LOCUS       NM_022456               9333 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB3A interacting protein (RAB3IP), transcript variant
            alpha 1, mRNA.
ACCESSION   NM_022456
VERSION     NM_022456.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9333)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 9333)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9333)
  AUTHORS   Meng,C., Gao,J., Ma,Q., Sun,Q. and Qiao,T.
  TITLE     LINC00943 knockdown attenuates MPP+-induced neuronal damage via
            miR-15b-5p/RAB3IP axis in SK-N-SH cells
  JOURNAL   Neurol Res 43 (3), 181-190 (2021)
   PUBMED   33208053
  REMARK    GeneRIF: LINC00943 knockdown attenuates MPP(+)-induced neuronal
            damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells.
REFERENCE   4  (bases 1 to 9333)
  AUTHORS   Choi,J., Sung,J.Y., Lee,S., Yoo,J., Rongo,C., Kim,Y.N. and Shim,J.
  TITLE     Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR
            Signaling via FGFR Signaling
  JOURNAL   Int J Mol Sci 21 (20), 7770 (2020)
   PUBMED   33092268
  REMARK    GeneRIF: Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated
            EGFR Signaling via FGFR Signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9333)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 9333)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   7  (bases 1 to 9333)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
  REMARK    GeneRIF: RABIN3 interacts with the cancer-related protein SSX2 and
            a novel nuclear protein, SSX2IP.
REFERENCE   8  (bases 1 to 9333)
  AUTHORS   Fischer,U., Schutz,N., Hemmer,D. and Meese,E.
  TITLE     GAS64, the first amplified and putative non-translated gene
  JOURNAL   Int J Oncol 20 (1), 173-176 (2002)
   PUBMED   11743660
REFERENCE   9  (bases 1 to 9333)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
REFERENCE   10 (bases 1 to 9333)
  AUTHORS   Newport,J. and Roemer,M.I.
  TITLE     Comparative perinatal mortality under medical care foundations and
            other delivery models
  JOURNAL   Inquiry 12 (1), 10-17 (1975)
   PUBMED   123217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB460944.1, AJ312896.1, AC025263.22 and AI912718.1.
            
            On Jun 2, 2019 this sequence version replaced NM_022456.4.
            
            Transcript Variant: This variant (alpha 1) has a distinct 5' UTR
            and lacks an in-frame portion of the 5' coding region, compared to
            variant alpha 2. The resulting isoform (alpha 1) has a shorter
            N-terminus, compared to isoform alpha 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.217874.1,
                                           SRR1660807.217890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247833.12/ ENSP00000247833.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB460944.1         175-176
            3-1857              AJ312896.1         1-1855
            1858-8981           AC025263.22        10153-17276         c
            8982-9333           AI912718.1         11-362              c
FEATURES             Location/Qualifiers
     source          1..9333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..9333
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="RAB3A interacting protein"
                     /db_xref="GeneID:117177"
                     /db_xref="HGNC:HGNC:16508"
                     /db_xref="MIM:608686"
     exon            1..172
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            173..448
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1580
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="isoform alpha 1 is encoded by transcript variant
                     alpha 1; SSX2 interacting protein; rab-3A-interacting
                     protein; rabin-3; rab3A-interacting protein"
                     /codon_start=1
                     /product="rab-3A-interacting protein isoform alpha 1"
                     /protein_id="NP_071901.2"
                     /db_xref="CCDS:CCDS8995.1"
                     /db_xref="GeneID:117177"
                     /db_xref="HGNC:HGNC:16508"
                     /db_xref="MIM:608686"
                     /translation="MANDPLEGFHEVNLASPTSPDLLGVYESGTQEQTTSPSVIYRPH
                     PSALSSVPIQANALDVSELPTQPVYSSPRRLNCAEISSISFHVTDPAPCSTSGVTAGL
                     TKLTTRKDNYNAEREFLQGATITEACDGSDDIFGLSTDSLSRLRSPSVLEVREKGYER
                     LKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATA
                     EKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSA
                     MSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLT
                     FSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRI
                     KLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSL
                     AKLGYFKEEL"
     exon            449..707
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            804..881
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1085
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1214
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1327
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1427
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1497
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..9333
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="major polyA site"
     regulatory      3490..3495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="hexamer: ATTAAA"
     polyA_site      3511
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
     regulatory      8955..8960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="hexamer: AATAAA"
     polyA_site      8979
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
     regulatory      9310..9315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
                     /note="hexamer: AATAAA"
     polyA_site      9333
                     /gene="RAB3IP"
                     /gene_synonym="RABIN3; RABIN8"
ORIGIN      
        1 gcaggcgcag tcccgcgttc cctcggcggc tgccggcgta gtgagcccgc cgccgtggag
       61 tgtagcggaa agggctcgcc gtcctcctcc gtttctcgct gcttcgggac gcgctctctg
      121 cggctctgtg agcgcccctg agcgccggca gcggccgcgg tgggttcttc aggttatctt
      181 atgatgaggc ttttgctatg gctaatgatc ccttggaagg cttccatgaa gtaaaccttg
      241 cttcacctac ttctccggac cttcttggtg tgtatgaatc aggaactcaa gagcagacta
      301 cctcaccaag tgtcatctac cggccacacc cttcagcttt atcctctgta cctatccagg
      361 caaatgcatt agatgtttct gaacttccta cacaacccgt gtattcatcc cccagacgtt
      421 taaattgtgc ggaaatatct agtatcagct ttcatgttac agacccagcc ccttgctcta
      481 cctctggagt cacagctgga ttaactaaat taactacaag aaaggacaac tataatgcag
      541 agagagagtt tttacagggt gctactataa cagaggcttg cgatggcagt gatgatattt
      601 ttgggttgag tactgatagt ctgtctcgtt tacgaagccc atctgttttg gaagttagag
      661 aaaagggcta tgaacgatta aaagaagaac tcgcaaaagc tcagagggaa ctgaagttaa
      721 aagatgaaga atgtgagagg ctttcaaaag tgcgagatca acttggacag gaattggaag
      781 aactcacagc tagtctattt gaggaagctc ataaaatggt gagagaagca aatatcaagc
      841 aggcaacagc agaaaaacag ctaaaagaag cacaaggaaa aattgatgta cttcaagctg
      901 aagtagctgc attgaagaca cttgtattgt ccagttctcc aacatcacct acgcaggagc
      961 ctttgccagg tggaaagaca ccttttaaaa aggggcatac aagaaataaa agcacaagca
     1021 gtgctatgag tggcagtcat caggacctca gtgtgataca gccaattgta aaagactgca
     1081 aagaggctga cttatccttg tataatgaat tccgattgtg gaaggatgag cccacaatgg
     1141 acaggacgtg tcctttctta gacaaaatct accaggaaga tatctttcca tgtttaacat
     1201 tctcaaaaag tgagttggct tcagctgttc tggaggctgt ggaaaacaat actctaagca
     1261 ttgaaccagt gggattacaa cctatccggt ttgtgaaagc ttctgcagtt gaatgcggag
     1321 gaccaaaaaa atgtgctctc actggccaga gtaagtcctg taaacacaga attaaattag
     1381 gggactcaag caactattat tatatttctc ctttttgcag atacaggatc acttctgtat
     1441 gtaacttttt tacatacatt cgatacattc agcagggact cgtgaaacag caggatgttg
     1501 atcagatgtt ttgggaggtt atgcagttga gaaaagagat gtcattggca aagctgggtt
     1561 atttcaaaga ggaactctga tgctctgcgt gggaccatgc ctgaactccc cgaataactg
     1621 aaaaatggct gaatattttt atggttactt gatatttatt tccaaggagt gagcctaaga
     1681 cttttttccc cttttgcaaa ttgctctaag aagtaccatg atttctttta aactgatcta
     1741 tgctgtgttt gcttattctt tagttgaaca cactatgaag aattccaggt gtactagtga
     1801 atgtaattta tagttgccaa aaaaaaaaaa aacctgaaat aaataaatgt tagattgaat
     1861 gtgtgtacat tttctcttct agctctgaca tggcatttag ggttagcaga atgtattaaa
     1921 tagtaatttt caaactacac agtagcttcc ttccttgtga gaggcaagaa agaagtctga
     1981 gtggatagta ctcactttcc aaggccccca cctctagaat ggctttattt ttatctgttt
     2041 tctatattgg gtttcaaaaa agattttatt tgaagaaata cttctgctgc tacaaagttt
     2101 gaaagttact attttaatta ttctgctctc tgtaactgaa agaatccctt tattttggtt
     2161 attcattaaa atataataga aggcagtcag attttatccc agagatgtat tcctgagtgt
     2221 cttgatatag tgtattcatg ttttatatgt gttgaccact atattgtcat tggagggaca
     2281 tagatgtaaa tgagtttgac gtgtgtcaaa ggggtttaaa ggggtgtgga ttgaatgaat
     2341 ggtacgtgcg aagtatatgc tgattataga accacttgat ctctgcattc caaattgtaa
     2401 aactgactca actggagaaa ttataacaaa gaggtttgtg gtagacatgt aataagtata
     2461 gaaaagcaaa aagaaaagag aaactgcttt agtttctgtt tagagaaagc tgctgttaat
     2521 atttttggat agtagccttt cagctttcag atattttcta cttacatatg catatttttg
     2581 aaacaaaaag taggcttttt ttttgctttt taaacctaaa cattaaatat attttccctt
     2641 gggtaaacct acacatccta atccctgttt atagaatttt aacataattt aattgtgttt
     2701 ggagatgagg tggttttcag tttatttttc atattataat gctgtgacga gtatccttat
     2761 ctgtacactt ctgaacattg tggagttctt tcatgtggat gcctggagat aaaattgtgt
     2821 cgagatatat atgtattttt aaatgtttga tctgcattgc tagattgcca tccagaaaag
     2881 ttaatcaatt tgtattcaca gcagcagtgt acaagagggc tggttttctg aagataacat
     2941 ttttttcagt cctgttcaga ggtttggtca atcttacctg tagatgactt cagccaccag
     3001 gctggatggg agcccacaga caaaaggaca ttggtgtatg ttatggtgaa aaccatcagt
     3061 accatgccta gctcaagaat gtgaaattga acctgaaaaa aactttgaac ctacaatttt
     3121 atgttctgaa aatagttatt ctaatgtgag ggcattaata agaatatgta ccatcaaagc
     3181 ttcagaagat tttccgtaca aactaaaatc acttttggag aaagtaccta aataaaaaga
     3241 gaaacaaatc caggagatac tgtacggttt gaaagaaagg taatcaaata ctcagaaaaa
     3301 gtttgttgat gacttaaaaa ggataaataa aaagtaagac taaagaaaat cagtataccc
     3361 attaataata aatctttagt aatctataag gggaagaatg cttttcaacc ttatacacta
     3421 gaagcatgct ctttaaaatt aatgcaacag gatgacgact tgatgtagaa actatatgtg
     3481 gaattataga ttaaaatgtg attgaaacat atttagaaaa tgtgattatc ttcctgatcc
     3541 tactcccttt aggaagaact tcttaaactg gaagcaggaa aaaaaaaaac cataaaagat
     3601 aaccataaaa gaatataagt tatggtatat tataaattct taatttagaa atcgtgcatc
     3661 agtagttagg cattgtggct catgcctgta atcccagcac tttgggaggc agaggcagaa
     3721 ggattacttg agctgcttga gcccaggagt ttgagacggg cctgggaaaa atagggaaac
     3781 tccatttaca cacacacaca cacacacaca cacacacaca ctgtgtccat gaacttggga
     3841 ggatgaggtg ggaggattgc ttgagcccag gggttcaagt ccaacttggg caacataggg
     3901 agaccttgtc tctaaaaaaa aaactaaagc taaactacaa actgtgaggc aatatctgca
     3961 acatttataa ctagtaatag cttagtatca agaatgtatg cagaaattct acaaaccaac
     4021 aaaaaaggac agtgtcacag aaaaacaggc aaaagactga accaggcctt ccacacaatt
     4081 agaagtgcat gtgggccaat aaacattaag aggttttcat ctctcaatca ggaaaacgta
     4141 aatcaagatg acaatgacat gttcaaattc attcgattgg tgaaaatgaa gaaacacaaa
     4201 gtcaagtttt ggagagggtt ttagtcatta ggatcactca catattgctg atgggggtat
     4261 caattggtat atccactgtg aaaaaccatt cactagaaaa gttgggccag gcccagtggc
     4321 tcatgcctct tggctttggg aggccaaggt aggaggatca cttgagccca agagttcaag
     4381 accagcttga gcaacatagg gagaccacat ctgcacaaaa agattttttt gaattagctg
     4441 ggcatggtgg tgcatgcctg tggtcccagc tacttgggaa gctgaggtgg aaggattgct
     4501 taagcccagg aggttgaggc tgcagtgaat catgattgtg ccactgcact cttaccttgg
     4561 gtgacagagt aagatcatac cttaaaaaaa aaaaaaaagt atacccatgg gtcagcaatt
     4621 tcacttttca gtatatactt gagaaatgct tgcacaggtc ccccagatca cacatataag
     4681 aatgttctgg aataaattaa aatgtctatt tttaggaagg tgtaatgtgt tcacagaatg
     4741 ggtgattatt acatggcagc aaaatgaatg aataccagct acttgcagca caataactca
     4801 gaatgaaaaa gcaattctga gaaaactata tgtgacatga tacttttctt ataaaagtca
     4861 agaacaacta aaactgaaca gctgtttagg cattgacata tgtgacaaaa cttttaaaaa
     4921 gtaataaagt tcaagatagt ggttacctct ggagaggtag aggaggagca aatctatgag
     4981 taagtcactg gtaatgtttt agtccctggg ttaggtggtg ggttttgggg tggttcattt
     5041 gtcattaaaa gtaagtacat gagctgggtg tagtggtgcg tgcttatagt cccagctact
     5101 tgggagtctg agataggaag atccttgagg ccagttcaag gctatagtgt gctatgattt
     5161 cacctgtgaa tagctactat attccaacct gggcaacgta gaccttgccc ccctttaaaa
     5221 aaattcaaaa acaaaataaa tgcatggaca aatgaataag agagttatgc atggaacatc
     5281 ggtggtgtat tatgaatcaa gcattattac tagctcagtt atatgtgcct tcattccaaa
     5341 acaaaaaata aaaggtaaga aaattgttga attgcatttg agagagagga aaggaaagaa
     5401 ttcaggtctg aatcttaggc ttttggcttg agctattgca gtttattgag atggggaaat
     5461 acatggtggg gaaagtttgg gtatgtgcat aacagagaca gaaattcagt gtttgacaga
     5521 tcaagtgtga ggtgcccact gagcatcaaa gtggatatgt taagcaggta ttggatgtac
     5581 aaatctaaat tcagtaaggt cagtccagga gaaaatttgg ggagtagtta gccatgggat
     5641 cagatgggcg ctttagggac actttggaga tgaagtacag cactgagccc tgagttcctg
     5701 tgacagagaa gcagcctgca aagacgaaag gaggagctgt taggaagagc aaggcaacag
     5761 aaaaggaaga accagcatgc tgattatgtt caggagagtg tttctacgct gaatttaatt
     5821 gccaagatta ccaattctaa agaagaggag gactcttgga caagttttta gaagttggtt
     5881 tggagctggg gtgagagcct ggcctaatgg agacagctct ggattgggag tcacttagac
     5941 ctacattctg gtctaggttt ggctcccaaa aactgggaag gttagttagg tggccactcc
     6001 tctctcttca tggtctctct cagcttgaag acaatttaca gtctttgact aagcatccac
     6061 actggaagaa caagatttgg tttctgaaca ttgggtctta gtccttaaaa taacttgcaa
     6121 cctgttacgt cttcacttac tcccatcgcc accacaagaa tcctgtgtgt ttttgttttg
     6181 tgcatccagt ctaaaacggg tctgctttta ttcataggct tttgttttca gtggtttttg
     6241 ttgttgcatt tttccctaga taaaatgttt tttctataag acactgctta aaagagtcca
     6301 atgcagtatg aatttgtatt tgtgtttaac ttttgtgctt aacagatctg ccatggctga
     6361 actctcagtt gcttaagcaa aattctgggg cttattctag gttcctttat ttgtcattgt
     6421 cactcccatt ccagttatca gcaaattcca tcagctgtct ccgagacatc ttaaatctgt
     6481 ctacctccct ccatgtccac tgctaccact ctgcccaagc tattatcatc tttcacctga
     6541 actcctgcac taatgtctgc tgtccttgca tccactcctg ccctcctaca atcactgacg
     6601 gcagccgcag ggatctttat aaaacgaaaa tcagataatg tcacttccct gcttaaagcc
     6661 ctttgagtgg cttcccattg cacttagaaa aaaaaaaaaa aaaaaaaact ggccaggtgc
     6721 gatggctcat gcctgtaatc ccagcacttt gggaggccga ggcgggcgga tcccctgagg
     6781 ttggtagttc gagacctgct tggccaacat ggagaaaccc tgtctctact aaaaacacaa
     6841 aattagtcag gtgtgatggc gcatgcctgt aatcccagct acttgggagg ctgagtcagg
     6901 agaaacgctc gaacccagga ggcagaggtt gtggtgagtt gacatcacgc cattgcactc
     6961 cagcctgggc aacaagagtg aaactccgtc tgaaaaaaaa aaaaaaaaac ccaaactcaa
     7021 tagaaaatca agttttcata gtggtagttg ttaacagaga aataacaatg aaagctttaa
     7081 aaaactccat gaaaatttgc aaaacttaaa aaaaaaatgt agaagaggac taaacttgat
     7141 aaaatattaa aagaattgaa acccttccta aaggcagctt ctcaagggag cacaagttca
     7201 cacacagttt acttttggag gaacgtctga ggtcatgagg actagattct agagctacag
     7261 gtctcaggga cagtctcgag ggatacaggg cccccatcac cacatcccca gatttaaccg
     7321 cagcagctca gcttttatct gtatctgttg gagctctcta ggaaatgtca ataccaaagc
     7381 aaacccaaat cacaactaga ttagattact attcaagaga atgattctct accgaaactc
     7441 tgcaaaatgg ggatatcaag agagttggaa aatgtaagac gtaaagacca taatcaggaa
     7501 aatacgcatc atatttgtta ttcactgaga gggaggaatt tccacttaaa tcctatttcc
     7561 agcagctgga ttgtgctctc agtggagtgc tctggattct gattaataga gattttctag
     7621 tcctcccagc aacttccttc tcaattctct tcactttccg cagatctcgg caccagggtt
     7681 gcatcttgtg ggctccattg tgttttcaca caatgtgcta tttgtccttc acagtgtttt
     7741 ggtttatttt tctgtttgtc catcttgttt ttgaacaatt gccagcattt aaaaatgagg
     7801 aaatctaaaa tctgcatttc aagctgctct tttttaaaat gtgccgtttc gacaacactg
     7861 agcccacagt cttgaatgac aacacttggg tggagctgag tgactccacc tgtcgggtgg
     7921 ctacaccctt gctcagggta tgcactccat ggtttgctct atggcccacc atcctggatt
     7981 gtctccctga caccaaggct aagggaccca ctttactcac ttatctgctg ggccttggaa
     8041 gtatttcagt tcggaacccc aattctaacc ttagcttctc aggccattaa atgaaatctc
     8101 atttctatga tgcttcctgt cacatcactg tgctgctgag aacatgaagt ctgtgggtga
     8161 attggtggac gggatccaga atcattactt ggcagtggat tatagtgtga tgactcattt
     8221 ccggtggtct ccaggagact tggctgggag cttctcttgg agtctagggt tagccagagg
     8281 ctacatgttt taggcatctt aattcatatt ttatctaaag gcatataaat ccttaaaaaa
     8341 aatcatttga cttcatcctt gctccctaca tccagccagt aaccattgct ttgttttaca
     8401 tcgcgtgctt caggctttac tacagcctac ctggattttg cagtagcttc ttaaactgct
     8461 taaactttgg atattgcccc agccaacaca ttctgccaca gagatctctc tgagttaaat
     8521 gggattgtat catgccccac acccaagcag atagaaactg tcaatagata cacttagaat
     8581 gaatatgcat ggaatcaaat tacattcaga atctaccact ataggtagtg aatacaacag
     8641 gatagcagag gctgggaagg gtaatggggg ttggggggtg ggaggataaa ggggttgggt
     8701 aatgggtgta aaaatctata gaaggaatat gatctgttgt ttggtagcac aatagggtaa
     8761 atacagttaa taatttattg tatatttcac aataaaggag tggatttgga atgttctcaa
     8821 cacaaatgat aaatgtttga ggtgatggat accccaatta ccctgatttg atcattatac
     8881 gttgtatgtt tgtatcaaaa tatcatatgt accccataaa tatgtacaac tattatgtat
     8941 ccataaaaat tggaaataaa ctaccaccat ctttcttcag cctattttcc tatctcctct
     9001 cgcaccatac taggcacaca atctctgtac ctgtgctgtc ttccaagcca ttgctcatgt
     9061 tttaagaaat atacttattg tttaatatat cctgtaccac tgtaggatga ctgtagttaa
     9121 caataatgtg tagtttcaaa tagctaatag ctggaaggaa gttgttgaat gtttccaaca
     9181 taaagaaatg ataagtgttt gagatgatgg atatgctaat taccctgatc tgatcactac
     9241 acattatatg tatggaaata tcattgtgta ccccatgaat atgggcaatt attatttgtt
     9301 aattaaaaaa ataaaaaaaa gacccaccca ctg
//
