LOCUS       NM_031934               1741 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RAB34, member RAS oncogene family (RAB34), transcript
            variant 1, mRNA.
ACCESSION   NM_031934 NR_024574
VERSION     NM_031934.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Lopez-Alcala,J., Gordon,A., Travez,A., Tercero-Alcazar,C.,
            Correa-Saez,A., Gonzalez-Rellan,M.J., Rangel-Zuniga,O.A.,
            Rodriguez,A., Membrives,A., Fruhbeck,G., Nogueiras,R.,
            Calzado,M.A., Guzman-Ruiz,R. and Malagon,M.M.
  TITLE     Localization, traffic and function of Rab34 in adipocyte lipid and
            endocrine functions
  JOURNAL   J Biomed Sci 31 (1), 2 (2024)
   PUBMED   38183057
  REMARK    GeneRIF: Localization, traffic and function of Rab34 in adipocyte
            lipid and endocrine functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Bruel,A.L., Ganga,A.K., Noskova,L., Valenzuela,I., Martinovic,J.,
            Duffourd,Y., Zikanova,M., Majer,F., Kmoch,S., Mohler,M., Sun,J.,
            Sweeney,L.K., Martinez-Gil,N., Thauvin-Robinet,C. and Breslow,D.K.
  TITLE     Pathogenic RAB34 variants impair primary cilium assembly and cause
            a novel oral-facial-digital syndrome
  JOURNAL   Hum Mol Genet 32 (18), 2822-2831 (2023)
   PUBMED   37384395
  REMARK    GeneRIF: Pathogenic RAB34 variants impair primary cilium assembly
            and cause a novel oral-facial-digital syndrome.
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Feng,Y., Tran,M.T., Lu,Y., Htike,K., Okusha,Y., Sogawa,C.,
            Eguchi,T., Kadowaki,T., Sakai,E., Tsukuba,T. and Okamoto,K.
  TITLE     Rab34 plays a critical role as a bidirectional regulator of
            osteoclastogenesis
  JOURNAL   Cell Biochem Funct 40 (3), 263-277 (2022)
   PUBMED   35285960
  REMARK    GeneRIF: Rab34 plays a critical role as a bidirectional regulator
            of osteoclastogenesis.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Zougman,A., Mann,M. and Wisniewski,J.R.
  TITLE     Identification and characterization of a novel ubiquitous nucleolar
            protein 'NARR' encoded by a gene overlapping the rab34 oncogene
  JOURNAL   Nucleic Acids Res 39 (16), 7103-7113 (2011)
   PUBMED   21586586
  REMARK    GeneRIF: NARR is ubiquitously expressed and resides in nucleoli
            where it colocalizes with ribosomal DNA gene clusters.
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Goldenberg,N.M., Grinstein,S. and Silverman,M.
  TITLE     Golgi-bound Rab34 is a novel member of the secretory pathway
  JOURNAL   Mol Biol Cell 18 (12), 4762-4771 (2007)
   PUBMED   17881736
  REMARK    GeneRIF: define Rab34 as a novel member of the secretory pathway
            acting at the Golgi
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Wang,T., Wong,K.K. and Hong,W.
  TITLE     A unique region of RILP distinguishes it from its related proteins
            in its regulation of lysosomal morphology and interaction with Rab7
            and Rab34
  JOURNAL   Mol Biol Cell 15 (2), 815-826 (2004)
   PUBMED   14668488
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Chen,T., Han,Y., Yang,M., Zhang,W., Li,N., Wan,T., Guo,J. and
            Cao,X.
  TITLE     Rab39, a novel Golgi-associated Rab GTPase from human dendritic
            cells involved in cellular endocytosis
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1114-1120 (2003)
   PUBMED   12684051
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Sun,P., Yamamoto,H., Suetsugu,S., Miki,H., Takenawa,T. and Endo,T.
  TITLE     Small GTPase Rah/Rab34 is associated with membrane ruffles and
            macropinosomes and promotes macropinosome formation
  JOURNAL   J Biol Chem 278 (6), 4063-4071 (2003)
   PUBMED   12446704
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Wang,T. and Hong,W.
  TITLE     Interorganellar regulation of lysosome positioning by the Golgi
            apparatus through Rab34 interaction with Rab-interacting lysosomal
            protein
  JOURNAL   Mol Biol Cell 13 (12), 4317-4332 (2002)
   PUBMED   12475955
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Morimoto,B.H., Chuang,C.C. and Koshland,D.E. Jr.
  TITLE     Molecular cloning of a member of a new class of
            low-molecular-weight GTP-binding proteins
  JOURNAL   Genes Dev 5 (12B), 2386-2391 (1991)
   PUBMED   1752434
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI523728.1, BC016841.1,
            AK074689.1 and BG251677.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031934.5.
            
            Summary: This gene encodes a protein belonging to the RAB family of
            proteins, which are small GTPases involved in protein transport.
            This family member is a Golgi-bound member of the secretory pathway
            that is involved in the repositioning of lysosomes and the
            activation of macropinocytosis. Alternative splicing of this gene
            results in multiple transcript variants. An alternatively spliced
            transcript variant produces the nine-amino acid residue-repeats
            (NARR) protein, which is a functionally distinct nucleolar protein
            resulting from a different reading frame. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1. Both variants 1 and 6 encode
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074689.1, BC091510.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395245.9/ ENSP00000378666.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BI523728.1         9-128
            121-765             BC016841.1         1-645
            766-1740            AK074689.1         766-1740
            1741-1741           BG251677.1         278-278
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1741
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /note="RAB34, member RAS oncogene family"
                     /db_xref="GeneID:83871"
                     /db_xref="HGNC:HGNC:16519"
                     /db_xref="MIM:610917"
     exon            1..656
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             603..1382
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rah; ras-related protein Rab-39; nine
                     amino-acid residue-repeats"
                     /codon_start=1
                     /product="ras-related protein Rab-34 isoform 1"
                     /protein_id="NP_114140.4"
                     /db_xref="CCDS:CCDS11240.1"
                     /db_xref="GeneID:83871"
                     /db_xref="HGNC:HGNC:16519"
                     /db_xref="MIM:610917"
                     /translation="MNILAPVRRDRVLAELPQCLRKEAALHGHKDFHPRVTCACQEHR
                     TGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFS
                     LQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVL
                     LFLVGSKKDLSTPAQYALMEKDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFE
                     ANVLAELEKSGARRIGDVVRINSDDSNLYLTASKKKPTCCP"
     exon            657..748
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            749..814
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            815..916
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            917..981
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1033
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1115
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1206
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1314
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1741
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /note="hexamer: ATTAAA"
     polyA_site      1741
                     /gene="RAB34"
                     /gene_synonym="NARR; OFD20; RAB39; RAH"
                     /note="major polyA site"
ORIGIN      
        1 acagcgttgg cggagcccga gcggagtggg actcgaggcc ctgtagccgg actgggcccc
       61 tcgccccctc ctccagcggc ctgcgggcct tggcagcgcc gcccctgccc acactgaccc
      121 cgtgtggcgg ggccgctccg cgcccccggg ccgctctgta atggtagggc agcctcagcc
      181 ccgagatgac gtcgggtctc cgcggccccg ggttattgta ggaaccatcc ggccccgcgt
      241 aatcgtagga actatccggc cccgcgtaat cgtagggtct gcgcgggccc ggcccccacc
      301 agacgggact ccccgccccc aattggcggc cgaagagtct cctcgcccca gagtcatctt
      361 cgggacgccc agggcccggg tgattttggg ctcgccgcgg ccccgggtga ttgtttcatc
      421 tccgtggccc gcggtggtcg tagcgtctcc gagaccgcgg actcccgtag ggtccccgtg
      481 gccccgagtt gtagtcggga caccccggcc gcgggtgatc gtcgggtctc cacgcgcccg
      541 ggtcgctgac gcggatccgg cctcggcgcc ttctcagggc gccctgcaag gccgcaggca
      601 ggatgaacat tctggcaccc gtgcggaggg atcgcgtcct ggcggagctg ccccagtgcc
      661 tgaggaagga ggccgctttg cacgggcaca aagacttcca cccccgcgtc acctgcgcct
      721 gccaggagca ccggacaggc accgtgggat ttaagatctc caaggtcatt gtggtggggg
      781 acctgtcggt ggggaagact tgcctcatta ataggttctg caaagacacc tttgataaga
      841 attacaaggc caccattgga gtggacttcg agatggaacg atttgaggtg ctgggcattc
      901 ccttcagttt gcagctttgg gataccgctg ggcaggagag gttcaaatgc attgcatcaa
      961 cctactatag aggagctcaa gccatcatca ttgtcttcaa cctgaatgat gtggcatctc
     1021 tggaacatac caagcagtgg ctggccgatg ccctgaagga gaatgaccct tccagtgtgc
     1081 ttctcttcct tgtaggttcc aagaaggatc tgagtacccc tgctcagtat gcgctgatgg
     1141 agaaagacgc cctccaggtg gcccaggaga tgaaggctga gtactgggca gtctcatctc
     1201 tcactggtga gaatgtccga gaattcttct tccgtgtggc agcactgacc tttgaggcca
     1261 atgtgctggc tgagctggag aaatcggggg ctcgacgcat tggggatgtt gtccgcatca
     1321 acagtgatga cagcaacctc tacctaactg ccagcaagaa gaagcccaca tgttgcccat
     1381 gagggctgag gagactgttc agagactgcc cagccctagg gcactgtgcc accctcattc
     1441 ctccagagct tgacccctgg acatttgcac tgactttatc cagaccaaag agctgcctct
     1501 tggtggcagt attcccacag aggggtagct gggatcatgc tagtcacttc ctgcccccag
     1561 gcaccgtgcc aaagactgga tgccccctac tcctcagggg actgtccagg gcgcccagtg
     1621 gtagtgaggg agagtgtctc tgttcttttg ctcagcctgc tgggcccttt gtgtttgagg
     1681 atgcttaatg attccagcct ctcactgtgc cttatgcatt aaaatttctt tgttacgagc
     1741 a
//
