LOCUS       NM_001164522            2870 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens RAB7B, member RAS oncogene family (RAB7B), transcript
            variant 2, mRNA.
ACCESSION   NM_001164522
VERSION     NM_001164522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Cain,R.J., Scortti,M., Monzo,H.J. and Vazquez-Boland,J.A.
  TITLE     Listeria InlB Expedites Vacuole Escape and Intracellular
            Proliferation by Promoting Rab7 Recruitment via Vps34
  JOURNAL   mBio 14 (1), e0322122 (2023)
   PUBMED   36656016
  REMARK    GeneRIF: Listeria InlB Expedites Vacuole Escape and Intracellular
            Proliferation by Promoting Rab7 Recruitment via Vps34.
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Vestre,K., Persiconi,I., Borg Distefano,M., Mensali,N.,
            Guadagno,N.A., Bretou,M., Walchli,S., Arnold-Schrauf,C., Bakke,O.,
            Dalod,M., Lennon-Dumenil,A.M. and Progida,C.
  TITLE     Rab7b regulates dendritic cell migration by linking lysosomes to
            the actomyosin cytoskeleton
  JOURNAL   J Cell Sci 134 (18) (2021)
   PUBMED   34494097
  REMARK    GeneRIF: Rab7b regulates dendritic cell migration by linking
            lysosomes to the actomyosin cytoskeleton.
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Lafalla Manzano,A.F., Gil Lorenzo,A.F., Bocanegra,V.,
            Costantino,V.V., Cacciamani,V., Benardon,M.E. and Valles,P.G.
  TITLE     Rab7b participation on the TLR4 (Toll-like receptor) endocytic
            pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS)
  JOURNAL   Cytokine 121, 154732 (2019)
   PUBMED   31153054
  REMARK    GeneRIF: Rab7b participation on the TLR4 (Toll-like receptor)
            endocytic pathway in Shiga toxin-associated Hemolytic Uremic
            Syndrome (HUS).
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Borg Distefano,M., Hofstad Haugen,L., Wang,Y., Perdreau-Dahl,H.,
            Kjos,I., Jia,D., Morth,J.P., Neefjes,J., Bakke,O. and Progida,C.
  TITLE     TBC1D5 controls the GTPase cycle of Rab7b
  JOURNAL   J Cell Sci 131 (17) (2018)
   PUBMED   30111580
  REMARK    GeneRIF: TBC1D5 is a GAP for Rab7b in the control of endosomal
            transport to the trans-Golgi.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Progida,C., Nielsen,M.S., Koster,G., Bucci,C. and Bakke,O.
  TITLE     Dynamics of Rab7b-dependent transport of sorting receptors
  JOURNAL   Traffic 13 (9), 1273-1285 (2012)
   PUBMED   22708738
  REMARK    GeneRIF: Rab7b is required for sortilin transport from endosomes to
            the TGN.
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   He,D., Chen,T., Yang,M., Zhu,X., Wang,C., Cao,X. and Cai,Z.
  TITLE     Small Rab GTPase Rab7b promotes megakaryocytic differentiation by
            enhancing IL-6 production and STAT3-GATA-1 association
  JOURNAL   J Mol Med (Berl) 89 (2), 137-150 (2011)
   PUBMED   20953574
  REMARK    GeneRIF: Rab7b may play important roles in megakaryopoiesis by
            activating NF-kappaB and promoting IL-6 production.
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Progida,C., Cogli,L., Piro,F., De Luca,A., Bakke,O. and Bucci,C.
  TITLE     Rab7b controls trafficking from endosomes to the TGN
  JOURNAL   J Cell Sci 123 (Pt 9), 1480-1491 (2010)
   PUBMED   20375062
  REMARK    GeneRIF: Rab7b is required for normal lysosome function, and, in
            particular, it is an essential factor for retrograde transport from
            endosomes to the trans-Golgi network.
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Yang,M., Chen,T., Han,C., Li,N., Wan,T. and Cao,X.
  TITLE     Rab7b, a novel lysosome-associated small GTPase, is involved in
            monocytic differentiation of human acute promyelocytic leukemia
            cells
  JOURNAL   Biochem Biophys Res Commun 318 (3), 792-799 (2004)
   PUBMED   15144907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AUXG01000006.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001164522.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Both variants 1 and 2
            encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.211542.1,
                                           SRR1803614.119416.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617070.5/ ENSP00000482499.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AUXG01000006.1     30745-30887
            144-212             AUXG01000006.1     39989-40057
            213-339             AUXG01000006.1     40594-40720
            340-555             AUXG01000006.1     41445-41660
            556-681             AUXG01000006.1     48475-48600
            682-2870            AUXG01000006.1     55212-57400
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2870
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /note="RAB7B, member RAS oncogene family"
                     /db_xref="GeneID:338382"
                     /db_xref="HGNC:HGNC:30513"
     exon            1..143
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            144..212
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..759
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /note="isoform a is encoded by transcript variant 2;
                     ras-related protein Rab-7b; Ras-related protein Rab-7"
                     /codon_start=1
                     /product="ras-related protein Rab-7b isoform a"
                     /protein_id="NP_001157994.1"
                     /db_xref="CCDS:CCDS73011.1"
                     /db_xref="GeneID:338382"
                     /db_xref="HGNC:HGNC:30513"
                     /translation="MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGAS
                     ILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIW
                     RGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINV
                     VQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC"
     exon            213..339
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            340..555
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            556..681
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            682..2870
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1508
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /note="major polyA site"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /note="hexamer: AATAAA"
     polyA_site      2870
                     /gene="RAB7B"
                     /gene_synonym="RAB7"
                     /note="major polyA site"
ORIGIN      
        1 aacagacttt cttttgcctg tctttgtccc agagcctctt ccctggccct gctgagacca
       61 ctgctctaag aagagaccac cagactgaga gaggactccc agctgccctc agagcggagg
      121 ccgagtgctg cacagccaca gctgctctga agcccttcca tgaatccccg gaagaaggtg
      181 gacctgaaac tcattatcgt cggagccatt ggtgtgggaa agacctccct ccttcaccaa
      241 tatgtgcaca agacgtttta tgaggaatac cagaccacac tgggggccag catcctctcc
      301 aagattatca tattgggtga cacaactttg aagttacaga tctgggacac gggcggtcag
      361 gagcggttcc gctccatggt gtccacgttc tacaagggct ccgatggctg catcctagct
      421 tttgatgtca ccgacctgga gtcttttgaa gccctggata tctggcgggg tgatgtcctg
      481 gccaagattg tccccatgga gcagtcctac cccatggtgt tgttggggaa caagatcgat
      541 ctggcagacc ggaaggtacc ccaggaagta gctcaaggct ggtgtagaga gaaagatatt
      601 ccttactttg aagtcagtgc caagaatgac atcaatgtgg tgcaagcgtt tgagatgctg
      661 gccagtaggg ctctgtcgag gtaccagagc atcttagaaa atcacctcac agaatccatc
      721 aagctctcgc cagaccagtc aaggagcaga tgctgctgac ctccagacgc ctgctctgga
      781 agcccagaaa cagagcctgc cccgagcctg gtcaccccag gcttgagaac aggtgaccat
      841 ccccctccag ccccactgcc tgcccaagca cagtgcaggg ggcctaagct ctgcggcaga
      901 gcccttgacc ctggtgctgg gcccagagtc agagggcagc ccctggctca ggctgagtat
      961 agtgagagcg tctggatgaa gcccggaatg tcagagccaa accctggtcc tgcagaagtc
     1021 accgtttccg cagtggctcc agctttcccc acccatccac ccctcaaaca ctcccgctcc
     1081 agaacacaca tctccgcaga ccggccactg attggagtct ggttacatcc tcctgtggac
     1141 agaccttcct cacccgctcc cacctcacac ccctcagcca caagcaaagc tttggacaat
     1201 ggcacagctc agcctccttc aacgagcaga ctaaggagta aaggtctgga ccccacatgc
     1261 tgggcccgcc tcagctcctg gcagaagctg tcgtgcctga gaccccctct gctccctcca
     1321 gggtagaaga ctgagggagc acaggagaag ccacaaggga ccatggctca ttcctccttg
     1381 ctgggtgctc aggcaactca cataaatctc tgagtctcaa tttgtttatc tgtcctgtgg
     1441 gggtgagatg tgccttgccc cctgtatcac agtgtggttt tgaggaccag aagctgtgct
     1501 taaatccagt agctgttgtc aatatgcatt tatttacttc tttgacaagt ttatttttgc
     1561 gtatctacta tgtacgatgc attgaagtcc agtgacaaac aaaacacagg gactctgccc
     1621 tcctggagcc gacatctggt gagggagaga cgcagactct agacagatat ttccaaatag
     1681 caggtaagtg ctataaacaa agggaaacag ggtaatggga tagagtgaca gggggtggga
     1741 tgagttgcta ttttagatga agtggtccag gagggcttcc ctgaggaggt ggcatttggt
     1801 ctgagggcta gagaatgaga aagcagctgt cacctgagag ctggagaaag aacattccag
     1861 ggagagggag catcaagacc caaagccctg aggcaaaaac aagcttgcca tgttccagga
     1921 acagtgaaag gacatccatt gacctaatac tcaaagctgc tgtcccaaag acaaagcaaa
     1981 ggggacccag ctcccttggg tggctcctag atgctctgct gcctgaccac cagagggcag
     2041 cagtgctcct tctcttccag gctgagcaga aagtggatgc tcatgaaggt tttaggagct
     2101 ggggttttgt ccttcagatg ctcaaagctt gttcatgggc ttggaggcat gtttagccct
     2161 ttgggatttg taaggcagag aattccaatt tcttaagcct agtaagaaat gagcaaaaac
     2221 ttcaatatat atgactcagg caagaaatca gcatctgtgg caaatactag aatgaaatgc
     2281 aagaaagctc actgcaagga gtctccctcc ctgcagattc caaggctgga atctttttct
     2341 tctggctcca ggcagcacag acagggccta gcctggagag ggtggacaag atgtcctctc
     2401 agggtcttca atggccaagt ccatgcccac tgcagaatct ttctgtctac ccgtaagtat
     2461 cctttcctga gttccaggca aagctgggga tgttagccta tgactgtcat ctgacttgga
     2521 aggtacacct aggggccggg gggaggtcag caggggagtt tgggagccac ttctcccccc
     2581 acgtggcact ggagtgtgaa ctggctcatt ctggacacca gcatggagcc agcacgggaa
     2641 caggggggca gcctagagca caagctctat ctgtgtcctt cagagctcct gggaaacatg
     2701 atgcgccctc atgggaatgg cattttgcat atcacacagg ctgtcctggg agtcaggcag
     2761 actggattgt cacgtgcggt gtgcatgcag cagcttgtgc actgcagtgg acctgtggac
     2821 catttctaaa ggtgcacaac aaataataaa tgtgtccttc tttgttttta
//
