LOCUS       NM_012414               7256 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens RAB3 GTPase activating non-catalytic protein subunit 2
            (RAB3GAP2), mRNA.
ACCESSION   NM_012414
VERSION     NM_012414.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7256)
  AUTHORS   Takats,S., Levay,L., Boda,A., Toth,S., Simon-Vecsei,Z., Rubics,A.,
            Varga,A., Lippai,M., Lorincz,P., Glatz,G. and Juhasz,G.
  TITLE     The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes
            autolysosome maturation through the Vps34 Complex I
  JOURNAL   FEBS J 288 (1), 190-211 (2021)
   PUBMED   32248620
  REMARK    GeneRIF: The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module
            promotes autolysosome maturation through the Vps34 Complex I.
REFERENCE   2  (bases 1 to 7256)
  AUTHORS   Abdel-Hamid,M.S., Abdel-Ghafar,S.F., Ismail,S.R., Desouky,L.M.,
            Issa,M.Y., Effat,L.K. and Zaki,M.S.
  TITLE     Micro and Martsolf syndromes in 34 new patients: Refining the
            phenotypic spectrum and further molecular insights
  JOURNAL   Clin Genet 98 (5), 445-456 (2020)
   PUBMED   32740904
  REMARK    GeneRIF: Micro and Martsolf syndromes in 34 new patients: Refining
            the phenotypic spectrum and further molecular insights.
            Review article
REFERENCE   3  (bases 1 to 7256)
  AUTHORS   Xu,W., Plummer,L., Quinton,R., Swords,F., Crowley,W.F.,
            Seminara,S.B. and Balasubramanian,R.
  TITLE     Hypogonadotropic hypogonadism due to variants in RAB3GAP2:
            expanding the phenotypic and genotypic spectrum of Martsolf
            syndrome
  JOURNAL   Cold Spring Harb Mol Case Stud 6 (3), a005033 (2020)
   PUBMED   32376645
  REMARK    GeneRIF: Hypogonadotropic hypogonadism due to variants in RAB3GAP2:
            expanding the phenotypic and genotypic spectrum of Martsolf
            syndrome.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7256)
  AUTHORS   Gumus,E.
  TITLE     Case report of four siblings in southeast Turkey with a novel
            RAB3GAP2 splice site mutation: Warburg micro syndrome or Martsolf
            syndrome?
  JOURNAL   Ophthalmic Genet 39 (3), 391-395 (2018)
   PUBMED   29419336
  REMARK    GeneRIF: Mutation in RAB3GAP2 gene is associated with Warburg micro
            syndrome and Martsolf syndrome.
REFERENCE   5  (bases 1 to 7256)
  AUTHORS   Rasnitsyn,A., Doucette,L., Seifi,M., Footz,T., Raymond,V. and
            Walter,M.A.
  TITLE     FOXC1 modulates MYOC secretion through regulation of the exocytic
            proteins RAB3GAP1, RAB3GAP2 and SNAP25
  JOURNAL   PLoS One 12 (6), e0178518 (2017)
   PUBMED   28575017
  REMARK    GeneRIF: show that FOXC1 regulates the expression of RAB3GAP1,
            RAB3GAP2 and SNAP25
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7256)
  AUTHORS   Aligianis,I.A., Morgan,N.V., Mione,M., Johnson,C.A., Rosser,E.,
            Hennekam,R.C., Adams,G., Trembath,R.C., Pilz,D.T., Stoodley,N.,
            Moore,A.T., Wilson,S. and Maher,E.R.
  TITLE     Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic
            subunit in a kindred with Martsolf syndrome
  JOURNAL   Am J Hum Genet 78 (4), 702-707 (2006)
   PUBMED   16532399
REFERENCE   7  (bases 1 to 7256)
  AUTHORS   Aligianis,I.A., Johnson,C.A., Gissen,P., Chen,D., Hampshire,D.,
            Hoffmann,K., Maina,E.N., Morgan,N.V., Tee,L., Morton,J.,
            Ainsworth,J.R., Horn,D., Rosser,E., Cole,T.R., Stolte-Dijkstra,I.,
            Fieggen,K., Clayton-Smith,J., Megarbane,A., Shield,J.P.,
            Newbury-Ecob,R., Dobyns,W.B., Graham,J.M. Jr., Kjaer,K.W.,
            Warburg,M., Bond,J., Trembath,R.C., Harris,L.W., Takai,Y.,
            Mundlos,S., Tannahill,D., Woods,C.G. and Maher,E.R.
  TITLE     Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro
            syndrome
  JOURNAL   Nat Genet 37 (3), 221-223 (2005)
   PUBMED   15696165
REFERENCE   8  (bases 1 to 7256)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 7256)
  AUTHORS   Nagano,F., Sasaki,T., Fukui,K., Asakura,T., Imazumi,K. and Takai,Y.
  TITLE     Molecular cloning and characterization of the noncatalytic subunit
            of the Rab3 subfamily-specific GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24781-24785 (1998)
   PUBMED   9733780
REFERENCE   10 (bases 1 to 7256)
  AUTHORS   Handley,M. and Sheridan,E.
  TITLE     RAB18 Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29300443
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA379077.1, AB020646.2,
            BC131573.1, AL117631.1, BX483077.1, AC103590.2 and N93244.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012414.3.
            
            Summary: The protein encoded by this gene belongs to the RAB3
            protein family, members of which are involved in regulated
            exocytosis of neurotransmitters and hormones. This protein forms
            the Rab3 GTPase-activating complex with RAB3GAP1, where it
            constitutes the regulatory subunit, whereas the latter functions as
            the catalytic subunit. This gene has the highest level of
            expression in the brain, consistent with it having a key role in
            neurodevelopment. Mutations in this gene are associated with
            Martsolf syndrome.[provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.233194.1,
                                           SRR1660807.139839.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358951.7/ ENSP00000351832.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DA379077.1         49-164
            117-844             AB020646.2         1-728
            845-3203            BC131573.1         776-3134
            3204-5077           AB020646.2         3088-4961
            5078-5097           AL117631.1         2175-2194
            5098-5597           BX483077.1         3-502
            5598-7240           AC103590.2         201273-202915       c
            7241-7256           N93244.1           26-41               c
FEATURES             Location/Qualifiers
     source          1..7256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..7256
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /note="RAB3 GTPase activating non-catalytic protein
                     subunit 2"
                     /db_xref="GeneID:25782"
                     /db_xref="HGNC:HGNC:17168"
                     /db_xref="MIM:609275"
     exon            1..231
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..4298
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /note="rab3 GTPase-activating protein 150 kDa subunit;
                     RGAP-iso; rab3-GAP p150; rab3-GAP regulatory subunit; RAB3
                     GTPase activating protein subunit 2 (non-catalytic)"
                     /codon_start=1
                     /product="rab3 GTPase-activating protein non-catalytic
                     subunit"
                     /protein_id="NP_036546.2"
                     /db_xref="CCDS:CCDS31028.1"
                     /db_xref="GeneID:25782"
                     /db_xref="HGNC:HGNC:17168"
                     /db_xref="MIM:609275"
                     /translation="MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDW
                     EDDGWGAWEENEPQEPEEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVP
                     KWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGF
                     TSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVT
                     IDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLS
                     PFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHVALAV
                     ASKLTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPATPLAVRFGLPDSRRHGESICL
                     SPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFS
                     PFGNSQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLN
                     NVTSQSWQPQTYQICLVDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKT
                     KSPNLDLVETEIKELILDIKYPATKKQALESILASERLPFSCLRNITQTLMDTLKSQE
                     LESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLDTPFSDNDLALLLRLDEKELLKL
                     QALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYEKDVLNIKKISEEEYVALGSF
                     FFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSICCLHTML
                     SLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMT
                     EKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKV
                     SSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANEERDAENPDEPK
                     EGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEE
                     ARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRD
                     VGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISIVELALE
                     QKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGE
                     MDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLAHH
                     LQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQ
                     TKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLA
                     LHLIEAVEAISLPSL"
     exon            232..296
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..420
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..502
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..550
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..626
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..728
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..828
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..927
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1076
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1156
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1246
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1386
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1603
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1747
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1830
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1895
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1986
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2114
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2328
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2426
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2532
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2693
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2922
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3096
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3203
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3270
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3341
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3377
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3452
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3671
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3761
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3983
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4142
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..7256
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7238..7243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /note="hexamer: AATAAA"
     polyA_site      7256
                     /gene="RAB3GAP2"
                     /gene_synonym="MARTS1; p150; RAB3-GAP150; RAB3GAP150;
                     SPG69; WARBM2"
                     /note="major polyA site"
ORIGIN      
        1 gtttctccgc cttctgcttg gctagagcta ttggggctcg gtggcggccg cagtggggtg
       61 gagggggcag ggcgtggtga ggtaaggtga gtgccgtagt ggggttccct ggagccatgg
      121 cctgctccat tgtccagttc tgctacttcc aggacctcca ggccgcccgg gacttcctct
      181 ttcctcacct gcgggaggag atcctcagcg gcgccttgcg gagggacccc agtaaatcaa
      241 cagactggga agatgatggt tggggagcat gggaagaaaa tgaaccacaa gaacctgaag
      301 aagaaggaaa tacttgcaaa acacaaaaaa cttcctggct ccaagattgt gttttatcct
      361 tatctccaac caatgatctt atggtgatag ctcgagagca aaaagctgta tttctagtgc
      421 caaaatggaa atatagtgat aaaggaaagg aagaaatgca atttgctgtt ggctggagtg
      481 gttccttaaa tgtcgaagaa ggggaatgtg taaccagtgc tctatgtatc ccactagcaa
      541 gccaaaagag gagttccact gggcgtcctg actggacctg cattgtggtg ggttttactt
      601 caggttatgt acgcttctac actgagaatg gtgtgctctt gcttgcacag cttttgaatg
      661 aggacccagt acttcaactt aaatgcagaa cctatgaaat accacgacat cccggcgtga
      721 ctgagcagaa tgaagagttg agtatcttat atccagctgc cattgtgact attgatggat
      781 ttagcctttt tcaatctctt cgtgcttgtc gaaatcaggt agcaaaagct gcagcatcag
      841 gcaatgagaa catacaacca ccaccattag cttataagaa atggggtcta caagatattg
      901 acactattat tgatcatgct agtgttggta ttatgactct gtcccccttt gatcaaatga
      961 agactgcctc caatataggt ggatttaatg cagcaattaa aaatagtcca cctgccatgt
     1021 ctcagtatat cactgtaggg tccaatccat ttactggctt cttctatgct ttagagggaa
     1081 gcacacaacc attattatcc catgttgcac tagcagttgc aagtaaactc acttctgctt
     1141 tatttaatgc tgccagtggt tggcttggtt ggaaaagtaa gcacgaagaa gaagctgtcc
     1201 aaaagcaaaa gccgaaggtt gagccagcta ccccattagc tgtaagattt ggacttccag
     1261 attctagacg ccatggtgaa agcatatgtc tgtctccatg taacacactg gcagcagtaa
     1321 cagatgattt cggcagagtt attttattgg atgtagctag aggaattgca atacgcatgt
     1381 ggaaagggta ccgcgacgca caaattggat ggattcaaac tgtagaggac ctccatgaaa
     1441 gagtgccaga aaaggcagat ttttccccct ttggaaattc tcagggtcca agtcgagtag
     1501 ctcaattcct tgtgatctat gcgccaagaa ggggaatttt agaagtgtgg agcacacagc
     1561 agggacctag agtaggagct ttcaatgtgg ggaagcactg caggctgctg tatcctggct
     1621 ataaaataat gggtttaaat aatgttacca gtcagagttg gcagccacag acttatcaga
     1681 tctgtctggt tgatccagtg tctggaagtg tgaaaacagt gaacgttccc ttccatttag
     1741 cactgagtga taagaagagt gaacgagcca aggatatgca cctagtgaag aaactagcag
     1801 ccttactgaa aacaaaatct cccaatcttg atttggttga aacagaaata aaggaattaa
     1861 ttcttgatat taaataccct gcaaccaaaa aacaagcttt ggaaagcatt ttggcaagtg
     1921 aacgtttacc attttcttgc cttagaaaca tcactcagac tttaatggac actttaaaaa
     1981 gtcaagaact tgagtctgtt gatgaaggat tgctacagtt ttgtgccaat aaactaaaac
     2041 tgctgcaact ctatgagtct gtcagtcaat taaattccct tgattttcat ttagacacac
     2101 cattctctga taatgacttg gctctgttac taaggcttga tgaaaaagaa ctgcttaagc
     2161 tccaggcatt actagagaaa tataagcaag agaacaccag gacaaatgtt cgattttctg
     2221 atgataaaga tggtgtgttg cctgtaaaaa cattcttgga atatttagaa tatgaaaagg
     2281 atgtgctcaa cataaagaaa ataagtgaag aggaatatgt ggctttaggt agtttctttt
     2341 tttggaagtg tttgcatgga gaaagctcca ctgaggatat gtgtcacact ttggagtcgg
     2401 ctggtcttag ccctcagctg ttgttgtctc tgctcctgag tgtttggctt tcaaaggaaa
     2461 aggatatttt ggataaacca cagtcaatct gctgtcttca taccatgctg tccctcctga
     2521 gcaagatgaa agtggccatc gatgagacct gggattctca gtctgtgtcc ccatggtggc
     2581 agcagatgcg cacagcctgt attcagtctg agaacaatgg agccgctctg ttgtctgcgc
     2641 atgttgggca ttctgttgct gcacagatat caaacaacat gacagagaaa aaattttccc
     2701 aaacagtttt gggtgctgat tcagaggccc tcactgattc ctgggaggca ctttctcttg
     2761 acactgagta ctggaaactc cttctgaaac agctggagga ttgtctcata cttcagactc
     2821 tgcttcacag caaagggaac actcagacct ccaaagtgtc atcactgcag gctgagccac
     2881 ttccaaggct ttctgttaaa aagttattag aaggaggaaa aggtggcatt gcagacagtg
     2941 tagccaagtg gatatttaaa caggacttca gccctgaagt attaaaactg gctaatgaag
     3001 aaagagatgc agaaaaccca gatgaaccca aagaaggtgt taacagaagt ttccttgagg
     3061 tatcagagat ggagatggac ttaggagcca taccagactt actgcattta gcctatgagc
     3121 agtttccttg tagccttgag ctcgatgtct tgcatgcaca ttgctgctgg gagtacgttg
     3181 ttcagtggaa taaagatcca gaggaagcac gtttttttgt taggtcaata gaacacttga
     3241 agcaaatatt taatgcacat gttcaaaatg gcattgcact gatgatgtgg aatacgttct
     3301 tagttaaaag attttctgct gctacatact taatggataa ggttggaaaa tcaccaaaag
     3361 ataggttatg ccgaagggat gtgggaatga gtgacacagc aatgacatct ttcctcggct
     3421 cctgtttgga tcttcttcag atcttaatgg aggcagatgt tagcagggat gaaatacagg
     3481 tgcctgtgct ggatactgag gatgcgtggc tctccgtgga aggaccaatc tccatagtgg
     3541 aactggccct tgaacagaag cacatccact acccactggt ggagcaccac tccatcctgt
     3601 gctccatctt gtatgcagtc atgaggtttt ctctgaagac cgtgaagcca ctttcacttt
     3661 ttgacagtaa gggaaaaaat gcatttttca aagacctaac ttcaattcag ttattaccta
     3721 gtggggaaat ggatccaaat tttatttctg tacgacaaca gttcttattg aaagttgtca
     3781 gtgcagctgt ccaggcccaa cattcagcca caaaggtcaa agatcccaca gaagaggcca
     3841 cacccactcc ttttgggaaa gaccaagatt ggccagctct agctgtggat ttagcccatc
     3901 accttcaagt tagtgaagat gttgttagaa ggcattatgt gggggaacta tacaactatg
     3961 gagttgacca cttaggagaa gaggccattc tacaggttca tgacaaagag gtccttgcct
     4021 ctcagctgct ggtgctcacg gggcaaaggc tggctcatgc gcttctccac acccagacaa
     4081 aagaaggaat ggagctgctt gccagacttc cacccacact gtgtacttgg ctgaaagcaa
     4141 tggaccccca ggaccttcaa aacactgaag tgccaattgc aacaacagct aaactagtaa
     4201 ataaagtaat tgagctttta ccagaaaaac atgggcaata tggtctagcc ttacacctca
     4261 ttgaagctgt ggaagccata tctcttcctt ctttatgaca cttacctact ggaaatagtc
     4321 taaaattatg attataacat gaagtagtgc atggttattt tacatagtaa gacctggaat
     4381 tttatgggaa aagtatgtct ttttttttcc ttttgtaaaa taaataaaag tatatacaac
     4441 ttttaaaaag tgcaaccctg gctaaattcc actcctttgg ttaatactga agataaaata
     4501 taaacaaatg tcaactctgt tataattaat acagatgttt tactgtttat ttctaattca
     4561 aacacttaag tagctttatt gttaaacttt gctatttaaa attggttata atttagatta
     4621 tgttcttata agattctata tttcctatct aaaatgttgt tgtaattcaa tttaaatgtg
     4681 ttcatgtaca gtccccatca gtagcgtata gaacacccca ctctccttta gtaaatgttg
     4741 agaaaatgcc tttgttgtca tgctccaaat cccacactgg gctgccacct gggagttctg
     4801 gataccgaaa ggttcctttc ccagaggttc tgctgttgcc atcagaggag gatgaccgtg
     4861 cttgaggagg aagaatgggt tcaagatcat catattcatc agaaggggac actaaataga
     4921 acccttaacc tgttgtactt gccaaaattg agaatcagag atgtgtaaaa tgcagcaaat
     4981 taattataat gtaagttaag atttgctttt tgccaagttg caaagttgta tccacatcag
     5041 gtcactgtaa aaatgtatta tcttgtaaaa cttatgtaaa aaaaaaaaaa aaaaaaaggc
     5101 aaagatacta aaaattttaa gtccgacttt atttttccta caagtgttta gaaatgcttc
     5161 tgggatttgc taatattatc tgtccttggg aacagtattg aaaaaactgc ttagtggtat
     5221 tacagcttta gcaaacctac ctcacagctg ggatgagagg ataaaataca actaattttg
     5281 taccctatag tgcctagagc agtccaagtg ctaaataaat atttactgat taaaaccaaa
     5341 ctatagctac tcgggaggct ggaggaggat cgcttgagcc caggagtttg aggccattct
     5401 gggcaatata gcaagaccct gtctcgaaaa aaaaaaaaaa aagaaaaaac caaactaacc
     5461 aaaactctgt aaaagagtgc tttgagctct acaaatacca agtatttatt gtggtatatt
     5521 tttagaatgt agccatacag tgtaattatg ggtatctgtc atggatcaca attattattc
     5581 atagtaagtc attgtgatac agaagtttgt ttcttcactt ccccttaaga agccaactat
     5641 agtaatcatg caaagttgag gagtatgtcc ttcagggata taaaaagaaa aacaaatctg
     5701 ttttttgagc taaaagagca catccaaaca agaatttaac tggctaaaat ttagtaatta
     5761 ctgttaagta actatcaaac ttgaaatctt acaagataaa tggttaagat gtcttgagta
     5821 tttgggatgg gggcctgtga gtctgattga gacatacatt ttacagagta gcagcactgg
     5881 aaagggctag tccaacctcc cagcctctgc ttgggtctcc gctgccccag ccacacacat
     5941 cctagaattc ttgtaaacat atctggctct gtgttaacag tcacttgtta tatgttttct
     6001 aagagattag ttcttcctgt gatttttcca agtacgctga aagtagtagt atgaacttaa
     6061 ggaggctagt caaagaaact tggagttata ggtattttta aagaataaat cctcaattcc
     6121 atcatcactt ggcggggagg gggcacttat taagcatttt agataataaa actggttaag
     6181 cttactctgg tagaacagac aatcaaatct ggggattgct gagaacaata ataagctgaa
     6241 gtatggctca cagaatccta acacaaatca ttaagtctct agttagattt gttatcctaa
     6301 aatttttcat agaattttaa aatctaattc tgacttgtat ggttaagaaa agcagttaaa
     6361 tattttacta cttatcaagg gcttttaaaa taaataaatc tgattgatag gaagaaaggc
     6421 aaataaatac ctatgtagac attctataat aacaaagagc catagatgat aaaggaatta
     6481 gattttaatg tagaatgggt ggtttctgaa acaaaggtat gtggtacttt gtagttattg
     6541 atgagaagcc agtaaccagt agtgttttcc tagatatatg cccaccctca cacaactttc
     6601 ttcattaaca aacattaaat atgcatttgt atcttattaa attatattgt ataatgctga
     6661 aggaaaacaa aaagtgttca aataatcata acttctacat tacaggttct gtttagatgc
     6721 agaactagag gggccagggt aaatgtagat aaagagatat atagcaccat gcttcttaat
     6781 gcttcatact tttgcaaaca gaaaaaaaaa gttttacttt tattataaaa cttcatctat
     6841 ggtcaaagta aacactgtta catttaaatt gctttttaaa aacaattgcg atctaaaaag
     6901 tcaaaaatct gaaatttaat aatatgagac ttacactgaa tataatgttc atttagaagt
     6961 tgctgtggtc cacttcattt ataaggaaca aatattttta cagtacacta tagcaacagc
     7021 aaaagccctc tctcaccctg ataggaatgg gtttgctggg tgtctagaag ttagattcct
     7081 gctgaataga attagccatc cttaaaagat tttaatccaa tactgaactg tttataaaat
     7141 gctttctcta ttgtaatgta ctgtaagtag tgaaattctg tatatactgc tattttctgt
     7201 ctgttcattg ttgtgaactt cttatgtata ttagtgaaat aaattttcag ctttca
//
