LOCUS       NM_016154               1159 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.
ACCESSION   NM_016154
VERSION     NM_016154.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Rawat,S., Chatterjee,D., Marwaha,R., Charak,G., Kumar,G., Shaw,S.,
            Khatter,D., Sharma,S., de Heus,C., Liv,N., Klumperman,J., Tuli,A.
            and Sharma,M.
  TITLE     RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval
            for cargo sorting to lysosomes
  JOURNAL   J Cell Biol 222 (1) (2023)
   PUBMED   36282215
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Gilleron,J., Bouget,G., Ivanov,S., Meziat,C., Ceppo,F., Vergoni,B.,
            Djedaini,M., Soprani,A., Dumas,K., Jacquel,A., Yvan-Charvet,L.,
            Venteclef,N., Tanti,J.F. and Cormont,M.
  TITLE     Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance,
            Adipose Tissue Dysfunction, and Insulin Resistance
  JOURNAL   Cell Rep 25 (12), 3329-3341 (2018)
   PUBMED   30566860
  REMARK    GeneRIF: the obesity-induced loss of Rab4b in adipose T cells may
            contribute to maladaptive white adipose tissue remodeling and
            insulin resistance by altering adipose T cell fate.
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   McCormick,D., Lin,Y.T. and Grey,F.
  TITLE     Identification of Host Factors Involved in Human Cytomegalovirus
            Replication, Assembly, and Egress Using a Two-Step Small
            Interfering RNA Screen
  JOURNAL   mBio 9 (3), e00716-18 (2018)
   PUBMED   29946045
  REMARK    GeneRIF: knockdown of RAB4B reduces the release of intact virion
            particles, suggesting that it plays a role in virion assembly and
            egress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Thean,L.F., Wong,Y.H., Lo,M., Loi,C., Chew,M.H., Tang,C.L. and
            Cheah,P.Y.
  TITLE     Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and
            MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC
            mutation-negative familial colorectal cancer patients
  JOURNAL   PLoS One 12 (3), e0173772 (2017)
   PUBMED   28306719
  REMARK    GeneRIF: real-time RT-PCR assays showed that expressions of MIA and
            MIA-RAB4B located 35 kb upstream of the deletion, were up-regulated
            in the polyps compared to the matched mucosa of the proband.
            MIA-RAB4B, the read-through long non-coding RNA (lncRNA), RAB4B,
            PIM2 and TAOK1 share common binding site of a microRNA, miR-24, in
            their 3'UTRs
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Cho,M.H., Castaldi,P.J., Wan,E.S., Siedlinski,M., Hersh,C.P.,
            Demeo,D.L., Himes,B.E., Sylvia,J.S., Klanderman,B.J., Ziniti,J.P.,
            Lange,C., Litonjua,A.A., Sparrow,D., Regan,E.A., Make,B.J.,
            Hokanson,J.E., Murray,T., Hetmanski,J.B., Pillai,S.G., Kong,X.,
            Anderson,W.H., Tal-Singer,R., Lomas,D.A., Coxson,H.O.,
            Edwards,L.D., MacNee,W., Vestbo,J., Yates,J.C., Agusti,A.,
            Calverley,P.M., Celli,B., Crim,C., Rennard,S., Wouters,E.,
            Bakke,P., Gulsvik,A., Crapo,J.D., Beaty,T.H. and Silverman,E.K.
  CONSRTM   ICGN Investigators; ECLIPSE Investigators; COPDGene Investigators
  TITLE     A genome-wide association study of COPD identifies a susceptibility
            locus on chromosome 19q13
  JOURNAL   Hum Mol Genet 21 (4), 947-957 (2012)
   PUBMED   22080838
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Khor,C.C., Davila,S., Breunis,W.B., Lee,Y.C., Shimizu,C.,
            Wright,V.J., Yeung,R.S., Tan,D.E., Sim,K.S., Wang,J.J., Wong,T.Y.,
            Pang,J., Mitchell,P., Cimaz,R., Dahdah,N., Cheung,Y.F., Huang,G.Y.,
            Yang,W., Park,I.S., Lee,J.K., Wu,J.Y., Levin,M., Burns,J.C.,
            Burgner,D., Kuijpers,T.W. and Hibberd,M.L.
  CONSRTM   Hong Kong-Shanghai Kawasaki Disease Genetics Consortium; Korean
            Kawasaki Disease Genetics Consortium; Taiwan Kawasaki Disease
            Genetics Consortium; International Kawasaki Disease Genetics
            Consortium; US Kawasaki Disease Genetics Consortium; Blue Mountains
            Eye Study
  TITLE     Genome-wide association study identifies FCGR2A as a susceptibility
            locus for Kawasaki disease
  JOURNAL   Nat Genet 43 (12), 1241-1246 (2011)
   PUBMED   22081228
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Yamamoto,H., Koga,H., Katoh,Y., Takahashi,S., Nakayama,K. and
            Shin,H.W.
  TITLE     Functional cross-talk between Rab14 and Rab4 through a dual
            effector, RUFY1/Rabip4
  JOURNAL   Mol Biol Cell 21 (15), 2746-2755 (2010)
   PUBMED   20534812
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Kaddai,V., Gonzalez,T., Keslair,F., Gremeaux,T., Bonnafous,S.,
            Gugenheim,J., Tran,A., Gual,P., Le Marchand-Brustel,Y. and
            Cormont,M.
  TITLE     Rab4b is a small GTPase involved in the control of the glucose
            transporter GLUT4 localization in adipocyte
  JOURNAL   PLoS One 4 (4), e5257 (2009)
   PUBMED   19590752
  REMARK    GeneRIF: Data conclude that Rab4b is a new important player in the
            control of GLUT4 trafficking in adipocyte.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   He,H., Dai,F., Yu,L., She,X., Zhao,Y., Jiang,J., Chen,X. and
            Zhao,S.
  TITLE     Identification and characterization of nine novel human small
            GTPases showing variable expressions in liver cancer tissues
  JOURNAL   Gene Expr 10 (5-6), 231-242 (2002)
   PUBMED   12450215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG706803.1, BC046927.1 and AI083750.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016154.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.200270.1,
                                           SRR1660809.99136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357052.8/ ENSP00000349560.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BG706803.1         37-55
            20-1155             BC046927.1         1-1136
            1156-1159           AI083750.1         14-17               c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1159
                     /gene="RAB4B"
                     /note="RAB4B, member RAS oncogene family"
                     /db_xref="GeneID:53916"
                     /db_xref="HGNC:HGNC:9782"
                     /db_xref="MIM:612945"
     exon            1..145
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..771
                     /gene="RAB4B"
                     /EC_number="3.6.5.2"
                     /note="ras-related GTP-binding protein 4b; small GTP
                     binding protein RAB4B"
                     /codon_start=1
                     /product="ras-related protein Rab-4B"
                     /protein_id="NP_057238.3"
                     /db_xref="CCDS:CCDS33030.1"
                     /db_xref="GeneID:53916"
                     /db_xref="HGNC:HGNC:9782"
                     /db_xref="MIM:612945"
                     /translation="MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVE
                     FGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAW
                     LTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEE
                     AFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC"
     exon            146..226
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            227..341
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            342..404
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            405..559
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            560..655
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            656..786
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1159
                     /gene="RAB4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4B"
                     /note="hexamer: CATAAA"
     polyA_site      1159
                     /gene="RAB4B"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggcg gtgccgggcc cggggagtag gaaggagccg gggctgtagc cggagtggag
       61 cggctgccag ccgaggagca ggcgcggccg cggcgccata ttgcggccct cagcggccgc
      121 gaccgagtca tggctgagac ctacgacttc ctcttcaaat tcctggtgat tggcagtgca
      181 ggaactggca aatcatgtct ccttcatcag ttcattgaga ataagttcaa acaggactcc
      241 aaccacacaa tcggcgtgga gtttggatcc cgggtggtca acgtgggtgg gaagactgtg
      301 aagctacaga tttgggacac ggctggccag gagcggtttc ggtcagtgac gcggagttat
      361 taccgagggg cggctggagc cctgctggtg tacgacatca ccagccggga gacatacaac
      421 tcactggctg cctggctgac ggatgcccgc accctggcca gccccaacat cgtggtcatc
      481 ctctgtggca acaagaagga cctggaccct gagcgggagg tcactttcct ggaggcctcc
      541 cgctttgccc aggagaatga gctgatgttc ctggagacca gcgctctcac aggcgagaac
      601 gtggaggagg cgttcctcaa gtgtgcccgc actatcctca acaagattga ctcaggcgag
      661 ctagacccgg agaggatggg ctctggcatt cagtacgggg atgcgtccct ccgccagctt
      721 cggcagcctc ggagtgccca ggccgtggcc cctcagccgt gtggctgctg agctctgtgg
      781 agccagctca cctgttctcc aggaccagcc ctgctggggc ccaggcccag gctctgagag
      841 gccgtgtcct aacctgccct ggccccggag aagctacgtt gccacctgtc ccccttccct
      901 ggcctggtgg ggcctggctt tggggcaaga ctgagccacg ggggaagggg gaatcccgta
      961 cctgctgctg cttcctctgt cttggctaac gtctgtcccc ctgaacccct aaccataccc
     1021 caagagctcc caaagcctga gaccagggtc atttgtcccc aactccccat ctggccctgc
     1081 tgttgctagt acctgttatt tattacctgg aggcctgtcc agcacccacc ctacccccat
     1141 aaagcattgt ttacacctg
//
