LOCUS       NM_001193532            2236 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RAB42, member RAS oncogene family (RAB42), transcript
            variant 1, mRNA.
ACCESSION   NM_001193532
VERSION     NM_001193532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513497.21.
            
            On Jul 10, 2020 this sequence version replaced NM_001193532.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352441.211226.1,
                                           SRR11853559.751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465518.3/ ENSP00000491546.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AL513497.21        91761-92240
            481-2236            AL513497.21        93190-94945
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2236
                     /gene="RAB42"
                     /note="RAB42, member RAS oncogene family"
                     /db_xref="GeneID:115273"
                     /db_xref="HGNC:HGNC:28702"
     exon            1..480
                     /gene="RAB42"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..904
                     /gene="RAB42"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAB42, member RAS homolog family; putative Ras-related
                     protein Rab-42; ras-related protein Rab-42"
                     /codon_start=1
                     /product="ras-related protein Rab-42 isoform 1"
                     /protein_id="NP_001180461.1"
                     /db_xref="CCDS:CCDS85943.1"
                     /db_xref="GeneID:115273"
                     /db_xref="HGNC:HGNC:28702"
                     /translation="MEAEGCRYQFRVALLGDAAVGKTSLLRSYVAGAPGAPEPEPEPE
                     PTVGAECYRRALQLRAGPRVKLQLWDTAGHERFRCITRSFYRNVVGVLLVFDVTNRKS
                     FEHIQDWHQEVMATQGPDKVIFLLVGHKSDLQSTRCVSAQEAEELAASLGMAFVETSV
                     KNNCNVDLAFDTLADAIQQALQQGDIKLEEGWGGVRLIHKTQIPRSPSRKQHSGPCQC
                     "
     exon            481..2236
                     /gene="RAB42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB42"
                     /note="hexamer: TATAAA"
     polyA_site      1024
                     /gene="RAB42"
                     /note="major polyA site"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB42"
                     /note="hexamer: AATAAA"
     polyA_site      2236
                     /gene="RAB42"
                     /note="major polyA site"
ORIGIN      
        1 ctagtttagt ccctttatcc tgtgaagtag gggtcatcat tagccccctt ttacagagga
       61 gagaattgag gcttcgagag agagaaactt ggccaggagt ttccactcgg tccgacgccc
      121 tcggtgcccc gccgggtacg gtggctgggc gcggggagcg gggggcggcg ccggcggggc
      181 cccgggcagg ggcggggtcg gggcgcggac aaaaccgccg cggggcggcg gggtggcgga
      241 cgcggccatg gaggccgagg gctgccgcta ccaatttcgg gtcgcgctgc tgggggacgc
      301 ggcggtgggc aagacgtcgc tgctgcggag ctacgtggca ggcgcgcctg gcgccccgga
      361 gccggagccc gagcccgagc ccacggtggg cgccgagtgc taccgccgcg cgctgcagct
      421 gcgggccggg ccgcgggtca agctgcaact ctgggacacc gcgggccacg agcgcttcag
      481 gtgcatcacc aggtcctttt accggaatgt ggtgggtgtc ctgctggtct ttgatgtgac
      541 aaacaggaag tcctttgaac acatccaaga ctggcaccag gaggtcatgg ccactcaggg
      601 cccggacaag gtcatcttcc tgctggttgg ccacaagagt gacctgcaga gcacccgctg
      661 tgtctcagcc caggaggccg aggagctagc tgcctccctg ggcatggcct tcgtggagac
      721 ctcggttaaa aacaactgca atgtggacct ggcctttgac accctcgctg atgctatcca
      781 gcaggccctg cagcaggggg acatcaagct agaagagggc tgggggggtg tccggctcat
      841 ccacaagacc caaatcccca ggtcccccag caggaagcag cactcaggcc catgccagtg
      901 ttgactctag gagagaaagg gttaaagcag tcccagcctt agcccacctg gtgggatggg
      961 gagtgttaat atctctctgg aggacaaatg acagaagggt tcatataaac agtatcctga
     1021 cacagtcatg cttcctggat tttggagtcg aggctttcta cagaaaagaa agttctgatg
     1081 gccaggcatg gtggctcacg cctgtaatcc tagcattttt ggaggccaag gacagtggat
     1141 cacctgaggt caggggttcg agaccagcct ggccaacatg gtgaaaccct gtctctacta
     1201 aaaatacaaa aattagccag gcgtggtggt gcatgcctgt aatcccagtt actccagagg
     1261 ctaaggcagg agaattgctt gaacctggga ggcagagatt gcagtgagcc aagactgcgc
     1321 cactgcactc cagcctgggc aacagagtga gactctgttt caaaaaaaaa aaagaaaaga
     1381 aaagaaaggc ctgagagacc agatgtgcaa cttcctgtcc ttgagcctca gtgtccctat
     1441 ctatcgatgg ggctcataaa agatcccacc ttgaagggag gtggtgacca caaatgagac
     1501 agtggacagg atgtgctcac ccagagcctg ccgcgctgtg aattgaatga caaaagctct
     1561 cattcccact ccctttttct tggctgcgat gtggccactc tggcagcatt cctgggctca
     1621 gacactgaga agccagcgtc aggaagctga tgcatgggca aaggcaggtg cggggaattc
     1681 cagggggagc ttggcttgga ggcttcttat gtcctcaggc taaaatgatt ctgggcatgg
     1741 gattaatatg tgacgtcaaa cccagggttg ctggccaatg cccccccgac caggcccagg
     1801 ggctgaaaaa tggatgttgg aggctgggat gaacatgaat gtgtagcaac tatgttgggc
     1861 acacagtggc cactgtgatg agccaccaag atcccccttt ctggctgggg aacccatcaa
     1921 ccctctcccc agctgctgga gtgccactgg atgatggact tcagcttgcc ccactctctg
     1981 ggaaaggccc tcccttcagg gcagcttgta tccaaagttc atctcctggg gggccttaaa
     2041 ggactccctc ttgccccagc tctggacaac tctgaaagtc aaaaccaact ttatcagtct
     2101 ctgtgggctt cattgaggac actgttgtga catcatagcc aagttatccc cttgcccaat
     2161 cctgcttcct tttcttcccc aaacaggtat ccatttcaag aatatcccct aataaacatc
     2221 tgcacactca tctcca
//
