LOCUS       NM_080879               1969 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens RAB40A, member RAS oncogene family (RAB40A), mRNA.
ACCESSION   NM_080879
VERSION     NM_080879.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Duan,X., Xu,L., Li,Y., Jia,L., Liu,W., Shao,W., Bayat,V., Shang,W.,
            Wang,L., Liu,J.P. and Tong,C.
  TITLE     Regulation of lipid homeostasis by the TBC protein dTBC1D22 via
            modulation of the small GTPase Rab40 to facilitate lipophagy
  JOURNAL   Cell Rep 36 (9), 109541 (2021)
   PUBMED   34469730
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Pereira-Leal,J.B. and Seabra,M.C.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF422143.1, AF132748.1,
            H24206.1 and Z69733.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_080879.2.
            
            Summary: This gene encodes a member of the Rab40 subfamily of Rab
            small GTP-binding proteins that contains a C-terminal suppressors
            of cytokine signaling box. [provided by RefSeq, Apr 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF422143.1, Z43570.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145743,
                                           SAMN03267768 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304236.2/ ENSP00000305648.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1091              AF422143.1         1-1091
            1092-1110           AF422143.1         1095-1113
            1111-1327           AF132748.1         834-1050
            1328-1346           H24206.1           9-27                c
            1347-1969           Z69733.1           22178-22800
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..1969
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /note="RAB40A, member RAS oncogene family"
                     /db_xref="GeneID:142684"
                     /db_xref="HGNC:HGNC:18283"
                     /db_xref="MIM:301065"
     exon            1..120
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /inference="alignment:Splign:2.1.0"
     exon            121..272
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1969
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1176
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /note="protein Rar-2; SOCS box-containing protein RAR2A"
                     /codon_start=1
                     /product="ras-related protein Rab-40A"
                     /protein_id="NP_543155.2"
                     /db_xref="CCDS:CCDS35357.1"
                     /db_xref="GeneID:142684"
                     /db_xref="HGNC:HGNC:18283"
                     /db_xref="MIM:301065"
                     /translation="MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYS
                     HLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSF
                     EGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCN
                     FNIIESFTELARIVLLRHRMNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPSTL
                     RSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKSSLCKVEIVCPPQSPPKNCTRNSCKI
                     S"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="RAB40A"
                     /gene_synonym="RAR2; RAR2A"
                     /note="major polyA site"
ORIGIN      
        1 ccaaacatgg atcctcatga ttttattttc tagattggct gataggctga ataatctcct
       61 gtagggtaag aagtgtcaac tgtatcaagc acatggaggt ggactggcta caggagaaag
      121 tgtgacgtgg gtgaaggagt tcttattgag ccatgggagg aagaaatagt acagaagagc
      181 aaagaataat aatgagtcag ctagacagaa gacaggagtc atcagatttg taccctagtt
      241 actcgaccca tcaactgact gtggtttttg ggaacaggcc cggcaccacc tctgcgcaca
      301 accccgcggg cctggctcag gcgggagtgc ggggccagca ccatgagcgc cccgggcagc
      361 cccgaccagg cctatgactt cctgctcaag ttcctgctgg tgggcgacag ggacgtaggc
      421 aagagtgaga tcctggagag cctgcaggat ggtgcagctg agtccccgta cagccatctc
      481 ggggggatcg actacaagac gaccaccatc ctgctggacg gccagcgggt gaagctgaag
      541 ctctgggata cgtcggggca gggaagattt tgtaccatat tccgctccta ctctcgtggt
      601 gcacaaggag tgatcctggt ctacgacatt gcaaaccgct ggtctttcga gggtatggat
      661 cgatggatta agaagattga ggaacatgcc cctggtgtcc ctaaaatcct ggtggggaat
      721 cgcctacatc tggcattcaa gaggcaggtg cccagggagc aggcccaggc ctacgccgag
      781 cgcctgggtg tgaccttctt tgaggtcagc cctctgtgca atttcaacat catagagtct
      841 ttcacggagc tggccaggat agtgctgctg cggcacagga tgaattggct cgggaggccg
      901 agcaaggtac tgagcttgca agacctctgc tgccgcacca tcgtgtcctg cacacctgtg
      961 catctggtgg acaagctccc gctccccagt accttaagaa gccacctcaa gtccttctcc
     1021 atggctaagg gcctgaatgc caggatgatg cgaggcctct cctactccct caccaccagc
     1081 tccactcaca agagcagcct ctgcaaagtg gagatcgtct gcccacccca gagcccaccc
     1141 aaaaactgca ccagaaacag ctgcaaaatt tcttaaggaa ggcaccaaaa ggaaacaagc
     1201 tggaatcgct ccaggaaaaa ctctggttac acctggaaga tggaagtcgc attgtagatt
     1261 caagaaatta gttttcagtt tctcacggga accatgctgc ttgggaatgt gtgtgatgcc
     1321 ttctgtcaat aaaaacacat tacacagttt gactttgaat ttctatttgg atgtgcatga
     1381 agctcttgtt ttaaacgtgt gtttataaag gggaaattag tactttgctc aactcttgat
     1441 aacgtgaaat tttgaatgtt acttatatca taatcacgct gcaacttttt ccttaaaata
     1501 accgcctttg ttagaatggt gatatggcaa tgatgagtat aaattcaagg aaatttgaga
     1561 agcaatgata gtgagataat tcagtcatcg atagtacaag aggggccttt ttgtaaacct
     1621 cctttttaat gtcaaagcac caatttataa aacactgcag atgcatatag agattgtata
     1681 taacagatct gtccagcttg tgcatgaaat ggatttgata aagtttttgc tatgttattt
     1741 actacatttg gggattaata cgtgatttat atgtatgttt ttctgtaaat ctactttttt
     1801 tgtacgagat gttctacaag atatgaagct aagggaggaa aacaccaaag atatctctag
     1861 ttatgttgaa catagccaat atggtttcaa tggatcaata agaaaaaacc atttcagtaa
     1921 ggaatgaaat acgtacttat ttgagaaaat gtttcttaac agtaaaaaa
//
