LOCUS       NM_013401               2325 bp    mRNA    linear   PRI 27-NOV-2024
DEFINITION  Homo sapiens RAB3A interacting protein like 1 (RAB3IL1), transcript
            variant 1, mRNA.
ACCESSION   NM_013401
VERSION     NM_013401.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2325)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 2325)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2325)
  AUTHORS   Zhang,R., Ji,Z., Yao,Y., Zuo,W., Yang,M., Qu,Y., Su,Y., Ma,G. and
            Li,Y.
  TITLE     Identification of hub genes in unstable atherosclerotic plaque by
            conjoint analysis of bioinformatics
  JOURNAL   Life Sci 262, 118517 (2020)
   PUBMED   33011223
  REMARK    GeneRIF: Identification of hub genes in unstable atherosclerotic
            plaque by conjoint analysis of bioinformatics.
REFERENCE   4  (bases 1 to 2325)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2325)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2325)
  AUTHORS   Guo,Z., Hou,X., Goody,R.S. and Itzen,A.
  TITLE     Intermediates in the guanine nucleotide exchange reaction of Rab8
            protein catalyzed by guanine nucleotide exchange factors Rabin8 and
            GRAB
  JOURNAL   J Biol Chem 288 (45), 32466-32474 (2013)
   PUBMED   24072714
  REMARK    GeneRIF: Intermediates in the guanine nucleotide exchange reaction
            of Rab8 protein catalyzed by guanine nucleotide exchange factors
            Rabin8 and GRAB.
REFERENCE   7  (bases 1 to 2325)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   8  (bases 1 to 2325)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   9  (bases 1 to 2325)
  AUTHORS   Williams,J.A., Chen,X. and Sabbatini,M.E.
  TITLE     Small G proteins as key regulators of pancreatic digestive enzyme
            secretion
  JOURNAL   Am J Physiol Endocrinol Metab 296 (3), E405-E414 (2009)
   PUBMED   19088252
  REMARK    Review article
REFERENCE   10 (bases 1 to 2325)
  AUTHORS   Luo,H.R., Saiardi,A., Nagata,E., Ye,K., Yu,H., Jung,T.S., Luo,X.,
            Jain,S., Sawa,A. and Snyder,S.H.
  TITLE     GRAB: a physiologic guanine nucleotide exchange factor for Rab3A,
            which interacts with inositol hexakisphosphate kinase
  JOURNAL   Neuron 31 (3), 439-451 (2001)
   PUBMED   11516400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006260.2, DR004757.1,
            BC022239.1 and BQ946081.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013401.3.
            
            Summary: This gene encodes a guanine nucleotide exchange factor for
            the ras-related protein Rab3A. The encoded protein binds Rab3a and
            the inositol hexakisphosphate kinase InsP6K1. Alternative splicing
            results in multiple transcript variants. A related pseudogene has
            been identified on chromosome 7. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022239.1, ERR3218374.354482.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394836.7/ ENSP00000378313.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AP006260.2         79738-79755         c
            19-41               DR004757.1         64-86
            42-69               BC022239.1         1-28
            70-667              BQ946081.1         55-652
            668-675             BC022239.1         627-634
            676-741             BQ946081.1         662-727
            742-2325            BC022239.1         701-2284
FEATURES             Location/Qualifiers
     source          1..2325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2-q12.3"
     gene            1..2325
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /note="RAB3A interacting protein like 1"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
     exon            1..210
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1348
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide exchange factor for Rab-3A; rabin3-like
                     1; rab3A-interacting-like protein 1; RAB3A interacting
                     protein (rabin3)-like 1"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform 1"
                     /protein_id="NP_037533.2"
                     /db_xref="CCDS:CCDS8014.1"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
                     /translation="MWSGPPQPDQGLPPPLAAVPVPWKSTDPCQGHRESPGALVETSA
                     GEEAQGQEGPAAAQLDVLRLRSSSMEIREKGSEFLKEELHRAQKELKLKDEECERLSK
                     VREQLEQELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTL
                     VITSTPASPNRELHPQLLSPTKAGPRKGHSRHKSTSSTLCPAVCPAAGHTLTPDREGK
                     EVDTILFAEFQAWRESPTLDKTCPFLERVYREDVGPCLDFTMQELSVLVRAAVEDNTL
                     TIEPVASQTLPTVKVAEVDCSSTNTCALSGLTRTCRHRIRLGDSKSHYYISPSSRARI
                     TAVCNFFTYIRYIQQGLVRQDAEPMFWEIMRLRKEMSLAKLGFFPQEA"
     exon            211..463
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            560..637
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            638..856
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            857..985
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1098
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1198
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1265
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2325
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /note="hexamer: AATAAA"
     polyA_site      2325
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /note="major polyA site"
ORIGIN      
        1 gtgacccgcc cagggcaggg tcggggctgg gctgggggcc gcgagcccag gcgtctgaga
       61 cctactgacc ggccgcgggc agggctgaca ggcggtgggg cggctcggcc cctggcggag
      121 tcggcggcgg gcggggacgc ggcgctggga ggacgcggcg gcgctgggaa cggacgcctg
      181 ggcgccccga ggcgccggga tgtggagcgg cccaccccag ccagaccagg gcctcccgcc
      241 gccccttgca gctgtcccgg tcccctggaa gagcacggac ccctgccaag gccacaggga
      301 gtccccagga gccctggtgg agacctctgc aggggaggag gcccaaggcc aggagggccc
      361 cgcagccgcc cagctggacg tgttgcgcct gcgcagctct tccatggaga tccgagagaa
      421 gggctccgag ttcctgaagg aggagctgca cagagcgcag aaggagctga agctaaagga
      481 cgaggaatgt gagcggctgt ccaaggtgcg ggagcagcta gaacaggagc tggaagagct
      541 gacggccagc ctgtttgagg aagctcacaa gatggttcga gaagccaaca tgaagcaggc
      601 ggcatcagaa aagcagctga aggaggctcg gggcaagatc gacatgctgc aggcagaggt
      661 gacagccttg aagacgctgg tcatcacgtc cacaccagcc tctcccaacc gcgagcttca
      721 cccccagctg ctgagcccca ccaaggccgg gccccgaaag ggccactctc gccacaagag
      781 caccagcagc accctctgcc ccgccgtgtg tcccgctgcg ggacacaccc tcaccccaga
      841 cagagagggc aaggaggtgg acacaatcct gtttgcagag ttccaggcct ggagggaatc
      901 ccccaccctg gacaagacct gccccttcct ggaaagggtg taccgagagg acgtgggccc
      961 ctgcctggac ttcacaatgc aggagctctc ggtgctggta cgggccgccg tggaggacaa
     1021 cacgctcacc attgagccgg tggcttcgca gacgctgccc acagtgaagg tggccgaggt
     1081 tgactgtagc agcaccaaca catgtgccct gagcgggctg acccgcacct gccgccaccg
     1141 aatccggctc ggggactcca aaagccatta ctacatctcg ccatcttccc gggccaggat
     1201 caccgcagtg tgcaacttct tcacctacat ccgctacatc cagcaaggcc tggtgcggca
     1261 ggacgcagag cccatgttct gggagatcat gaggttgcgg aaggagatgt cactggccaa
     1321 gctcggcttc ttcccccagg aggcttaggg cgcggcccag gcctgaaggg gagctctgag
     1381 acagagcaaa cacccacccc agaacaagcc gacacacagg gagacggggg cctggagcca
     1441 gccctgagcc agaggcagaa tggatggaca gacaggccat ggaggcagca ctgagccagc
     1501 accacacgtc catcctggga cagacgggcc tggacttcac ggcaagaccc ccctctcttc
     1561 cccactgggt tctgccacca ccaggaggat ttcaagaaag caccaaagac cagggagctc
     1621 ggatccatac tcggggggcc tcagcccttg ggaggggaca cctgaggcag ccagcgcccc
     1681 ctccccagtc cccagaactg cctgcaggtg ccttgttgct ggcttgtctt cagaaaggga
     1741 ctgttctggg tggctggatc tccagggtac cctccacccc agctgccaag ccctgggcca
     1801 gcagcacccc cttgtggcca tcctgtgcct tgttcccggt ggcctcccta ttggactact
     1861 aggaggggct ggcagggcct ccatagcaca gaattgcccc aaagccttgt taagatgagt
     1921 caagacccct cccccgcttc ctcccttcct ttcccccttc ctccctcccc cttcataaag
     1981 gcctcccttg tcaccttccc tcccaccccg tctcagccct gtgctcctgg aggccctgct
     2041 cccaaaaccg ctggaaggac tggggcactt tctgccacag tagaacacag acagggcttc
     2101 agatcaccca cgcctgtttt cagctgtggg tggccatgca gacacgcgcc ctggcatgtg
     2161 gggcctgggt gggcaggcag gacctgggcc ctcccaccca tcagagccca ctcaggacca
     2221 gcgttcggag ctcccacctg gacgcatccc tcaccacgtc cggatttcct tctttggatg
     2281 gaatgtaacg cgatctctat ttaataaagg caggctttgt tggta
//
