LOCUS       NM_004283               4240 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB3D, member RAS oncogene family (RAB3D), mRNA.
ACCESSION   NM_004283
VERSION     NM_004283.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4240)
  AUTHORS   Liang,Z., Shi,Y. and Guan,Z.
  TITLE     CircECE1 promotes osteosarcoma progression through regulating RAB3D
            by sponging miR-588
  JOURNAL   J Orthop Surg Res 18 (1), 587 (2023)
   PUBMED   37559140
  REMARK    GeneRIF: CircECE1 promotes osteosarcoma progression through
            regulating RAB3D by sponging miR-588.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4240)
  AUTHORS   Tan,Q., Wu,X., Ji,F., Wu,S. and Yan,L.
  TITLE     [miR-125b-5p inhibits proliferation and migration of osteosarcoma
            cells by negatively regulating RAB3D expression]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (1), 68-75 (2023)
   PUBMED   36856212
  REMARK    GeneRIF: [miR-125b-5p inhibits proliferation and migration of
            osteosarcoma cells by negatively regulating RAB3D expression].
REFERENCE   3  (bases 1 to 4240)
  AUTHORS   Yang,T., Sun,J., Wang,W., Li,D., Yang,X., Jia,A., Ma,Y. and Fan,Z.
  TITLE     Hsa_circ_0006732 regulates colorectal cancer cell proliferation,
            invasion and EMT by miR-127-5p/RAB3D axis
  JOURNAL   Mol Cell Biochem 477 (12), 2751-2760 (2022)
   PUBMED   35616807
  REMARK    GeneRIF: Hsa_circ_0006732 regulates colorectal cancer cell
            proliferation, invasion and EMT by miR-127-5p/RAB3D axis.
REFERENCE   4  (bases 1 to 4240)
  AUTHORS   Lin,X., Zhong,L., Wang,N., Chu,X. and Liu,B.
  TITLE     Hsa_circ_0103232 promotes melanoma cells proliferation and invasion
            via targeting miR-661/RAB3D
  JOURNAL   Cell Cycle 21 (17), 1811-1826 (2022)
   PUBMED   35549813
  REMARK    GeneRIF: Hsa_circ_0103232 promotes melanoma cells proliferation and
            invasion via targeting miR-661/RAB3D.
REFERENCE   5  (bases 1 to 4240)
  AUTHORS   Kat,M., Burgisser,P.E., Janssen,H., De Cuyper,I.M., Conte,I.L.,
            Hume,A.N., Carter,T., Voorberg,J., Margadant,C. and Bierings,R.
  TITLE     GDP/GTP exchange factor MADD drives activation and recruitment of
            secretory Rab GTPases to Weibel-Palade bodies
  JOURNAL   Blood Adv 5 (23), 5116-5127 (2021)
   PUBMED   34551092
  REMARK    GeneRIF: GDP/GTP exchange factor MADD drives activation and
            recruitment of secretory Rab GTPases to Weibel-Palade bodies.
REFERENCE   6  (bases 1 to 4240)
  AUTHORS   Raffaniello,R.D. and Raufman,J.P.
  TITLE     Cytosolic RAB3D is associated with RAB escort protein (REP), not
            RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from
            guinea pig stomach
  JOURNAL   J Cell Biochem 72 (4), 540-548 (1999)
   PUBMED   10022613
REFERENCE   7  (bases 1 to 4240)
  AUTHORS   Nishio,H., Suda,T., Sawada,K., Miyamoto,T., Koike,T. and
            Yamaguchi,Y.
  TITLE     Molecular cloning of cDNA encoding human Rab3D whose expression is
            upregulated with myeloid differentiation
  JOURNAL   Biochim Biophys Acta 1444 (2), 283-290 (1999)
   PUBMED   10023084
REFERENCE   8  (bases 1 to 4240)
  AUTHORS   Chen,X.N., Shi,Z.Y., Korenberg,J.R. and Sehgal,A.
  TITLE     Assignment of the GOV (Glioblastoma overexpressed) gene to human
            chromosome band 19p13.2 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 230-231 (1998)
   PUBMED   10072586
REFERENCE   9  (bases 1 to 4240)
  AUTHORS   Sehgal,A., Keener,C., Boynton,A.L., Young,R.F., Vermeulen,S.S.,
            Yonemura,K.S., Kohler,E.P., Aldape,H.C., Simrell,C.R. and
            Murphy,G.P.
  TITLE     Isolation and characterization of a novel gene from human
            glioblastoma multiforme tumor tissue
  JOURNAL   Int J Cancer 71 (4), 565-572 (1997)
   PUBMED   9178809
REFERENCE   10 (bases 1 to 4240)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA241826.1, BC016471.1, AC011472.7, AF019226.1 and BQ011121.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004283.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016471.1, GQ891464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222120.8/ ENSP00000222120.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA241826.1         12-23
            13-1891             BC016471.1         1-1879
            1892-2585           AC011472.7         121318-122011       c
            2586-4141           AF019226.1         1620-3175
            4142-4240           BQ011121.1         40-138              c
FEATURES             Location/Qualifiers
     source          1..4240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4240
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /note="RAB3D, member RAS oncogene family"
                     /db_xref="GeneID:9545"
                     /db_xref="HGNC:HGNC:9779"
                     /db_xref="MIM:604350"
     exon            1..189
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /inference="alignment:Splign:2.1.0"
     exon            190..478
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..910
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /note="Rab3D upregulated with myeloid differentiation;
                     glioblastoma overexpressed; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="ras-related protein Rab-3D"
                     /protein_id="NP_004274.1"
                     /db_xref="CCDS:CCDS12257.1"
                     /db_xref="GeneID:9545"
                     /db_xref="HGNC:HGNC:9779"
                     /db_xref="MIM:604350"
                     /translation="MASAGDTQAGPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMY
                     DIANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFE
                     FFEASAKENINVKQVFERLVDVICEKMNESLEPSSSSGSNGKGPAVGDAPAPQPSSCS
                     C"
     exon            479..597
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /inference="alignment:Splign:2.1.0"
     exon            598..722
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /inference="alignment:Splign:2.1.0"
     exon            723..4240
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4240
                     /gene="RAB3D"
                     /gene_synonym="D2-2; GOV; RAB16; RAD3D"
                     /note="major polyA site"
ORIGIN      
        1 cttctgggcg gagcccgcgc gggatccggg tggctgcagg ctgctggctt ctgcggctgc
       61 ggggtcgggg tcgcggccag ggccaagccg cagcgagttc acaggcggaa cccctgcagg
      121 cggcgccccc tacgcgaggt cacccctggg aaggagcgca gcccacccgg cccctccgca
      181 tccgagcagg acgcccgtct cctctccctg aggatttcag gtctccctgt cccaggaggc
      241 ttgtgccaag atggcatcag ctggagacac ccaggcaggc ccacgggatg cagcagatca
      301 gaacttcgac tatatgttca aactgctact gataggcaac agcagtgtgg gcaagacttc
      361 cttcctgttc cgatacgcgg acgactcctt cactcccgcc ttcgtcagta ctgtgggcat
      421 cgatttcaag gtcaagaccg tctaccgcca tgacaagagg atcaagctgc agatctggga
      481 cacagcgggc caggagcgct accgcaccat caccacggcc tactaccggg gagccatggg
      541 cttcctgctc atgtatgaca tcgccaatca ggaatccttt gccgctgtgc aggactgggc
      601 cacgcaaatc aagacctact cctgggacaa cgcccaggtc atcctggtgg ggaacaagtg
      661 tgacctggag gacgaacgtg ttgtgcctgc tgaggatggc cggaggctcg ccgacgacct
      721 tggtttcgag ttctttgaag ccagtgccaa ggagaacatc aatgtgaagc aggtcttcga
      781 gcgcctggtg gatgtcatct gcgagaagat gaacgagtcc ctggaaccca gctccagctc
      841 aggcagcaac gggaaaggcc cggccgtggg ggatgctcca gccccccagc ccagcagctg
      901 cagctgctag agatggcccc caacccccca cccacccctc tcctgcctcg gcagggactg
      961 tgatcgaggc gtgagccaca gtggttatct ccaagctcag ggcaatccct tccctcctgt
     1021 caactgctcc ccgactcctg catggctcat tccttcacaa tgtcgccgtg gctgccaggt
     1081 tcctcaggca gccccggtgg gaggctgcgg accatgggga ctcagctctg catggcaggc
     1141 agaggcccag ggacactgac gtgcatgagc ttgctgcttt ccagggtgtg ttgagggtgg
     1201 ccatgggtga cacgtcccac tctttctgat ggaggggcat ccgtggtgcc ttctagctta
     1261 gaaccatttt ccaggtctct tctgggttgg gcaggactga tattcccaag ctggtggaag
     1321 atggttcatc ttcctcgcac agtgtgggtt cttggagttc atccagggaa ggcggcgcct
     1381 ctttctcagg tcctgcaggc tggtctctga gcctgccccc acgaactttc tggattccaa
     1441 ggtgggatgg tgatcccttt gacccctgca gaccctctac ttgcgaaaag cagcattgaa
     1501 gcagcctttt cccattgtag aagggacagg gagtcagatc ccctcaaccc cccggcttca
     1561 gggaccccag aagtgccttc caagcttccc ccaagatcca catcacccac gaccctgcca
     1621 ctgtttttgc tgtgttcacc acatctctga tcctgaagtg aattctggaa ctatggacca
     1681 cattagactg ggcagagatt cgcccaaccc ctagcactcc ggctctgggc tttcggccag
     1741 aagttaatta acctcagagc caggagcctg gggctggggc ctccctccca ggccctgttt
     1801 agctgtttag ctggttgtgt tttaagcaag ttcttgccca atcatgcatc ctgctagaaa
     1861 aggaaatgaa gcaacgttcc cagccaccgc aggcagttgt cggcgacttt ctgatgtaag
     1921 cacctgggct ccgacttgag gggggccctt caagacccaa tgtccatttc ccaatccttg
     1981 tcatcggcag ggcccaggga tgtgacaatt tttgctaatg gaggagtcac ttcttttttt
     2041 ttttttttct ttttgagatg gtctggctct gtcacccagg ctggagtgca gtggtgcaat
     2101 catagctcac cacagcctca aactaggggt cacttctaag ggatgctggg ggttgggcgg
     2161 aaggggtgag gaggtaggat tgagtaactt gctgtcactg cttgtacttt gtagacagcc
     2221 tgagagtggc aggaccttat gtgaatgggg gggatggact gtgatcagtg ccggggagtc
     2281 tctgaagctg gggtccccac ctccaggggc ttctgctcag aggttacgtg tgcagtttga
     2341 agatgtacat cttgacctcc ggtttagagg cactttctgc ccatcagatt ccaaactcta
     2401 ggggcgcagc accttttctt tgctcccaaa caccaaccaa caccccttca caggaccagc
     2461 actgttagga tggctaagtg gatgttttat gttcccacgt ccctgactct gtttcagagg
     2521 ttgtgtctgc tctcccagcc cctgaagcca aaatgacttc ctgcagcttt catgagctca
     2581 gcctcttccc tggggtatgt gtgaggggga aagcctggtt caagtttaga tttatttcta
     2641 gggagccctg gtttcttcat accagaggct acccttagaa ctttggagtg gggtatcttt
     2701 ttttcatttg tttttttgat acagagtctc gctctattgc ccaggctgga gtgcggtggc
     2761 acaatctcag cttactgcaa cctccacctc cagggttcaa gcgattctcc tgcctcagcc
     2821 tcccgagtag ctggcattac aggcacctgc caccacaccc ggctaaattt tgtattttta
     2881 gtagagaagg ggtttcacca tgttggtgag gcttgtctca aactgacttc aagtgatcca
     2941 cttgcttcgg cctcccaaag tgctgggatt acaggcgtga gccatcacgc ccagccgagg
     3001 gtatctttta taccaacaaa ttagatgact gaggtgtaat ggacaaatcc tatgcacaaa
     3061 gtgagggtat ctgaatatgt gggcgggagt caaaaatttt tagctacttt aacactaaag
     3121 tcaaactaaa gtagcttcaa aaagacttct caagatgcag tatggcctgc tgaggttttt
     3181 ttgttttttt tttttttaag acagagagtc gctcgtcgcc caggccgcag tgcagtagca
     3241 tgatctcagc tcactgcaac ctccacctcc cgggttcaag cgattctcct gtctcagcct
     3301 cctaagtagc tgggactaca ggcacctgcc accacgccca tctaagtttt gcatttttag
     3361 tagcgacggt ttcaccttgt tggccaggct ggttttgttg gccaattgtc tctaaactgc
     3421 tgtcaaaaaa aggaatggat cagattgtct tgaatagggc agagctaacc tgtaatcacc
     3481 tgtgtgatga gaaacagctt tgactgcatt ttactcctga cctggcctaa gctttctgtt
     3541 tacataagat ttttcaagaa ttcaacttca agtagcagcc gagagagctg cctcaggatt
     3601 ctctcaaaaa ctgggaataa tatgggaaca tttgtttctt ctaaaaataa ggcaaatgtt
     3661 acattgaatg atttgggggg tgaggtttaa ttggaaatgg tctctgggga ctgaaaactg
     3721 atgtttttgc agattacctc agggaaacgg aggtttgttg agtttacaga cacattaaac
     3781 caaaggccgt gggaaaaccc ctctccagct ccaggggatt ggtcaggacc acccactaac
     3841 cagtgccttc cttcttaaca ttcactttta gcagcttgtg tttattttac atgggcagtt
     3901 ttgatgggaa attgccatga ccacaggggt ttggagttct gctttttttt tttcttcttc
     3961 tttttcgggg gactggggga ctcctcccaa gatcacattt tagcatcttt ctctcctact
     4021 ccatttagaa aaataagtaa caggtgaaat gtggtctcag tgttaacggg ataattctgc
     4081 taccggctcc tccctgatga ttctgaaata cactactgaa cgagctctgg ctggtccttt
     4141 ctatcctgga tgtggttctt ctgtgtagca attccttgat gtccagtttg gaaagatgta
     4201 ctcttctcaa caagaaaaac ttaaatccgt cgtgcccaaa
//
