LOCUS       NM_001363807            1074 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB41, member RAS oncogene family (RAB41), transcript
            variant 2, mRNA.
ACCESSION   NM_001363807 XM_017029488
VERSION     NM_001363807.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Nozawa,T., Toh,H., Iibushi,J., Kogai,K., Minowa-Nozawa,A.,
            Satoh,J., Ito,S., Murase,K. and Nakagawa,I.
  TITLE     Rab41-mediated ESCRT machinery repairs membrane rupture by a
            bacterial toxin in xenophagy
  JOURNAL   Nat Commun 14 (1), 6230 (2023)
   PUBMED   37802980
  REMARK    GeneRIF: Rab41-mediated ESCRT machinery repairs membrane rupture by
            a bacterial toxin in xenophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Ogawa,M., Matsuda,R., Takada,N., Tomokiyo,M., Yamamoto,S.,
            Shizukuishi,S., Yamaji,T., Yoshikawa,Y., Yoshida,M., Tanida,I.,
            Koike,M., Murai,M., Morita,H., Takeyama,H., Ryo,A., Guan,J.L.,
            Yamamoto,M., Inoue,J.I., Yanagawa,T., Fukuda,M., Kawabe,H. and
            Ohnishi,M.
  TITLE     Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy
            via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated
            K63-linked ubiquitination
  JOURNAL   Cell Microbiol 20 (8), e12846 (2018)
   PUBMED   29582580
  REMARK    GeneRIF: Streptococcus pneumoniae is entrapped by selective
            autophagy in pneumolysin- and ubiquitin-p62-LC3 cargo-dependent
            manners. Streptococcus pneumoniae-containing autophagic vesicles
            (PcAV) were formed only in the presence of Rab41-positive intact
            Golgi apparatuses. Nedd4-1 was recruited to PcAV which played a
            pivotal role in K63-linked polyubiquitin chain (K63Ub) generation
            on PcAV and elimination of intracellular bacteria.
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Liu,S., Hunt,L. and Storrie,B.
  TITLE     Rab41 is a novel regulator of Golgi apparatus organization that is
            needed for ER-to-Golgi trafficking and cell growth
  JOURNAL   PLoS One 8 (8), e71886 (2013)
   PUBMED   23936529
  REMARK    GeneRIF: distinctive Rab41 effects on Golgi organization,
            ER-to-Golgi trafficking and cell growth
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Haas,A.K., Fuchs,E., Kopajtich,R. and Barr,F.A.
  TITLE     A GTPase-activating protein controls Rab5 function in endocytic
            trafficking
  JOURNAL   Nat Cell Biol 7 (9), 887-893 (2005)
   PUBMED   16086013
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Pereira-Leal,J.B. and Seabra,M.C.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357752.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2018 this sequence version replaced XM_017029488.2.
            
            Summary: This gene encodes a small GTP-binding protein that belongs
            to the largest family within the Ras superfamily. These proteins
            function as regulators of membrane trafficking. They cycle between
            inactive GDP-bound and activated GTP-bound states, which is
            controlled by GTP hydrolysis-activating proteins (GAPs). This
            family member can be activated by the GAP protein RN-Tre, and it is
            localized to the Golgi complex. [provided by RefSeq, May 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.2892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374473.6/ ENSP00000363597.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL357752.19        97248-97417         c
            171-229             AL357752.19        96998-97056         c
            230-283             AL357752.19        96734-96787         c
            284-389             AL357752.19        96216-96321         c
            390-501             AL357752.19        95965-96076         c
            502-595             AL357752.19        95546-95639         c
            596-659             AL357752.19        95260-95323         c
            660-1074            AL357752.19        94587-95001         c
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1074
                     /gene="RAB41"
                     /note="RAB41, member RAS oncogene family"
                     /db_xref="GeneID:347517"
                     /db_xref="HGNC:HGNC:18293"
     exon            1..170
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..715
                     /gene="RAB41"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RAB41, member RAS homolog family; ras-related protein
                     Rab-41"
                     /codon_start=1
                     /product="ras-related protein Rab-41 isoform 2"
                     /protein_id="NP_001350736.1"
                     /db_xref="CCDS:CCDS87756.1"
                     /db_xref="GeneID:347517"
                     /db_xref="HGNC:HGNC:18293"
                     /translation="MSAFGHDEAWMEAGGFGLEAAERTEYQSLCKSKLLFLGEQSVGK
                     TSIISRFMYNSFGCACQATVGIDFLSKTMYLEDQIVQLQLWDTAGQERFHSLIPSYIR
                     DSTIAVVVYDITNINSFKETDKWVEHVRAERGDDVVIMLLGNKIDLDNKRQVTAEQGE
                     EKSRNLNVMFIETSAKTGYNVKKLFRRVASALLSTRTSPPPKEGTVEIELESFEESGN
                     RSYC"
     exon            171..229
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            230..283
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            284..389
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            390..501
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            502..595
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            596..659
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     exon            660..1074
                     /gene="RAB41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB41"
                     /note="hexamer: AATAAA"
     polyA_site      1074
                     /gene="RAB41"
                     /note="major polyA site"
ORIGIN      
        1 caggctgagc gttggaagcc attttggctg caacctacct gaagcgatgt ctgcctttgg
       61 tcacgacgag gcctggatgg aggccggagg ctttggtctg gaggctgccg aaagaacgga
      121 ataccagtct ctgtgcaaat ctaaactctt attcctggga gagcagagcg tagggaagac
      181 atccatcatc agccgcttca tgtacaacag cttcggctgc gcctgccagg caactgttgg
      241 aattgacttc ttgtctaaga ccatgtactt ggaggaccaa atagttcagc tgcagctatg
      301 ggacacagct ggccaggagc gctttcacag cctaattcct agctacattc gtgattcaac
      361 tattgcagtg gttgtctatg acattacaaa catcaattct tttaaggaga cagataagtg
      421 ggtagaacac gtgcgagcag aaagaggtga cgatgttgtc atcatgttgt tgggtaacaa
      481 gattgatttg gataacaaaa gacaagtcac tgcagaacag ggtgaagaaa aatccagaaa
      541 cctcaatgtg atgtttattg agaccagtgc caaaaccggt tacaacgtga aaaagctgtt
      601 ccggcgtgtg gcttctgccc ttctttccac aaggacttca cctccaccaa aagaggggac
      661 ggttgaaatc gaactggaat ccttcgagga gtcaggcaac agaagctatt gttgacagct
      721 taggctttct ctgcctcatt tgatggattt cttacatttg ggcttgccat accagttctc
      781 ctccccacct cgttttatga tacatggcca cttactctct tccaattcct aggcttgggg
      841 taaaaacaga acccctgaaa gtgctatcat tttttcctga ccgcatctca cagctactgg
      901 gtggaagctt cttgcagcac ctgggaattc taccttacct tctccgacag ctaaaagaca
      961 tctgtagaga atacagttct acagcagctg acatacttca aaggccaata caattcattc
     1021 tccactgttt gttgttgttt acctacaccc tcaataaatg gttctttaac ctaa
//
