LOCUS       NM_004162               2518 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RAB5A, member RAS oncogene family (RAB5A), transcript
            variant 1, mRNA.
ACCESSION   NM_004162
VERSION     NM_004162.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Silva,P., Hernandez,N., Tapia,H., Gaete-Ramirez,B., Torres,P.,
            Flores,T., Herrera,D., Caceres-Verschae,A., Acuna,R.A.,
            Varas-Godoy,M. and Torres,V.A.
  TITLE     Tumor-derived hypoxic small extracellular vesicles promote
            endothelial cell migration and tube formation via
            ALS2/Rab5/beta-catenin signaling
  JOURNAL   FASEB J 38 (11), e23716 (2024)
   PUBMED   38847490
  REMARK    GeneRIF: Tumor-derived hypoxic small extracellular vesicles promote
            endothelial cell migration and tube formation via
            ALS2/Rab5/beta-catenin signaling.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Qiao,L., Dong,C., Jia,W. and Sun,G.
  TITLE     RAB5A in triple-negative breast cancer: a critical role in
            macrophage reshaping in an exosomal miR-21-dependent manner
  JOURNAL   Endocr Relat Cancer 31 (5), e230257 (2024)
   PUBMED   38470169
  REMARK    GeneRIF: RAB5A in triple-negative breast cancer: a critical role in
            macrophage reshaping in an exosomal miR-21-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Liu,S., Wang,K., Zhao,Z., Pang,Y., Liu,F., Wang,P., Wang,Z. and
            Yang,X.
  TITLE     miR-451a suppresses the proliferation and migration of high-grade
            serous ovarian cancer by targeting RAB5A through the
            Ras/Raf/MEK/ERK pathway
  JOURNAL   J Gene Med 26 (1), e3649 (2024)
   PUBMED   38282155
  REMARK    GeneRIF: miR-451a suppresses the proliferation and migration of
            high-grade serous ovarian cancer by targeting RAB5A through the
            Ras/Raf/MEK/ERK pathway.
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Oechslin,N., Da Silva,N., Ankavay,M., Moradpour,D. and
            Gouttenoire,J.
  TITLE     A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and
            early endosomes in hepatitis E virus replication
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2307423120 (2023)
   PUBMED   38109552
  REMARK    GeneRIF: A genome-wide CRISPR/Cas9 screen identifies a role for
            Rab5A and early endosomes in hepatitis E virus replication.
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Khumukcham,S.S., Penugurti,V., Bugide,S., Dwivedi,A., Kumari,A.,
            Kesavan,P.S., Kalali,S., Mishra,Y.G., Ramesh,V.A.,
            Nagarajaram,H.A., Mazumder,A. and Manavathi,B.
  TITLE     HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors
            of Rab5 to regulate endocytosis-coupled focal adhesion turnover
  JOURNAL   J Biol Chem 299 (11), 105311 (2023)
   PUBMED   37797694
  REMARK    GeneRIF: HPIP and RUFY3 are noncanonical guanine nucleotide
            exchange factors of Rab5 to regulate endocytosis-coupled focal
            adhesion turnover.
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Alexandrov,K., Horiuchi,H., Steele-Mortimer,O., Seabra,M.C. and
            Zerial,M.
  TITLE     Rab escort protein-1 is a multifunctional protein that accompanies
            newly prenylated rab proteins to their target membranes
  JOURNAL   EMBO J 13 (22), 5262-5273 (1994)
   PUBMED   7957092
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Bucci,C., Parton,R.G., Mather,I.H., Stunnenberg,H., Simons,K.,
            Hoflack,B. and Zerial,M.
  TITLE     The small GTPase rab5 functions as a regulatory factor in the early
            endocytic pathway
  JOURNAL   Cell 70 (5), 715-728 (1992)
   PUBMED   1516130
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Rousseau-Merck,M.F., Zahraoui,A., Touchot,N., Tavitian,A. and
            Berger,R.
  TITLE     Chromosome assignment of four RAS-related RAB genes
  JOURNAL   Hum Genet 86 (4), 350-354 (1991)
   PUBMED   1999336
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC330362.1, BC018288.1, AK312618.1, AK309287.1 and BJ991078.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004162.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1059340.1,
                                           SRR1660807.142255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273047.9/ ENSP00000273047.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DC330362.1         18-317
            301-559             BC018288.1         1-259
            560-1166            AK312618.1         291-897
            1167-1490           AK309287.1         1035-1358
            1491-1856           BJ991078.1         1-366               c
            1857-2518           BC018288.1         1558-2219
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..2518
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /note="RAB5A, member RAS oncogene family"
                     /db_xref="GeneID:5868"
                     /db_xref="HGNC:HGNC:9783"
                     /db_xref="MIM:179512"
     exon            1..425
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     exon            426..681
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..1166
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAS-associated protein RAB5A; ras-related protein Rab-5A"
                     /codon_start=1
                     /product="ras-related protein Rab-5A isoform 1"
                     /protein_id="NP_004153.2"
                     /db_xref="CCDS:CCDS2633.1"
                     /db_xref="GeneID:5868"
                     /db_xref="HGNC:HGNC:9783"
                     /db_xref="MIM:179512"
                     /translation="MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQ
                     FHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDI
                     TNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFM
                     ETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN"
     exon            682..833
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     exon            834..956
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1050
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..2518
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /note="hexamer: AATAAA"
     polyA_site      2518
                     /gene="RAB5A"
                     /gene_synonym="RAB5"
                     /note="major polyA site"
ORIGIN      
        1 agttcgctgc gtgcagcgac gtggcggcgg ggccggcacc gggcagcgga agtggctccg
       61 gcggtgggac ttgagtgttt gtgttttggt tcgtgaagga gccggcggct ggccttaggg
      121 gaggaggcag agggaggagg aggaggaaga attagtcgga actccagcgc cggcggcggc
      181 ggcggcggcg gaggaggaga aaggaaagag gaagggggag cggcgagagg cggagacgga
      241 gcccgacagg ggcggcacca cggcacgagc cccgcacagt ccagtgtgag gggagcggcg
      301 ctaagagcag gcgacgccgc cgccgccacc accaccgcca tagatacact ctcatcctac
      361 gggccacgcc tgggccttgc tgccaggaag cttcggcccc gcagctcggc ttgctgcggt
      421 ctcaggtttc tttacctcca gaaagaagaa tattggcccc ttgaattctg gaagttcatt
      481 gaagagtctg aaattaggga cttatttcaa atttggacat ggctagtcga ggcgcaacaa
      541 gacccaacgg gccaaatacg ggaaataaaa tatgccagtt caaactagta cttctgggag
      601 agtccgctgt tggcaaatca agcctagtgc ttcgttttgt gaaaggccaa tttcatgaat
      661 ttcaagagag taccattggg gctgcttttc taacccaaac tgtatgtctt gatgacacta
      721 cagtaaagtt tgaaatatgg gatacagctg gtcaagaacg ataccatagc ctagcaccaa
      781 tgtactacag aggagcacaa gcagccatag ttgtatatga tatcacaaat gaggagtcct
      841 ttgcaagagc aaaaaattgg gttaaagaac ttcagaggca agcaagtcct aacattgtaa
      901 tagctttatc gggaaacaag gccgacctag caaataaaag agcagtagat ttccaggaag
      961 cacagtccta tgcagatgac aatagtttat tattcatgga gacatccgct aaaacatcaa
     1021 tgaatgtaaa tgaaatattc atggcaatag ctaaaaaatt gccaaagaat gaaccacaaa
     1081 atccaggagc aaattctgcc agaggaagag gagtagacct taccgaaccc acacaaccaa
     1141 ccaggaatca gtgttgtagt aactaaacct ctagtttgaa ctagctggaa tagtcttctg
     1201 cttcctaaat gttaataaca atggaattgg agcatttaac cagcccagta tgacttccaa
     1261 aagaagagac ttatgataga gtcaagtttc taatacagaa ttattttaag tgttttgaac
     1321 ttaattttta ataacatgca tgggtccctc tcactaatgt ttcaacaata gggaaaaatg
     1381 agaactatgt ggacacttgt ttcattggaa ggttaggggg aataatttct catcactagg
     1441 aatatagaca aatgactgtc tgggcccaca cagttaacca gcccatttct ccacactggt
     1501 acagtagtca cctgtgaaaa aaaaattgga acttactaat ttgggctttt caaaaacatt
     1561 ctttgtttag aaggagattc taaagttatt tatgatgctt agccatagta ttcaggcaaa
     1621 tgttcatttc tcctggtacc tgtatttaaa atgtacattc cacattttaa taaattaacc
     1681 acaagaaaat aatcccacat atacaaggtc aggggtgggg aagagtatta atggtatctt
     1741 aattataccc agtctggttt ttttttttta aatggggtaa aaatcaaatg caaccccatc
     1801 ttgttttagg aattttgaga actaataaat gcaccttaat ggtcagtgtt cctttcaaac
     1861 atgtgagttc tttaacaaaa atgaaataaa ccaggtgtct gtgatttcta attaatcacc
     1921 gctggccatt acacaggttt tgttgtttgg ggtggggagg gggcttttgt tcccttttga
     1981 cataatatag tcaatgcact aacaattatg tatattcaaa cttgattatt ttaaattcga
     2041 tcttcagctg tactgtaaat agggtactgc attgtagtct ccatatctgt attacttttc
     2101 tgtaatattt aagagttgct taaaagcata caaaatgtac tgttactaaa acagctaatt
     2161 atttctctct ccccctttga caggaagggg cttcagttgt tcctccatgg ctagaaccat
     2221 aataaacaat gtacccgtaa tttgtaacat aaagtattgc aatatgttag taacaatctt
     2281 gcagccttcc tttccaaagt tcattttatt ttgatcagtt cagtatattg cactaattat
     2341 tttaggtatt ttcattatat gaaagctacc atgtgtcaga gatgatttaa tctatttaag
     2401 tgttggactg ctaggagaac ttgtacattt atgataatgc agaattagga aaacggttca
     2461 ccagtgttta gttttatatt gaggtgctca ggttggaata aagtggtata aaaagcaa
//
