LOCUS       NM_016577               5596 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB6B, member RAS oncogene family (RAB6B), transcript
            variant 1, mRNA.
ACCESSION   NM_016577
VERSION     NM_016577.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5596)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5596)
  AUTHORS   Aizawa,M. and Fukuda,M.
  TITLE     Small GTPase Rab2B and Its Specific Binding Protein
            Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi
            Morphology
  JOURNAL   J Biol Chem 290 (36), 22250-22261 (2015)
   PUBMED   26209634
REFERENCE   4  (bases 1 to 5596)
  AUTHORS   Seifert,W., Kuhnisch,J., Maritzen,T., Lommatzsch,S., Hennies,H.C.,
            Bachmann,S., Horn,D. and Haucke,V.
  TITLE     Cohen syndrome-associated protein COH1 physically and functionally
            interacts with the small GTPase RAB6 at the Golgi complex and
            directs neurite outgrowth
  JOURNAL   J Biol Chem 290 (6), 3349-3358 (2015)
   PUBMED   25492866
REFERENCE   5  (bases 1 to 5596)
  AUTHORS   Lindsay,A.J., Jollivet,F., Horgan,C.P., Khan,A.R., Raposo,G.,
            McCaffrey,M.W. and Goud,B.
  TITLE     Identification and characterization of multiple novel Rab-myosin Va
            interactions
  JOURNAL   Mol Biol Cell 24 (21), 3420-3434 (2013)
   PUBMED   24006491
REFERENCE   6  (bases 1 to 5596)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 5596)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 5596)
  AUTHORS   Garcia-Saez,I., Tcherniuk,S. and Kozielski,F.
  TITLE     The structure of human neuronal Rab6B in the active and inactive
            form
  JOURNAL   Acta Crystallogr D Biol Crystallogr 62 (Pt 7), 725-733 (2006)
   PUBMED   16790928
  REMARK    GeneRIF: Conformational changes in human neuronal Rab6B between its
            inactive GDP and active GTP-like state are observed mainly in the
            switch I and switch II regions, confirming their role as a
            molecular switch.
REFERENCE   9  (bases 1 to 5596)
  AUTHORS   Opdam,F.J., Echard,A., Croes,H.J., van den Hurk,J.A., van de
            Vorstenbosch,R.A., Ginsel,L.A., Goud,B. and Fransen,J.A.
  TITLE     The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type
            specifically expressed and localised to the Golgi apparatus
  JOURNAL   J Cell Sci 113 (Pt 15), 2725-2735 (2000)
   PUBMED   10893188
REFERENCE   10 (bases 1 to 5596)
  AUTHORS   Chen,D., Guo,J. and Gahl,W.A.
  TITLE     RAB GTPases expressed in human melanoma cells
  JOURNAL   Biochim Biophys Acta 1355 (1), 1-6 (1997)
   PUBMED   9030196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080128.21, DA221889.1 and AF166492.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016577.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3012615.1,
                                           SRR14038193.922420.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285208.9/ ENSP00000285208.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC080128.21        43156-43190
            36-530              DA221889.1         1-495
            531-1345            AF166492.1         452-1266
            1346-5596           AC080128.21        110553-114803
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..5596
                     /gene="RAB6B"
                     /note="RAB6B, member RAS oncogene family"
                     /db_xref="GeneID:51560"
                     /db_xref="HGNC:HGNC:14902"
                     /db_xref="MIM:615852"
     exon            1..486
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..1043
                     /gene="RAB6B"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     GTPase RAB6B; ras-related protein Rab-6B; small
                     GTP-binding protein"
                     /codon_start=1
                     /product="ras-related protein Rab-6B isoform 1"
                     /protein_id="NP_057661.3"
                     /db_xref="CCDS:CCDS3082.1"
                     /db_xref="GeneID:51560"
                     /db_xref="HGNC:HGNC:14902"
                     /db_xref="MIM:615852"
                     /translation="MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQA
                     TIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQ
                     QTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTG
                     YNVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC"
     exon            487..545
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            546..599
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            600..705
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            706..817
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            818..911
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            912..978
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     exon            979..5596
                     /gene="RAB6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5569..5574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB6B"
                     /note="hexamer: AATAAA"
     polyA_site      5596
                     /gene="RAB6B"
                     /note="major polyA site"
ORIGIN      
        1 acagagcgca ggcgccggcg gaggaggcag gcgggagggg gccgactggc gcggctctgg
       61 agagcgctcc tccgccccgc gcgccgtccc tgcgccccgc tccgcccgcg cctctctccc
      121 agcgccgcgc ctcgggcgta aagagcgcgc ccctcgcacc gcagccagtg ccgaccgcag
      181 cagcccagcc ccagccttcc tccgcctccg cctctctctc ctcctcctcc tccgccgccg
      241 gacacgcagc cgcaggccgg gaccgggacg cagctgggga gtcagggacg cgcgcagcca
      301 gcccttcccc ctccggctcc cgcaccgccg gccgcctccc ctcgccctcc tactctcccc
      361 tccctgctcc ttcgcttttt cctcctcctc ctctcccggc cccggctgcc agcaccatgt
      421 ccgcaggggg agattttggg aatccactga gaaaattcaa gttggtgttc ttgggggagc
      481 agagcgtcgg gaagacgtct ctgattacga ggttcatgta cgacagcttc gacaacacat
      541 accaggcaac cattgggatt gacttcttgt caaaaaccat gtacttggag gaccgcacgg
      601 tgcgactgca gctctgggac acagctggtc aggagaggtt ccgcagcctg atccccagct
      661 acatccggga ctccacggtg gctgtggtgg tgtacgacat cacaaatctc aactccttcc
      721 aacagacctc taagtggatc gacgacgtca ggacagagag gggcagtgat gttatcatca
      781 tgctggtggg caacaagacg gacctggctg ataagaggca gataaccatc gaggaggggg
      841 agcagcgcgc caaagaactg agcgtcatgt tcattgagac cagtgcgaag actggctaca
      901 acgtgaagca gctttttcga cgtgtggcgt cggctctacc cggaatggag aatgtccagg
      961 agaaaagcaa agaagggatg atcgacatca agctggacaa accccaggag cccccggcca
     1021 gcgagggcgg ctgctcctgc taatgcagag ccgacctgtg gcttcccatg acactccttg
     1081 cttgttgtgt tgcttcctat tggctagctt cctaaggggg gagggaaccg agttatcaag
     1141 atgggaggat ttttcttttc tctctgtctt taggagtagg gtgggatggg gagggaggct
     1201 gggcatcagg gatcacatca ctcttaacgg ctgttactta aacaactatt ttttggtttg
     1261 gttgtaatat attgtacttt attaagattg ccaaaaactg ttaaaattta aaaaaaattt
     1321 aaatcatgtg tatacaattt tttgccagat aaaaatgtag tcatttttat ttgaaagatg
     1381 tgctttttgt ttttgtatat ttgtaaactt atagagaacc ttttccacac acctcctcct
     1441 tcctgttctc tttgaaccat tcatcacctc tgccttcctc ctatccccag cccaataaat
     1501 taaaacaatt aactgagcaa attaattagg cttcagtctg gggccatctg gccccactct
     1561 ctaggcccta ctccagttaa atcaaacatt ggttgaacac atcagcctct gaaaaggtag
     1621 ctctgactct tgtctttcca tggccagagt gggtcgtcaa cctcgtgtgg agctgagacc
     1681 aaggtctgtg ggctctaggc agcccggcag cagcccccag aggaactgct cccacctctc
     1741 cttctctttc cctgaaaagc cttgaagggg gttgagggta caggcaacct tgtgttctct
     1801 gtgccctcag ggactggcag agcaagaggc catcagaagg acgaggtgct gttggcaatt
     1861 gcagctgcgt ggtgcgtggt ttatagactg gggtgccatg tgtacttctg aaaatatttt
     1921 aaccagccca cccagcagtc agtacacatg cctgggccaa gtctaagaaa ctcagtgtgt
     1981 gatgttgggc agtgtgccat cctgaagcct tcctcctgga tgtcagggaa gctggaccac
     2041 ctggagttga tcctctgtga tggggaggcg gggggggggg ggggtgttgt ctgcagaacc
     2101 accaccttga aagatccatg ttcttagagc ctcagctgct aatattgttg agtgctttct
     2161 ggaaaagctg atttgttgct atgttttcac cccagtggca tggcgcagtt gaagtctttg
     2221 tggacatatc tttgtggcta ctgtggctgc gctgtggtca cctgaggatg tggttcaggt
     2281 ggggtctcca gaaggctgct tgcccccaga gagccatctc ttccattttt gattcattcc
     2341 tgagaatggc ttagtcctga gaatctgcaa agtctctgaa gagaactctc tcttcccact
     2401 aagtgatata acctacttgg ccagcattcc aaatagactc agactcactg ccctgagcct
     2461 gcacagagcc aggtgcaatg ggcagtgagt ctggccaaaa tgtaaacccc accctccctg
     2521 ctgtcattgg ctctccctcc aggctgctgc tgggcatgtc atagatggga tgaatgacca
     2581 tctggggtat ggtgggctga actccacaag gtcgttggaa tgaattttga aacttctcag
     2641 aaattaatct gaaatggcag gcagtaagtg cagcagaatc tggcaggact gatatttgtg
     2701 cagtgggcct gccacacacc ctctgcctag gaggctgtat gccagagctc atctctagca
     2761 aggaatttat cttcaggtga agaagagagg aagcaggatc ccactgagca cctcttgcag
     2821 aaggcaagga ccaatgtttg aacgtgtttc agatgtcatg tgtttagttt ttatatgtgt
     2881 gtacataatt atatatagag atagacttgt gtatacacct tccacaaaca catcctcacg
     2941 gagatacatg tgctcaatgt atattcttgt ttctcctgct ctcaagttgg aacttgcatt
     3001 gtgataagtt ttggaaattc aaaagtactg caacgtgttg aaataagaaa tacttaatat
     3061 tgtcaaataa cttgtgattg tcttgccatc aataaaataa tgcatagttg tgttaaacta
     3121 caggcaaaca tagcccacgg gaatatctcc accatttctc tatgtacttt atatgcacgg
     3181 gtgtgcatgc ctgtgtgggc cagtgtcccc ccaccatggg cacaccccca agtggtgctt
     3241 gttggaagag tgcttactta cctcgagaga atttacagga gtccacatga cagtgtcctg
     3301 cctggttggc agcgggggcc atcacctgtg gcctctgaga ccgccccatt tacaggaatc
     3361 tgcactgggt ctcagtgaat gaacgtatgg tagattttta ttttcttggc actaaagatt
     3421 agctttttta aaaaaacatc ccataaaaca gtagaaactc agttcccttc tcaggggcac
     3481 acacatccaa ggcaccgtgg actgtgtttc catcctggcc tagaggagca gtaaaagata
     3541 gcatttggtt tgacatggcc ttagtgagtc ctgcctttcc tagcatgcac acaacatcct
     3601 ctctttgagt ttgggttctc cccagcccct tggcctctga ggctgagggt ggcttcctcc
     3661 catcctccca tctcagtggt tccatggcgc tcccttcggc acgtgcggtt tccgcccctc
     3721 ccttcctggg gtgtggaaag gcagccagac ctctttttca gaagttgttg gttccctgat
     3781 ttttgtcttg agcaggcacc atccctgtcc ccttgcttgc aggtagaatt ggcacagagt
     3841 taaggttcca taataaactg ttaggtgctc ttgaagaaga tgtcatggca ttgcctcagc
     3901 accccagcaa gagcattgca tctttgctga atccagatgg gttagcagag ggcaaattgg
     3961 aggattcctt tgaggaaatg ttctcaattg agcaattcag tccctctccc caaagactag
     4021 acgtgacctg gcagattagc aggatcctct tggccttctt ttttggggat ggtgggagtg
     4081 aagggggtga atcttaaaag cttatcaaca aagctcctgt tctgcaggca tcaggaaagt
     4141 tgagtgtaag atggaaaaag caaacagcct atttacaagt ggaaacacat tggttctgat
     4201 cactcctaac ttgctgggtg atcatacata catcaacatg aaggtgtgac atcagaatca
     4261 tgagcaccat ggctgcagtt gtgtgatcca aggctagttg gcttggtagc tgttggcagc
     4321 agtttccctt ggtcagaggc ctccttgcta tctatcgctg ctctcttctt gtcatcctta
     4381 aacattcagt catgttccca ggtctgaggg gagcaatggc cagaccagtt tcagtatctc
     4441 tggcaacaga aacaaggatt gaaatggtgg tagttaagag tgcagacaca tctggggtgc
     4501 aacgtctgca tcatcctggt ggctagccag tgcggggagg ccctgccctg ggataccagt
     4561 tgtgacaata aagggatggc cctcctggct tcagcatcct gcaggtagag cagcctcatt
     4621 ccttcacaag atggaaggca ggtgaggatg tcaggatgag atgggaccag gtagccgagg
     4681 acagtgaggc atgtctgagc cacttgaggg gcagctgaac agaaggatgt ctgtgtgcat
     4741 caaccgagca gattgtgcgc acactcgttt ccgaactgcc tctccccaaa gaatgtgagg
     4801 cattgtcacc ttgttacagc tatgtgaagc agagctgtca caacttttcc tgtctacagg
     4861 caggaaaacc aggatggaga agggcaactt gcttattaag atcacccagc aagttaggag
     4921 tgatcagaac cagtgaagtt tccatttttc atccattgct gccctgtgtg tgaacaaatg
     4981 tgactccata tttattacac agcaaggact gctgtgtgtg ggtgtgttcc tcagaccatc
     5041 tctactcttt ttggttagga cactaggttc ttcccagcat atgagtgaga atattggtgg
     5101 tattttgggc tcctctactg cacaagggcc agtccccaag tctactctga ttgattgtca
     5161 tgggcaccca cacagatcag gacacccttt gaatttttgt ttgacatgaa ctatttaggt
     5221 gttccaaaac cttgggatct caatgtgcaa actccttgga ctccagaccc ctgtctggtt
     5281 ggcactccca gcagtgtgtg gtttcatcag gaaatccttg cagcaggggt ttagatggtt
     5341 ccttcaggag gtgggaagcc tccatagcat tgaaggccag cctgcatctc gcggtgtgtg
     5401 tccacttctc ccctcacttt cccctcaccc atccctttaa agtgattggc tgtgaggagc
     5461 acagagggtg gcaattccat ctgttatggg ctcagaagac atagccgcca tgttgatttc
     5521 acattaaact gtgtaaaatg tggaaaagac tcagcatgtt ggtcaaacaa taaactgtcc
     5581 taattctcaa aacaaa
//
