LOCUS       NM_017516               1885 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RAB39A, member RAS oncogene family (RAB39A), mRNA.
ACCESSION   NM_017516 XM_084662
VERSION     NM_017516.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Chano,T. and Avnet,S.
  TITLE     RAB39A: a Rab small GTPase with a prominent role in cancer stemness
  JOURNAL   J Biochem 164 (1), 9-14 (2018)
   PUBMED   29648608
  REMARK    GeneRIF: Molecular pathways regulated by RAB39A are
            transcriptionally maintained by the formation of molecular complex
            with RXRB, NCOR and HDAC that also contribute to cancer stemness.
            Review article
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Corbier,C. and Sellier,C.
  TITLE     C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and
            regulates autophagy
  JOURNAL   Small GTPases 8 (3), 181-186 (2017)
   PUBMED   27494456
  REMARK    GeneRIF: C9ORF72 causes suboptimal autophagy
            Review article
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Steger,M., Tonelli,F., Ito,G., Davies,P., Trost,M., Vetter,M.,
            Wachter,S., Lorentzen,E., Duddy,G., Wilson,S., Baptista,M.A.,
            Fiske,B.K., Fell,M.J., Morrow,J.A., Reith,A.D., Alessi,D.R. and
            Mann,M.
  TITLE     Phosphoproteomics reveals that Parkinson's disease kinase LRRK2
            regulates a subset of Rab GTPases
  JOURNAL   Elife 5, e12813 (2016)
   PUBMED   26824392
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Gambarte Tudela,J., Capmany,A., Romao,M., Quintero,C.,
            Miserey-Lenkei,S., Raposo,G., Goud,B. and Damiani,M.T.
  TITLE     The late endocytic Rab39a GTPase regulates the interaction between
            multivesicular bodies and chlamydial inclusions
  JOURNAL   J Cell Sci 128 (16), 3068-3081 (2015)
   PUBMED   26163492
  REMARK    GeneRIF: our findings indicate that Rab39a favours chlamydial
            replication and infectivity. This is the first report showing that
            a late endocytic Rab GTPase is involved in chlamydial infection
            development.
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Seto,S., Sugaya,K., Tsujimura,K., Nagata,T., Horii,T. and Koide,Y.
  TITLE     Rab39a interacts with phosphatidylinositol 3-kinase and negatively
            regulates autophagy induced by lipopolysaccharide stimulation in
            macrophages
  JOURNAL   PLoS One 8 (12), e83324 (2013)
   PUBMED   24349490
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Becker,C.E., Creagh,E.M. and O'Neill,L.A.
  TITLE     Rab39a binds caspase-1 and is required for caspase-1-dependent
            interleukin-1beta secretion
  JOURNAL   J Biol Chem 284 (50), 34531-34537 (2009)
   PUBMED   19833722
  REMARK    GeneRIF: Results show that Rab39a interacts with caspase-1 and
            suggest that Rab39a functions as a trafficking adaptor linking
            caspase-1 to IL-1beta secretion.
            Erratum:[J Biol Chem. 2016 Nov 18;291(47):24800. doi:
            10.1074/jbc.A109.046102.. PMID: 27864526]
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Stankovic,T., Byrd,P.J., Cooper,P.R., McConville,C.M., Munroe,D.J.,
            Riley,J.H., Watts,G.D., Ambrose,H., McGuire,G., Smith,A.D.,
            Sutcliffe,A., Mills,T. and Taylor,A.M.
  TITLE     Construction of a transcription map around the gene for ataxia
            telangiectasia: identification of at least four novel genes
  JOURNAL   Genomics 40 (2), 267-276 (1997)
   PUBMED   9119394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001024.6, HY107079.1, AK292969.1, BC028064.1 and AP003307.3.
            
            On Nov 22, 2018 this sequence version replaced NM_017516.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028064.1, SRR1803612.171552.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320578.3/ ENSP00000322594.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AP001024.6         176719-176745
            28-55               HY107079.1         1-28
            56-606              AK292969.1         1-551
            607-1221            BC028064.1         504-1118
            1222-1222           AP003307.3         32607-32607
            1223-1701           BC028064.1         1120-1598
            1702-1702           AP003307.3         33087-33087
            1703-1783           BC028064.1         1600-1680
            1784-1784           AP003307.3         33169-33169
            1785-1885           BC028064.1         1682-1782
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..1885
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /note="RAB39A, member RAS oncogene family"
                     /db_xref="GeneID:54734"
                     /db_xref="HGNC:HGNC:16521"
                     /db_xref="MIM:619558"
     exon            1..348
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..775
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /note="rab-related GTP-binding protein; rab-39; RAB39,
                     member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-39A"
                     /protein_id="NP_059986.1"
                     /db_xref="CCDS:CCDS8338.1"
                     /db_xref="GeneID:54734"
                     /db_xref="HGNC:HGNC:16521"
                     /db_xref="MIM:619558"
                     /translation="METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPT
                     VGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFE
                     HVKDWLEEAKMYVQPFRIVFLLVGHKCDLASQRQVTREEAEKLSADCGMKYIETSAKD
                     ATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFVPNTVHSSEEAVKPRKECFC"
     exon            349..1885
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /note="hexamer: ATTAAA"
     polyA_site      1459
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /note="major polyA site"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
                     /note="hexamer: AGTAAA"
     polyA_site      1885
                     /gene="RAB39A"
                     /gene_synonym="K28; RAB39"
ORIGIN      
        1 agccgcagga atatgctgga aggcggcggg cgggcgcccg cgaggtgctg aaaggacagt
       61 tcccgccgcc gaacttagcc cgcgggtggg gcggcccggg agccagcggg gcacgtgagc
      121 gatggagacc atctggatct accagttccg cctcatcgtg atcggggact ccaccgtggg
      181 caagtcctgc ctcctgcacc gcttcaccca gggccgcttc cccgggctgc gctcccccgc
      241 ctgcgacccc accgtcggcg tggacttctt ctcccgcctg ctggagatcg agccgggcaa
      301 gaggatcaag ctacagctct gggacacggc gggacaggag cggttcagat caataacccg
      361 atcttattac cgcaactcag ttggtggatt tttagtattt gacattacta accgacgatc
      421 ttttgaacat gtgaaagatt ggctagaaga agcaaaaatg tatgtacagc catttcggat
      481 tgtatttctg ctagtgggac ataaatgtga tttagcttca caacgtcaag ttacaaggga
      541 agaagctgaa aaactgtcag cagactgtgg aatgaagtat atagaaacct cagcaaagga
      601 tgctacaaat gttgaagaat ccttcacaat cttgacgaga gacatatatg aacttattaa
      661 aaagggagaa atttgtattc aggatggctg ggaaggggtt aaaagtggtt ttgttccaaa
      721 tactgtgcat tcttctgagg aagcagtaaa gcccaggaaa gaatgcttct gctgacttca
      781 aacatgctga agaactaaca ggaacagatt gggtgtcagt tcaggataaa taccaacatt
      841 aacagcagaa tgatgcaatg aaagaattta aaaaggttac aaacccacac caatactatt
      901 ttataaggta tttgattcag agcatgatgc ttacttgtta cactactaga ttgggtattt
      961 tgctaaatta ccaagcaaag cagacaatct ttttcttgaa attacctcca ttcttacttt
     1021 gttagcatac gctgacctta gtgtccagat atgtcactat tactcatttt tcttgacagt
     1081 tcaaatggat ttttgtgcat atatagtcaa ttgaaaagat tttatcagga attacattct
     1141 cttgagttaa ttaatattga atagcaaaat gcatttaaat atgcactgtt cacctgcaga
     1201 gtaaacaatc tcagaagtat cgactaggac gtaaatagca gttccttata taaagtacca
     1261 ggttttttcc ccattctctg gaaatgtttg tcctccctta attttgcctc aacacaagaa
     1321 aataagtttt atgtccattt ttgttcccta atttattgct tctaaaaatg cattatgttt
     1381 tacaaagata tctaaggatc caagcaaact actttaagca aatatttgta aaattaaaaa
     1441 cggaggaccg ctcaccaaat gtttgaaatg ttgctttttt tttttgagac agggtcttgt
     1501 tttgtcaccc aggctggagt gcagtggggc aatcttggct ccctgcaacc tctgcttcct
     1561 gggttcaggt gattgtcagt accttacctc agcctcctga gtagctggaa ctgcagatgt
     1621 gcgccaccat gcccggctaa tttttgtatt ataagtagac acagggtttc ataatgttcc
     1681 ccaggctggt ctccaactcc tcgcctcaag caattcgccc ccctcggcct ccaaagtgct
     1741 ggaattatag gcatgagctg ccgtgcctgg actatcagca gcacatgttt tgctgttacg
     1801 gtgtactgtt cgtatttaga caagaagaac aaaatttatt tatgtattga cattttcaaa
     1861 gaaagtaaat gcaatttact ttgaa
//
