LOCUS       NM_004914               4990 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RAB36, member RAS oncogene family (RAB36), transcript
            variant 3, mRNA.
ACCESSION   NM_004914
VERSION     NM_004914.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4990)
  AUTHORS   Arunachalam,V., Lea,R., Hoy,W., Lee,S., Mott,S., Savige,J.,
            Mathews,J.D., McMorran,B.J. and Nagaraj,S.H.
  TITLE     Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study
  JOURNAL   Genome Med 16 (1), 29 (2024)
   PUBMED   38347632
  REMARK    GeneRIF: Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4990)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4990)
  AUTHORS   Zhu,Y., Liang,S., Pan,H., Cheng,Z. and Rui,X.
  TITLE     Inhibition of miR-1247 on cell proliferation and invasion in
            bladder cancer through its downstream target of RAB36
  JOURNAL   J Biosci 43 (2), 365-373 (2018)
   PUBMED   29872024
  REMARK    GeneRIF: these results provide the first clues regarding the role
            of miR-1247 might be a potential therapeutic agent and diagnostic
            marker of bladder cancer by inhibiting RAB36 expression.
REFERENCE   4  (bases 1 to 4990)
  AUTHORS   Nottingham,R.M., Pusapati,G.V., Ganley,I.G., Barr,F.A.,
            Lambright,D.G. and Pfeffer,S.R.
  TITLE     RUTBC2 protein, a Rab9A effector and GTPase-activating protein for
            Rab36
  JOURNAL   J Biol Chem 287 (27), 22740-22748 (2012)
   PUBMED   22637480
  REMARK    GeneRIF: These data show that RUTBC2 can act as a Rab36 GAP in
            cells and suggest that RUTBC2 links Rab9A function to Rab36
            function in the endosomal system.
REFERENCE   5  (bases 1 to 4990)
  AUTHORS   Chen,L., Hu,J., Yun,Y. and Wang,T.
  TITLE     Rab36 regulates the spatial distribution of late endosomes and
            lysosomes through a similar mechanism to Rab34
  JOURNAL   Mol Membr Biol 27 (1), 23-30 (2010)
   PUBMED   19961360
  REMARK    GeneRIF: Rab36 may regulate the spatial distribution of late
            endosomes and lysosomes through a similar mechanism to Rab34.
REFERENCE   6  (bases 1 to 4990)
  AUTHORS   Wang,L., Zhu,Y.F., Guo,X.J., Huo,R., Ma,X., Lin,M., Zhou,Z.M. and
            Sha,J.H.
  TITLE     A two-dimensional electrophoresis reference map of human ovary
  JOURNAL   J Mol Med (Berl) 83 (10), 812-821 (2005)
   PUBMED   16021519
REFERENCE   7  (bases 1 to 4990)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 4990)
  AUTHORS   Zhou,J., Fogelgren,B., Wang,Z., Roe,B.A. and Biegel,J.A.
  TITLE     Isolation of genes from the rhabdoid tumor deletion region in
            chromosome band 22q11.2
  JOURNAL   Gene 241 (1), 133-141 (2000)
   PUBMED   10607907
REFERENCE   9  (bases 1 to 4990)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 4990)
  AUTHORS   Mori,T., Fukuda,Y., Kuroda,H., Matsumura,T., Ota,S., Sugimoto,T.,
            Nakamura,Y. and Inazawa,J.
  TITLE     Cloning and characterization of a novel Rab-family gene, Rab36,
            within the region at 22q11.2 that is homozygously deleted in
            malignant rhabdoid tumors
  JOURNAL   Biochem Biophys Res Commun 254 (3), 594-600 (1999)
   PUBMED   9920784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000029.17 and AC000102.1.
            
            On Jun 27, 2020 this sequence version replaced NM_004914.4.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (3) has the same N- and C-termini, but is shorter than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023061.1, SRR11853565.19429.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000263116.8/
                                                ENSP00000263116.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC000029.17        125151-125225
            76-156              AC000029.17        126279-126359
            157-248             AC000029.17        129737-129828
            249-314             AC000029.17        132135-132200
            315-416             AC000029.17        132707-132808
            417-481             AC000029.17        135642-135706
            482-533             AC000029.17        137666-137717
            534-615             AC000029.17        138572-138653
            616-706             AC000029.17        138837-138927
            707-826             AC000029.17        140553-140672
            827-2632            AC000029.17        141174-142979
            2633-4990           AC000102.1         474-2831
FEATURES             Location/Qualifiers
     source          1..4990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..4990
                     /gene="RAB36"
                     /note="RAB36, member RAS oncogene family"
                     /db_xref="GeneID:9609"
                     /db_xref="HGNC:HGNC:9775"
                     /db_xref="MIM:605662"
     exon            1..75
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            76..156
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..891
                     /gene="RAB36"
                     /note="isoform 3 is encoded by transcript variant 3; small
                     GTP-binding protein Rab36; ras-related protein Rab-36"
                     /codon_start=1
                     /product="ras-related protein Rab-36 isoform 3"
                     /protein_id="NP_004905.3"
                     /db_xref="CCDS:CCDS13805.2"
                     /db_xref="GeneID:9609"
                     /db_xref="HGNC:HGNC:9775"
                     /db_xref="MIM:605662"
                     /translation="MRSSLTPLGPPVSRDRVIASFPKWYTPEACLQLREHFHGQVSAA
                     CQRRNTGTVGLKLSKVVVVGDLYVGKTSLIHRFCKNVFDRDYKATIGVDFEIERFEIA
                     GIPYSLQIWDTAGQEKFKCIASAYYRGAQVIITAFDLTDVQTLEHTRQWLEDALRENE
                     AGSCFIFLVGTKKDLLSGAACEQAEADAVHLAREMQAEYWSVSAKTGENVKAFFSRVA
                     ALAFEQSVLQDLERQSSARLQVGNGDLIQMEGSPPETQESKRPSSLGCC"
     exon            157..248
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            249..314
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            315..416
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            417..481
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            482..533
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            534..615
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            616..706
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            707..826
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     exon            827..4990
                     /gene="RAB36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3653..3658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB36"
                     /note="hexamer: ATTAAA"
     polyA_site      3672
                     /gene="RAB36"
                     /note="major polyA site"
     regulatory      4933..4938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB36"
                     /note="hexamer: AACAAA"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB36"
                     /note="hexamer: AACAAG"
     polyA_site      4977
                     /gene="RAB36"
     polyA_site      4990
                     /gene="RAB36"
ORIGIN      
        1 gttgccatgg tgatcgccgc cgctggctca ggcggaccag gccgcgcgga gccccagctt
       61 tcacagccat cgctggactg tggaagaatg aggtcctccc tgacaccttt ggggccccct
      121 gtgagccgcg accgtgtcat cgccagcttc cctaagtggt acacgccgga agcctgtttg
      181 cagctcaggg agcacttcca cgggcaggtc agcgctgcct gccaacgcag gaacacgggg
      241 actgtcgggc tcaaactctc caaggtggtg gtggttggcg atctctacgt ggggaagacc
      301 agcctcatcc acaggttttg caagaatgtt tttgatcgag actacaaggc caccattggg
      361 gtggactttg aaattgagcg ctttgagatt gctgggattc cctatagcct ccagatctgg
      421 gacacagctg ggcaggagaa gttcaagtgc atcgcatctg cctactaccg gggtgcccag
      481 gtgatcatca cggcctttga cctcactgac gtgcagaccc tggagcatac caggcagtgg
      541 ttggaggatg ctctgaggga gaacgaggca ggctcctgct tcatcttcct cgtgggaacc
      601 aagaaggacc ttctgtcagg ggccgcatgt gagcaggccg aagcagacgc tgtgcacctg
      661 gccagggaga tgcaggccga gtactggtca gtgtcggcca agactggcga gaacgtgaag
      721 gcattcttca gccgcgtagc cgccctggca ttcgagcagt cggtgctgca ggacctggag
      781 aggcagagca gtgcccggct ccaggtcggc aatggagacc taatccaaat ggaagggagt
      841 ccgcccgaga cccaggagag caagaggccc tccagcctgg gctgctgcta actggggcct
      901 gcgtggaagg cctccgctcc ctgcacacac acggacagga atttccgtga ctgtggtgtg
      961 gagactggag cccaagctct gcagcgtgtc gccctcaagc tgtaggccca tgttccagtc
     1021 cctccaccca cccaccgggc tcagctccag ggcacagtca cttgtccgtt gcaggttggg
     1081 cactagaaaa ggcccccact ggctgcctgg gagccccaca ccaccgggcc agtgcaggca
     1141 ctgtggtgat cccataaaag gccagtccat ttgcagggtc atcagacagt cacctttggc
     1201 ctcaagaggc ctcagaactg caaactcctg cgtcggtcta tactactcgg ccatggccca
     1261 catcagcagt caaccctgca ctctttccca gcgatcttgg atgtgtcccc aggatccgtc
     1321 acagtgttcc aggcaacctg gacttgtcaa agtcagcacc tgaaggagag gccacctgcc
     1381 attccccctg ggagttttct gttgtcagca ggacttatgg ttctgggtct cagagcttca
     1441 ggcctcactg tccttctgcc acggatgctc aaggttcctg ggcagaccag cacctctgga
     1501 ggacaatgga caaaatgtct cttagacctg ttctggctga agggctatct ctggcacctc
     1561 tgagatccct aggtcctgcc ctcctggtcc gtgggccagg atgtgcagaa caaccactca
     1621 ggcctttctg gcccacctgg acagtgcatt tacctgtgtg ctgcgggagg cagactgcac
     1681 agctgtccta gggtaactca ctctgcagcc cttgaacatg gcactgccct cctctggcac
     1741 tcatgctggg cctgtgccca ctgctgcctc tccatccctc tctcattggc ctatacatct
     1801 cttaggacct ttgtaatggt gtccatgcac ctttagagga cttcagaggc cctgccaagt
     1861 ctagcatgtt cctgtctcca acaccgcctc ctgcacatgc agagcagaca gaaatacccc
     1921 acacattccc cagcctctct gcccagtatg ctcatccaca gggttttctc actgctatga
     1981 accagcccca cagccccagg cccctgtcac ctggctatgc ccactcatcc cacccgtctc
     2041 gtgctgttgc ttcccgtaga tggcgagcac cttgcaggca gccttctgat cagtactgct
     2101 ctcctagggc ctggcacact gcagctgccc tgtaaatgtt cagctcagcg attgccaaat
     2161 accagttagg gaagaacact ggcatctttt tctattcatt cccccttcaa catatttttt
     2221 gtagtttttt atataaatga cttttttttt tttttgagat ggagtttcac ccttgttgcc
     2281 caggctggag tgcaatggcg taatctcggc tcagtgcaac ctctgcctcc caggttgaag
     2341 cgattctcct gcctcagcct cccaagtagc tgggattaca ggcatgcacc accatgcctg
     2401 gctaattttg tatttttagt agagatgggg tttctccatg ttggtcaggc tgctctcgga
     2461 ctcctgatct caggtgacct gcccacctcg gcctcccgaa gtgctgggat tacaagggtg
     2521 agccaccatg cccggccata aatgatttta ttcattttta tgttttcttt tgggcggcgg
     2581 gatggagtct ctgtcaccca ggctggcgtg caatggcacg atcttggctc actgcaagct
     2641 tccccttccg ggttcatgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg
     2701 cacgtgtgac catgccgggc taatttttta tatttttagt agagagaggt ttcaccgtgt
     2761 tagccaggat ggtctcgatg atctgacctc gtgatctgcc cgcctcggcc tcccaaagtg
     2821 ctgggattac aggcctgagc caccgcgtcc ggcctccata aatgactttt aaaggggttg
     2881 tatgtttagt gtgaacaaag acagtacaaa gcatataaaa tacaaggtga aagccccccc
     2941 cccgccacat tagctgcgcc cctgaagtgt ctccagcaga agagatggat gaatggaagg
     3001 acacacagat ggacagagag caggaaagac tgttagctct gctaacagtc aggactattc
     3061 cttctggact ctgtgccttt gcctgcacag ctagtgttga tggcttgttt gttgttttca
     3121 ccagagtgag ctccttctgg acatactgcc tggcagcctg ccttcctagg gagctggcgc
     3181 caaggcctct ccctgatggc acacaaggag cctccttcct gtagcagcgc ccagttttca
     3241 tgtggatgga ttgtagttca tttgaccctc cccatccgcg ggccatccgg cttgtgtcca
     3301 gcttttagct cttgccaatg gtgctgcagt ggccattctt gtagttatag ctttgcgtac
     3361 tcaggaaggc ccttctcccg actgcggccc ccagcctggt ccactaaatg cagcctgtgg
     3421 tcgggcagac agcattgggg tccattagga agaccaggtt tgctgggcat aagcttcaca
     3481 ggacgggaga acctgcccat ggtggactgt cgttctccac agctcccttc ccttgcccct
     3541 tcgggcctcc aggatatgtt tgcgggggtg ggtgtggtgt ccagctgtta ccagcttctg
     3601 agctagagct gtactgcctc acgtacaccc ccacctctgt aaatggtcct tgattaaatc
     3661 gtcctcatat tacctcctgc aatgtgccag ctgattccca cacaccctga ctgacatagt
     3721 tgtggcctct cgaactttga tatttggcct gggaggacag aagagtaagg tcgccacgga
     3781 aacgcaaggg gctcagttgt ccccccaccc caagttgatg cagcatcttc tcggtcagaa
     3841 ttgcttcagg gtggtttgcg caccctcact ttgatgattt aatgaagaca tttccttctt
     3901 tcccagcatc gggcagtaag tttcctgggc agaggcactt tctgttggtc tggtcttgtg
     3961 ggcccaggca agcagccccc tgcagccaag gtgcggcaat gaccacagtg accgcgtcca
     4021 agtgctgccg aaacgccttt ttcctcttcc ctgtttccct ggaccctttc ctgctctctg
     4081 tccatctgtg tgtccttccg ttcacctgtc tcttctgctg gagacacgta cctgaagcag
     4141 gtcctctcct gtcacttcct ggctccccag ggctaggtcc cagggtgctc tcgctctggc
     4201 tttcgaggct cctcaccacc cagcccaccc cacccccaca ggcccctgtg ctccagtttc
     4261 atccctggtc acaatgcagt ctgcagatgc cagacccctc ttctgtgccc aacggctggg
     4321 acacccctac tcccagagag gcctctgtgg acacccccac agctctcgca gcacttgata
     4381 ccttgagtgt gattggtcac atctgggctt tctcccccac ccatctgtgg aaccccaaga
     4441 gccaggacag tgacctcatc acctctactg tctcccctag cacctctggg aggaagggcc
     4501 cacagtaggt gctcaataga tgtgtaaaga aggcagggaa gcaagaaggt tgctcaaaca
     4561 agaccatgtt cccagcagac agattgcact ctgacccaga tgccaccaca cgaaacttac
     4621 acctgcctgg ggaacaatcc tgtgcttggc tctccttggt ggccagggac agttgtgcct
     4681 catccctcac ttgcaaaccc cagtcctgtc tgacccagag accctcacag ggcatcagcc
     4741 agtgaaggcg gtttggggct ggaggatatg ttctgatctt gggaagagct tggtaggagc
     4801 cagccacaga aagtttcagg gcagaactga acaggtctcg ggaaggacac ttcatgccag
     4861 ctagagaggc tctgggcaca ggaaagaatt ggacttcggg cagaaaaatg tttgtgctat
     4921 ttagtactat gtaacaaatc actccaaaac ttcattgctt aaagcaacaa gcatgtatta
     4981 tttctcatga
//
