LOCUS       NM_001006638            2613 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens RAB37, member RAS oncogene family (RAB37), transcript
            variant 2, mRNA.
ACCESSION   NM_001006638
VERSION     NM_001006638.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Xin,L., Li,S.H., Liu,C., Zeng,F., Cao,J.Q., Zhou,L.Q., Zhou,Q. and
            Yuan,Y.W.
  TITLE     Methionine represses the autophagy of gastric cancer stem cells via
            promoting the methylation and phosphorylation of RAB37
  JOURNAL   Cell Cycle 19 (20), 2644-2652 (2020)
   PUBMED   32926650
  REMARK    GeneRIF: Methionine represses the autophagy of gastric cancer stem
            cells via promoting the methylation and phosphorylation of RAB37.
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Li,Y., Yang,X., Du,X., Lei,Y., He,Q., Hong,X., Tang,X., Wen,X.,
            Zhang,P., Sun,Y., Zhang,J., Wang,Y., Ma,J. and Liu,N.
  TITLE     RAB37 Hypermethylation Regulates Metastasis and Resistance to
            Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma
  JOURNAL   Clin Cancer Res 24 (24), 6495-6508 (2018)
   PUBMED   30131385
  REMARK    GeneRIF: This study shows that RAB37 hypermethylation is involved
            in NPC metastasis and chemoresistance, and that our prognostic
            model can identify patients who are at a high risk of distant
            metastasis and might benefit from for docetaxel IC.
            Erratum:[Clin Cancer Res. 2022 Jan 15;28(2):430. doi:
            10.1158/1078-0432.CCR-21-4242.. PMID: 35045963]
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Wang,Y.S., Tzeng,H.T., Tsai,C.H., Cheng,H.C., Lai,W.W., Liu,H.S.
            and Wang,Y.C.
  TITLE     VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis,
            possesses a tumor metastasis suppressor function
  JOURNAL   Cancer Lett 437, 79-88 (2018)
   PUBMED   30165196
  REMARK    GeneRIF: Findings indicate that patients with low vesicle
            associated membrane protein 8 (VAMP8)/low rab GTP-binding protein
            RAB37 (RAB37) expression profile showed significantly high risk of
            death even after adjusting for tumor metastasis parameter.
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Tzeng,H.T., Su,C.C., Chang,C.P., Lai,W.W., Su,W.C. and Wang,Y.C.
  TITLE     Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus
            skews macrophages toward tumor-suppressing phenotype
  JOURNAL   Int J Cancer 143 (7), 1753-1763 (2018)
   PUBMED   29717487
  REMARK    GeneRIF: Low RAB37 expression is associated with lung cancer.
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   Cho,S.H., Kuo,I.Y., Lu,P.F., Tzeng,H.T., Lai,W.W., Su,W.C. and
            Wang,Y.C.
  TITLE     Rab37 mediates exocytosis of secreted frizzled-related protein 1 to
            inhibit Wnt signaling and thus suppress lung cancer stemness
  JOURNAL   Cell Death Dis 9 (9), 868 (2018)
   PUBMED   30158579
  REMARK    GeneRIF: Rab37-mediated SFRP1 secretion suppresses cancer stemness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2613)
  AUTHORS   Wu,C.Y., Tseng,R.C., Hsu,H.S., Wang,Y.C. and Hsu,M.T.
  TITLE     Frequent down-regulation of hRAB37 in metastatic tumor by genetic
            and epigenetic mechanisms in lung cancer
  JOURNAL   Lung Cancer 63 (3), 360-367 (2009)
   PUBMED   18687502
  REMARK    GeneRIF: Promoter/exon1 methylation is the predominant mechanism in
            down-regulation of the hRAB37, and can serve as a potential
            prediction biomarker of NSCLC progression.
REFERENCE   7  (bases 1 to 2613)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   8  (bases 1 to 2613)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 2613)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   10 (bases 1 to 2613)
  AUTHORS   Masuda,E.S., Luo,Y., Young,C., Shen,M., Rossi,A.B., Huang,B.C.,
            Yu,S., Bennett,M.K., Payan,D.G. and Scheller,R.H.
  TITLE     Rab37 is a novel mast cell specific GTPase localized to secretory
            granules
  JOURNAL   FEBS Lett 470 (1), 61-64 (2000)
   PUBMED   10722846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098068.1, AC016888.23 and BC016615.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001006638.2.
            
            Summary: Rab proteins are low molecular mass GTPases that are
            critical regulators of vesicle trafficking. For additional
            background information on Rab proteins, see MIM 179508.[supplied by
            OMIM, Apr 2006].
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter, 5' UTR, and alternate start codon, and includes an
            alternate coding exon, compared to variant 3. The resulting isoform
            (2) has a distinct and longer N-terminus, compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.54290.1, AK098068.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392613.10/ ENSP00000376389.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1938              AK098068.1         40-1977
            1939-2578           AC016888.23        117211-117850
            2579-2613           BC016615.1         1620-1654
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2613
                     /gene="RAB37"
                     /note="RAB37, member RAS oncogene family"
                     /db_xref="GeneID:326624"
                     /db_xref="HGNC:HGNC:30268"
                     /db_xref="MIM:609956"
     exon            1..110
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..689
                     /gene="RAB37"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RAB37, member of RAS oncogene family; ras-related protein
                     Rab-37"
                     /codon_start=1
                     /product="ras-related protein Rab-37 isoform 2"
                     /protein_id="NP_001006639.1"
                     /db_xref="CCDS:CCDS32722.1"
                     /db_xref="GeneID:326624"
                     /db_xref="HGNC:HGNC:30268"
                     /db_xref="MIM:609956"
                     /translation="MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTC
                     FLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTAGQERFRSVTHAYYRD
                     AQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADMSSERVIRSEDGET
                     LAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYVESQKKRSS
                     CCSFM"
     exon            111..221
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            222..263
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            264..330
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            331..383
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            384..449
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            450..506
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            507..583
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     exon            584..2613
                     /gene="RAB37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2588..2593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB37"
                     /note="hexamer: ATTAAA"
     polyA_site      2613
                     /gene="RAB37"
                     /note="major polyA site"
ORIGIN      
        1 acctctcgtc cagggacatg acgggcacgc caggcgccgt tgccacccgg gatggcgagg
       61 cccccgagcg ctccccgccc tgcagtccga gctacgacct cacgggcaag gtgatgcttc
      121 tgggagacac aggcgtcggc aaaacatgtt tcctgatcca attcaaagac ggggccttcc
      181 tgtccggaac cttcatagcc accgtcggca tagacttcag gaacaaggtg gtgactgtgg
      241 atggcgtgag agtgaagctg cagatctggg acaccgctgg gcaggaacgg ttccgaagcg
      301 tcacccatgc ttattacaga gatgctcagg ccttgcttct gctgtatgac atcaccaaca
      361 aatcttcttt cgacaacatc agggcctggc tcactgagat tcatgagtat gcccagaggg
      421 acgtggtgat catgctgcta ggcaacaagg cggatatgag cagcgaaaga gtgatccgtt
      481 ccgaagacgg agagaccttg gccagggagt acggtgttcc cttcctggag accagcgcca
      541 agactggcat gaatgtggag ttagcctttc tggccatcgc caaggaactg aaataccggg
      601 ccgggcatca ggcggatgag cccagcttcc agatccgaga ctatgtagag tcccagaaga
      661 agcgctccag ctgctgctcc ttcatgtgaa tcccaggggg cagagaggag gctctggagg
      721 cacacaggat gcagccttcc ccctcccagg cctggcttat tccaagaggc tgagccaatg
      781 gggagaaaga tggaggactc actgcacagc cgcttcctag cagggagcta tactccaact
      841 cctacttgag ttcctgcggt ctccccgcat ccacagggag ggtaaaacac ttagctttta
      901 ttttaatagt acataattta ataccaaaaa aggcgcctgg atccccaaaa aaccgaggct
      961 gggagctagt ggcccttttg ctttctagga cttggggggc cggccctccc tcctaagcat
     1021 aacaaaggtg gtgttgctcc agctcagccc caggggacac agatgcactt tgggggtgag
     1081 ggcaggtaat gactccatcg caccctcagt tcagctggac agaggctcag gtgaccccag
     1141 ccttcactgt ctcccgctct ccaggagctt atcttcgccc catctcccaa ataagtgggc
     1201 ccttgtgctg tgaggaagac caaagcctca gggaagataa gagatatgga gatgggaggg
     1261 ggaggacaag gggcagagag tagggtctag ctggctatct ctggccttac taacaccccc
     1321 ctggaggcat gccccttttc tccagcacac aagcacattg gggcacctgg aaatattggt
     1381 tccaggctcc tgttctctgg acttcagatc ctgggggagc ccctcccccc cctgaatccc
     1441 tggcttagct accttcctgc ctgtgcacct aaaaacctca ggtcagaact aggaaaagag
     1501 ttttgttttt atttttttga aatggagtct cgttctgtcg cccaggctga ggtgcagtag
     1561 tgcaatctcc gctcactaca acctccactc cctggggctc aagcgatcct cccacctcag
     1621 ccgccgaagt agctgggact ataggtgtgt accatcacac ctggctaatt tttgtatttt
     1681 ttgtagacac agggtttcgc catgttgccc aggctggtct tgaattcctg agctcaagca
     1741 acctgccggc ctcggcctcc caaagtactg ggattacacg cagaaggcac catgcccagg
     1801 ctagatgtgt cttatcccaa tcctttggca ggcatgcagc tccacaggcg atttcttcaa
     1861 gcagctgaag tgtttagccc tcctgggtta agagccagat aaggagaaat ccctttccta
     1921 ggtttggaat gtgttgtgaa aaaaaagaga aatccctggc tcctggagct ggtgggagac
     1981 aagattaagc aaacctcccc tgacatgtat ccctttgacc ccaagctctg cctcctccct
     2041 gaccacccat gccctttcct ttaacttctc aaacagatac cagggcctaa actgctttac
     2101 ctcccctcct actgagtcag gttaggtggt gggaggtcac ccatttccga gttaaaccaa
     2161 tgcaatatga gtaaaacaaa gtcatgtggg tatgtctggg gtagagagag gggtagcaag
     2221 ttcatgtgtc ctccttggtc acatatctcc caaagctccg atccctgcca tgggaagtgg
     2281 acaggaaaca tgaggtcatg acctgcaggc atctttactg cagctctgcc ggcctggagg
     2341 gggagagggg gaggaagaag tatgcgctgc acatttctga ggctactgca tttgctttca
     2401 aggcagaaat cttgctctga gcagtcagcg gctccagttt gggcccgata aggaagttct
     2461 ccgtggcctc cctcaggcag agcagggagg aggctgacat tgccagtctc ttctggggcc
     2521 caaggcaggt tgcaggagat ccaatcccat agacagctct gggcctcttg catttgagtt
     2581 tttcagaatt aaactgcagt attttggaaa gca
//
