LOCUS       NM_198490               4478 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RAB43, member RAS oncogene family (RAB43), transcript
            variant 1, mRNA.
ACCESSION   NM_198490 XM_290714
VERSION     NM_198490.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4478)
  AUTHORS   Bae,W.J., Woo,K.J., Ahn,J.M., Yang,C.M., Kim,Y.S., Kim,S. and
            Lee,D.
  TITLE     miR-4742-5p promotes invasiveness of gastric cancer via targeting
            Rab43: An in vitro study
  JOURNAL   Biochem Biophys Res Commun 613, 180-186 (2022)
   PUBMED   35597125
  REMARK    GeneRIF: miR-4742-5p promotes invasiveness of gastric cancer via
            targeting Rab43: An in vitro study.
REFERENCE   2  (bases 1 to 4478)
  AUTHORS   Guo,L., Gao,R., Gan,J., Zhu,Y., Ma,J., Lv,P., Zhang,Y., Li,S. and
            Tang,H.
  TITLE     Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3,
            promotes proliferation and epithelial-mesenchymal transition in
            hepatocellular carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 525 (2), 425-432 (2020)
   PUBMED   32102752
  REMARK    GeneRIF: Downregulation of TNFRSF19 and RAB43 by a novel miRNA,
            miR-HCC3, promotes proliferation and epithelial-mesenchymal
            transition in hepatocellular carcinoma cells.
REFERENCE   3  (bases 1 to 4478)
  AUTHORS   Jiang,Y., Sun,Y., Hu,J., Yu,N., Liu,H., Fan,J., Ning,X., Li,Y.,
            Liu,B., Sun,Y., Zhang,J., Qiu,X., Fu,S., Zhou,C. and Xu,H.
  TITLE     A germline mutation in Rab43 gene identified from a cancer family
            predisposes to a hereditary liver-colon cancer syndrome
  JOURNAL   BMC Cancer 19 (1), 613 (2019)
   PUBMED   31226964
  REMARK    GeneRIF: A germline mutation of Rab43 gene is identified to be
            associated with the onset of a familial liver-colon cancer
            syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4478)
  AUTHORS   Samuelsson,M., Potrzebowska,K., Lehtonen,J., Beech,J.P.,
            Skorova,E., Uronen-Hansson,H. and Svensson,L.
  TITLE     RhoB controls the Rab11-mediated recycling and surface reappearance
            of LFA-1 in migrating T lymphocytes
  JOURNAL   Sci Signal 10 (509) (2017)
   PUBMED   29233918
  REMARK    GeneRIF: vesicle-associated RhoB is a regulator of the
            Rab11-mediated recycling of LFA-1 to the cell surface, an event
            that is necessary for T lymphocyte motility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4478)
  AUTHORS   Li,C., Wei,Z., Fan,Y., Huang,W., Su,Y., Li,H., Dong,Z., Fukuda,M.,
            Khater,M. and Wu,G.
  TITLE     The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and
            Sorting of GPCRs
  JOURNAL   Cell Rep 21 (4), 1089-1101 (2017)
   PUBMED   29069590
  REMARK    GeneRIF: Rab43 directly interacts with GPCRs and controls the
            forward ER-to-Golgi traffic of nascent GPCRs.
REFERENCE   6  (bases 1 to 4478)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4478)
  AUTHORS   Dejgaard,S.Y., Murshid,A., Erman,A., Kizilay,O., Verbich,D.,
            Lodge,R., Dejgaard,K., Ly-Hartig,T.B., Pepperkok,R., Simpson,J.C.
            and Presley,J.F.
  TITLE     Rab18 and Rab43 have key roles in ER-Golgi trafficking
  JOURNAL   J Cell Sci 121 (Pt 16), 2768-2781 (2008)
   PUBMED   18664496
  REMARK    GeneRIF: Rab18 and Rab43 have key roles in ER-Golgi trafficking.
REFERENCE   8  (bases 1 to 4478)
  AUTHORS   Haas,A.K., Yoshimura,S., Stephens,D.J., Preisinger,C., Fuchs,E. and
            Barr,F.A.
  TITLE     Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs
            required to maintain a functional Golgi complex in human cells
  JOURNAL   J Cell Sci 120 (Pt 17), 2997-3010 (2007)
   PUBMED   17684057
  REMARK    GeneRIF: Results indicate that Rab1 and Rab43 are key Rabs required
            for the biogenesis and maintenance of a functional Golgi structure,
            and suggest that other Rabs acting at the Golgi complex are likely
            to be functionally redundant.
REFERENCE   9  (bases 1 to 4478)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
  REMARK    GeneRIF: Rab43 is the target of RN-tre and is required for Shiga
            toxin uptake.
REFERENCE   10 (bases 1 to 4478)
  AUTHORS   Guo,J.H., Chen,L., Chen,S., Liu,X., Saiyin,H., Deng,Q., Zhuang,Y.,
            Wan,B., Yu,L. and Zhao,S.Y.
  TITLE     Isolation, expression pattern of a novel human RAB gene RAB41 and
            characterization of its intronless homolog RAB41P
  JOURNAL   DNA Seq 14 (6), 431-435 (2003)
   PUBMED   15018353
  REMARK    GeneRIF: The results of PCR amplification indicated that human
            RAB41 is widely expressed in brain, testis, lung, heart, ovary,
            colon, kidney, uterus and spleen but not in liver.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB220260.1, AY166852.2, AC108673.11 and CA450364.1.
            
            On Nov 30, 2019 this sequence version replaced NM_198490.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1-5 all encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.19817.1,
                                           SRR11853561.21171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315150.10/ ENSP00000319781.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB220260.1         1-22
            23-1232             AY166852.2         1-1210
            1233-4133           AC108673.11        49657-52557         c
            4134-4478           CA450364.1         21-365              c
FEATURES             Location/Qualifiers
     source          1..4478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..4478
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /note="RAB43, member RAS oncogene family"
                     /db_xref="GeneID:339122"
                     /db_xref="HGNC:HGNC:19983"
     exon            1..519
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..954
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /note="isoform a is encoded by transcript variant 1;
                     ras-related protein Rab-43; ras-related protein Rab-41"
                     /codon_start=1
                     /product="ras-related protein Rab-43 isoform a"
                     /protein_id="NP_940892.1"
                     /db_xref="CCDS:CCDS33850.1"
                     /db_xref="GeneID:339122"
                     /db_xref="HGNC:HGNC:19983"
                     /translation="MAGPGPGPGDPDEQYDFLFKLVLVGDASVGKTCVVQRFKTGAFS
                     ERQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDITK
                     RSSFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLSELREVSLAEAQSLAEHYDILCAIE
                     TSAKDSSNVEEAFLRVATELIMRHGGPLFSEKSPDHIQLNSKDIGEGWGCGC"
     exon            520..703
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            704..4478
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4456..4461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /note="hexamer: ATTAAA"
     polyA_site      4478
                     /gene="RAB43"
                     /gene_synonym="RAB11B; RAB41"
                     /note="major polyA site"
ORIGIN      
        1 agactggtgt ggcacggagc tgaggaccgg ccggagcttt gcggagggcc cggcttggcg
       61 ggtccggggg ggagccgaac ccgcggggca ccgggtccgg gcggggccga gccgggccgg
      121 ggcgggagcc agccggggtg gggcggggcc gaggccgagg caggcggtcg gcagtgctgg
      181 gggttcaggt gttgcggcgg ctccacgtag ccaggcggcc cgtgggctgg agcgggcgga
      241 gctcggcccg cggcttgcgt gagctcaggc cggtcccagc gtccagagcg ccggcccttc
      301 ggcttcttct aggccatggc agggccgggc ccaggcccgg gggacccgga cgagcagtac
      361 gatttcctgt tcaagctggt gctggtgggc gacgcaagcg tgggcaagac gtgcgtggtg
      421 cagcgcttca agaccggcgc cttctcggag cgccagggaa gcaccatcgg cgtcgacttc
      481 accatgaaga cgctggagat ccagggcaag cgggtcaagc tgcagatctg ggacacggcc
      541 ggccaggagc ggttccgcac catcacccag agctactacc gcagtgccaa tggggccatc
      601 cttgcctacg acatcaccaa gaggagctcc ttcctgtcgg tgcctcactg gattgaggat
      661 gtgaggaagt atgcgggctc caacattgtg cagctgctga tcgggaacaa gtcagacctc
      721 agcgagcttc gggaggtctc cttggctgag gcacagagcc tggctgagca ctatgacatc
      781 ctgtgtgcca ttgagacgtc tgccaaggac tcgagcaacg tggaggaggc cttcctgagg
      841 gtggccacgg agctcatcat gcggcacggg ggccccttgt tcagcgagaa gagccccgac
      901 cacatccagc tgaacagcaa ggacatcgga gaaggctggg gctgcgggtg ctgaccaggg
      961 gccgggccgg cagactgggg gttccccacc tccttgctct ccccagcctg ccaagcccag
     1021 ccctccagag ccagccctcc tgggtaccgg caactacagc agccgggtga agctctggag
     1081 ctctgcatcc tgtggcctgg ctgcgggatg gaggctctcc ttgaggaagg ggaagcagga
     1141 taccctggcg ggccaccctg ccagccagca gctggccctc caccatcttc acattccaag
     1201 actggcctga acccgccggt gtgggccaca gtaggagggg ccagcagtcc tccctgtccc
     1261 atgcctgctg gctctgaccg tttcctctca tgggtttgct ttacctgtgg cagcaggttg
     1321 ctgctttcca gggatgtgtc cagtgccctg ggttcttccc ggtcatcctg gggctctgca
     1381 cagagcagca gagctagagc catgagaccc acagacttgg tgcctgagcg cagctccagg
     1441 gaagccccag ccccttccag gcggggaacc tgcttcctgc cttcactgcc cccgcagcac
     1501 tcacagacat ctccctgggg tctggctcac tgccttatca ggacctctga gttttctgac
     1561 tttctgtgta gcttctcatt ttcatcagca cagcatgggg tcacggccca cagctaggtg
     1621 gggtcacggc ccacagctag gtggggactg tctgctggct cagggcccag tgttttgcca
     1681 ctcaggttgc aaaattagct aatccttcag tgccagcact cagaagtctg gcaggtgggg
     1741 gaatgagatg agaaagtgga catttaaggt ccaagtagaa gcttgcatcc ttgaggctca
     1801 gggatgagag ggcaccgcaa ggcacccagc cttaccccac aagcaggaat cctgccagcc
     1861 gagcgtgggt cccagtctat ggaatcgagt ctcccagaca aaaaaggaga ggccctggcg
     1921 gtccttggcc tggcccattt tattccctgg acccttaact gcctcaccct gagctgggca
     1981 ccaaggttag aaggcaaaag tggggtaggg ggatgtggga agcagcattg tcctctgggc
     2041 atgtggctca gaggtatcac agtgacaaaa gagccagggc tagggctgga ggggccaggt
     2101 gatcttcctt agccaatccc agtccgtctg tgtcagccca gctctgcctc gcagccccct
     2161 cagcatgggt gcccccagaa gtaagcagct cttggaccca cgagcagggc tgcgtcggtt
     2221 tgtggtctag ctcccagggg caggccaggc atggctcagt gcagtccctg ggccagtgag
     2281 aggcctcccc catgcctccc tgccctctgc actaagcact ttccaggcag gcctggccat
     2341 agggcaagag caggccttac agcagtgcca cggtgaccca agaggcaggg ttggggcctg
     2401 gacagggttt cctctgctga gactgagaca agcagggctt gatgctggtg gtggagccag
     2461 catctcacct gccaggcttc cttttgggca gggaggctac ctgtggaatg gctgagcctg
     2521 gttctgcagg ggaggaaggc tgccaggagc tgaggggcta gcacctgcat tgaggggagt
     2581 ctgggtgcat cagattgggg ggcgccagag gcgaggctgc ctggctccct ttctcagcag
     2641 ctttgcttgt ggcaggggtg agagtggagc tgagtggggt ctgggctctg cccctgcgcc
     2701 tccactgcag tgcctgggct ccccttgcag ggcagacagt gcctggcact gaggggtgcc
     2761 cccagacccc gctgggactg gatgtgccgt gggcagtgcc ttcctccagc ctcacaacct
     2821 ttctgctggg gctgaagttt ctggggtcac atggtcagaa ggggctgagc tggtctttca
     2881 ctgcaggccc actctgaaag agaaatccca tgaagcctgt ccttgcagag cccctctgtt
     2941 tttgggggaa cagggagcat tcacagggtc ttgggaacaa aggcctgggc ctccccgttt
     3001 gaatttcagc cccagttcca gggcaagtcc cagccaccca agcatactta ccagtactgc
     3061 ccaccaccac ccactgccca cctctaagaa gcccggctct cctactctgc ttccaggctg
     3121 gggcctcaca ggtggggctg ttaccttcct cagggcttag ggagggaggg aggacatgga
     3181 cagggccttc caccctggct ccttcacagg gatggtagct gaccggtgat gggttcattt
     3241 gtcaccttgg actgtgagcc acttccactt ctcgcccccc aggcaggagc accctcactc
     3301 caagggcttg gcctggaaag gcaggctcac ctgggactca acgttccttc ccccgccgcc
     3361 actgtgcccc ccgtccctcc accccagaag ccctgacctc atttgggcac cttgctgtcc
     3421 tctgggcttc tcctctgccc aggtcaccct gtggcaggcc tgggccctca ggatgtttca
     3481 aaggctccac agctccaccg ctccacctgg cttcactcca gcaccctgtc cctggagcac
     3541 ctctgtcctg tctgggccaa cctggtctcc ctgccccatg ccctcccctg gctcttagca
     3601 acctgccctt ttattcatgc catttggggt cacagatgcc tagctggaca cagctcccag
     3661 aactggctcc accctggggc cttgccccta gtaccccctg gcaggagcaa cccaccccat
     3721 ggtcgaggtt cccctacccc tggatcctgg actgaagcca tttcctacag agaagcgttc
     3781 ccaccccctc tcaggcacaa aagccggtgt ccagggactc aagacctgta cctggggttg
     3841 caggggctcc tgccctgctg tatcccacca ggagggggcc ccactgccct tccggccctt
     3901 aaaactgggc tgggagagaa gacggggaag tgtgtgagac aaaacaaagc cggcttgttt
     3961 cctccccttg gcaggctaag ctctcccggc agcccgggct ctggggcgga aggagaacag
     4021 tgtcatctct tcctttgttg ataaattgcc aaagagtggg aacaggtggg gtcaggggcc
     4081 agagtgcagg ggagggggca atggtggagg tggcgggggg aagcagaggg aggtgggctg
     4141 aggcctcggt ggggccagtg cgacgctggc ttaaggagct ggaggggttc ctaatacaca
     4201 tttaattcag tttctcttcc ctaagaggct gccggagttg gggcctcctc cagcagagac
     4261 cctcggaccc ctgcagggcc tggacttggg gtgaacaggg cttcagtcag cgcaagtatt
     4321 ccatttgcat ttggtaattt ttcatgccac ctatttatga atatataaat ctttatacca
     4381 aatctatttt ttaaaacatg gaaaagttgc ctttatggaa acttggcaga gccagagtgt
     4441 acacattcct aaaccattaa acagatttct ataacaag
//
