LOCUS       NM_004578               2987 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RAB4A, member RAS oncogene family (RAB4A), transcript
            variant 1, mRNA.
ACCESSION   NM_004578
VERSION     NM_004578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Szentgyorgyi,V., Lueck,L.M., Overwijn,D., Ritz,D., Zoeller,N.,
            Schmidt,A., Hondele,M., Spang,A. and Bakhtiar,S.
  TITLE     Arf1-dependent LRBA recruitment to Rab4 endosomes is required for
            endolysosome homeostasis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39325073
  REMARK    GeneRIF: Arf1-dependent LRBA recruitment to Rab4 endosomes is
            required for endolysosome homeostasis.
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Su,R., Su,M. and Lu,Y.
  TITLE     Ras-related Protein in Brain 4A (Rab4A) is Downregulated by miR-496
            to inhibit the Progression of Gastric Cancer
  JOURNAL   Comb Chem High Throughput Screen 27 (18), 2734-2740 (2024)
   PUBMED   38523522
  REMARK    GeneRIF: Ras-related Protein in Brain 4A (Rab4A) is Downregulated
            by miR-496 to inhibit the Progression of Gastric Cancer.
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Naslavsky,N. and Caplan,S.
  TITLE     Receptor-mediated internalization promotes increased endosome size
            and number in a RAB4- and RAB5-dependent manner
  JOURNAL   Eur J Cell Biol 102 (3), 151339 (2023)
   PUBMED   37423034
  REMARK    GeneRIF: Receptor-mediated internalization promotes increased
            endosome size and number in a RAB4- and RAB5-dependent manner.
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Karthikeyan,S., Casey,P.J. and Wang,M.
  TITLE     RAB4A GTPase regulates epithelial-to-mesenchymal transition by
            modulating RAC1 activation
  JOURNAL   Breast Cancer Res 24 (1), 72 (2022)
   PUBMED   36307864
  REMARK    GeneRIF: RAB4A GTPase regulates epithelial-to-mesenchymal
            transition by modulating RAC1 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   van der Sluijs,P., Hull,M., Huber,L.A., Male,P., Goud,B. and
            Mellman,I.
  TITLE     Reversible phosphorylation--dephosphorylation determines the
            localization of rab4 during the cell cycle
  JOURNAL   EMBO J 11 (12), 4379-4389 (1992)
   PUBMED   1425574
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   Bailly,E., McCaffrey,M., Touchot,N., Zahraoui,A., Goud,B. and
            Bornens,M.
  TITLE     Phosphorylation of two small GTP-binding proteins of the Rab family
            by p34cdc2
  JOURNAL   Nature 350 (6320), 715-718 (1991)
   PUBMED   1902553
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Rousseau-Merck,M.F., Zahraoui,A., Touchot,N., Tavitian,A. and
            Berger,R.
  TITLE     Chromosome assignment of four RAS-related RAB genes
  JOURNAL   Hum Genet 86 (4), 350-354 (1991)
   PUBMED   1999336
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Stibbs,H.H. and Seed,J.R.
  TITLE     Short-term metabolism of (14-C) tryptophan in rats infected with
            Trypanosoma brucei gambiense
  JOURNAL   J Infect Dis 131 (4), 459-462 (1975)
   PUBMED   1117200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI546021.1, AL162595.17,
            BC004309.1 and AY585832.1.
            
            On May 17, 2019 this sequence version replaced NM_004578.3.
            
            Summary: This gene is a member of the largest group in the Ras
            superfamily of small GTPases, which regulate membrane trafficking.
            The encoded protein is associated with early endosomes and is
            involved in their sorting and recycling. The protein also plays a
            role in regulating the recycling of receptors from endosomes to the
            plasma membrane. Alternatively spliced transcript variants have
            been observed for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY585832.1, SRR1660809.11697.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366690.5/ ENSP00000355651.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BI546021.1         55-175
            122-151             AL162595.17        109948-109977
            152-1864            BC004309.1         131-1843
            1865-2987           AY585832.1         1844-2966
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2987
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="RAB4A, member RAS oncogene family"
                     /db_xref="GeneID:5867"
                     /db_xref="HGNC:HGNC:9781"
                     /db_xref="MIM:179511"
     exon            1..260
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..886
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-4A; HTLV-1 related endogenous
                     sequence"
                     /codon_start=1
                     /product="ras-related protein Rab-4A isoform 1"
                     /protein_id="NP_004569.2"
                     /db_xref="CCDS:CCDS31050.1"
                     /db_xref="GeneID:5867"
                     /db_xref="HGNC:HGNC:9781"
                     /db_xref="MIM:179511"
                     /translation="MSQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNH
                     TIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYN
                     ALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTG
                     ENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQAPNAQECGC
                     "
     exon            261..341
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            342..456
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            457..519
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..674
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            675..770
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            771..898
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..2987
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="hexamer: ATTAAA"
     polyA_site      1104
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="major polyA site"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="hexamer: AATGAA"
     polyA_site      1502
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
     regulatory      2574..2579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="hexamer: AATAAA"
     polyA_site      2597
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="hexamer: AATAAA"
     polyA_site      2706
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
                     /note="hexamer: TATAAA"
     polyA_site      2797
                     /gene="RAB4A"
                     /gene_synonym="HRES-1; HRES-1/RAB4; HRES1; RAB4"
ORIGIN      
        1 ctcttcctcc tcgcggtcgc ggccggacgg agggtggagg gccctgcgcc tgcgcggagc
       61 tggagtccgg ctgggccgca gccgctggga gaccggcggt tgccgtgggg accggtcggg
      121 cccctccctc ctccggtccc ccgccccagg tccttcccca ccgagacgcg ccggcggacc
      181 gcgggcgagt gcagccggtg acccggcgag aggcggcgcc gctcccaaga tgtcgcagac
      241 ggccatgtcc gaaacctacg attttttgtt taagttcttg gttattggaa atgcaggaac
      301 tggcaaatct tgcttacttc atcagtttat tgaaaaaaaa ttcaaagatg actcaaatca
      361 tacaatagga gtggaatttg gttcaaagat aataaatgtt ggtggtaaat atgtaaagtt
      421 acaaatatgg gatacagcag gacaagaacg attcaggtcc gtgacgagaa gttattaccg
      481 aggcgcggcc ggggctctcc tcgtctatga tatcaccagc cgagaaacct acaatgcgct
      541 tactaattgg ttaacagatg cccgaatgct agcgagccag aacattgtga tcatcctttg
      601 tggaaacaag aaggacctgg atgcagatcg tgaagttacc ttcttagaag cctccagatt
      661 tgctcaagaa aatgagctga tgtttttgga aacaagtgcg ctcacagggg agaatgtaga
      721 agaggctttt gtacagtgtg caagaaaaat acttaacaaa atcgaatcag gtgagctgga
      781 cccagaaaga atgggctcag gtattcagta cggagatgct gccttgagac agctgaggtc
      841 accgcggcgc gcacaggccc cgaacgctca ggagtgtggt tgttaggaga gcacacaggt
      901 gttcatacag tggcatttgg gacacaatcg ttggaacctg aagaatctga agtttttttt
      961 accaccatct ttttctactc tgtatggaag tagatcttta tggggaaaag agaatttggg
     1021 gtgttctgca agccagtcaa agtggcacag caaatcatat aaatcgaatt aaatggacaa
     1081 caccgttaga tgtgtatgta aaaattttct gtttcatatt tttcctttca ctttcggttt
     1141 aaaacatgct atatgtactg tatgtcctgt agcccagtgc ggctccacag catggaatct
     1201 gatgtatgat atgatagaat gtggcactaa atgcagtttc agattttatt ttttttaatc
     1261 atatgaacta aaattgtcaa ttgtgaggtg tgcttttctc atcatgttgg ttatattgca
     1321 caattggtta tatttatgac ctgatattca aagactctgg cattgatagc cagtgtgttt
     1381 tcttatttaa ctccgtttac tacattctac atggtgttta cgtgatccac acttgaaata
     1441 ctagatcagt agacattcac taatatacca aaataaaatg aaaaattgag tttttccgtg
     1501 aactttatac tgtccagctc tgttgatttt aaagcctctt catccaggtc agttcaggaa
     1561 gtatatctgg agtacctgct ctgtttttgg ctgtgagact agcactaagg attctggtac
     1621 ctttacccaa acctactggg ctactaatac ttctctcagc agttgatcaa atacaataga
     1681 ccatgtaagc tggggccgct catccacttc cagtttgctg gtctccctgc tagaaaacac
     1741 attgtactgt gctttttctg gaattcagta taatggcatc actgcctgtt tttcacatct
     1801 tttgtttcct gttcatttta aggaaaccta ctaaatccag ttaatattaa atggacacca
     1861 ctcattaaga aatttcttta tggcttctgc tgaatactta aatgccttac tacagttatc
     1921 cagttgacat gtttttaatt catataaggt atattgggta tattgaagta tatattgtat
     1981 tacaaagact tgttcttgta ttttaaaatg tcagtgcaaa aaatatatgg tggaaccttt
     2041 ctttaaagtt gaaatgcagt attatttaaa tctgaaaggt taaaaagctt tcttcacctt
     2101 atatatgttc ttccactgtg actttttagt tgaagactag taaattaact tttagttaga
     2161 agatgcctac tgcttttgtt gtttatttta atcagcagag cacagagaca cataaaaact
     2221 ctgggaaatg actaggataa aaatatcagt atgtatctgt tttagatatt ttgagttttg
     2281 ctttttttat gccttgaata ttttatttca aaaagtatct gaagcaaatt ctcagactga
     2341 actacttctt agacctcact gtaagaatat tttattcaat gtctcattta tgatagattt
     2401 gcaagctgct catttttgaa cagctttttg catgggatag gagcatgtct attctaacac
     2461 atcagcttat tcaaaagcaa gaattttaaa aataagataa atgtaaagtt gttttataaa
     2521 cgatcctgtt aattaaacca cagacaccat atatccttct gcatcctttg gccaataaaa
     2581 gttgctggag aaccaaacca tggtggttct taatcaggct ttgcctttag ggagaatgag
     2641 gaggagagat aattgggtat tgttcaggct agtaataaat gtcatgtttc tatttcccgc
     2701 aactcattaa gttttcagga agctcttaat ttagatttct aggaaagtaa ttattcagtc
     2761 ttcctagaaa aagattataa agaccattta aactggagat tgtaatttat tcttttacag
     2821 tccagcattt aagtgaaaat gagaacatca caatttggga atctgtaatg gttttgttga
     2881 aaacattact tgtggcttgt ataagagtgg ctgaattcaa gaacattgat tcttagcaga
     2941 tcaataatag tatttaaaga atctgatgct aaaattagaa acctaaa
//
