LOCUS       NM_004637               2185 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA.
ACCESSION   NM_004637 NM_018533
VERSION     NM_004637.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Gulec Taskiran,A.E., Husnugil,H.H., Soltani,Z.E., Oral,G.,
            Menemenli,N.S., Hampel,C., Huebner,K., Erlenbach-Wuensch,K.,
            Sheraj,I., Schneider-Stock,R., Akyol,A., Liv,N. and Banerjee,S.
  TITLE     Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning
            and Drug Resistance in Nutrient-Limited Cancer Cells
  JOURNAL   Traffic 25 (9), e12956 (2024)
   PUBMED   39313937
  REMARK    GeneRIF: Post-Transcriptional Regulation of Rab7a in Lysosomal
            Positioning and Drug Resistance in Nutrient-Limited Cancer Cells.
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Talaia,G., Bentley-DeSousa,A. and Ferguson,S.M.
  TITLE     Lysosomal TBK1 responds to amino acid availability to relieve
            Rab7-dependent mTORC1 inhibition
  JOURNAL   EMBO J 43 (18), 3948-3967 (2024)
   PUBMED   39103493
  REMARK    GeneRIF: Lysosomal TBK1 responds to amino acid availability to
            relieve Rab7-dependent mTORC1 inhibition.
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Tudorica,D.A., Basak,B., Puerta Cordova,A.S., Khuu,G., Rose,K.,
            Lazarou,M., Holzbaur,E.L.F. and Hurley,J.H.
  TITLE     A RAB7A phosphoswitch coordinates Rubicon Homology protein
            regulation of Parkin-dependent mitophagy
  JOURNAL   J Cell Biol 223 (7) (2024)
   PUBMED   38728007
  REMARK    GeneRIF: A RAB7A phosphoswitch coordinates Rubicon Homology protein
            regulation of Parkin-dependent mitophagy.
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Tahoun,M. and Sadaka,A.S.
  TITLE     Deregulated expression of autophagy genes; PIK3C3 and RAB7A in
            COVID-19 patients
  JOURNAL   Hum Immunol 85 (3), 110801 (2024)
   PUBMED   38609772
  REMARK    GeneRIF: Deregulated expression of autophagy genes; PIK3C3 and
            RAB7A in COVID-19 patients.
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Bottger,G., Nagelkerken,B. and van der Sluijs,P.
  TITLE     Rab4 and Rab7 define distinct nonoverlapping endosomal compartments
  JOURNAL   J Biol Chem 271 (46), 29191-29197 (1996)
   PUBMED   8910576
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Simon,I., Zerial,M. and Goody,R.S.
  TITLE     Kinetics of interaction of Rab5 and Rab7 with nucleotides and
            magnesium ions
  JOURNAL   J Biol Chem 271 (34), 20470-20478 (1996)
   PUBMED   8702787
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Meresse,S., Gorvel,J.P. and Chavrier,P.
  TITLE     The rab7 GTPase resides on a vesicular compartment connected to
            lysosomes
  JOURNAL   J Cell Sci 108 (Pt 11), 3349-3358 (1995)
   PUBMED   8586647
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 2 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301462
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Chavrier,P., Parton,R.G., Hauri,H.P., Simons,K. and Zerial,M.
  TITLE     Localization of low molecular weight GTP binding proteins to
            exocytic and endocytic compartments
  JOURNAL   Cell 62 (2), 317-329 (1990)
   PUBMED   2115402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU122058.1, AF498942.1,
            BC008721.2, AK094449.1 and CA748697.1.
            
            On Aug 31, 2019 this sequence version replaced NM_004637.5.
            
            Summary: RAB family members are small, RAS-related GTP-binding
            proteins that are important regulators of vesicular transport. Each
            RAB protein targets multiple proteins that act in exocytic /
            endocytic pathways. This gene encodes a RAB family member that
            regulates vesicle traffic in the late endosomes and also from late
            endosomes to lysosomes. This encoded protein is also involved in
            the cellular vacuolation of the VacA cytotoxin of Helicobacter
            pylori. Mutations at highly conserved amino acid residues in this
            gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2
            neuropathies. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.21575.1,
                                           SRR11853563.23689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265062.8/ ENSP00000265062.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AU122058.1         48-412
            366-765             AF498942.1         181-580
            766-965             BC008721.2         756-955
            966-1065            AK094449.1         694-793
            1066-1404           BC008721.2         1056-1394
            1405-1665           AK094449.1         1133-1393
            1666-2185           CA748697.1         16-535              c
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..2185
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="RAB7A, member RAS oncogene family"
                     /db_xref="GeneID:7879"
                     /db_xref="HGNC:HGNC:9788"
                     /db_xref="MIM:602298"
     exon            1..177
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            178..238
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..809
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /EC_number="3.6.5.2"
                     /note="Ras-associated protein RAB7; RAB7, member RAS
                     oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_004628.4"
                     /db_xref="CCDS:CCDS3052.1"
                     /db_xref="GeneID:7879"
                     /db_xref="HGNC:HGNC:9788"
                     /db_xref="MIM:602298"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            239..365
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            366..584
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            585..713
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     exon            714..2185
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="hexamer: ATTAAA"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="hexamer: TATAAA"
     polyA_site      1482
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="major polyA site"
     polyA_site      1486
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="major polyA site"
     regulatory      1777..1782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="hexamer: ATTAAA"
     polyA_site      1783
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="RAB7A"
                     /gene_synonym="CMT2B; PRO2706; RAB7"
                     /note="major polyA site"
ORIGIN      
        1 agtcttggcc ataaagcctg aggcggcggc agcggcggag ttggcggctt ggagagctcg
       61 ggagagttcc ctggaaccag aacttggacc ttctcgcttc tgtcctccgt ttagtctcct
      121 cctcggcggg agccctcgcg acgcgcccgg cccggagccc ccagcgcagc ggccgcgttt
      181 gaaggatgac ctctaggaag aaagtgttgc tgaaggttat catcctggga gattctggag
      241 tcgggaagac atcactcatg aaccagtatg tgaataagaa attcagcaat cagtacaaag
      301 ccacaatagg agctgacttt ctgaccaagg aggtgatggt ggatgacagg ctagtcacaa
      361 tgcagatatg ggacacagca ggacaggaac ggttccagtc tctcggtgtg gccttctaca
      421 gaggtgcaga ctgctgcgtt ctggtatttg atgtgactgc ccccaacaca ttcaaaaccc
      481 tagatagctg gagagatgag tttctcatcc aggccagtcc ccgagatcct gaaaacttcc
      541 catttgttgt gttgggaaac aagattgacc tcgaaaacag acaagtggcc acaaagcggg
      601 cacaggcctg gtgctacagc aaaaacaaca ttccctactt tgagaccagt gccaaggagg
      661 ccatcaacgt ggagcaggcg ttccagacga ttgcacggaa tgcacttaag caggaaacgg
      721 aggtggagct gtacaacgaa tttcctgaac ctatcaaact ggacaagaat gaccgggcca
      781 aggcctcggc agaaagctgc agttgctgag ggggcagtga gagttgagca cagagtcctt
      841 cacaaaccaa gaacacacgt aggccttcaa cacaattccc ctctcctctt ccaaacaaaa
      901 catacattga tctctcacat ccagctgcca aaagaaaacc ccatcaaaca cagttacacc
      961 ccacatatct ctcacacaca cacacacacg cacacacaca cacacagatc tgacgtaatc
     1021 aaactccagc ccttgcccgt gatggctcct tggggtctgc ctgcccaccc acatgagccc
     1081 gcgagtatgg cagcaggaca agccagcggt ggaagtcatt ctgatatgga gttggcattg
     1141 gaagcttatt ctttttgttc actggagaga gagagaactg tttacagtta atctgtgtct
     1201 aattatctga ttttttttat tggtcttgtg gtctttttac cccccctttc ccctccctcc
     1261 ttgaaggcta ccccttggga aggctggtgc cccatgcccc attacaggct cacacccagt
     1321 ctgatcaggc tgagttttgt atgtatctat ctgttaatgc ttgttacttt taactaatca
     1381 gatcttttta cagtatccat ttattatgta atgcttctta gaaaagaatc ttatagtaca
     1441 tgttaatata tgcaaccaat taaaatgtat aaattagtgt aagaaattct tggattatgt
     1501 gtttaagtcc tgtaatgcag gcctgtaagg tggagggttg aaccctgttt ggattgcaga
     1561 gtgttactca gaattgggaa atccagctag cggcagtatt ctgtacagta gacacaagaa
     1621 ttatgtacgc cttttatcaa agacttaaga gccaaaaagc ttttcatctc tccaggggga
     1681 aaactgtcta gttcccttct gtgtctaaat tttccaaaac gttgatttgc ataatacagt
     1741 ggtatgtgca atggataaat tgccgttatt tcaaaaatta aaattctcat tttctttctt
     1801 ttttttcccc cctgctccac acttcaaaac tcccgttaga tcagcattct actacaagag
     1861 tgaaaggaaa accctaacag atctgtccta gtgattttac ctttgttcta gaaggcgctc
     1921 ctttcagggt tgtggtattc ttaggttagc ggagcttttt cctcttttcc ccacccatct
     1981 ccccaatatt gcccattatt aattaacctc tttctttggt tggaaccctg gcagttctgc
     2041 tcccttccta ggatctgccc ctgcattgta gcttgcttaa cggagcactt ctcctttttc
     2101 caaaggtcta cattctaggg tgtgggctga gttcttctgt aaagagatga acgcaatgcc
     2161 aataaaattg aacaagaaca atgat
//
