LOCUS       NM_002867              12780 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens RAB3B, member RAS oncogene family (RAB3B), mRNA.
ACCESSION   NM_002867
VERSION     NM_002867.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12780)
  AUTHORS   Yao,G., Yu,S., Hou,F., Xiao,Z., Li,G., Ji,X. and Wang,J.
  TITLE     Rab3B enhances the stabilization of DDX6 to promote lung
            adenocarcinoma aggressiveness
  JOURNAL   Mol Med 30 (1), 75 (2024)
   PUBMED   38834947
  REMARK    GeneRIF: Rab3B enhances the stabilization of DDX6 to promote lung
            adenocarcinoma aggressiveness.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12780)
  AUTHORS   Xu,J., Xue,B., Gong,M., Ling,L., Nie,S., Li,F., Wang,M., Fang,M.,
            Chen,C., Liu,Q. and Han,Y.
  TITLE     circ_0000337 Promotes the Progression of Cervical Cancer by
            miR-155-5p/RAB3B Axis
  JOURNAL   Biochem Genet 62 (3), 2195-2209 (2024)
   PUBMED   37882923
  REMARK    GeneRIF: circ_0000337 Promotes the Progression of Cervical Cancer
            by miR-155-5p/RAB3B Axis.
REFERENCE   3  (bases 1 to 12780)
  AUTHORS   Liu,X.S., Chen,Y.L., Chen,Y.X., Wu,R.M., Tan,F., Wang,Y.L.,
            Liu,Z.Y., Gao,Y. and Pei,Z.J.
  TITLE     Pan-cancer analysis reveals correlation between RAB3B expression
            and tumor heterogeneity, immune microenvironment, and prognosis in
            multiple cancers
  JOURNAL   Sci Rep 14 (1), 9881 (2024)
   PUBMED   38688977
  REMARK    GeneRIF: Pan-cancer analysis reveals correlation between RAB3B
            expression and tumor heterogeneity, immune microenvironment, and
            prognosis in multiple cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12780)
  AUTHORS   Hu,J., Wang,Q., Fan,X., Zhen,J., Wang,C., Chen,H., Liu,Y., Zhou,P.,
            Zhang,T., Huang,T., Wang,R. and Lv,Z.
  TITLE     Long noncoding RNA ENST00000436340 promotes podocyte injury in
            diabetic kidney disease by facilitating the association of PTBP1
            with RAB3B
  JOURNAL   Cell Death Dis 14 (2), 130 (2023)
   PUBMED   36792603
  REMARK    GeneRIF: Long noncoding RNA ENST00000436340 promotes podocyte
            injury in diabetic kidney disease by facilitating the association
            of PTBP1 with RAB3B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12780)
  AUTHORS   Tsunedomi,R., Yoshimura,K., Kimura,Y., Nishiyama,M., Fujiwara,N.,
            Matsukuma,S., Kanekiyo,S., Matsui,H., Shindo,Y., Watanabe,Y.,
            Tokumitsu,Y., Yoshida,S., Iida,M., Suzuki,N., Takeda,S., Ioka,T.,
            Hazama,S. and Nagano,H.
  TITLE     Elevated expression of RAB3B plays important roles in
            chemoresistance and metastatic potential of hepatoma cells
  JOURNAL   BMC Cancer 22 (1), 260 (2022)
   PUBMED   35277124
  REMARK    GeneRIF: Elevated expression of RAB3B plays important roles in
            chemoresistance and metastatic potential of hepatoma cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12780)
  AUTHORS   Weber,E., Jilling,T. and Kirk,K.L.
  TITLE     Distinct functional properties of Rab3A and Rab3B in PC12
            neuroendocrine cells
  JOURNAL   J Biol Chem 271 (12), 6963-6971 (1996)
   PUBMED   8636125
REFERENCE   7  (bases 1 to 12780)
  AUTHORS   Weber,E., Berta,G., Tousson,A., St John,P., Green,M.W.,
            Gopalokrishnan,U., Jilling,T., Sorscher,E.J., Elton,T.S.,
            Abrahamson,D.R. et al.
  TITLE     Expression and polarized targeting of a rab3 isoform in epithelial
            cells
  JOURNAL   J Cell Biol 125 (3), 583-594 (1994)
   PUBMED   8175882
REFERENCE   8  (bases 1 to 12780)
  AUTHORS   Rousseau-Merck,M.F., Zahraoui,A., Touchot,N., Tavitian,A. and
            Berger,R.
  TITLE     Chromosome assignment of four RAS-related RAB genes
  JOURNAL   Hum Genet 86 (4), 350-354 (1991)
   PUBMED   1999336
REFERENCE   9  (bases 1 to 12780)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   10 (bases 1 to 12780)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU119030.1, BC005035.1 and AL589663.19.
            
            On Nov 22, 2018 this sequence version replaced NM_002867.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.81310.1,
                                           SRR1803612.264224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371655.4/ ENSP00000360718.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AU119030.1         65-88
            25-1576             BC005035.1         1-1552
            1577-12780          AL589663.19        77586-88789         c
FEATURES             Location/Qualifiers
     source          1..12780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..12780
                     /gene="RAB3B"
                     /note="RAB3B, member RAS oncogene family"
                     /db_xref="GeneID:5865"
                     /db_xref="HGNC:HGNC:9778"
                     /db_xref="MIM:179510"
     exon            1..149
                     /gene="RAB3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..809
                     /gene="RAB3B"
                     /note="brain antigen RAB3B"
                     /codon_start=1
                     /product="ras-related protein Rab-3B"
                     /protein_id="NP_002858.2"
                     /db_xref="CCDS:CCDS560.1"
                     /db_xref="GeneID:5865"
                     /db_xref="HGNC:HGNC:9778"
                     /db_xref="MIM:179510"
                     /translation="MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYAD
                     DTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMY
                     DITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFD
                     FFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCS
                     C"
     exon            150..377
                     /gene="RAB3B"
                     /inference="alignment:Splign:2.1.0"
     exon            378..496
                     /gene="RAB3B"
                     /inference="alignment:Splign:2.1.0"
     exon            497..621
                     /gene="RAB3B"
                     /inference="alignment:Splign:2.1.0"
     exon            622..12780
                     /gene="RAB3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12759..12764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3B"
                     /note="hexamer: ATTAAA"
     polyA_site      12780
                     /gene="RAB3B"
                     /note="major polyA site"
ORIGIN      
        1 agccctcagg cgccactgtg aggacctgac cggaccagac catcccgcag cgccccgccc
       61 cggccccctc cgcgccctcc cgacgccagg tcctgccgtc ccgccgaccg tccgggagcg
      121 aacccgtcgt cccgcactcg gagtccgcga tggcttcagt gacagatggt aaaactggag
      181 tcaaagatgc ctctgaccag aattttgact acatgtttaa actgcttatc attggcaaca
      241 gcagtgttgg caagacctcc ttcctcttcc gctatgctga tgacacgttc accccagcct
      301 tcgttagcac cgtgggcatc gacttcaagg tgaagacagt ctaccgtcac gagaagcggg
      361 tgaaactgca gatctgggac acagctgggc aggagcggta ccggaccatc acaacagcct
      421 attaccgtgg ggccatgggc ttcattctga tgtatgacat caccaatgaa gagtccttca
      481 atgctgtcca agactgggct actcagatca agacctactc ctgggacaat gcacaagtta
      541 ttctggtggg gaacaagtgt gacatggagg aagagagggt tgttcccact gagaagggcc
      601 agctccttgc agagcagctt gggtttgatt tctttgaagc cagtgcaaag gagaacatca
      661 gtgtaaggca ggcctttgag cgcctggtgg atgccatttg tgacaagatg tctgattcgc
      721 tggacacaga cccgtcgatg ctgggctcct ccaagaacac gcgtctctcg gacaccccac
      781 cgctgctgca gcagaactgc tcatgctagg caaggcccac cttcctgacc tcccctcatt
      841 gtggccccac acccagtctg cttctccctg ttacacactg tccgctctca gcccactctc
      901 cctgttacac actgcccaca ctcagagcaa gatgagttgc tgctattctt tgcctgcccc
      961 tggggttctc tgcagatggt cccagtaata gatactcagc actagactaa cataacaggt
     1021 cactacacgg gtgcagaatc actttacaaa agaagactct gttttacgaa ggggattcac
     1081 tacagggact tagagaacag tctcttttct gcctttaaaa tgagagttcc tccatttacc
     1141 aaaatttgac acgcacacat tcttcagggg catgccaatt gcgtaaagtg aggctcgcct
     1201 gcatagctaa tcctgttaaa gacaacttct caaagcacaa cgtgcttgtt tcctatcggg
     1261 ctccctgcgg ggctttctct cactacaagt caagcttggg ctctcaaagc cctgcgcctg
     1321 ttaccacgga tgcccacagg gcctgggcag ttgctgtggc gacaggaaga gctaatcttc
     1381 agagagctca gactctctaa tgatgctgaa ggagcaaagg ctgagtcaga aacacactta
     1441 agagaaaagg attggccggg cgcggtggct cacgcctgta atcccagcac tttgggaggc
     1501 cgaggcgggt ggatcatgag gtcaggagat cgagaccatc ctggctaaca aggtgaaacc
     1561 ccgtctctac taaaaataca aaaaattagc cgggcgcggt ggcgggcgcc tgtagtccca
     1621 gctactcggg aggctgaggc aggagaatgg cgtgaacccg ggaagcggag cttgcagtga
     1681 gccgagattg cgccactgca gtccgcagtc cggcctgggc gacagagcga gactccgtct
     1741 caaaaaaaaa aaaaaaaaaa aaaagagaaa aggattatcc cctacaaaat gtcagaggtt
     1801 cctgctatat gaaagagcaa gtaggtatgc tcaagaaaga caaacagaga aaaagagaaa
     1861 caggcaagat caagaaacag atcatgagtt tctgattttg ctgctttcca gttggttctt
     1921 aactgtggga acttagtgaa attggttatt agttcttaga ctcctagaac ctgaggattt
     1981 tagatttgac gggatgccca aatttaccta gtctgactag tcagttctaa ccttcctttt
     2041 tctgacaagt gactgtcaag cctaacaatc aaatctcttt cttttaaagc acaccttcta
     2101 ggcagggaca ggagctcatt ttccacacca tctttgtcaa ctctcataga aagttttcct
     2161 tgtatcgagc tcaaatctgc ctcctggaaa ttcttcttct tcttccctcc ctgttggtac
     2221 cagctctgct gtcagagact tcacagtctg tgctccctct gccctgtgac gtcttcagac
     2281 tatttgagaa caggaatcat gactcctggg acttgccttt tctctaggtc aaatacctct
     2341 ataattccat ctgctgttct tcatagggtc ttctccctat cctgcccttt tcctccaatc
     2401 catcttttaa ctgctcttga gcagtctaac tgagaagtat gattcaaagc aaaataaatc
     2461 ttaaggtggc atgactctga aaaaattgag aaaattgaac tcagagatcc cgatcccaac
     2521 ccctttctcc tgggagtgaa accttagttt ctaccagaga gtgtgggaaa ccacttctgg
     2581 tggaagcccc ttaattaaat acctgaggaa aaaaataaaa gaaactcaga gaccagaata
     2641 aattagctca ttattctagc ttgcttggcc acagggacat attttgtttt ggctgaaata
     2701 atgacatgga actggcagtg attccagaaa acctttcttc tctatcatgg cctgaatcct
     2761 cagccacctc aaaagtcagc gggcaggagg agtctctcgc cagttttctt ttcatttcaa
     2821 atgaggctca ttgtcctaga aaagtaatta actagcaacc agtccaatga ctaaataaaa
     2881 ggaccatcca gctgtggctc acacctgtaa tcccagcact ttggaaagcc aaggcaggag
     2941 gaacacttga ggccaggagt ttgagaccag cctgggcaat gtggtcaaat tctatcccta
     3001 caaaaaaaaa aattagccag atgtgatggt gcatgcctgt agtcccagct acttgggagg
     3061 ctgaggcagg aggattgctt gagcccaaga atttgaggtt gcagtgagct gtaattatgc
     3121 cactgcattc cagtctgggt gacagagtaa gaataagacc ctgtctctct gtctctcttt
     3181 ctctcttttt ttttttaaag gagtcagctc tacaaagatg ttgctttctt tgatgcaatg
     3241 cagagagcag agctttggac ttggaatcag gagacccgga ctctgtcatt aaatcaactg
     3301 tgactctggg ccagttactt tccacttttg agtcttgatt tcctacttat aaaatgaggg
     3361 agcttatttg gatgatcttt aaggtctctt ttggcactaa taactcggtg tctctttttt
     3421 ttcaccttca ccatttcagt tgatccacca aacaaacctg agagatcagg attggcatcc
     3481 aagagttgtc tcggccaact ctgatgtcat gcttactctg tactagacat tgttccaagc
     3541 attttacgtg cattaactca tttatcttcc caacatcttg tgagggaggc actatagtga
     3601 gcctcatttg aagatgagga aacaaaggta caaagaggtt ctagctggac ctctaaagtc
     3661 acataataag taagtggtag agctggagtt cacatccagg cagtaggctc caaggtctgt
     3721 gctcttaacc acattctggg ctgcatcttt tatagacaaa ctatgatcca gagagattac
     3781 gagacttgga tcacatacca agagagtgtt aaagccacat taggattcaa ttccagggcc
     3841 atcagattcc aagtccactg gagaaaagat gtatatctct aatctgttaa caaattgctc
     3901 aactactcag actaatccca ggtgatggat gtctaatgct caggaaaggc gagtcagtct
     3961 ctgaggcaac agatcccatg ggcctgggta gaaaatgccc agtgcttccc agtcccaagt
     4021 gctggctttc cctgtatctg cctctgccag gcaacactta tcaggctccc aatcagcagg
     4081 agcctccatg ctccactttg aacagcctct atgctccagc aatggggcat ttgtgaagag
     4141 tgacttgatt aacttttctg accatgggta taatacagtt gcttcagagg gcagtggttc
     4201 tgggtgtgat ttttacactg taacattgta tacagtgtca tggataatta ctattttttt
     4261 ctggtcatta acactcacct actctagtac taggatttca gaccaaggtc ctcatgacgc
     4321 ctggatattt tagtatctat atccaataat cttttctctc ctactgaata tccaggcaaa
     4381 gatgaaatcg ttttctttaa aactgtcaaa ttctgtaaaa ctcaggagcc agttcaaggg
     4441 aacaagcatc ttcacaatag atggaatcaa gagttaaatg ttatagtggc aagcttgtct
     4501 actgggcaac agacaaccag acctgcttgt gagatggcag ctccccagcc ctgctctgtg
     4561 acctcatttc tgtcaaatga aaggcagcag cttccagctg attgcagcat agtgttcatc
     4621 aatcacagta atagcgcaat tagccaccaa ggttcaagct gtgtaatatg tgttagtggc
     4681 aacttgtcct ggatttaatc ttcctcaaca atccaaataa aatatttaaa aactcttgac
     4741 ttctggctgg gcgcagcagc tcatgcctgt aatcccagca ctttgggagg ccgaggtggg
     4801 cagatcacct gaggtcagga gttcaagacc agcctgggca acatggtgaa acccccatct
     4861 ctactaaaaa tacaaaaatt agccaggcgt ggtggtgggc acctgaaatc cctactcagg
     4921 aggctgaggc agagaatcgc ttgaacctgg gaggcagagg ttgcagtgag ccgagatcgt
     4981 gccactgcac ttcagcctgg gtgacagagc gagactccat ctcaaaacaa aacaagcaaa
     5041 caaacaacaa caacaaaaaa cacctcttga cttctaaaga cgcaaaagtg gccaaaagtg
     5101 caatacagta ttgtgtttat ttacatctat tttaaatgca tgtgtatctg taaatacaaa
     5161 gtgattcgtg actcattgtc tcctcagtct atagcattat taacttctag gagcagcagt
     5221 ggagtagagt gtactgaatg gtcacagact catcgattat cagatctgga aaggagctta
     5281 gagaagatct gttccaggct cctattttat agaagggaag gttgacatcc aaagaatgga
     5341 aggaaatctc ctaattattc tgagagtatc acagtgatgg agccaggact aggtcctgga
     5401 tcacctctaa gaagacactt agctatttga ctatcgacta gggcctagca ttattaagca
     5461 ctagataaat acagatgaaa aaaaaaatga tccctgcctg caaggtccta tgatctaatg
     5521 gagatgctgt ttctaaaata ttattatccc aatttggcag tcaaggaaac agccctggaa
     5581 aagttaacat gctcaagtca cccactagca tcatttgaac cctcctctgt ctgactcatg
     5641 ctctttcaaa tttttttctt cagattgtct tagcagaagg gtagatggga tataccctct
     5701 ggtagtacca ggctcccaag gattcttaga gttaaataac ctcagttaat taaatagcca
     5761 caattgcttg gtgaccgaag ccttataaca tccacagaat aagaccattc tccagacctg
     5821 actccccaac tcatatcacc tgctcctgcc ggccactaag ctccttgctt ggatatcgag
     5881 ttttctggag tatcctgagg aatgtttgtt tgactttgtt tgccaacagt ttaggggaag
     5941 gggaaagaac tacaataacc agtgtcctgg gatctcattg atttcagatt ccctgcccca
     6001 agcctacacc caattacctg ccatagttgg ggaatcaagt agcatcctgt ggctggaagt
     6061 aaatgcaaaa cactagtccg tgagatataa atactgttaa atgatggttt tttaaggtcc
     6121 tgatccatta tatgaagtag acaaaattca aatttattta ttcatttatt ttctcaacaa
     6181 atgaatatat attatgtgcc aggatacaag tagtggcaaa ttagacacag ttcttgcttt
     6241 catgaaacgt atagcttcat gatttagtat agacattgtc aaatcatcac ccaaatataa
     6301 ttacaaagta ctctaaagga aaggcacgtg atgctgtgag aacactcaac tgggaaaccg
     6361 gaatcacctt tgagaaactg tttcaggggc tcttggaaga gtctactgct cccaaatatc
     6421 tctgctaccc actggccatt gctttacatt cctcaactaa gctttcacct tttagtacta
     6481 acctttgatg actgatcaaa tacaaatgcc ccaagaagac tgaggatagg agaaagaata
     6541 tctctacctg tgaaacattg ttagactgcc tggctaggag ttcattgttg ttttctgaag
     6601 gacgtaacca accactccaa aacttacagg cttaaaacaa caaacatgta tcatttctta
     6661 tgattctgtg ggttggctgg gtggttcttc tggctgaggc aggatggtct aggatagcta
     6721 catccacatg tctggggtcc cagctgagat gactggggct gttgaggcct ttctccctgt
     6781 ggtgtcatcc tccagaaggc tgcccagatt tgtccatatg gtagcaggag tttcctcgaa
     6841 gcaagagagg gcaagatcca acacagaagc acttttcaag ctctgtttcc atcacatttg
     6901 ccaatgtctc actgatgaac acaagttcca tggccaagtc cagttttaag aaatggagaa
     6961 atagggcttg gctcagtggc tcatgtctgt aatcccagca ctttgggagg ccaaggcatg
     7021 cggatcattt gaggtcagga gttccagacc agcctggcca acatggtgaa aacccatctc
     7081 tactaaaaat acaaaaatta gctgggtgtg gtggcgggca tctgtaatcc cagctatttg
     7141 ggaggctgaa gcacaagaat tgcttgaacc caggaggagg aggttgcaat gagcctaaat
     7201 cgcaccactg cacttcagcc tgggcgatag agccagactc agtctcaaaa aaaaaaaagg
     7261 ggagggggaa atagatgcca tctctttatg ggaggagcta caaaatatgg tgaccaattt
     7321 ttcaatctac cacaggaagc accctcagtc ctctgaaact aagtctggta gatgtcctgg
     7381 ggtcttaaaa catggctccg atgatatcac caaagacaag tggcaaaact gtatagggca
     7441 gggcagtctt atcatttgtt taatagtgat ccaaaggatt tactttggag gaatcaagac
     7501 actcgagatg aagaagtttt gatgcttgtt aaacagtcca tttggatacc tcttagctat
     7561 ccccgaggga tgaatctgac ttctcatttc acaggattca ccgtagataa tggttgtaat
     7621 tcctaccgga agttcctggc cagaagccca gcagaaagat tcagtatata tagaaaagat
     7681 ggctccaaga acagttgggc cttctgttct aactgtactt ccttctttga tgtactcgtc
     7741 tagtcccgag gctttagatg ccaagtcttt gataataacg tgtatctaag tgcctactgg
     7801 acattttcat gtctcaaact taacatgtcc aaattgaaac tcttgattct gcccccaaac
     7861 ttgtttgaac cccagtcttc acagaaaact catccttaat tctttgattt ttctcttttt
     7921 ctcagcctcc ttgtctaatc tagcagcaga tcctagggtt ttacttctaa atatatctca
     7981 aatctgatca tttttctcca ttttcattgg catgaccttg gtccaggcca ccattgtttt
     8041 ctgccctaga gagctaccac agagttccta acatttccct acttacgtaa ttactccact
     8101 ctagtccatt ctgtctcaca ggagtaacat tttttatata tatatatata tatatatata
     8161 tatatatata tatatatata tttttttttt tttaatagag acggtcttgc tatgttgccc
     8221 aagctggttt caaattctgg cctcaagcga tcctcttgcc ttggcctcct gagtcactag
     8281 gattgtacgt atgagccacc gcatccagcc tcaatggcaa tctcttaaaa atctaaataa
     8341 atgaacggct cagtaacact gaggtttact tcacacaaaa acaatccaaa ccttggcaag
     8401 acggtgaaac cctgtctcta caaaaaatac aaaaaattaa ctgggcaaag tagcctgcac
     8461 ctatagtccc agctacttgg gaggctgagg tgggaggatc gattgagccc tggaggtcaa
     8521 gaatacagtg agccatagcc atgattgtac actgtgccac tccagcctgg gtgacagagc
     8581 aagaccctgt ccccctctca aaaaaaaaaa aaaaagaaag aaagaaagaa aaaaaagaag
     8641 aaaaggaaag aaatgaagag aattcagaga cttccattat tattaatacc tattttattg
     8701 attctgtttc tagccctgag tccgctccta acttgctata ggatctctgg taaatcattt
     8761 cctgtaataa gcagctgtca cctctctcct tgtttcttcc agaaatagta atctcttctt
     8821 tagtagtact actactccct aacccaaacc aggtgattct agtgaagact gtcaataaac
     8881 ggagcatgtg atcaagcagg gcccatcaga atccttccct aagattttta taaaaagctg
     8941 gacctattct ttttccattt gagtggcaaa tatttgaaga tatgaggtct aaagctgtga
     9001 tggcttattc tccatccctg tgtaaattct ggtctatagt aagcgaaaac aaggccatta
     9061 ggcagagggc agcagagaca taaggtgaga aagagtgtgg tctctggttt tctagaccct
     9121 gattctggtt tggaggcttg gctgatcacc tcttcctttg attctgatag aaagctcaat
     9181 gtatctttct aataaaaccc ccctttgctt tgcttgttgg agttaggttc ttatcccttg
     9241 caaccaaaaa tatattgtct cttcttttgt tctcagtttt ctcatttata tatccttcta
     9301 gctccaaagc acagaaattc taaaacaaac aaacaaacaa acaaaaacaa acaaaaaaaa
     9361 cctgggtcat tcagaaaatc ccactgatat agactttctg atccagaatg tataatctga
     9421 aaagaagcct accctcgtct ccatcctctc ttcttgtacc tgaaggaacg aagaagaggg
     9481 atttctcaag gtgagaagca gttctccatg gacactgatg acagcacagg caaagtttcc
     9541 tatgactagg gatcactgtc cacacagagt ctggcttccc aggtatccag caggtagaca
     9601 aaacagctaa ctccactgcc actcctttct ccacatccgt tcctatttct cagccatctc
     9661 agtgacatcc gccatcttga gagtcaacta ctgactggac tgagttgtgt ggtatatgct
     9721 tctgtttact tctcttctgt cttttttaag tggccaaata gcaaacgctt aaataggaaa
     9781 tctctgggag acttgaataa aagactttgc ttggtagaaa atcatgtcac agaaaggcta
     9841 atagacagca aagtaaatca gcaagtccct gagcagtagg attaggattc ctgtctcctt
     9901 tcagattcaa atgcatctgt ttctggggtt aacagtggac tgttaagagg ctgtgcagct
     9961 tgggttaagt cattcttatc tctgggcttc aggagcttag accagatagt ttctacaggc
    10021 tctcttggtg ctgatgcctt gggattctgt ggctgttttc tgtaagatct gcaaggggga
    10081 aacaggattt tggcagcaat cctttcatta ctaaagcttc ctttcttttc gggtacagtg
    10141 aaaagagcca aggctgtgtg accccctcat cacttagcca ggcgtatggt cctggtttct
    10201 gaggctgcca gaaagcatct tagcaatttg tgtttggatg gtccatgcct gactattcta
    10261 ggctggaggt tcctaaagag taacaagagg aagagaaaca agaatctctg acacttgttg
    10321 agaatagagc acagtcccat ttgtttgaaa agagacacca ggcagccatg tttatgtgcc
    10381 agaaatgcat tccacctcaa ggaggactta atttatggac ccgtgtgtgc caggctgagc
    10441 tgggcaagat ctttctcagg acaaactctg ccatgcagct aaaagcctgg aaactaaagg
    10501 atttcatgta gtaaactatc ttccaacccc tgtagacatc agaccacagg atgaggtttc
    10561 agaaggtcat aaggcagaat agttaagcct acagggctta cagtctgaca gacctgggtt
    10621 cagttcttgg gtcttcatca ctagttttgt gacttcggga agatgactcc cggagcctca
    10681 gtgagcctca gttacttcat atgtaaatga agtaatacta tctacttcac aaggctgttg
    10741 aaaggattaa atggagaatg ggtgtaaaac ccttagtgca gtgccgtgca cacacagtag
    10801 atgccgaacg tgtgatgttg gcactacaca atgtgtaatc ccaatcaggc agagctaggc
    10861 aggcaaatct aatccaggat ctttgtaagg ggactgagaa ccagagactg gagaaagcca
    10921 gtgtaaacac catgagcaaa ggagcaagag aaggggcatt gtgtaagtag gagatggagc
    10981 ttgaacttac taagtggatc agggtagaag aatccagtca ggaccaaggg aggagagtcc
    11041 aggaaaatgc catgagcagc tctgtagcat gaccttgttg ggctgggtta aagtagggtc
    11101 tgccaccagt catgtgacag aaaggtacct catgcacttc ctccttcccc cagaaatcag
    11161 cctccaggag tgaggaatga gcccagaatg agagtttaga gtgctccaga gcctttgtta
    11221 gaggtgccct ccgacattca gaaaaccagg attccagaga cctgggtttg agtcctgact
    11281 ttgcagcata ctaactgtgt gatcttgaac caacatattt tcacctaatg aggctgacaa
    11341 tcttccctac ttcacaaaat agttatgaga gtcaaataaa agtacatttt agaaagtgaa
    11401 atgctgtgga catttaaggt ggagccactg tgagagtcta gggggataga tggtattcgt
    11461 ctcagaatga aacgaataca cccctctcag agccctttcc aaggatcccc tccttctttc
    11521 agctccttcc ctccacctca atacacactc ctgtcccagg aacctaacct catctagaaa
    11581 taccagggcc agcatgcctt acacctagag gtttggttgg cttcagagaa acttctggag
    11641 gctaaaagca gccaagaaga atcagccact acatgctggg cctggatgaa cagagcagtg
    11701 agctgtgatg gggctggggc tggggcccag gaggagcagg caggagagtt tgtatgcacc
    11761 gtgattcaaa tattataaca aaaatcatcg atcatgtgtt aggcacttta cagttcccaa
    11821 agcactttcc catccatgcc ctgatgatct ttgacacaac actgtgatgt gggttttatt
    11881 atttccagta cagatgagga agactgaggc ctgcatcagt gaagcaacct atccaagact
    11941 acatagagaa ggcagtaaat ggcagggtta gtctcagaac aggggagggt ctgttccccc
    12001 cgcagtgggc agtcctaatt ctgaacttca cctatctggg ggtgatagag gggaacaaga
    12061 ggaagcctgc tgaagagaaa acctaaacat ctgttttgtc tacgtatgac ttcctctgct
    12121 tgtgggagag aaggaaggaa aggaacacat tgttgtcagc cccacaaccc caacagaatt
    12181 aaaccctgga gcaggttgaa cagcagaggc ttccctcaga tcaaggagcc aggagcagat
    12241 gatctatctc tgtggccaca cagagagatg tcaccttatg caatttgcat atcatattca
    12301 attcccccaa ctgctctttc taatttattc aactggggac caggctggtc tcatgccaac
    12361 ctaggagatg taccatagca gtatgagcag aattcctcag gaggaacaat tagcaaaaac
    12421 tgcagttgcc tctcgatagg cctgagcaga gagaggaaca atagctctca cgtctctcct
    12481 catcagattc taactaagca gatgttctca tgcttttttc ttcttcctat gttctgtata
    12541 ctgacacctc ttctcagtgg catatgaaat atgaaatgtc atgtgttgtg agtttgtata
    12601 aatataaagg aatatatata cacagtagca aaagagaaga tctcatttac aaatatctat
    12661 ggtgtttcct tgttctgtgt tgatctgttt tattgataca aactgaattt tcttaatgta
    12721 tcttctatct ctattatagt ggcaatgatg gtatatgcat taaagttctt ctgaattgtg
//
