LOCUS       NM_001257357            4259 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens RAB44, member RAS oncogene family (RAB44), mRNA.
ACCESSION   NM_001257357 XM_003403440 XM_003403441 XM_003403791
VERSION     NM_001257357.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4259)
  AUTHORS   Kadowaki,T., Yamaguchi,Y., Ogawa,K., Tokuhisa,M., Okamoto,K. and
            Tsukuba,T.
  TITLE     Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit
            differential localization in mast cells
  JOURNAL   FEBS Open Bio 11 (4), 1165-1185 (2021)
   PUBMED   33641252
  REMARK    GeneRIF: Rab44 isoforms similarly promote lysosomal exocytosis, but
            exhibit differential localization in mast cells.
REFERENCE   2  (bases 1 to 4259)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z85996.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001257357.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments, including Human DA432810.1,
            DN831166.1, Xenopus BX744908.1, and RNAseq data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2149004,
                              SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612677.6/ ENSP00000481054.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                Z85996.1           22325-22414
            91-309              Z85996.1           28723-28941
            310-421             Z85996.1           38327-38438
            422-596             Z85996.1           39978-40152
            597-743             Z85996.1           41772-41918
            744-834             Z85996.1           42527-42617
            835-930             Z85996.1           42992-43087
            931-1118            Z85996.1           44862-45049
            1119-2701           Z85996.1           45650-47232
            2702-2783           Z85996.1           50361-50442
            2784-2898           Z85996.1           52076-52190
            2899-3000           Z85996.1           53199-53300
            3001-3077           Z85996.1           55172-55248
            3078-4259           Z85996.1           56502-57683
FEATURES             Location/Qualifiers
     source          1..4259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..4259
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="RAB44, member RAS oncogene family"
                     /db_xref="GeneID:401258"
                     /db_xref="HGNC:HGNC:21068"
     exon            1..90
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            91..309
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3168
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="RASD family, member 3; RAS-like, family 13"
                     /codon_start=1
                     /product="ras-related protein Rab-44"
                     /protein_id="NP_001244286.1"
                     /db_xref="CCDS:CCDS75442.1"
                     /db_xref="GeneID:401258"
                     /db_xref="HGNC:HGNC:21068"
                     /translation="METGQRTSRKVRKLGSNRRRQTREPADGEGAAVAPEPESWSSQA
                     AAELQAFFQDCGAKERGFVTREDLAVAKFSFLGSKEESEMIFDWVDVERKGHLSLEEF
                     SSGLKNIFGSSQSPHRLRRRKPLPSKRVSATTSFPALEEADAEEKEAFLAFMEQLGTG
                     HLLPKQMEIWQLWGQLRQEEPQLAGNLAGFLAKMTSRLQEAQADKEALELTLRKRDSD
                     HHREVQQLYEEMEQQIRQEKQQLQAESDSRGLALTSQMQDVLEAKEREVQRLAEGQRE
                     LEAQLSHLRSTHQEAASENQQLQEAKRDLAGRLEEVRGQLQVTRGRLDAARGRVSWQV
                     EEKLSFPGAGEKTPDPQAASPEEAPLPGLFGDNDDWDQLLSNFGSPPHGALQLCWSPP
                     PTPRATSGPQTPRVVRQISISEPQAFLFGQEPSSDPDGAPRTPPGVTFSAKDNKGVDP
                     HEQDIRAEQPVEPHDPDPNQEPGSTPEGRLLWGLSGSLVAPAFKVLIPLEDGPPPPAN
                     SPPPQAPAGSSKQIQASDPDDKGPGSWAPPSGAQPGAGAGPQEPTQTPPTMTERETQP
                     GPSPTTALTGVGPAKPPRQRDALQQDLHATGSEPRLGTQRARALTLGPAEPFQGLEFV
                     GPVPTERLEQGQAGPAVQEGLPEGLREAHGQVLGLGELSAFPHQELEEEPRSEEGKQE
                     GRGGQDLSSEQSEQSVEAHGLETAHSELPQQDSLLVSLPSATPQAQVEAEGPTPGKSA
                     PPRGSPPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLTTAHAEEQGPPHSREPRAE
                     SRLEDPGMDSREAGLTPSPGDPMAGGGPQANPDYLFHVIFLGDSNVGKTSFLHLLHQN
                     SFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERYHSMTRQLLRKADGVVLMYD
                     ITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEAGQQLAQELGVYF
                     GECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPKRFGCCS"
     exon            310..421
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            422..596
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            597..743
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            744..834
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            835..930
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1118
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..2701
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2783
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2898
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3000
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3077
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..4259
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3440..3445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="hexamer: AATACA"
     polyA_site      3462
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="major polyA site"
     regulatory      4238..4243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="hexamer: AATATA"
     polyA_site      4259
                     /gene="RAB44"
                     /gene_synonym="dJ431A14.3; RASD3; RASL13"
                     /note="major polyA site"
ORIGIN      
        1 ctagagctcg tgggctccgc agggcagcag tcaccctacc accaggtccc agagcccagg
       61 gctgtgtgtt ccactgggag cctttgagag ggccaacgca ccatggagac tggacagaga
      121 acatctcgaa aagtccggaa gctgggctcc aaccggcggc ggcagacaag agagccagct
      181 gatggtgaag gcgctgcagt ggccccagag ccagagtctt ggtcctctca ggcagcggca
      241 gaactgcagg ccttcttcca ggactgtggt gccaaggaga ggggctttgt cacccgcgag
      301 gacctggcgg tggccaagtt cagcttcctg ggcagcaagg aagagtcaga gatgatcttc
      361 gactgggtgg atgtggagcg gaagggacac ctgtcccttg aagaattcag ctctggactc
      421 aaaaacatct ttggctccag ccagagcccc cacaggctcc gcagaaggaa gccactgccc
      481 tctaagcggg tatctgctac caccagcttc ccagctctgg aggaggcgga tgctgaggag
      541 aaggaggcgt tccttgcctt catggagcag ctggggactg gacacttact tcccaagcag
      601 atggaaatct ggcaactgtg ggggcagctg cggcaggagg agccccagct ggcaggcaac
      661 ctggcaggct ttctggccaa gatgaccagc cgcctgcagg aggcccaggc ggacaaggag
      721 gccctggagc tgaccctgag gaagcgtgac tctgaccacc accgcgaggt ccagcagctc
      781 tatgaggaga tggagcagca gatccgccag gagaagcagc agctgcaggc tgagagcgac
      841 tctcggggcc tggccctcac ctcccagatg caggacgtcc tagaggccaa ggagcgcgag
      901 gtgcagcgac tagctgaggg ccagagggag ctggaggccc agctctccca cctcaggagc
      961 acacatcagg aggctgcctc agagaaccag cagctgcagg aggccaagcg tgacctggct
     1021 gggcggctgg aggaggtgcg ggggcagctg caggtgacca gggggcgcct ggacgccgcc
     1081 aggggccggg tgtcctggca ggtggaggag aaactgagtt ttcctggagc gggtgagaag
     1141 accccagacc ctcaggctgc ctcccctgag gaggcccccc tgcctgggct atttggggac
     1201 aacgatgact gggaccagct actgagcaac tttggcagcc ctccgcacgg agccctgcag
     1261 ctctgctgga gcccgccccc gaccccaaga gccacctcag gcccccagac accccgtgtg
     1321 gtcaggcaga tctccatctc ggagccacag gcttttctat ttggtcagga gccatcttca
     1381 gatccagatg gggctccaag gaccccacct ggggtgactt tcagcgccaa ggacaataaa
     1441 ggagtggacc cacatgagca ggacattaga gcagagcagc ctgttgaacc gcacgacccg
     1501 gaccccaacc aggagccagg gtccacaccc gagggccgcc tcctctgggg tctctcagga
     1561 agcctggtgg cacctgcatt caaagtgctc attcctttgg aggatgggcc ccctccccct
     1621 gcgaactctc cccctcccca ggccccagct gggtccagca aacagatcca ggcctcagac
     1681 ccagatgaca agggccctgg gtcttgggct cctcccagcg gggctcagcc tggggctgga
     1741 gcaggacccc aggaacccac acaaacccct cccaccatga ctgagcggga aacccagccc
     1801 ggaccctcac ccacaactgc cctcacagga gtgggcccag ccaagccgcc caggcagaga
     1861 gatgccctcc agcaggacct gcatgccact ggctctgagc caagactggg gacccagagg
     1921 gctagagccc tcaccctggg gccagctgag cccttccagg gcctggaatt tgtgggtccg
     1981 gtgcccacag agaggctgga gcagggccag gcgggcccag cggtgcagga gggccttcct
     2041 gaggggctaa gagaagctca tggccaggtc cttgggctgg gtgagctgtc tgccttcccc
     2101 caccaggagc tggaagagga acccaggtct gaggaaggaa aacaagaggg cagaggtggg
     2161 caggacctca gttcagagca gtcagagcag tcggttgagg ctcacggcct agaaactgcg
     2221 cattcggaac tcccccagca agactctctg cttgtttctc tcccatctgc cacaccacag
     2281 gctcaggtgg aagcagaagg ccccactcct ggaaaatcgg cacctccaag gggctctcct
     2341 cccagggggg ctcagcctgg ggctggagca ggaccccagg aacccacgca aacccctccc
     2401 accatggctg agcaggaagc ccaacccagg ccatccctca cgactgctca cgcagaagaa
     2461 caaggcccgc ctcactccag ggaaccaagg gcagagagca ggcttgaaga tccaggaatg
     2521 gactccaggg aagctgggct gaccccatcc ccgggagacc ccatggctgg agggggaccc
     2581 caggccaacc ctgattacct cttccatgtc atctttctgg gagactccaa cgtgggcaaa
     2641 acatccttcc tgcacctgct gcaccagaat tctttcgcca ccggattgac agctaccgtg
     2701 ggagtagatt ttcgggtcaa aaccttgctg gtggacaaca agtgctttgt gctgcagctc
     2761 tgggacacag ctggccaaga gaggtaccac agtatgacgc gacagctgct ccgcaaggct
     2821 gacggggtgg tgctcatgta cgacatcacc tcccaggaga gctttgccca cgtgcgctac
     2881 tggctagact gtctccagga tgcagggtcg gatggggtgg tcatccttct cctgggaaac
     2941 aagatggact gtgaggagga acggcaagtg tccgtggaag ctgggcagca actggcccag
     3001 gaactggggg tctattttgg ggagtgcagt gccgccttgg gtcacaacat cctggagcct
     3061 gtagtaaacc tggccaggtc actcaggatg caagaagaag gcctgaagga ctcgctggtg
     3121 aaggtggccc ccaagaggcc gcccaagaga ttcggctgtt gctcctgatc acctgtcctg
     3181 tcctgggtag gatggacacc catggggttt cctgtccctc agctcctgtc ctttgttcct
     3241 ggacagcaac gacacagagg accagcttgg aggttcagga aaacccttct caactcagga
     3301 ctcggatccc agagcagggc cgcatcacct ctgcctttca cactccaaag gagggctttg
     3361 ctgagtgaac aaggcttgag gggcaggggt atggcaaaac tctccaaaca aagaaagtct
     3421 agaaaaacga cttaaggaaa atacaccaaa atattggccg cacatctgtg ggtgtaaaat
     3481 tttagggaga atgtgggggg ggggtgttac tttccatttt acacatattt gtattttcag
     3541 attttcaaca ataacagtat tcaatacata atcagaaaaa agagatgtgg aggaggagga
     3601 gagaaacttc ccaaggagct cccttgggtg ctgctggctc ctaattagtg taacctgtta
     3661 atcacatgtt gctcggtgtt agagcggtcc ctctgtgctc tgcttggcag ggcgctgttg
     3721 gcctggtctc cctcgctatt tctatttgca agcatgggct ttcttcccag cagaatctgg
     3781 ttcctgggaa gagtaatgtt ccaaaggcct ctgatatgcc tcgatgccct cctgtcttcc
     3841 agagccccaa cctcactccc tttccccacc atacaaaaca cacctcccag gggtcacatt
     3901 tgggggtccc gccccctgct ccaatgccat ggtgtcccca agcacagggc tttggcctga
     3961 gttgtcagtc tctggatgca tttgaggggc agctagggtg tggctggggg gtccaagcag
     4021 ctggggagcc gagactcaga atcattcaca cacttctatt tggagctttt gtggaagttt
     4081 ccagaattcc ataatattca cctcctgaat ggtggctgcc ccttatcagc tagggctggg
     4141 gtttccagtg ccctcggaga gcttgcttta gagtcttgga gagacggcca tggtcttcgt
     4201 ttgtatgtct gtcacatctt accatcatca caaattgaat atacaacatg tgccaggca
//
