LOCUS       NM_032144               3073 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.
ACCESSION   NM_032144
VERSION     NM_032144.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3073)
  AUTHORS   He,L., Pan,X., Wang,X., Cao,Y., Chen,P., Du,C. and Huang,D.
  TITLE     Rab6c is a new target of miR-218 that can promote the progression
            of bladder cancer
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34515321
  REMARK    GeneRIF: Rab6c is a new target of miR218 that can promote the
            progression of bladder cancer.
REFERENCE   2  (bases 1 to 3073)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3073)
  AUTHORS   Bhat,S., Kabekkodu,S.P., Jayaprakash,C., Radhakrishnan,R., Ray,S.
            and Satyamoorthy,K.
  TITLE     Gene promoter-associated CpG island hypermethylation in squamous
            cell carcinoma of the tongue
  JOURNAL   Virchows Arch 470 (4), 445-454 (2017)
   PUBMED   28255813
  REMARK    GeneRIF: This is the first study to report hypermethylation of
            LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue
REFERENCE   4  (bases 1 to 3073)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   5  (bases 1 to 3073)
  AUTHORS   Shin,Y.C., Jang,T.H., Yoon,J.H., Jeon,J.H. and Park,H.H.
  TITLE     Crystallization and preliminary X-ray crystallographic studies of
            Rab6A'(Q72L): a GTP-locked form
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 9),
            1077-1080 (2012)
   PUBMED   22949199
  REMARK    GeneRIF: Rab6A'(Q72L) was then purified to homogeneity and
            crystallized at 293 K. X-ray diffraction data were collected to a
            resolution of 1.9 A from a crystal belonging to space group
            P22(1)2(1) with unit-cell parameters a = 36.84, b = 96.78, c =
            109.99 A
REFERENCE   6  (bases 1 to 3073)
  AUTHORS   Tian,K., Wang,Y. and Xu,H.
  TITLE     WTH3 is a direct target of the p53 protein
  JOURNAL   Br J Cancer 96 (10), 1579-1586 (2007)
   PUBMED   17426708
  REMARK    GeneRIF: The negative role played by the WTH3 gene in MDR
            development is through its proapoptotic potential that is regulated
            by multiple mechanisms at the transcription level, and one of these
            mechanisms is linked to the p53 gene.
REFERENCE   7  (bases 1 to 3073)
  AUTHORS   Tian,K., Jurukovski,V., Wang,X.P., Kaplan,M.H. and Xu,H.
  TITLE     Epigenetic regulation of WTH3 in primary and cultured
            drug-resistant breast cancer cells
  JOURNAL   Cancer Res 65 (21), 10024-10031 (2005)
   PUBMED   16267028
  REMARK    GeneRIF: The behavior of WTH3 in primary drug-resistant breast
            cancer epithelial cells was similar to that in a model system where
            epigenetic regulation of the WTH3 gene was linked to the MDR
            phenotype.
REFERENCE   8  (bases 1 to 3073)
  AUTHORS   Shan,J., Yuan,L., Budman,D.R. and Xu,H.P.
  TITLE     WTH3, a new member of the Rab6 gene family, and multidrug
            resistance
  JOURNAL   Biochim Biophys Acta 1589 (2), 112-123 (2002)
   PUBMED   12007787
REFERENCE   9  (bases 1 to 3073)
  AUTHORS   Shan,J., Mason,J.M., Yuan,L., Barcia,M., Porti,D., Calabro,A.,
            Budman,D., Vinciguerra,V. and Xu,H.
  TITLE     Rab6c, a new member of the rab gene family, is involved in drug
            resistance in MCF7/AdrR cells
  JOURNAL   Gene 257 (1), 67-75 (2000)
   PUBMED   11054569
REFERENCE   10 (bases 1 to 3073)
  AUTHORS   Fitzgerald,M.L. and Reed,G.L.
  TITLE     Rab6 is phosphorylated in thrombin-activated platelets by a protein
            kinase C-dependent mechanism: effects on GTP/GDP binding and
            cellular distribution
  JOURNAL   Biochem J 342 (Pt 2) (Pt 2), 353-360 (1999)
   PUBMED   10455022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079776.5.
            
            On May 17, 2019 this sequence version replaced NM_032144.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL136727.1, SRR1803611.68708.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410061.4/ ENSP00000387307.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3073              AC079776.5         151908-154980
FEATURES             Location/Qualifiers
     source          1..3073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..3073
                     /gene="RAB6C"
                     /gene_synonym="WTH3"
                     /note="RAB6C, member RAS oncogene family"
                     /db_xref="GeneID:84084"
                     /db_xref="HGNC:HGNC:16525"
                     /db_xref="MIM:612909"
     exon            1..3073
                     /gene="RAB6C"
                     /gene_synonym="WTH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1215
                     /gene="RAB6C"
                     /gene_synonym="WTH3"
                     /note="rab6-like protein WTH3"
                     /codon_start=1
                     /product="ras-related protein Rab-6C"
                     /protein_id="NP_115520.2"
                     /db_xref="CCDS:CCDS46408.1"
                     /db_xref="GeneID:84084"
                     /db_xref="HGNC:HGNC:16525"
                     /db_xref="MIM:612909"
                     /translation="MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQA
                     IIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQ
                     QTTKWIDDVRTERGSDVIITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAG
                     YNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGGCSCYSPMSSSTLP
                     QKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB6C"
                     /gene_synonym="WTH3"
                     /note="hexamer: AATAAA"
     polyA_site      3073
                     /gene="RAB6C"
                     /gene_synonym="WTH3"
                     /note="major polyA site"
ORIGIN      
        1 actcagcagg ttgggctgcg gcggcggcgg ctggggaagc cgaagcgccg cgcgtgagag
       61 atcccggata catctgcggt ttgggctccg ccaccctccg tctctctccc gcaggtctct
      121 gagccgggtg cggaaggagg gaacggccct agccttggga agccaaagca cacccctggc
      181 tcctgccgac accgccctcc ttcccttccc agccgcgggc ctcgctccgt gctcggctac
      241 tctgccggga ggcggcggcg gctgccagtc tgtggcgagc cctgctgccc tccagccggg
      301 ctcctccagc cgggctcctc caccggccct tgcaggggcg cagagagctc ggcgcccgcc
      361 cttccgctcg cctttttcgt cagccggctg gaggagcatc ggtccgggag gtctctgggc
      421 tgaggcggcg acagctcctc tagttccacc atgtccgcgg gcggagactt cgggaatccg
      481 ctgaggaaat tcaagctggt gttcctgggg gagcaaagcg ttgcaaagac atctttgatc
      541 accagattca ggtatgacag ttttgacaac acctatcagg caataattgg cattgacttt
      601 ttatcaaaaa ctatgtactt ggaggatgga acaatcgggc ttcggctgtg ggatacggcg
      661 ggtcaggaac gtctccgtag cctcattccc aggtacatcc gtgattctgc tgcagctgta
      721 gtagtttacg atatcacaaa tgttaactca ttccagcaaa ctacaaagtg gattgatgat
      781 gtcagaacag aaagaggaag tgatgttatc atcacgctag taggaaatag aacagatctt
      841 gctgacaaga ggcaagtgtc agttgaggag ggagagagga aagccaaagg gctgaatgtt
      901 acgtttattg aaactagggc aaaagctgga tacaatgtaa agcagctctt tcgacgtgta
      961 gcagcagctt tgccgggaat ggaaagcaca caggacggaa gcagagaaga catgagtgac
     1021 ataaaactgg aaaagcctca ggagcaaaca gtcagcgaag ggggttgttc ctgctactct
     1081 cccatgtcat cttcaaccct tcctcagaag cccccttact ctttcattga ctgcagtgtg
     1141 aatattggct tgaacctttt cccttcatta ataacgtttt gcaattcatc attgctgcct
     1201 gtctcgtgga ggtgatctat tagcttcaca agcacaaaaa aagtcagcgt cttcattatt
     1261 tatattttac aaaaagccaa attatttcag catattccgg tgataacttt aaaaattaga
     1321 tacattttct taacattttt ttctttttta atgttatgat aatgtacttc aaaatgatgg
     1381 aaatctcaac agtatgagta tggcttggtt aacgagcagt atgttcacag cctgctttat
     1441 ctctccttgc tcttctcacc tctcccttac cccgttccct atttccgtgt tcttacctag
     1501 cctcccccca cttcctcaaa acaaacaaga gatggcaaag cagcagtccg accaagccca
     1561 ctggaattat cctttaattt tacagatacc acttgctgta ggctgtggac caagatgtcc
     1621 agaattattc ttgagcactg atgtaaatta cttagatctt ctttgaggtc agaattcagc
     1681 gatcacggta ggcagtgctt gaatgagaaa agcctcctgg tgcatcttca aaatgagtcc
     1741 taaagaacat actgagtact tataagtagc agaacataaa atgtatttct gactaacaca
     1801 aatggtcctt tcacatgtgc tttattagac tctgggagag aaaagtaacc aagtgcttca
     1861 gaacaggttt ttagtattta cttcttcatg gtaagataat gaagttctaa tgaactattt
     1921 ctcccaaggt tttaaaattg tcaagagtta ttctgtttgt ttaaaaagta agaaacctct
     1981 gtaagcaata gattttgctt gggttttctt tcttaaaaaa ataatactat gcaggcaaga
     2041 caccataaaa gtttaattcc ttacagaaga accagtggaa gaatttaaat ttggcactac
     2101 gatcaaaact actgaattag cagaaataac gatatctaaa gcttaccagc aaaagaaccc
     2161 tcagcagaat agcaaaaact ttgctcagga catttgaggt caaattgaag acggaagacg
     2221 gaagacggaa accggaaacc gttttcttgt aagcccctag aggcagatca ggtaaagcat
     2281 acatagtaga gggaaaggag agaatggaaa taaaactgaa tattatgcag atttatgcct
     2341 tattttttag cattttttaa ggttgggtct ttcaggctgg ttttggtttg tattagatct
     2401 gtatagttta actagtgatt tagttttata tttaagctac gattaatatt ttttctttgg
     2461 cgatatttct ttgctttttt tttttttaac aactttccat ttttagatgt ttcgttgaat
     2521 ctatttagag cttcaccatg gcaatatgta tttcccttaa aacactgcaa acaaatatac
     2581 taggagtgtg cccttttaat ctttactagt tattgtgaga ttgctgtgta agctaataaa
     2641 cacatttgta aatacattgt ttgcaggaag aaaacttcga gttacaggtc aggaaaagcc
     2701 tgctgaattt atgttgtaaa cgttacttaa cacagtataa agatgaaaag acaacaaaag
     2761 tatcttcata cttcctcatc ccctcattgc aacaaaacct taaactggga gaaccttagt
     2821 cccctctctt tcctcttcct cctccacttc ccacttattg tcactttgta atattcagag
     2881 agcacttgga ttatggatct gaatagagaa atgcttacag ataatcatta gcccacatac
     2941 cagtaactta tacttaaaga tgggatggag ttataaagtg cttttataat acaatataat
     3001 tgctaaaggc aagggttgac tctttgtttt attttgacat ggcatgtcct gaaataaata
     3061 ttgattcact atg
//
