LOCUS       NM_022337               1432 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAB38, member RAS oncogene family (RAB38), mRNA.
ACCESSION   NM_022337
VERSION     NM_022337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Unapanta,A., Shavarebi,F., Porath,J., Shen,Y., Balen,C., Nguyen,A.,
            Tseng,J., Leong,W.S., Liu,M., Lis,P., Di Pietro,S.M. and Hiniker,A.
  TITLE     Endogenous Rab38 regulates LRRK2's membrane recruitment and
            substrate Rab phosphorylation in melanocytes
  JOURNAL   J Biol Chem 299 (10), 105192 (2023)
   PUBMED   37625589
  REMARK    GeneRIF: Endogenous Rab38 regulates LRRK2's membrane recruitment
            and substrate Rab phosphorylation in melanocytes.
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   Iwagawa,T., Masumoto,H., Tabuchi,H., Tani,K., Conklin,B.R. and
            Watanabe,S.
  TITLE     Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia
            using human induced pluripotent stem cell-derived RPE
  JOURNAL   J Gene Med 25 (2), e3464 (2023)
   PUBMED   36413603
  REMARK    GeneRIF: Evaluation of CRISPR/Cas9 exon-skipping vector for
            choroideremia using human induced pluripotent stem cell-derived
            RPE.
REFERENCE   3  (bases 1 to 1432)
  AUTHORS   Bianchetti,E., Bates,S.J., Nguyen,T.T.T., Siegelin,M.D. and
            Roth,K.A.
  TITLE     RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in
            Glioblastoma Cells
  JOURNAL   Cells 10 (7), 1643 (2021)
   PUBMED   34209035
  REMARK    GeneRIF: RAB38 Facilitates Energy Metabolism and Counteracts Cell
            Death in Glioblastoma Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1432)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1432)
  AUTHORS   Gerondopoulos,A., Langemeyer,L., Liang,J.R., Linford,A. and
            Barr,F.A.
  TITLE     BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine
            nucleotide exchange factor
  JOURNAL   Curr Biol 22 (22), 2135-2139 (2012)
   PUBMED   23084991
  REMARK    GeneRIF: BLOC-3 is a Rab32 and Rab38 guanine nucleotide exchange
            factor, with a specific function in the biogenesis of
            lysosome-related organelles.
REFERENCE   6  (bases 1 to 1432)
  AUTHORS   Bultema,J.J., Ambrosio,A.L., Burek,C.L. and Di Pietro,S.M.
  TITLE     BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and
            Rab32 proteins to mediate protein trafficking to lysosome-related
            organelles
  JOURNAL   J Biol Chem 287 (23), 19550-19563 (2012)
   PUBMED   22511774
  REMARK    GeneRIF: that Rab38 and Rab32 are the specific factors that direct
            the ubiquitous machinery to mediate transport from early endosomes
            to maturing LROs.
REFERENCE   7  (bases 1 to 1432)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   8  (bases 1 to 1432)
  AUTHORS   Wang,F., Zhang,H., Zhang,X., Wang,Y., Ren,F., Zhang,X., Zhai,Y. and
            Chang,Z.
  TITLE     Varp interacts with Rab38 and functions as its potential effector
  JOURNAL   Biochem Biophys Res Commun 372 (1), 162-167 (2008)
   PUBMED   18477474
  REMARK    GeneRIF: Varp physically interacts with Rab38, and preferentially
            binds to the active GTP-bound form of Rab38 both in vitro and in
            vivo.
REFERENCE   9  (bases 1 to 1432)
  AUTHORS   Suzuki,T., Miyamura,Y., Inagaki,K. and Tomita,Y.
  TITLE     Characterization of the human RAB38 and RAB7 genes: exclusion of
            new major pathological loci for Japanese OCA
  JOURNAL   J Dermatol Sci 32 (2), 131-136 (2003)
   PUBMED   12850305
  REMARK    GeneRIF: Not a new major locus for Japanese oculocutaneous
            albinisms.
REFERENCE   10 (bases 1 to 1432)
  AUTHORS   Jager,D., Stockert,E., Jager,E., Gure,A.O., Scanlan,M.J., Knuth,A.,
            Old,L.J. and Chen,Y.T.
  TITLE     Serological cloning of a melanocyte rab guanosine
            5'-triphosphate-binding protein and a chromosome condensation
            protein from a melanoma complementary DNA library
  JOURNAL   Cancer Res 60 (13), 3584-3591 (2000)
   PUBMED   10910072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL546159.3, AP001642.4, AP005436.1 and BC015808.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022337.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.115677.1,
                                           SRR5189667.129443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243662.11/ ENSP00000243662.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL546159.3         25-187
            164-261             AP001642.4         57411-57508         c
            262-542             AP001642.4         31903-32183         c
            543-1403            AP005436.1         108070-108930       c
            1404-1432           BC015808.1         1394-1422
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..1432
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /note="RAB38, member RAS oncogene family"
                     /db_xref="GeneID:23682"
                     /db_xref="HGNC:HGNC:9776"
                     /db_xref="MIM:606281"
     exon            1..261
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..695
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /note="Rab-related GTP-binding protein; melanoma antigen
                     NY-MEL-1"
                     /codon_start=1
                     /product="ras-related protein Rab-38"
                     /protein_id="NP_071732.1"
                     /db_xref="CCDS:CCDS8281.1"
                     /db_xref="GeneID:23682"
                     /db_xref="HGNC:HGNC:9776"
                     /db_xref="MIM:606281"
                     /translation="MQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGV
                     DFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVA
                     KWKNDLDSKLSLPNGKPVSVVLLANKCDQGKDVLMNNGLKMDQFCKEHGFVGWFETSA
                     KENINIDEASRCLVKHILANECDLMESIEPDVVKPHLTSTKVASCSGCAKS"
     exon            262..542
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1432
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /note="hexamer: AATAAA"
     polyA_site      1432
                     /gene="RAB38"
                     /gene_synonym="NY-MEL-1; rrGTPbp"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagagcc caggctgcgc ttccctggtc aggcacggca cgtctggccg gccgccagga
       61 tgcaggcccc gcacaaggag cacctgtaca agttgctggt gattggcgac ctgggcgtgg
      121 ggaagaccag tatcatcaag cgctacgtgc accagaactt ctcttcgcac taccgggcca
      181 caatcggcgt ggacttcgcg ctcaaggtgc tccactggga cccggagact gtggtgcgcc
      241 tgcagctctg ggatatcgca ggtcaagaaa gatttggaaa catgacgagg gtctattacc
      301 gagaagctat gggtgcattt attgtcttcg atgtcaccag gccagccaca tttgaagcag
      361 tggcaaagtg gaaaaatgat ttggactcca agttaagtct ccctaatggc aaaccggttt
      421 cagtggtttt gttggccaac aaatgtgacc aggggaagga tgtgctcatg aacaatggcc
      481 tcaagatgga ccagttctgc aaggagcacg gtttcgtagg atggtttgaa acatcagcaa
      541 aggaaaatat aaacattgat gaagcctcca gatgcctggt gaaacacata cttgcaaatg
      601 agtgtgacct aatggagtct attgagccgg acgtcgtgaa gccccatctc acatcaacca
      661 aggttgccag ctgctctggc tgtgccaaat cctagtaggc acctttgctg gtgtctggta
      721 ggaatgacct cattgttcca caaattgtgc ctctattttt accattttgg gtaaacgtca
      781 ggatagagat accacatgtg gcaagccaaa gatctatgcc tctgtttttt cagtgagaga
      841 gaaatagcaa atgttctttc tatgctttcc tcaccatcat cacagtgttt acaaactttt
      901 gaaaatattt agtctgttac aaacttctgt catgtagctg accaaaatcc tgcagggcca
      961 cagtcggcac tgttatttgc ttcttttaat cagcaaaggc ctcaagtctt aaaataaaag
     1021 gggagaagaa caaactagct gtcaagtcaa ggactggctt tcaccttgcc ctggtgtctt
     1081 tttccagatt tcagtatatt ctctgatggc ctgacaggcc tattaagtag atgtgatatt
     1141 ttctcccaag atgacctcca ttctcggcag acctaagagt tgcctctgag ttagctcttt
     1201 ggaatcgtga acacaggtgt gctatattgt ccttgtccta actgtcactt gccatggcct
     1261 gaatgttggc ttaactgaat attgtatgaa aagacatgcc tccatatgtg cctttctgtt
     1321 agctttctct gactcaagct gtggggctcc tctatacatg ctatacatgt aatatatatt
     1381 atatatattt ttgcaagtga acaataaaac attaaaagat gctgtttccc ta
//
