LOCUS       NM_001414458            5576 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens RAB5B, member RAS oncogene family (RAB5B), transcript
            variant 5, mRNA.
ACCESSION   NM_001414458 XM_047429281
VERSION     NM_001414458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5576)
  AUTHORS   Fan,H., Zhou,D., Zhang,X., Jiang,M., Kong,X., Xue,T., Gao,L.,
            Lu,D., Tao,C. and Wang,L.
  TITLE     hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary
            syndrome progression by sponging the miR-619-5p/Rab5b axis
  JOURNAL   Mol Hum Reprod 29 (11) (2023)
   PUBMED   37882757
  REMARK    GeneRIF: hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic
            ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.
REFERENCE   2  (bases 1 to 5576)
  AUTHORS   Alan Harris,R., Archer,K.J., Goodarzi,M.O., York,T.P., Rogers,J.,
            Dunaif,A., McAllister,J.M. and Strauss,J.F. 3rd.
  TITLE     Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are
            associated with polycystic ovary syndrome
  JOURNAL   Gene 852, 147062 (2023)
   PUBMED   36423778
  REMARK    GeneRIF: Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and
            RAB5B are associated with polycystic ovary syndrome.
REFERENCE   3  (bases 1 to 5576)
  AUTHORS   Huang,H., Pan,J., Spielberg,D.R., Hanchard,N.A., Scott,D.A.,
            Burrage,L.C., Dai,H., Murdock,D., Rosenfeld,J.A., Mohammad,A.,
            Huang,T., Lindsey,A.G., Kim,H., Chen,J., Ramu,A., Morrison,S.A.,
            Dawson,Z.D., Hu,A.Z., Tycksen,E., Silverman,G.A., Baldridge,D.,
            Wambach,J.A., Pak,S.C., Brody,S.L. and Schedl,T.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     A dominant negative variant of RAB5B disrupts maturation of
            surfactant protein B and surfactant protein C
  JOURNAL   Proc Natl Acad Sci U S A 119 (6) (2022)
   PUBMED   35121658
  REMARK    GeneRIF: A dominant negative variant of RAB5B disrupts maturation
            of surfactant protein B and surfactant protein C.
REFERENCE   4  (bases 1 to 5576)
  AUTHORS   Christensen,J.R., Kendrick,A.A., Truong,J.B., Aguilar-Maldonado,A.,
            Adani,V., Dzieciatkowska,M. and Reck-Peterson,S.L.
  TITLE     Cytoplasmic dynein-1 cargo diversity is mediated by the
            combinatorial assembly of FTS-Hook-FHIP complexes
  JOURNAL   Elife 10, e74538 (2021)
   PUBMED   34882091
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5576)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5576)
  AUTHORS   Callaghan,J., Nixon,S., Bucci,C., Toh,B.H. and Stenmark,H.
  TITLE     Direct interaction of EEA1 with Rab5b
  JOURNAL   Eur J Biochem 265 (1), 361-366 (1999)
   PUBMED   10491193
REFERENCE   7  (bases 1 to 5576)
  AUTHORS   Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     The small GTPases Rab5a, Rab5b and Rab5c are differentially
            phosphorylated in vitro
  JOURNAL   FEBS Lett 453 (1-2), 20-24 (1999)
   PUBMED   10403367
REFERENCE   8  (bases 1 to 5576)
  AUTHORS   Bao,S., Zhu,J. and Garvey,W.T.
  TITLE     Cloning of Rab GTPases expressed in human skeletal muscle: studies
            in insulin-resistant subjects
  JOURNAL   Horm Metab Res 30 (11), 656-662 (1998)
   PUBMED   9918381
REFERENCE   9  (bases 1 to 5576)
  AUTHORS   Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P.,
            Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M.
  TITLE     Co-operative regulation of endocytosis by three Rab5 isoforms
  JOURNAL   FEBS Lett 366 (1), 65-71 (1995)
   PUBMED   7789520
REFERENCE   10 (bases 1 to 5576)
  AUTHORS   Wilson,D.B. and Wilson,M.P.
  TITLE     Identification and subcellular localization of human rab5b, a new
            member of the ras-related superfamily of GTPases
  JOURNAL   J Clin Invest 89 (3), 996-1005 (1992)
   PUBMED   1541686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034102.32.
            
            On Nov 25, 2022 this sequence version replaced XM_047429281.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.6826.1,
                                           SRR14038193.146687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC034102.32        186960-187221       c
            263-365             AC034102.32        181825-181927       c
            366-620             AC034102.32        174176-174430       c
            621-772             AC034102.32        171201-171352       c
            773-895             AC034102.32        170495-170617       c
            896-989             AC034102.32        169846-169939       c
            990-5576            AC034102.32        164616-169202       c
FEATURES             Location/Qualifiers
     source          1..5576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..5576
                     /gene="RAB5B"
                     /note="RAB5B, member RAS oncogene family"
                     /db_xref="GeneID:5869"
                     /db_xref="HGNC:HGNC:9784"
                     /db_xref="MIM:179514"
     exon            1..262
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1105
                     /gene="RAB5B"
                     /EC_number="3.6.5.2"
                     /note="isoform 3 is encoded by transcript variant 5;
                     ras-related protein Rab-5B"
                     /codon_start=1
                     /product="ras-related protein Rab-5B isoform 3"
                     /protein_id="NP_001401387.1"
                     /db_xref="GeneID:5869"
                     /db_xref="HGNC:HGNC:9784"
                     /db_xref="MIM:179514"
                     /translation="MGVAEEGTGRPGTPKLVTLDQQNEELSQVVELSFQDFGDLGLNR
                     VGEGDEGVLKPGNPLPFPLPPLQYPPPSTLSHSDNLAMTSRSTARPNGQPQASKICQF
                     KLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQ
                     ERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADL
                     ANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGR
                     SRGVDLHEQSQQNKSQCCSN"
     exon            263..365
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            366..620
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            621..772
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            773..895
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            896..989
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            990..5576
                     /gene="RAB5B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3585
                     /gene="RAB5B"
                     /note="major polyA site"
     regulatory      5558..5563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB5B"
                     /note="hexamer: AATAAA"
     polyA_site      5576
                     /gene="RAB5B"
ORIGIN      
        1 gagctgcagc tgtttgtctg ttcgacacag gcttggggcc gacgggggag acggagcccc
       61 aggtaccgag ctgatggagc ccaaagggca ggggcggaag cgcccgggag atgagagcag
      121 cctggcctga gagcggaggc gggtctggtc ctaagcgagg ggttagagtg gcccaccgga
      181 gaggggagaa gggggccggg ccccggcagg cctaatgggg gtcgctgagg aggggactgg
      241 gcggcctggg accccgaagt tggtaacact ggatcaacaa aatgaagagc tgagccaagt
      301 ggtagaactc tcatttcaag attttggtga cttgggttta aacagagttg gagagggaga
      361 tgaaggagtg ttgaagcctg gaaatcccct ccccttcccc ctcccccctt tacagtatcc
      421 ccctccctcc accctttccc attctgataa tctggccatg actagcagaa gcacagctag
      481 gcccaatggg caaccccagg ccagcaaaat ttgccagttc aaattggtcc tgctgggaga
      541 atctgcagtg ggaaagtcaa gcctggtatt acgttttgtc aaagggcagt tccatgagta
      601 ccaggagagc accattggag cggccttcct cacccagtcc gtttgtctag atgacacaac
      661 agtgaagttt gagatctggg acacagctgg gcaggagcga tatcacagct tagcccccat
      721 gtactacagg ggtgcccaag ctgcaatcgt ggtttacgac attactaatc aggaaacctt
      781 tgcccgagca aagacatggg tgaaggaact acagcgacag gccagtccta gcatcgttat
      841 tgccctggca gggaacaaag ctgacctggc caacaaacgt atggtggagt atgaagaggc
      901 ccaggcatat gcagatgaca acagcttatt gttcatggag acttcagcca agacagctat
      961 gaacgtgaat gatctcttcc tggcaatagc taagaagttg ccaaagagtg aaccccagaa
     1021 tctgggaggt gcagcaggcc gaagccgggg tgtggatctc catgaacagt cccagcagaa
     1081 caagagccag tgttgtagca actgaggggg tggctagcag caaacaagta tggagctagc
     1141 acaagagcta agaaataacc tccatcccta cccctcagca cacaacccct acggtaacag
     1201 cacactgagc cctggctccc aagggctgcc tcctgacagc tccgtcatgg cactttttaa
     1261 cgcttcagca acaaacacca ggcagctgtt gccactggcc tcctaccccc tactctgggg
     1321 cttgggggtc aactcccccc aggacttacc ttccaaaaca aactttcttc actttgtatt
     1381 ataggtacaa gacagcgact tacgtatctt ttctcctcct ccctagtgtt cctccccatt
     1441 ttttcagaaa acacttctga ctcctgtccc ttccccttct gcttttggtc agtccctgtt
     1501 cttgagcctc ttttctcctc tccccaggat gcagaaagtg gtgaacccag gaactgagga
     1561 aggaggtttc cagttcattt acattaaggg ccctggggga gaataaagct cagagcagga
     1621 gggagtaagg aaacatttcc tttttgtttt tatttggttg gagtttctca tatttgaaaa
     1681 cattgcggta tccatgattt ggccttgtgg agggtgttcc taggtagagg tgagaatggg
     1741 gaggcaagat ctcaggcacc aggcaggagg tgccttgtaa gctaactggg cggaggtgga
     1801 ggtgcagtgt caactgtggc tctgtaactc ttcaaaggcc cagtttcccc tcacgcagcc
     1861 tcttaggtag cgtttcccct aatcgtgggg gttggacccc agagtcttcc aaagaatttt
     1921 cactggttgc ctgcatcttt ggctctgctg tgatctgatt ggaggaggga cagtttctgg
     1981 tacccatcct ctgatttata catatgcatt ttttcccctc tggcctttag atggcctcag
     2041 ccccagccac catatacccc tgcagtttgc actttaattg atggtagttc agttggggta
     2101 cttgttttat ggaagttttg attgatttac ttgccctccc accttctttt taattcaatg
     2161 aaatctgagg ttaatgcgag gttcgaggag aggttataga taaaactacc agtggcagct
     2221 actcaagtcc tatctccact gttagcttcc tccaactcta attattaacc tatattcttg
     2281 ccaagctaac tattgactat aggtttgcct ttcctggaga attaattgag caattgagga
     2341 gtgtctcagg atagcacagg ccaaggtagg ggagtaaaaa ggaggtcagg caaaagggag
     2401 gagttttctg tcctttccca ggtttcacac tcaatttgat atccattacc atgtcttttc
     2461 tacttccttg taaataggta tgatctttat tcccactgta cagtctgttc tatcctctgc
     2521 ctcccatcag gccctgtttc tttgttcctt tgttaatatc ttgaatttag tccctccatc
     2581 cttaatcccc ccatccctcc ccatcatgca accagtggtt taatccatgt accaataggg
     2641 gctagtacca cagaggcctc ctgtggtgcc ctcgtatcat accacctgtt cctgtggaga
     2701 gggaatgacc ggcactgaag gtaccttaca actggctcat attatcagag gaccttggtc
     2761 ctttctaaat ctctagtctc tcttcatatc cttcatcagg tgttttaaga tgtctctgag
     2821 aagccatcaa ggcaaaagag aactttaagt tccttgttcc agcccggagt tttgggaaag
     2881 aaagaaagga aaggtcacag tgacctagga ttggaacctt cctgcccttt tggcttgcag
     2941 actgccttct atcccagaac agctgagaaa tctatgaagc tgagattctg aaggacccag
     3001 cttaggttct tccacttagg cctcaattcc cttccttttc caggggcagc cttagttccc
     3061 atggccctga aacacacaca tttccccctt cctttcccag aagccactgg ccccccatag
     3121 cacccagtgc atccttttta caagtggaag aactaggatg gctttccaaa gtcttctaga
     3181 aatgaagttc tttctctgtg cagctttccc ccttggagca ggagtgaaga tgtttcatta
     3241 tcttgggcct gggaaaccac ttccccaggc ttctccctcc ccccaccccc ataggaacag
     3301 gatttggcct tagcttctgg gcctatcggc tgccttccct ctacttccta ccacctcttc
     3361 tgccttcctt tgagctctgt tgggcttggg gatcttagtt ttcttttgtt tatttcccag
     3421 ctcatttttt tcttctggtc agttttttta agggggggtg ttgtggtttt ttgtttttgt
     3481 tttgcttctg agaaagcatt tgcctttctt cctctcccaa cataacaatc gtggtaacag
     3541 aatgcgactg ctgatttacc gatgtattta atgtaagtaa aaaaaggaaa aaaagaaaag
     3601 ggcattggag tgttgctttt ttttatttta ttgttattat tattattatt tttgctattt
     3661 gtcaggtact aggaatttgg aagaaaggat acccagtaat gttctactga atcagaaaca
     3721 cacctttccc tgcatcttga tacatcttta ttccctttaa tcttttctta aacatctagt
     3781 ttagaaaata gcccttctat tgctatttaa tcacccctct tctaaggcca ctagattgtt
     3841 catcaaatca aaccctatta tatcttttta ggccctctta acagaatgta tatgtgtagg
     3901 gtatggtctg tggatctttg ggcccactga tcagattaga gagaggggtg ctatttgaag
     3961 tagtatacaa aaatgtatgt gcatatttct tttttttttt ttaattgaga cggagtctct
     4021 gtcgctagcc tggagtacag tggcacgatc ttggctcaca gcaatctccg cctcctgagt
     4081 tcaagtgatt ctcctgcctc agcctcctga gtagctagga ttacaggcac gcaccaacac
     4141 acccagctaa tttttgtatt tttagtagag acggggtttc accatgttgg tcaggctggt
     4201 cttgaactcc tgacctcgtg atccacccac cttggcctcc caaagtgctg ggattacggg
     4261 cgtgagccac tgcgcccggc cgtatgtgca tatttctagg atccatttct atatgtttct
     4321 caaaggggtc catgacccaa aggttgaaaa acatcactga gttagttttc ttgtagcttc
     4381 cacctcaacg ggaaaatttc ctctggatct gctcttgact cctagtgtac ttcaaaccct
     4441 tcagtccacc acagtctaaa ggtcgaggga agggaaatga aataggatta tgtgtggttg
     4501 cagtaggctt taaattccaa agaatctgaa ggtggatagg aaagaggact ggtgccagac
     4561 aaatctgaca ttctaggcct gtctctgtca acttaaccag ctgtggcctt gatcaagtta
     4621 gttagtgcct tccgcctcgt ttcttcatct gtaaagtaaa agctgaagat taaggtcaat
     4681 tatgtaaagt atgtgtgtca cacaaaagta gatgacacta ttaggaagga ggcttttaga
     4741 tagtccctaa ctgacttctc tgtatcttcc tttggctgag actttttttt ttttaggttg
     4801 aagctcgctt tctctctctc tccctctttc tccctctctc tctctctctc actctctctc
     4861 tctccatata tatatacata tatatatata tatatatttt ttttttaaca actggtagga
     4921 taggttgggc attagccttc ttcagtgatt tgattgtata cagattgaaa tcctttccat
     4981 ttccaaacac ttaagagcca aagccaactt gccaactttt cactgtcggt tcccttacct
     5041 tatatctctt ggtaataccc cccacccccg ttccctgatt cctggtaaaa gctctagttg
     5101 gagagccgaa aggaaaggaa atgatctttc aaaattaaag gtgaacacct tcacttaaac
     5161 tgattaaaat tgcagctcca ccgtccggcc tctagagggc agtgtatgga tacatttgtc
     5221 cagattgggg gactaggttt gataaatttt gtcctgcatc aaatgacaaa agggtaatag
     5281 gaaatgtatt atatttatgc cccttacttt gagataagag actacaacct tcatacttcg
     5341 gggtgttaag ctgccattgc tcttgttaag gggcagtttg ttttttaaga gatggggtct
     5401 tgctctgttg tccaggctgg agtgcagtgc cgcgatcttg gctcagtgca acctcgaact
     5461 cctgggctta agcgatcctc ccgcctcagc ctcccgagta ctgggactac aggcgtgtgc
     5521 caccaagggg cgattattat tttttttttc tacgcaaaat aaaagacggc tattca
//
