LOCUS       NM_004794                945 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB33A, member RAS oncogene family (RAB33A), mRNA.
ACCESSION   NM_004794
VERSION     NM_004794.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Lambert,B., Vandeputte,J., Remacle,S., Bergiers,I., Simonis,N.,
            Twizere,J.C., Vidal,M. and Rezsohazy,R.
  TITLE     Protein interactions of the transcription factor Hoxa1
  JOURNAL   BMC Dev Biol 12, 29 (2012)
   PUBMED   23088713
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Itoh,T., Kanno,E., Uemura,T., Waguri,S. and Fukuda,M.
  TITLE     OATL1, a novel autophagosome-resident Rab33B-GAP, regulates
            autophagosomal maturation
  JOURNAL   J Cell Biol 192 (5), 839-853 (2011)
   PUBMED   21383079
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Zou,L., Zhou,J., Zhang,J., Li,J., Liu,N., Chai,L., Li,N., Liu,T.,
            Li,L., Xie,Z., Liu,H., Wan,Y. and Wu,Y.
  TITLE     The GTPase Rab3b/3c-positive recycling vesicles are involved in
            cross-presentation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15801-15806 (2009)
   PUBMED   19717423
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Jacobsen,M., Repsilber,D., Gutschmidt,A., Neher,A., Feldmann,K.,
            Mollenkopf,H.J., Ziegler,A. and Kaufmann,S.H.
  TITLE     Ras-associated small GTPase 33A, a novel T cell factor, is
            down-regulated in patients with tuberculosis
  JOURNAL   J Infect Dis 192 (7), 1211-1218 (2005)
   PUBMED   16136464
  REMARK    GeneRIF: expression was down-regulated in patients with TB and was
            predominantly expressed in CD8+ T cells.
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Schimmoller,F., Simon,I. and Pfeffer,S.R.
  TITLE     Rab GTPases, directors of vesicle docking
  JOURNAL   J Biol Chem 273 (35), 22161-22164 (1998)
   PUBMED   9712825
  REMARK    Review article
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Zheng,J.Y., Koda,T., Fujiwara,T., Kishi,M., Ikehara,Y. and
            Kakinuma,M.
  TITLE     A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized
            to the medial Golgi cisternae
  JOURNAL   J Cell Sci 111 (Pt 8), 1061-1069 (1998)
   PUBMED   9512502
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Koda,T. and Kakinuma,M.
  TITLE     Molecular cloning of a cDNA encoding a novel small GTP-binding
            protein
  JOURNAL   FEBS Lett 328 (1-2), 21-24 (1993)
   PUBMED   7688322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001157.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004794.2.
            
            Summary: The protein encoded by this gene belongs to the small
            GTPase superfamily, Rab family. It is GTP-binding protein and may
            be involved in vesicle transport. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001157.1, D14889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257017.5/ ENSP00000257017.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               BC001157.1         164-1108
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..945
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /note="RAB33A, member RAS oncogene family"
                     /db_xref="GeneID:9363"
                     /db_xref="HGNC:HGNC:9773"
                     /db_xref="MIM:300333"
     exon            1..359
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..815
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /note="Small GTP-binding protein S10"
                     /codon_start=1
                     /product="ras-related protein Rab-33A"
                     /protein_id="NP_004785.1"
                     /db_xref="CCDS:CCDS14621.1"
                     /db_xref="GeneID:9363"
                     /db_xref="HGNC:HGNC:9773"
                     /db_xref="MIM:300333"
                     /translation="MAQPILGHGSLQPASAAGLASLELDSSLDQYVQIRIFKIIVIGD
                     SNVGKTCLTFRFCGGTFPDKTEATIGVDFREKTVEIEGEKIKVQVWDTAGQERFRKSM
                     VEHYYRNVHAVVFVYDVTKMTSFTNLKMWIQECNGHAVPPLVPKVLVGNKCDLREQIQ
                     VPSNLALKFADAHNMLLFETSAKDPKESQNVESIFMCLACRLKAQKSLLYRDAERQQG
                     KVQKLEFPQEANSKTSCPC"
     exon            360..945
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /note="hexamer: AATAAA"
     polyA_site      945
                     /gene="RAB33A"
                     /gene_synonym="RabS10"
                     /note="major polyA site"
ORIGIN      
        1 acacacgcac agagctcgct cgcctcgagc gcacgaacgt ggacgttctc tttgtgtgga
       61 gccctcaagg ggggttgggg ccccggttcg gtccggggga gatggcgcag cccatcctgg
      121 gccatgggag cctgcagccc gcctcggccg ctggcctggc gtccctggag ctcgactcgt
      181 cgctggacca gtacgtgcag attcgcatct tcaaaataat cgtgattggg gactccaacg
      241 tgggcaagac ctgcctgacc ttccgcttct gcgggggtac cttcccagac aagactgaag
      301 ccaccatcgg cgtggacttc agggagaaga ccgtggaaat cgagggcgag aagatcaagg
      361 ttcaggtgtg ggacacagca ggtcaggaac gtttccgcaa aagcatggtc gagcattact
      421 accgcaacgt acatgccgtg gtcttcgtct atgacgtcac caagatgaca tctttcacca
      481 acctcaaaat gtggatccaa gaatgcaatg ggcatgctgt gcccccacta gtccccaaag
      541 tgcttgtggg caacaagtgt gacttgaggg aacagatcca ggtgccctcc aacttagccc
      601 tgaaatttgc tgatgcccac aacatgctct tgtttgagac atcggccaag gaccccaaag
      661 agagccagaa cgtggagtcg attttcatgt gcttggcttg ccgattgaag gcccagaaat
      721 ccctgctgta tcgtgatgct gagaggcagc aggggaaggt gcagaaactg gagttcccac
      781 aggaagctaa cagtaaaact tcctgtcctt gttgaaacca aacgatataa atacaagata
      841 aattatcact ggagtttttt ctttcccttt tttctgtgcc tgcataatgc tgacacctgc
      901 ttgtttccat acaaattgat atcaaaataa aatttgtata gatta
//
