LOCUS       NM_006834               1065 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens RAB32, member RAS oncogene family (RAB32), mRNA.
ACCESSION   NM_006834
VERSION     NM_006834.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1065)
  AUTHORS   Hop,P.J., Lai,D., Keagle,P.J., Baron,D.M., Kenna,B.J., Kooyman,M.,
            Shankaracharya, Halter,C., Straniero,L., Asselta,R., Bonvegna,S.,
            Soto-Beasley,A.I., Wszolek,Z.K., Uitti,R.J., Isaias,I.U.,
            Pezzoli,G., Ticozzi,N., Ross,O.A., Veldink,J.H., Foroud,T.M.,
            Kenna,K.P. and Landers,J.E.
  CONSRTM   Project MinE ALS Sequencing Consortium
  TITLE     Systematic rare variant analyses identify RAB32 as a susceptibility
            gene for familial Parkinson's disease
  JOURNAL   Nat Genet 56 (7), 1371-1376 (2024)
   PUBMED   38858457
  REMARK    GeneRIF: Systematic rare variant analyses identify RAB32 as a
            susceptibility gene for familial Parkinson's disease.
REFERENCE   2  (bases 1 to 1065)
  AUTHORS   Gustavsson,E.K., Follett,J., Trinh,J., Barodia,S.K., Real,R.,
            Liu,Z., Grant-Peters,M., Fox,J.D., Appel-Cresswell,S.,
            Stoessl,A.J., Rajput,A., Rajput,A.H., Auer,R., Tilney,R., Sturm,M.,
            Haack,T.B., Lesage,S., Tesson,C., Brice,A., Vilarino-Guell,C.,
            Ryten,M., Goldberg,M.S., West,A.B., Hu,M.T., Morris,H.R.,
            Sharma,M., Gan-Or,Z., Samanci,B., Lis,P., Perinan,M.T., Amouri,R.,
            Ben Sassi,S., Hentati,F., Tonelli,F., Alessi,D.R. and Farrer,M.J.
  CONSRTM   Global Parkinson's Genetics Program (GP2)
  TITLE     RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage,
            association, and functional analyses
  JOURNAL   Lancet Neurol 23 (6), 603-614 (2024)
   PUBMED   38614108
  REMARK    GeneRIF: RAB32 Ser71Arg in autosomal dominant Parkinson's disease:
            linkage, association, and functional analyses.
REFERENCE   3  (bases 1 to 1065)
  AUTHORS   Wu,Y., He,B., Hua,J., Hu,W., Han,Y. and Zhang,J.
  TITLE     Deciphering the molecular regulatory of RAB32/GPRC5A axis in
            chronic obstructive pulmonary disease
  JOURNAL   Respir Res 25 (1), 116 (2024)
   PUBMED   38448858
  REMARK    GeneRIF: Deciphering the molecular regulatory of RAB32/GPRC5A axis
            in chronic obstructive pulmonary disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1065)
  AUTHORS   Chen,P., Lu,Y., He,B., Xie,T., Yan,C., Liu,T., Wu,S., Yeh,Y.,
            Li,Z., Huang,W. and Zhang,X.
  TITLE     Rab32 promotes glioblastoma migration and invasion via regulation
            of ERK/Drp1-mediated mitochondrial fission
  JOURNAL   Cell Death Dis 14 (3), 198 (2023)
   PUBMED   36922509
  REMARK    GeneRIF: Rab32 promotes glioblastoma migration and invasion via
            regulation of ERK/Drp1-mediated mitochondrial fission.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1065)
  AUTHORS   Zou,L., Zhou,J., Zhang,J., Li,J., Liu,N., Chai,L., Li,N., Liu,T.,
            Li,L., Xie,Z., Liu,H., Wan,Y. and Wu,Y.
  TITLE     The GTPase Rab3b/3c-positive recycling vesicles are involved in
            cross-presentation in dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15801-15806 (2009)
   PUBMED   19717423
REFERENCE   7  (bases 1 to 1065)
  AUTHORS   Hirota,Y. and Tanaka,Y.
  TITLE     A small GTPase, human Rab32, is required for the formation of
            autophagic vacuoles under basal conditions
  JOURNAL   Cell Mol Life Sci 66 (17), 2913-2932 (2009)
   PUBMED   19593531
  REMARK    GeneRIF: Results suggest that Rab32 facilitates the formation of
            autophagic vacuoles whose membranes are derived from the ER and
            regulates the clearance of aggregated proteins by autophagy.
REFERENCE   8  (bases 1 to 1065)
  AUTHORS   Shibata,D., Mori,Y., Cai,K., Zhang,L., Yin,J., Elahi,A.,
            Hamelin,R., Wong,Y.F., Lo,W.K., Chung,T.K., Sato,F., Karpeh,M.S.
            Jr. and Meltzer,S.J.
  TITLE     RAB32 hypermethylation and microsatellite instability in gastric
            and endometrial adenocarcinomas
  JOURNAL   Int J Cancer 119 (4), 801-806 (2006)
   PUBMED   16557577
  REMARK    GeneRIF: RAB32 inactivation may represent a component of the
            oncogenic pathway of microsatellite-unstable gastrointestinal
            adenocarcinomas
REFERENCE   9  (bases 1 to 1065)
  AUTHORS   Alto,N.M., Soderling,J. and Scott,J.D.
  TITLE     Rab32 is an A-kinase anchoring protein and participates in
            mitochondrial dynamics
  JOURNAL   J Cell Biol 158 (4), 659-668 (2002)
   PUBMED   12186851
  REMARK    GeneRIF: Rab32 is a dual function protein that participates in both
            mitochondrial anchoring of PKA and synchronization of mitochondrial
            fission.
REFERENCE   10 (bases 1 to 1065)
  AUTHORS   Bao,X., Faris,A.E., Jang,E.K. and Haslam,R.J.
  TITLE     Molecular cloning, bacterial expression and properties of Rab31 and
            Rab32
  JOURNAL   Eur J Biochem 269 (1), 259-271 (2002)
   PUBMED   11784320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015061.1 and BQ018663.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006834.4.
            
            Summary: The protein encoded by this gene anchors the type II
            regulatory subunit of protein kinase A to the mitochondrion and
            aids in mitochondrial fission. The encoded protein also appears to
            be involved in autophagy and melanosome secretion. Variations in
            this gene may be linked to leprosy. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279832.1511.1, BC015061.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367495.4/ ENSP00000356465.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1062              BC015061.1         144-1205
            1063-1065           BQ018663.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..1065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3"
     gene            1..1065
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /note="RAB32, member RAS oncogene family"
                     /db_xref="GeneID:10981"
                     /db_xref="HGNC:HGNC:9772"
                     /db_xref="MIM:612906"
     exon            1..289
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..717
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /codon_start=1
                     /product="ras-related protein Rab-32"
                     /protein_id="NP_006825.1"
                     /db_xref="CCDS:CCDS5210.1"
                     /db_xref="GeneID:10981"
                     /db_xref="HGNC:HGNC:9772"
                     /db_xref="MIM:612906"
                     /translation="MAGGGAGDPGLGAAAAPAPETREHLFKVLVIGELGVGKTSIIKR
                     YVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEAVGA
                     FVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQNKDSSQSPSQVDQ
                     FCKEHGFAGWFETSAKDNINIEEAARFLVEKILVNHQSFPNEENDVDKIKLDQETLRA
                     ENKSQCC"
     exon            290..567
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1065
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1048..1053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /note="hexamer: AATAAA"
     polyA_site      1065
                     /gene="RAB32"
                     /gene_synonym="PARK26"
                     /note="major polyA site"
ORIGIN      
        1 agactcggag tcgaggcgcg cccgacagcc gcagcgctca tggcgggcgg aggagccggg
       61 gaccccggcc tgggggcggc cgccgcccca gcgcccgaga cccgcgagca cctcttcaag
      121 gtgctggtga tcggcgagct tggcgtgggc aagaccagca tcatcaagcg ctacgtccac
      181 cagctcttct cccagcacta ccgggccacc atcggggtgg acttcgccct caaggtcctc
      241 aactgggaca gcaggactct ggtgcgcctg cagctgtggg acatcgcggg gcaggagcga
      301 tttggcaaca tgacccgagt atactacaag gaagctgttg gtgcttttgt agtctttgat
      361 atatcaagaa gttccacatt tgaggcagtc ttaaaatgga aaagtgatct ggatagtaaa
      421 gttcatcttc caaatggcag ccctatccct gctgtcctct tggctaacaa atgtgaccag
      481 aacaaggaca gtagccagag tccttcccag gtggaccaat tctgcaaaga acatggcttt
      541 gccggatggt ttgaaacctc tgcaaaggat aacataaaca tagaggaagc tgcccggttc
      601 ctagtggaga agattcttgt aaaccaccaa agctttccta atgaagaaaa cgatgtggac
      661 aaaattaagc tagatcaaga gaccttgaga gcagagaaca aatcccagtg ttgctgatat
      721 atggcttctg cttctcttgt gtgtgcctca gctctgaaga agttcctgag aatgggttac
      781 agatgtcatg ttagctggga gtcttcccac atgtggcact tcaaaaggca gcaccactgg
      841 gcgcctgcac ttatttgaaa atggaacttt gggagaagta tccctgctag tggctctgta
      901 acttaacaga tgacaattag gcttttgtca ttgttgccat catatggaag ataatgttta
      961 catcctttta aacattttta tatgacaatt cctcaggatt tggtaaggct tccaagttgt
     1021 agcttttagt gtaagtgctg gggtggtaat aaaatgttac ctcca
//
