LOCUS       NM_006822               3829 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAB40B, member RAS oncogene family (RAB40B), mRNA.
ACCESSION   NM_006822
VERSION     NM_006822.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3829)
  AUTHORS   Duncan,E.D., Han,K.J., Trout,M.A. and Prekeris,R.
  TITLE     Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and
            activity during cell migration
  JOURNAL   J Cell Biol 221 (4) (2022)
   PUBMED   35293963
  REMARK    GeneRIF: Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization
            and activity during cell migration.
REFERENCE   2  (bases 1 to 3829)
  AUTHORS   Linklater,E.S., Duncan,E.D., Han,K.J., Kaupinis,A., Valius,M.,
            Lyons,T.R. and Prekeris,R.
  TITLE     Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton
            dynamics during cell migration
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33999101
  REMARK    GeneRIF: Rab40-Cullin5 complex regulates EPLIN and actin
            cytoskeleton dynamics during cell migration.
REFERENCE   3  (bases 1 to 3829)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3829)
  AUTHORS   .
  TITLE     Rab40b and Tks5 interact at invadopodia during metastasis
  JOURNAL   J Cell Sci 129 (23), e2301 (2016)
   PUBMED   27909076
  REMARK    GeneRIF: This is the first study that identifies a new Rab40b-Tks5-
            and miR-204-dependent invadopodia transport pathway that regulates
            MMP2 and MMP9 secretion, and extracellular matrix remodeling during
            cancer progression.
REFERENCE   5  (bases 1 to 3829)
  AUTHORS   Jacob,A., Linklater,E., Bayless,B.A., Lyons,T. and Prekeris,R.
  TITLE     The role and regulation of Rab40b-Tks5 complex during invadopodia
            formation and cancer cell invasion
  JOURNAL   J Cell Sci 129 (23), 4341-4353 (2016)
   PUBMED   27789576
  REMARK    GeneRIF: This is the first study that identifies a new Rab40b-Tks5-
            and miR-204-dependent invadopodia transport pathway that regulates
            MMP2 and MMP9 secretion, and extracellular matrix remodeling during
            cancer progression.
REFERENCE   6  (bases 1 to 3829)
  AUTHORS   Li,Y., Jia,Q., Wang,Y., Li,F., Jia,Z. and Wan,Y.
  TITLE     Rab40b upregulation correlates with the prognosis of gastric cancer
            by promoting migration, invasion, and metastasis
  JOURNAL   Med Oncol 32 (4), 126 (2015)
   PUBMED   25790780
  REMARK    GeneRIF: High expression level of Rab40b was significantly
            correlated with gastric cancer invasion and lymph node metastasis.
REFERENCE   7  (bases 1 to 3829)
  AUTHORS   Jacob,A., Jing,J., Lee,J., Schedin,P., Gilbert,S.M., Peden,A.A.,
            Junutula,J.R. and Prekeris,R.
  TITLE     Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia
            formation and invasion of breast cancer cells
  JOURNAL   J Cell Sci 126 (Pt 20), 4647-4658 (2013)
   PUBMED   23902685
  REMARK    GeneRIF: Rab40b mediates trafficking of MMP2/9 during invadopodia
            formation and metastasis of breast cancer cells.
REFERENCE   8  (bases 1 to 3829)
  AUTHORS   Spano,S., Liu,X. and Galan,J.E.
  TITLE     Proteolytic targeting of Rab29 by an effector protein distinguishes
            the intracellular compartments of human-adapted and broad-host
            Salmonella
  JOURNAL   Proc Natl Acad Sci U S A 108 (45), 18418-18423 (2011)
   PUBMED   22042847
REFERENCE   9  (bases 1 to 3829)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   10 (bases 1 to 3829)
  AUTHORS   Pereira-Leal,J.B. and Seabra,M.C.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024361.21.
            
            On Nov 23, 2018 this sequence version replaced NM_006822.2.
            
            Summary: The protein encoded by this gene has similarity to a yeast
            protein which suggests a role of the gene product in regulating
            secretory vesicles. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.217315.1,
                                           SRR1803611.119876.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000571995.6/ ENSP00000461785.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC024361.21        49620-49863         c
            245-305             AC024361.21        15661-15721         c
            306-366             AC024361.21        12152-12212         c
            367-444             AC024361.21        10745-10822         c
            445-667             AC024361.21        9656-9878           c
            668-3829            AC024361.21        6138-9299           c
FEATURES             Location/Qualifiers
     source          1..3829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3829
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="RAB40B, member RAS oncogene family"
                     /db_xref="GeneID:10966"
                     /db_xref="HGNC:HGNC:18284"
                     /db_xref="MIM:619550"
     exon            1..244
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..939
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="GTP-binding protein homologous to Saccharomyces
                     cerevisiae SEC4; SOCS box-containing protein RAR; protein
                     Rar"
                     /codon_start=1
                     /product="ras-related protein Rab-40B"
                     /protein_id="NP_006813.1"
                     /db_xref="CCDS:CCDS11816.1"
                     /db_xref="GeneID:10966"
                     /db_xref="HGNC:HGNC:18284"
                     /db_xref="MIM:619550"
                     /translation="MSALGSPVRAYDFLLKFLLVGDSDVGKGEILASLQDGAAESPYG
                     HPAGIDYKTTTILLDGRRVKLQLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSF
                     DGIDRWIKEIDEHAPGVPKILVGNRLHLAFKRQVPTEQAQAYAERLGVTFFEVSPLCN
                     FNITESFTELARIVLLRHGMDRLWRPSKVLSLQDLCCRAVVSCTPVHLVDKLPLPIAL
                     RSHLKSFSMANGLNARMMHGGSYSLTTSSTHKRSSLRKVKLVRPPQSPPKNCTRNSCK
                     IS"
     exon            245..305
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            306..366
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            367..444
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            445..667
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            668..3829
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="hexamer: AATAAA"
     polyA_site      1729
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="major polyA site"
     regulatory      3401..3406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="hexamer: AATAAA"
     polyA_site      3418
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
                     /note="hexamer: CATAAA"
     polyA_site      3829
                     /gene="RAB40B"
                     /gene_synonym="RAR; SEC4L"
ORIGIN      
        1 gagcaaggac tcggggcccg cgcggcgcct ctcggggccg ggccgccgcc tctgcgctca
       61 gccccgcagg ccgggcatgg gtgggggcgc cgggccgtca cgatgagcgc cctgggcagc
      121 ccggtccggg cctacgactt tctgctcaag ttcctgctgg tgggcgacag cgacgtgggc
      181 aagggcgaga tcctggcgag cctgcaggat ggcgcggccg agtccccgta cggccacccg
      241 gcgggcatcg actacaagac gaccaccatc ctgctggacg ggcggcgggt gaagctgcag
      301 ctctgggata cttcaggcca gggaagattt tgtaccatat tccgctccta ctcccggggc
      361 gcacagggtg tgatcctggt ctatgacatt gcgaaccgct ggtcttttga cggcattgat
      421 cgatggatta aggagatcga tgagcatgcc cccggagtcc ccaagatcct ggtggggaac
      481 cgcctgcacc tggcgttcaa gcggcaggtg cccacggagc aggcccaggc ctacgccgag
      541 cgcctgggcg tgaccttctt tgaggtcagc cctctgtgca atttcaacat cacagagtcg
      601 ttcacggagc tggccaggat cgtgctgctg cggcatggga tggaccggct ctggcggccg
      661 agcaaggtgc tgagcttgca agacctctgc tgccgggcgg tcgtgtcctg cacgccggtg
      721 cacctggtgg acaagctccc gctccccatt gccttaagaa gccacctcaa gtccttctcg
      781 atggccaacg gcctgaatgc caggatgatg cacggcggtt cctactccct caccaccagc
      841 tccacccaca aaaggagcag cctccgcaaa gtgaagctcg tccgcccccc ccagagcccc
      901 cccaaaaact gcaccagaaa cagctgcaaa atttcttaag gaaggcactg aaagaaacac
      961 ggcggaatct ctccaggaga agctcggcgt tacccccggc agctggtgga tgcatctcag
     1021 atcccggttc ctctcggcga atgctgcttg cgaatgtgtg cgacgccttc cgtgtgatgg
     1081 aaacacacta ccccgtcgga cttcgaattt ctacgtggat gtgcatgaag ctcttgtttt
     1141 cgatgtgtgt ttgtaaaggg aaaattagta ctctgctcga ctcttggtaa catgaaattc
     1201 tgaatgttac tttatcatga ttgcactgca actttttcct taaaataact gcttttgtaa
     1261 gaacggtgat attggagtga ttagtataaa ttcaatggaa tttgagaagc aatggcagcg
     1321 ggataattta gagtcactga tattacgaga ggggtctttt tgtaaacctc cttttcaatg
     1381 tcaaagcgcc aatttataaa acgctgcaga tgtagaggtt atgtgcaact gatctgtcca
     1441 gtttgtgtat gaaatggatt tgataaagtt tttgctagtt atttactaca ttttgggatt
     1501 aataagtgat ttatatgcat atttttctgt aaatctacag ttttttgtac aagatattct
     1561 acaagttatg aagctaaggg aagaaaatgc caaagatacc tctagttatg ttgaacacag
     1621 ccagcacagt ttcgacatgt caaggaagag ctgtttcagt aaagaatgaa gtgaaaacac
     1681 ttatttagga aaatgtttct caacaataaa atgtatagtt gtttctctct tggtagagtt
     1741 ggcgaccggt tctttcgaat tttgtattta tttatttatt tatttttgag acagagtttc
     1801 gctcttgttg cccagggtgg agtacaatgg cacgatctgg gctcaccaca acctccgcct
     1861 cccgggttca agcgattctc ctgcctcagc ctcccgagta gctgggatta cagaggtgca
     1921 ccaccacgcc cggctaattt ttgtattttt agtagagatg gggtttcacc atgttggtca
     1981 ggctggtgtt gaactcctaa cctcaggtga tccacccacc ttggcctccc aaagtgctgg
     2041 gattacaggc gtgagccact gcgcccggcc agattttgtg tatttcttat agccctttac
     2101 ttcactgcgc cactgcctgg tgtagacatc acatatcgga gctaatacac gacactggca
     2161 acaaggctga atccttgaac tgttgtcgcc tgttgagaaa ggattccttt tccggaacag
     2221 aagtgcagag gaggagagag cggagagtta aaagctggca cccaggcatg tgcctgtctg
     2281 agaaatcaga gccgtgctcc tgagcctcgg tgaggagctc cgaggggctg tcaggaattc
     2341 cgcatgaaga tgtagcccct gaccccgact gcctcagagc agggctgacc gcaaagacct
     2401 ccagggccgc tctcttccct ggtcacactg ttgaacgttt ctctgtggct gggggtcgca
     2461 aatgagggac taaaccaaaa aaacgaagcg agaaaatacc cagatgttcc tagttcctgc
     2521 tgatgatctg tagattctta gaaacttaag ggacccagct gggtgtgatg gctcacacct
     2581 gtaatcccag cacttcagga ggccgaggca gccggatcag aggtcaggag ttcaagacca
     2641 gtctggccaa cgtgatgaaa ccccgtctct aataaaatta caaaaattgg cttggcatgg
     2701 cagcgcacac ctgtaatccc agctactcag gaggctgaag caggagaatc acttgaacct
     2761 gggaggcagg ggttgcagtg agccgagatc gtaccactgc accccagcct gggcgacaag
     2821 tgaaactcca tctaaaaaaa aaaaaaaaaa agaaatttaa gggaccctag aatcaggggc
     2881 aaagcctgta ttcagagatg gtggaaccga ggcccagaca ggagagagga gcactggtcc
     2941 ctgcgggtgg acccaggctt gggggtgtct ggccacctgg gcacggcagc cacggggaca
     3001 aagtccacgg ggaggcaggg gtgtggtctg tgggcagaag gtgaaccctg aggggacagt
     3061 gtctggagag ggtggccagc ctcgtgcagg cacgctgcaa agacctgtgc acccttctct
     3121 ctgctgtgcc acaggtgggg tgagaacgac agggccgacc tcccagctgc aaacacaagg
     3181 acactgagat gcacagaaag gagagtccac gttgaagaaa cccacgttga ggggcctctt
     3241 ctccctccgt tcccagctcg ctgatggtga agggtaagga aatggatcct cccattgcaa
     3301 cattaaacca ggccaaacct gtatttttct cttccttcct ttttcttgtt ttgtaattga
     3361 tgtctcctcg ggactactga taatgtccta gaaagaataa aataaagttt cccaaggctt
     3421 tgtgactcag agctctttgg aggtgttcac cgaatgcacg ggccgcccgg aggccttggc
     3481 cctccaggga aacaccacca gaagtcccca gaagcggaac atgtagcaag gaggctcccc
     3541 gagatctccc agagggagca cagccctgcc aagttattgg ttttggactt ccggcttcca
     3601 gagctacgag aaaataaata tttgttattt aagtcaccag gtttgtggcg attgttacgg
     3661 cagcctcagg aaactcctac aaggaagtga gttacgctca cggcagaaag tgctacagca
     3721 aaccaaggca gaacaaaaac agacgaaacc taatacagac cggactaagt agaagactgt
     3781 gtgtttgggt ggtgaatata caaaaaacat aaatataaat taaacctta
//
