaaaggaat gtctaaaaat gaaatccctt gatatagagg
     4141 gacctagacg gacaggatat gctaaaataa tttcaaattc tagcacaatt ttagagtaga
     4201 ataagtcatt tttttagact aataaaatta atggctgtca tgttcactct gaaaaaaatc
     4261 taaatgactg aaatgtacag aaataaaaat tagcaaacaa ttattctagg gatattttca
     4321 gattttactt catttcttga aatgcgtgtg ccatatgcaa ttgcatttct tgtgccaaga
     4381 aactaataga acttatttca ctttaccttt ttttaaaatg tgaatttagt tattatagtt
     4441 caattttatg gccttacaga tggcttttat tttgtttgca gctgacactg cagttccttt
     4501 catgcaaaat accataaact gtttgatgaa aatcatgccc ctaatggaaa ctctctagtt
     4561 tttccatata actatcctac tgtacatgtt taaacatatt ttatttttgc tccaatggct
     4621 taatgtgaaa agctcctgca gataagtgga cctgtcatgt ggttaatctt gtttaagcca
     4681 attcattaac tgtgtactga tactgatgct atgttttttt taaatggatt ttattccagg
     4741 tgaacttttt ttttataata atgttcgtct aaaataaaaa ctacataatg aaaatgaaaa
//
