LOCUS       NM_198896               3326 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB6A, member RAS oncogene family (RAB6A), transcript
            variant 2, mRNA.
ACCESSION   NM_198896
VERSION     NM_198896.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3326)
  AUTHORS   Yang,L., Zhu,Z., Zheng,Y., Yang,J., Liu,Y., Shen,T., Li,M., He,H.,
            Huang,H. and Dai,W.
  TITLE     RAB6A functions as a critical modulator of the stem-like subsets in
            cholangiocarcinoma
  JOURNAL   Mol Carcinog 62 (10), 1460-1473 (2023)
   PUBMED   37278569
  REMARK    GeneRIF: RAB6A functions as a critical modulator of the stem-like
            subsets in cholangiocarcinoma.
REFERENCE   2  (bases 1 to 3326)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3326)
  AUTHORS   Huber,M.E., Kurapova,R., Heisler,C.M., Karamooz,E., Tafesse,F.G.
            and Harriff,M.J.
  TITLE     Rab6 regulates recycling and retrograde trafficking of MR1
            molecules
  JOURNAL   Sci Rep 10 (1), 20778 (2020)
   PUBMED   33247182
  REMARK    GeneRIF: Rab6 regulates recycling and retrograde trafficking of MR1
            molecules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3326)
  AUTHORS   Yang,L., Liu,G., Li,X., Xia,Z., Wang,Y., Lin,W., Zhang,W., Zhang,W.
            and Li,X.
  TITLE     Small GTPase RAB6 deficiency promotes alveolar progenitor cell
            renewal and attenuates PM2.5-induced lung injury and fibrosis
  JOURNAL   Cell Death Dis 11 (10), 827 (2020)
   PUBMED   33012781
  REMARK    GeneRIF: Small GTPase RAB6 deficiency promotes alveolar progenitor
            cell renewal and attenuates PM2.5-induced lung injury and fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3326)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3326)
  AUTHORS   Beranger,F., Cadwallader,K., Porfiri,E., Powers,S., Evans,T., de
            Gunzburg,J. and Hancock,J.F.
  TITLE     Determination of structural requirements for the interaction of
            Rab6 with RabGDI and Rab geranylgeranyltransferase
  JOURNAL   J Biol Chem 269 (18), 13637-13643 (1994)
   PUBMED   8175798
REFERENCE   7  (bases 1 to 3326)
  AUTHORS   Rousseau-Merck,M.F., Zahraoui,A., Touchot,N., Tavitian,A. and
            Berger,R.
  TITLE     Chromosome assignment of four RAS-related RAB genes
  JOURNAL   Hum Genet 86 (4), 350-354 (1991)
   PUBMED   1999336
REFERENCE   8  (bases 1 to 3326)
  AUTHORS   Goud,B., Zahraoui,A., Tavitian,A. and Saraste,J.
  TITLE     Small GTP-binding protein associated with Golgi cisternae
  JOURNAL   Nature 345 (6275), 553-556 (1990)
   PUBMED   2112230
REFERENCE   9  (bases 1 to 3326)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   10 (bases 1 to 3326)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB989138.1, BI552973.1,
            BQ422263.1, CB067721.1, BC003617.2 and BU685989.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_198896.1.
            
            Summary: This gene encodes a member of the RAB family, which
            belongs to the small GTPase superfamily. GTPases of the RAB family
            bind to various effectors to regulate the targeting and fusion of
            transport carriers to acceptor compartments. This protein is
            located at the Golgi apparatus, which regulates trafficking in both
            a retrograde (from early endosomes and Golgi to the endoplasmic
            reticulum) and an anterograde (from the Golgi to the plasma
            membrane) directions. Myosin II is an effector of this protein in
            these processes. This protein is also involved in assembly of human
            cytomegalovirus (HCMV) by interacting with the cellular protein
            Bicaudal D1, which interacts with the HCMV virion tegument protein,
            pp150. Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (2) has an alternate exon with the
            same size in the coding region, compared to variant 1. The
            resulting isoform (b, also known as RAB6A) is the same size but has
            three different aa in an internal segment, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.184230.1,
                                           SRR1803616.265743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336083.8/ ENSP00000336850.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               CB989138.1         87-199
            114-664             BI552973.1         131-681
            665-1137            BQ422263.1         229-701
            1138-1510           CB067721.1         11-383              c
            1511-2788           BC003617.2         1489-2766
            2789-3071           BC003617.2         2768-3050
            3072-3326           BU685989.1         12-266              c
FEATURES             Location/Qualifiers
     source          1..3326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..3326
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="RAB6A, member RAS oncogene family"
                     /db_xref="GeneID:5870"
                     /db_xref="HGNC:HGNC:9786"
                     /db_xref="MIM:179513"
     exon            1..509
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1066
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="isoform b is encoded by transcript variant 2; Rab
                     GTPase; RAB6, member RAS oncogene family; ras-related
                     protein Rab-6A"
                     /codon_start=1
                     /product="ras-related protein Rab-6A isoform b"
                     /protein_id="NP_942599.1"
                     /db_xref="CCDS:CCDS8224.1"
                     /db_xref="GeneID:5870"
                     /db_xref="HGNC:HGNC:9786"
                     /db_xref="MIM:179513"
                     /translation="MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQA
                     TIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQ
                     QTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAG
                     YNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC"
     exon            510..568
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            569..622
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            623..728
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            729..840
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            841..934
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1001
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..3326
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="hexamer: AATATA"
     polyA_site      3007
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
     regulatory      3048..3053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="major polyA site"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
                     /note="hexamer: AATAAA"
     polyA_site      3326
                     /gene="RAB6A"
                     /gene_synonym="RAB6"
ORIGIN      
        1 actcagcagg ttgggctgcg gcggcggcgg cagctgtgga agctcaggcg ctgcgcgtga
       61 gaggtcccag atacgtctgc ggttccggct ccgccaccct cagcttctct tccccaggtc
      121 tgggagccga gtgcggaagg agggaacggc cctagctttg ggaagccaga ggacacccct
      181 ggctcctgcc gacaccgccc tccttccctt cccagccgcg ggcctcgctc ggtgctaggc
      241 tactctgccg ggaggcggcg gcggctgcca gtctgtggag agtcctgctg ccctccagcc
      301 gggctcctcc accgggcctt gcaggggccg agagagctcg gtgcccgccc ttccgctcgc
      361 ctttttcgtc agctggctgg agcagcatcg gtccgggagg tctctaggct gaggcggcgg
      421 ccgctcctct agttccacaa tgtccacggg cggagacttc gggaatccgc tgaggaaatt
      481 caagctggtg ttcctggggg agcaaagcgt tggaaagaca tctttgatca ccagattcat
      541 gtatgacagt tttgacaaca cctatcaggc aacaattggc attgactttt tatcaaaaac
      601 tatgtacttg gaggatcgaa cagtacgatt gcaattatgg gacacagcag gtcaagagcg
      661 gttcaggagc ttgattccta gctacattcg tgactccact gtggcagttg ttgtttatga
      721 tatcacaaat gttaactcat tccagcaaac tacaaagtgg attgatgatg tcagaacaga
      781 aagaggaagt gatgttatca tcatgctagt aggaaataaa acagatcttg ctgacaagag
      841 gcaagtgtca attgaggagg gagagaggaa agccaaagag ctgaatgtta tgtttattga
      901 aactagtgca aaagctggat acaatgtaaa gcagctcttt cgacgtgtag cagcagcttt
      961 gccgggaatg gaaagcacac aggacagaag cagagaagat atgattgaca taaaactgga
     1021 aaagcctcag gagcaaccag tcagtgaagg aggctgttcc tgctaatctc ccatgtcatc
     1081 ttcaaccttc ttcagaagct cactgctttg gcccccttac tctttcattg actgcagtgt
     1141 gaatattggc ttgaaccttt tcccttcagt aataacgtat tgcaattcat cattgctgcc
     1201 tgtctcgtgg agatgatcta ttagcttcac aagcacaaca aaagtcagtg tcttcattat
     1261 ttatatttta caaaaagcca aaatatttca gcatattcca gtgataactt taaaaattag
     1321 atacattttc ttaacatttt tttctttttt aatgttatga taatgtactt caaaatgatg
     1381 gaaatctcaa cagtatgagt atggcttggt taacgagcgg tatgttcaca gcctacttta
     1441 tctctccttg cttttctcac ctctcactta cccccattcc ctattaccct attcttacct
     1501 agcctccccc gacttcctca aaacaaacaa gagatggcaa agcagcagtt ctaccaagcc
     1561 cattggaatt atcctttaat tttacagata ccacttgctg taggctacgg accaagatgt
     1621 ccaaaattat tcttgagcac tgatataaat tacggtcttc tttgaggtca aaattcagcc
     1681 atcatggtag gcagtgcttg aatgagaaaa ggctcctggt gcatcttcaa aatgagtcct
     1741 aaagaacata ctgagtactt agaagtagaa gaacataaga tgtatttctg actaaaacaa
     1801 atggctcttt cacatgtgct ttattagact ctgggagaga aaattaacca agtgcttcag
     1861 aacaggtttt tagtatttaa ttcttcacgg taagaaaatg aagttctaat gaactgtttc
     1921 tcccaaggtt ttaaaattgt caagagttat tctgtttgtt taaaaaataa gaaacctctt
     1981 taagcaatag attttgcttg ggttttcttt tttaaaaaca taatactgtg caggcaaggc
     2041 actgtaaaag ttttaattcc ttccagaaga accagtggaa gaatttaaat ttggcgctac
     2101 gatcaaaact actgaattag tagaaataat gatgtctaaa gcttaccaac aaaagaaccc
     2161 tcagcagaat aacaaaaact ttgctcagga catttgaggt caaattgaag acggaaaccg
     2221 gaaaccgttt tcttgtaagc ccctagaggc agatcaggta aagcatacat agtagaggga
     2281 aaggagagaa tggaaataaa actcaatatt atgcagattt atgccttatt ttttagcatt
     2341 ttttaaggtt gggtctttca ggctggtttt ggtttgtatt agatctgtat agtttaatta
     2401 actggtgatt tagttttata tttaagctac aattaatctt ttttctttgg tgatatttat
     2461 ttctttgcct tttttttttt taacaacttt caatcttcag atgtttcgtt gaatctattt
     2521 agagcttcac catggcaata tgtatttccc ttaaaacact gcaaacaaat atactaggag
     2581 tgtgcccttt taatctttac tagttattgt gagattgctg tgtaagctaa taaacacatt
     2641 tgtaaataca ttgtttgcag gacgaaaact tctgagttac agctcaggaa aagcctgctg
     2701 aatttatgtt gtaagcatta cttaacacag tataaagatg aaaagacaac aaaaatatct
     2761 tcatacttcc tcatcccctc attggaacaa aaccttaaac tgggagaacc ttagtcccct
     2821 ctctttcctc ttcctcctcc acttcccact tattgtcacc ttgtaatatt cagagagcac
     2881 ttggattatg gatctgaata gagaaatgct tacagataat cattagccca cataccagta
     2941 acttatactt aaagatggga tggagttgta aagtgctttt ataatacaat ataattgtta
     3001 aaggcaaggg ttgactcttt gttttatttt gacatggcat gtcctgaaat aaatattgat
     3061 tcaatatggc agatgggtca tattctttat ttggaagaag ttgtgacttc tgacatgggt
     3121 gtgattgtct tcctacactg ttgcatttga ttctttttat gtatttttaa gaaagtaacc
     3181 agttatactg cttttaatat tgattggtct ttttatttgg cttggagttc ttcaaagcat
     3241 tgaagtgtgt tcatagtcca ggtttttttt ttaataaaca caattttgct gccaaaaata
     3301 tataaataaa acacgaaaga aaacaa
//
