LOCUS       NM_004583               1640 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RAB5C, member RAS oncogene family (RAB5C), transcript
            variant 2, mRNA.
ACCESSION   NM_004583
VERSION     NM_004583.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Wang,X., Cheng,J., Shen,L., Chen,M., Sun,K., Li,J., Li,M., Ma,C.
            and Wei,L.
  TITLE     Rab5c promotes RSV and ADV replication by autophagy in respiratory
            epithelial cells
  JOURNAL   Virus Res 341, 199324 (2024)
   PUBMED   38242290
  REMARK    GeneRIF: Rab5c promotes RSV and ADV replication by autophagy in
            respiratory epithelial cells.
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Koop,K., Yuan,W., Tessadori,F., Rodriguez-Polanco,W.R., Grubbs,J.,
            Zhang,B., Osmond,M., Graham,G., Sawyer,S., Conboy,E., Vetrini,F.,
            Treat,K., Ploski,R., Pienkowski,V.M., Klosowska,A., Fieg,E.,
            Krier,J., Mallebranche,C., Alban,Z., Aldinger,K.A., Ritter,D.,
            Macnamara,E., Sullivan,B., Herriges,J., Alaimo,J.T., Helbig,C.,
            Ellis,C.A., van Eyk,C., Gecz,J., Farrugia,D., Osei-Owusu,I.,
            Ades,L., van den Boogaard,M.J., Fuchs,S., Bakker,J., Duran,K.,
            Dawson,Z.D., Lindsey,A., Huang,H., Baldridge,D., Silverman,G.A.,
            Grant,B.D., Raizen,D., van Haaften,G., Pak,S.C., Rehmann,H.,
            Schedl,T. and van Hasselt,P.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Macrocephaly and developmental delay caused by missense variants in
            RAB5C
  JOURNAL   Hum Mol Genet 32 (21), 3063-3077 (2023)
   PUBMED   37552066
  REMARK    GeneRIF: Macrocephaly and developmental delay caused by missense
            variants in RAB5C.
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Wang,Z., Li,F., Zhang,H., Hu,X., Chen,Y. and Huang,C.
  TITLE     RAB5C, a new mRNA binding target of HuR, regulates breast cancer
            cell proliferation
  JOURNAL   Cell Biol Int 47 (2), 374-382 (2023)
   PUBMED   36480789
  REMARK    GeneRIF: RAB5C, a new mRNA binding target of HuR, regulates breast
            cancer cell proliferation.
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Wen,X., Yan,Z., Du,J., Dai,J., Liu,M., Wang,X. and Wang,N.
  TITLE     Effects of miR-145 targeting rab5c and regulating MAPK / ERK
            signaling pathway on proliferation and invasion of thyroid
            papillary carcinoma cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (1), 44-47 (2023)
   PUBMED   37213158
  REMARK    GeneRIF: Effects of miR-145 targeting rab5c and regulating MAPK /
            ERK signaling pathway on proliferation and invasion of thyroid
            papillary carcinoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Li,X., Chen,X., Fu,C., Xie,M. and Ouyang,S.
  TITLE     Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in
            Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression
  JOURNAL   Chemotherapy 68 (3), 119-130 (2023)
   PUBMED   36657426
  REMARK    GeneRIF: Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance
            in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression.
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Clemens,D.L., Lee,B.Y. and Horwitz,M.A.
  TITLE     Deviant expression of Rab5 on phagosomes containing the
            intracellular pathogens Mycobacterium tuberculosis and Legionella
            pneumophila is associated with altered phagosomal fate
  JOURNAL   Infect Immun 68 (5), 2671-2684 (2000)
   PUBMED   10768959
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Bucci,C., Chiariello,M., Lattero,D., Maiorano,M. and Bruni,C.B.
  TITLE     Interaction cloning and characterization of the cDNA encoding the
            human prenylated rab acceptor (PRA1)
  JOURNAL   Biochem Biophys Res Commun 258 (3), 657-662 (1999)
   PUBMED   10329441
REFERENCE   8  (bases 1 to 1640)
  AUTHORS   Alvarez-Dominguez,C. and Stahl,P.D.
  TITLE     Interferon-gamma selectively induces Rab5a synthesis and processing
            in mononuclear cells
  JOURNAL   J Biol Chem 273 (51), 33901-33904 (1998)
   PUBMED   9852039
REFERENCE   9  (bases 1 to 1640)
  AUTHORS   Han,H.J., Sudo,K., Inazawa,J. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (RABL) encoding a small
            GTP-binding protein homologous to the Ras-related RAB gene
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 137-139 (1996)
   PUBMED   8646882
REFERENCE   10 (bases 1 to 1640)
  AUTHORS   Albertsen,H.M., Smith,S.A., Mazoyer,S., Fujimoto,E., Stevens,J.,
            Williams,B., Rodriguez,P., Cropp,C.S., Slijepcevic,P., Carlson,M.
            et al.
  TITLE     A physical map and candidate genes in the BRCA1 region on
            chromosome 17q12-21
  JOURNAL   Nat Genet 7 (4), 472-479 (1994)
   PUBMED   7951316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC106039.1.
            
            On Jun 2, 2019 this sequence version replaced NM_004583.3.
            
            Summary: Members of the Rab protein family are small GTPases of the
            Ras superfamily that are thought to ensure fidelity in the process
            of docking and/or fusion of vesicles with their correct acceptor
            compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.995024.1,
                                           SRR3476690.947981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346213.9/ ENSP00000345689.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1640              BC106039.1         15-1654
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1640
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /note="RAB5C, member RAS oncogene family"
                     /db_xref="GeneID:5878"
                     /db_xref="HGNC:HGNC:9785"
                     /db_xref="MIM:604037"
     exon            1..97
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     exon            98..351
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..836
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /EC_number="3.6.5.2"
                     /note="isoform a is encoded by transcript variant 2;
                     RAB5C, member of RAS oncogene family; ras-related protein
                     Rab-5C"
                     /codon_start=1
                     /product="ras-related protein Rab-5C isoform a"
                     /protein_id="NP_004574.2"
                     /db_xref="CCDS:CCDS11419.1"
                     /db_xref="GeneID:5878"
                     /db_xref="HGNC:HGNC:9785"
                     /db_xref="MIM:604037"
                     /translation="MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKG
                     QFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYD
                     ITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLF
                     METSAKTAMNVNEIFMAIAKKLPKNEPQNATGAPGRNRGVDLQENNPASRSQCCSN"
     exon            352..503
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     exon            504..626
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     exon            627..720
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1640
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /note="hexamer: AATATA"
     polyA_site      1640
                     /gene="RAB5C"
                     /gene_synonym="L1880; RAB5CL; RAB5L; RABL"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggag gccggagcct gggacaccgc cggcggggag agaagcggat cccgtccgag
       61 ccccggcccc aagtaacgcc gccgccccgg agccgccttg gaggtccccc tccccactaa
      121 gtgcctcttt gcatagcacc agtccccacc cgcacgctct ctggaccact acagctggac
      181 gggcaatggc gggtcgggga ggcgcagcac gacccaatgg accagctgct gggaacaaga
      241 tctgtcaatt taagctggtt ctgctggggg agtctgcggt aggcaaatcc agcctcgtcc
      301 tccgctttgt caagggacag tttcacgagt accaggagag cacaattgga gcggccttcc
      361 tcacacagac tgtctgcctg gatgacacaa cagtcaagtt tgagatctgg gacacagctg
      421 gacaggagcg gtatcacagc ctggccccca tgtactatcg gggggcccag gctgccatcg
      481 tggtctatga catcaccaac acagatacat ttgcacgggc caagaactgg gtgaaggagc
      541 tacagaggca ggccagcccc aacatcgtca ttgcactcgc gggtaacaag gcagacctgg
      601 ccagcaagag agccgtggaa ttccaggaag cacaagccta tgcagacgac aacagtttgc
      661 tgttcatgga gacatcagca aagactgcaa tgaacgtgaa cgaaatcttc atggcaatag
      721 ctaagaagct tcccaagaac gagccccaga atgcaactgg tgctccaggc cgaaaccgag
      781 gtgtggacct ccaggagaac aacccagcca gccggagcca gtgctgcagc aactgagccc
      841 cccttgcctg cccgctgccc ccgcctcctc cgcctgaatg acccgactgg aatccactct
      901 aaccaatcgc acttaacgac tcgggccacc actggggggg cagggggagg ggtccaccat
      961 gatttctcca tataattttg atcataggcc ggagtgagtc attccacctg cacctttctg
     1021 tacaaatact aattcaattt taagtcttaa gtcacttttt taatatatat gatcttctgc
     1081 tcttcccact tcctcccctt tctactgctc tcccattttc ccttgctggg agtagccaca
     1141 tgctcttgcc ccccaaccct tgtatatggg gacagtgggg tcagtgcagc taccctttct
     1201 ttccctcctg cggaacagcg gacccagcaa gagcatccac atcctcactt tgttcggagt
     1261 ggtctttggt ttgggcggtg gggcagacct tgggaagggg cttaggaagg gagaggcagc
     1321 tcttccttca gctggctctc atcaggctgc agccccctcc ccgctcccac ctccctgctg
     1381 ggaaaccaca gcattatcac agcattattg tgacagccac gaacccattg cccacaaccc
     1441 ctccaccctc ggtcacccca acctctggct ctgagccctg ttctgaccaa atcatgatga
     1501 tgagtatttg ggggtgggtg ggtaaggggg ggagtgggag gggacggaac caactttttc
     1561 tgtattttgt attgtatgtt ttcttcaaca tgtaaccaat cagtatcttg tcaatatagt
     1621 cagccgatcg atcgacctca
//
