LOCUS       NM_002866               1496 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB3A, member RAS oncogene family (RAB3A), mRNA.
ACCESSION   NM_002866
VERSION     NM_002866.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Dou,D., Aiken,J. and Holzbaur,E.L.F.
  TITLE     RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of
            synaptic vesicle precursors
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38512027
  REMARK    GeneRIF: RAB3 phosphorylation by pathogenic LRRK2 impairs
            trafficking of synaptic vesicle precursors.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Lv,G., Ko,M.S., Das,T. and Eliezer,D.
  TITLE     Molecular and functional interactions of alpha-synuclein with Rab3a
  JOURNAL   J Biol Chem 298 (9), 102239 (2022)
   PUBMED   35809645
  REMARK    GeneRIF: Molecular and functional interactions of alpha-synuclein
            with Rab3a.
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Dolce,L.G., Ohbayashi,N., Silva,D.F.C.D., Ferrari,A.J.R.,
            Pirolla,R.A.S., Schwarzer,A.C.A.P., Zanphorlin,L.M., Cabral,L.,
            Fioramonte,M., Ramos,C.H.I., Gozzo,F.C., Fukuda,M., Giuseppe,P.O.
            and Murakami,M.T.
  TITLE     Unveiling the interaction between the molecular motor Myosin Vc and
            the small GTPase Rab3A
  JOURNAL   J Proteomics 212, 103549 (2020)
   PUBMED   31698103
  REMARK    GeneRIF: Unveiling the interaction between the molecular motor
            Myosin Vc and the small GTPase Rab3A.
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Khosravi-Far,R., Lutz,R.J., Cox,A.D., Conroy,L., Bourne,J.R.,
            Sinensky,M., Balch,W.E., Buss,J.E. and Der,C.J.
  TITLE     Isoprenoid modification of rab proteins terminating in CC or CXC
            motifs
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6264-6268 (1991)
   PUBMED   1648736
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Rousseau-Merck,M.F., Zahraoui,A., Bernheim,A., Touchot,N.,
            Miglierina,R., Tavitian,A. and Berger,R.
  TITLE     Chromosome mapping of the human ras-related rab3A gene to 19p13.2
  JOURNAL   Genomics 5 (4), 694-698 (1989)
   PUBMED   2687157
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Araki,W., Ohno,K., Matsunaga,K., Nakamura,H., Sugimoto,C. and
            Shimada,T.
  TITLE     [Two sisters with pseudoidiopathic hypoparathyroidism presenting
            extensive intracranial calcification]
  JOURNAL   Nihon Naika Gakkai Zasshi 78 (1), 81-82 (1989)
   PUBMED   2732579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB497194.1, BC011782.2, BM717329.1 and AC068499.1.
            
            On May 17, 2019 this sequence version replaced NM_002866.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.406746.1,
                                           SRR3476690.1020029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2155550
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222256.9/ ENSP00000222256.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               DB497194.1         33-285
            254-1104            BC011782.2         241-1091
            1105-1106           BM717329.1         312-313
            1107-1479           BC011782.2         1092-1464
            1480-1496           AC068499.1         21602-21618         c
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1496
                     /gene="RAB3A"
                     /note="RAB3A, member RAS oncogene family"
                     /db_xref="GeneID:5864"
                     /db_xref="HGNC:HGNC:9777"
                     /db_xref="MIM:179490"
     exon            1..147
                     /gene="RAB3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..810
                     /gene="RAB3A"
                     /note="RAS-associated protein RAB3A"
                     /codon_start=1
                     /product="ras-related protein Rab-3A"
                     /protein_id="NP_002857.1"
                     /db_xref="CCDS:CCDS12372.1"
                     /db_xref="GeneID:5864"
                     /db_xref="HGNC:HGNC:9777"
                     /db_xref="MIM:179490"
                     /translation="MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMY
                     DITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFE
                     FFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLSDQQVPPHQDC
                     AC"
     exon            148..375
                     /gene="RAB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            376..494
                     /gene="RAB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            495..619
                     /gene="RAB3A"
                     /inference="alignment:Splign:2.1.0"
     exon            620..1496
                     /gene="RAB3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB3A"
                     /note="hexamer: AATAAA"
     polyA_site      1479
                     /gene="RAB3A"
                     /note="major polyA site"
ORIGIN      
        1 gcaggacgtc acggaggact gcaggggcct gagccgctgc tgccgccgcc gccgcgcagc
       61 cccacatcaa cgcaccgggg tcctgtcacc gccaccgcca aaaaagtcac cgccgctagg
      121 gtcgccgttg catcggtgca gggcaagatg gcatccgcca cagactcgcg ctatgggcag
      181 aaggagtcct cggatcagaa cttcgactac atgttcaaga ttctcatcat cggcaacagc
      241 agcgtgggca agacgtcctt cctcttccgc tatgctgacg actcgttcac gcctgccttc
      301 gtcagcaccg tgggcatcga cttcaaggtc aagaccatct atcgcaacga caagaggatc
      361 aagctgcaga tctgggacac agcagggcaa gagcggtacc ggaccatcac caccgcatac
      421 taccggggcg ctatgggctt catcctcatg tatgacatca ccaacgagga atccttcaat
      481 gcagtgcagg actggtccac ccagatcaag acctactcat gggacaatgc ccaggtgctg
      541 ctggtaggaa acaagtgtga catggaggat gagcgggtgg tgtcatcaga acgtggccgg
      601 cagctagctg accaccttgg gttcgagttc tttgaggcaa gcgccaagga caacattaac
      661 gtcaagcaga cctttgagcg cctggtggat gtcatctgcg agaagatgtc cgagtcgttg
      721 gacacggcgg accctgcggt cacaggcgcc aagcagggcc cacagctcag tgaccagcag
      781 gtgccaccgc accaggactg cgcctgctga gagccatccc actccctttc ccctcttccc
      841 tgtcttcccc accttccccc aactacccgg gcctgacccg gcccctacca gccacgggca
      901 caagacccct gctcctgact tagcccgtca cccttattta ttattgtagc tatttattta
      961 tttattgaag atgtccccca ggggcccagg ctcccctgcc cgccccaagc cctgcccctc
     1021 ctgtacatat agccctttcc ccactcagct gtggtgtctc gtggccccgt gaactcaccg
     1081 ctcaccctcc tgaacccccc ccccccgcct ttttttaaaa ttcaccccca tccacagttg
     1141 tcagttgtga agaggggcca gatgacaccc taaagcaggc tgatcgggca atgggaggtg
     1201 gccaggcctg ccagcccctc ggctctgccg cggtgggccg aggccgctgt tgggggtttc
     1261 cctgtgtgga ccatggggat cagagtctgg cctgccaggc tcctctcccc gttttctctt
     1321 ttggtggggg ggtgtgctgt gggtattcac caccctggga cccccccccc ccccgcccac
     1381 cagacctgtt ctgacctcat gagtgtcaaa cgtgcccccc agttccttag gagatgtcat
     1441 gacaacacta cacgcaccca ataaagcgaa tggaccatcc atgtgtgtcc ctgtga
//
