LOCUS       NM_012233               4891 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens RAB3 GTPase activating protein catalytic subunit 1
            (RAB3GAP1), transcript variant 2, mRNA.
ACCESSION   NM_012233
VERSION     NM_012233.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4891)
  AUTHORS   Ullah,W., Ilyas,M., Tariq,M., Imdad,M., Ullah,I., Efthymiou,S.,
            Faheem,M., Abbas,M., Aamir,M., Nouman,M. and Houlden,H.
  CONSRTM   SYNAPS Study Group
  TITLE     Exome sequencing identifies a novel pathogenic variant in RAB3GAP1
            causing Warburg Micro syndrome in a Pakistani family
  JOURNAL   Int J Dev Neurosci 83 (4), 368-373 (2023)
   PUBMED   37186309
  REMARK    GeneRIF: Exome sequencing identifies a novel pathogenic variant in
            RAB3GAP1 causing Warburg Micro syndrome in a Pakistani family.
REFERENCE   2  (bases 1 to 4891)
  AUTHORS   Gandhi,S., Nor Rashid,N., Mohamad Razif,M.F. and Othman,S.
  TITLE     Proteasomal degradation of p130 facilitate cell cycle deregulation
            and impairment of cellular differentiation in high-risk Human
            Papillomavirus 16 and 18 E7 transfected cells
  JOURNAL   Mol Biol Rep 48 (6), 5121-5133 (2021)
   PUBMED   34169395
  REMARK    GeneRIF: Proteasomal degradation of p130 facilitate cell cycle
            deregulation and impairment of cellular differentiation in
            high-risk Human Papillomavirus 16 and 18 E7 transfected cells.
REFERENCE   3  (bases 1 to 4891)
  AUTHORS   Khalesi,R., Razmara,E., Asgaritarghi,G., Tavasoli,A.R.,
            Riazalhosseini,Y., Auld,D. and Garshasbi,M.
  TITLE     Novel manifestations of Warburg micro syndrome type 1 caused by a
            new splicing variant of RAB3GAP1: a case report
  JOURNAL   BMC Neurol 21 (1), 180 (2021)
   PUBMED   33910511
  REMARK    GeneRIF: Novel manifestations of Warburg micro syndrome type 1
            caused by a new splicing variant of RAB3GAP1: a case report.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4891)
  AUTHORS   Yang,D., Wang,X., Yang,J., Liu,D. and Li,D.
  TITLE     [Analysis of a case of Warburg micro syndrome type 1 due to variant
            of RAB3GAP1 gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 37 (12), 1384-1386 (2020)
   PUBMED   33306828
  REMARK    GeneRIF: [Analysis of a case of Warburg micro syndrome type 1 due
            to variant of RAB3GAP1 gene].
REFERENCE   5  (bases 1 to 4891)
  AUTHORS   Abdel-Hamid,M.S., Abdel-Ghafar,S.F., Ismail,S.R., Desouky,L.M.,
            Issa,M.Y., Effat,L.K. and Zaki,M.S.
  TITLE     Micro and Martsolf syndromes in 34 new patients: Refining the
            phenotypic spectrum and further molecular insights
  JOURNAL   Clin Genet 98 (5), 445-456 (2020)
   PUBMED   32740904
  REMARK    GeneRIF: Micro and Martsolf syndromes in 34 new patients: Refining
            the phenotypic spectrum and further molecular insights.
            Review article
REFERENCE   6  (bases 1 to 4891)
  AUTHORS   Oishi,H., Sasaki,T., Nagano,F., Ikeda,W., Ohya,T., Wada,M., Ide,N.,
            Nakanishi,H. and Takai,Y.
  TITLE     Localization of the Rab3 small G protein regulators in nerve
            terminals and their involvement in Ca2+-dependent exocytosis
  JOURNAL   J Biol Chem 273 (51), 34580-34585 (1998)
   PUBMED   9852129
REFERENCE   7  (bases 1 to 4891)
  AUTHORS   Nagano,F., Sasaki,T., Fukui,K., Asakura,T., Imazumi,K. and Takai,Y.
  TITLE     Molecular cloning and characterization of the noncatalytic subunit
            of the Rab3 subfamily-specific GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24781-24785 (1998)
   PUBMED   9733780
REFERENCE   8  (bases 1 to 4891)
  AUTHORS   Fukui,K., Sasaki,T., Imazumi,K., Matsuura,Y., Nakanishi,H. and
            Takai,Y.
  TITLE     Isolation and characterization of a GTPase activating protein
            specific for the Rab3 subfamily of small G proteins
  JOURNAL   J Biol Chem 272 (8), 4655-4658 (1997)
   PUBMED   9030515
REFERENCE   9  (bases 1 to 4891)
  AUTHORS   Warburg,M., Sjo,O., Fledelius,H.C. and Pedersen,S.A.
  TITLE     Autosomal recessive microcephaly, microcornea, congenital cataract,
            mental retardation, optic atrophy, and hypogenitalism. Micro
            syndrome
  JOURNAL   Am J Dis Child 147 (12), 1309-1312 (1993)
   PUBMED   8249951
REFERENCE   10 (bases 1 to 4891)
  AUTHORS   Handley,M. and Sheridan,E.
  TITLE     RAB18 Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29300443
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA333844.1, D31886.1 and
            AC017031.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_012233.2.
            
            Summary: This gene encodes the catalytic subunit of a Rab GTPase
            activating protein. The encoded protein forms a heterodimer with a
            non-catalytic subunit to specifically regulate the activity of
            members of the Rab3 subfamily of small G proteins. This protein
            mediates the hydrolysis of GTP bound Rab3 to the GDP bound form.
            Mutations in this gene are associated with Warburg micro syndrome.
            Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.25332.1,
                                           SRR1803617.197158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264158.13/ ENSP00000264158.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA333844.1         28-41
            15-3649             D31886.1           1-3635
            3650-4891           AC017031.10        4187-5428
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.3"
     gene            1..4891
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="RAB3 GTPase activating protein catalytic subunit 1"
                     /db_xref="GeneID:22930"
                     /db_xref="HGNC:HGNC:17063"
                     /db_xref="MIM:602536"
     exon            1..34
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2962
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rab3-GAP p130; RAB3 GTPase-activating protein 130 kDa
                     subunit; RAB3 GTPase activating protein subunit 1
                     (catalytic)"
                     /codon_start=1
                     /product="rab3 GTPase-activating protein catalytic subunit
                     isoform 2"
                     /protein_id="NP_036365.1"
                     /db_xref="CCDS:CCDS33294.1"
                     /db_xref="GeneID:22930"
                     /db_xref="HGNC:HGNC:17063"
                     /db_xref="MIM:602536"
                     /translation="MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSL
                     GKPLEKGIFTSGTWEEKSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQ
                     DLLGMNNDFPPRAHCLVRWYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTG
                     CQVPLFVQIHHKWRRMYVGECQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGC
                     PLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPI
                     SELHLATTWPHLTEGIIVDNDVYSDLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKI
                     CRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIHKLSVSNMVHTAKKKIR
                     KHRGVEESPLNNDVLNTILLFLFPDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKS
                     APSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDL
                     RCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDK
                     EKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHG
                     KLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSD
                     MESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAW
                     ETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHLLPCVIHAAVLKVKEEESL
                     ENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTE
                     KCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEEL
                     KRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMYSVLTKEDFRLAG
                     AFSSDTSFF"
     exon            35..90
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..166
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..299
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..378
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..498
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..664
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..764
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..846
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..915
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..989
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1082
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1252
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1342
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1515
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1570
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1939
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2077
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2305
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2402
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2506
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2622
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2725
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..4891
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3369..3374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="hexamer: AATAAA"
     polyA_site      3391
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="hexamer: GATAAA"
     polyA_site      3620
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
     regulatory      4447..4452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="hexamer: AATAAA"
     polyA_site      4469
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="major polyA site"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
                     /note="hexamer: AATAAA"
     polyA_site      4891
                     /gene="RAB3GAP1"
                     /gene_synonym="MARTS2; P130; RAB3GAP; RAB3GAP130; WARBM1"
ORIGIN      
        1 cccggcgctc ctcaagatgg ctgccgacag tgagcccgaa tccgaggtat ttgagatcac
       61 ggacttcacc actgcctcgg aatgggaaag gtttatttcc aaagttgaag aagtcttgaa
      121 tgactggaaa ctgattggaa actctttggg aaagccactc gaaaagggta tatttacttc
      181 tggcacatgg gaagagaaat cagatgaaat ttcctttgct gacttcaagt tctcagtcac
      241 tcatcattat cttgtacaag agtccactga taaagaagga aaggatgagt tattagagga
      301 tgttgttcca caatctatgc aagatttgct gggtatgaat aatgactttc ctccaagagc
      361 acattgcctg gtaagatggt atgggctacg tgagttcgtg gtgattgccc ctgctgcaca
      421 cagtgacgct gttctcagcg aatctaagtg caaccttctt ctgagttctg tttctattgc
      481 cttgggaaac actggctgtc aggtgccact ctttgtgcaa attcaccaca aatggcgaag
      541 aatgtatgta ggagaatgtc aaggtcctgg tgtacgaact gatttcgaaa tggttcatct
      601 tagaaaagtg ccaaatcagt acactcactt atcaggtctg ctggatatct tcaaatcaaa
      661 gattggatgt cctttaactc cattgcctcc agttagtatt gctattcgat ttacctatgt
      721 acttcaagat tggcagcagt atttttggcc tcagcaacct ccagacatag atgcccttgt
      781 aggaggagaa gttggaggct tggagtttgg caagttacca tttggtgcct gcgaagatcc
      841 tattagtgaa ctccatttag ctactacatg gcctcatctg accgaaggga tcattgtgga
      901 taatgatgtt tattctgatt tggatcctat tcaagctcca cattggtctg ttagagttcg
      961 aaaagctgag aatcctcagt gtttgctagg tgattttgtc actgaatttt ttaaaatttg
     1021 ccgtcgaaag gagtcaactg atgagattct tggacgatct gcatttgagg aagaaggcaa
     1081 agaaactgct gatataactc atgctttgtc aaaattgaca gagccggcat cagttccaat
     1141 tcataaatta tcagtttcaa atatggtaca cactgcaaag aagaaaatcc gaaaacacag
     1201 aggtgtagag gagtcaccgc taaataatga tgttcttaat actattctcc tgttcttatt
     1261 ccctgatgct gtttctgaga aaccattaga tggaactact tcaacagata ataataatcc
     1321 tccatcagag agtgaagact ataatctcta caatcagttc aagtctgcac catctgacag
     1381 tttaacatac aaactggctt tgtgtctctg tatgatcaat ttttaccatg gagggttgaa
     1441 aggagtggca cacctctggc aggaatttgt tcttgaaatg cgtttccgat gggaaaacaa
     1501 ctttctgatt ccaggattag caagtggacc cccagatctg aggtgttgtt tactgcatca
     1561 gaaactacag atgttaaatt gttgtattga aagaaagaag gcacgtgatg aggggaaaaa
     1621 gacaagtgct tcagatgtca ctaatatata tccaggggat gctggaaaag caggagacca
     1681 gttggtgcca gataatctaa aagaaacaga taaggaaaag ggagaggtag gaaaatcttg
     1741 ggattcctgg agtgacagcg aagaagaatt ttttgaatgc ctaagtgata ctgaagaact
     1801 taaaggaaat ggacaagaga gtggcaagaa aggaggacct aaggagatgg caaatttaag
     1861 gccggaagga cggctctatc agcatgggaa acttacactg ctgcataatg gagaacctct
     1921 ctacattcca gtaacccagg aaccagcacc tatgacagaa gatctgctag aagagcagtc
     1981 tgaagtttta gctaaattag gtacatcggc agagggggct caccttcgag cacgcatgca
     2041 gagtgcctgt ctgctctcag atatggagtc ttttaaggca gctaatccag gttgctccct
     2101 ggaagatttt gtgaggtggt attcaccccg ggattatatt gaagaggagg tgattgatga
     2161 aaagggcaat gtggtgctga aaggagaact gagtgcccgg atgaagattc caagcaatat
     2221 gtgggtagaa gcctgggaaa cagctaagcc aattcctgct agaaggcaaa ggagactctt
     2281 tgatgataca cgggaagcag aaaaggtgct gcactatctg gcaatccaga aacctgcaga
     2341 ccttgctcgg cacctgttac cttgtgtgat tcatgcagct gtactcaagg taaaggaaga
     2401 agaaagtctc gaaaacattt cttcagttaa gaagatcata aagcagataa tatcccattc
     2461 cagtaaagtt ttgcacttcc ccaatccaga agacaagaaa ttggaagaaa tcattcacca
     2521 gattactaat gtggaagctc tcattgccag agctcggtca ctaaaagcca agtttggaac
     2581 tgagaaatgt gaacaggagg aggaaaagga agatcttgaa aggtttgtga gttgcctgct
     2641 ggagcagcct gaagtgttag tcaccggtgc aggaagagga catgctggca ggatcattca
     2701 caagctgttt gtgaatgccc agagggctgc agctatgact ccaccagagg aggaattgaa
     2761 gagaatgggc tccccagagg aaagaaggca gaactccgtg tcagacttcc caccccctgc
     2821 tggccgggaa ttcattttgc gcaccactgt gccgcgccct gctccctact ccaaagctct
     2881 gcctcagcgg atgtacagtg ttctcaccaa agaggacttt agacttgcag gtgccttttc
     2941 atcagatact tccttcttct gattcttcta gcattactcg ttggtggctt cagagacagt
     3001 gctgcctcct cctgagggag ggaaggtacc agggagaacc tgggaggtcc tggagagggc
     3061 cctgtccagt tgggtgatca ggaatcaaac cagcatcgga aagacttccc agcaccaagc
     3121 ttgagctgtg tcgtttcgtg gagggggcag cgaggatggg cttgagctgt tgagagattt
     3181 ctgccctaga gatggccttt gtatatgggg gggtggtggg gggacacaaa cacatcagac
     3241 actccgtcct cacactggca ggacggtgtt catcgcattc tcttctgtga ccagcctcta
     3301 ggctagcggc tgcattcgtg gtctgtgcaa acacttcgtg gttctatata tcagcagcaa
     3361 gtgtgcaaaa taaaggacct gttaactcag atttctggat attttggtgg tagcttctag
     3421 tcccagaatc tgtgttttta aaatactaca tgacattctg tctattcaat cacctggtgg
     3481 tcatctttct tgtactaatt aactgttgat gagcattttg gatattctag gagaaagcct
     3541 ataatttcac atagtttctc tttttcatgt aactgtaacc taaatgtatt acttctgata
     3601 aaactatata tcaaatgtca ctgcaaatta gttttatatc tgtcatgtga gatttgtctt
     3661 acttattttt cttttggttg ccatggaagt tatggccctg aaaatcgtct ccctcccctt
     3721 ctcttgctgt acagcatgcg ttctcttttt gtggttgctg gctgggtact gtatttaatg
     3781 aagtagagaa tagcacttgc aaaaatacag tcttggtacc tagagactgt catgcagata
     3841 gtataatttg gtatatgtgc taatgcattg agtagaggat tattttaaca cactattttg
     3901 cttttgtatt ttagttaaaa taatcgatgg ggatgtgtag cccccccgtg tgaggatgac
     3961 atcaccacat ttctagtttc atggagctca agatgtcttg tgtctgtgtg gctagatggc
     4021 ctctgcttgg taatcttatt tttaggccta aaattcccac ttaaatccaa agtaaaaatg
     4081 gttatactga agcataaacc ttgcctgtgt aattttaaaa aattaataga gctgtgcaaa
     4141 ccctgttatt tttgtaaaaa aaaaaaaaaa tacatatcta tatataatat gtgtgtgtgt
     4201 gtgacatatg cacacgtctc tgtgtatgtg aagtagggga ggccctgggg gatgacctcc
     4261 cagcctttat gatgcttttc tctatgctgc tggacttcat tcttactggt ccacgcagat
     4321 gcaggcggcc tgaggccagt gctgtaccaa gtagaagacg gttcctaagg acagagtttg
     4381 tctgttttct aacaaagaaa aattctacaa aggagaggtt gggcgttaca aaggcattgt
     4441 gaatctaata aaaggaaagt gtcgctttct gtggcgtttt ctttcatttt ctcccgctga
     4501 ggcatttcag tctaatttca tgtggttttg tgctgtctca gctctaatgt ttgcagcctg
     4561 ctgagcctaa caaggcagtg gtctcaagaa cattctttgt gcctttttaa agtactccat
     4621 tttattttta tgatagttat gtatttattt cacagatata tttaagtacc cactttgtgt
     4681 caggtacagt acaagcaatg aagataaaac agaaaccaaa acacactccc ttacagggaa
     4741 aactgacacc acgttgccac aaaatgttga gtatagtcaa ctctgctgtg tggatcggag
     4801 ggcctgcatt tatcctacaa ataattgaat gtaatcctac attcatgtat tcattggcag
     4861 tacggagtaa taaatgcagc aatgtcataa a
//
