LOCUS       NM_032846               2914 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB2B, member RAS oncogene family (RAB2B), transcript
            variant 1, mRNA.
ACCESSION   NM_032846
VERSION     NM_032846.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2914)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2914)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2914)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2914)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2914)
  AUTHORS   Jin,J., Wu,Y., Zhou,D., Sun,Q. and Wang,W.
  TITLE     miR-448 targets Rab2B and is pivotal in the suppression of
            pancreatic cancer
  JOURNAL   Oncol Rep 40 (3), 1379-1389 (2018)
   PUBMED   30015954
  REMARK    GeneRIF: High RAB2B expression is associated with pancreatic
            cancer.
REFERENCE   6  (bases 1 to 2914)
  AUTHORS   Aizawa,M. and Fukuda,M.
  TITLE     Small GTPase Rab2B and Its Specific Binding Protein
            Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi
            Morphology
  JOURNAL   J Biol Chem 290 (36), 22250-22261 (2015)
   PUBMED   26209634
  REMARK    GeneRIF: Data show that Rab2B and a Rab2B-specific effector,
            GARI-L4, regulate Golgi morphology.
REFERENCE   7  (bases 1 to 2914)
  AUTHORS   Ostrowski,M., Carmo,N.B., Krumeich,S., Fanget,I., Raposo,G.,
            Savina,A., Moita,C.F., Schauer,K., Hume,A.N., Freitas,R.P.,
            Goud,B., Benaroch,P., Hacohen,N., Fukuda,M., Desnos,C.,
            Seabra,M.C., Darchen,F., Amigorena,S., Moita,L.F. and Thery,C.
  TITLE     Rab27a and Rab27b control different steps of the exosome secretion
            pathway
  JOURNAL   Nat Cell Biol 12 (1), 19-30 (2010)
   PUBMED   19966785
REFERENCE   8  (bases 1 to 2914)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 2914)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 2914)
  AUTHORS   Ni,X., Ma,Y., Cheng,H., Jiang,M., Guo,L., Ji,C., Gu,S., Cao,Y.,
            Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human Rab (Rab2B)
            gene
  JOURNAL   J Hum Genet 47 (10), 548-551 (2002)
   PUBMED   12376746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020839.1, AL161747.5 and BC066366.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032846.3.
            
            Summary: Members of the Rab protein family are nontransforming
            monomeric GTP-binding proteins of the Ras superfamily that contain
            4 highly conserved regions involved in GTP binding and hydrolysis.
            Rab proteins are prenylated, membrane-bound proteins involved in
            vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM,
            Apr 2006].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.44832.1,
                                           SRR1803615.188454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397762.6/ ENSP00000380869.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-982               BC020839.1         4-985
            983-2817            AL161747.5         75354-77188         c
            2818-2914           BC066366.1         2376-2472
FEATURES             Location/Qualifiers
     source          1..2914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2914
                     /gene="RAB2B"
                     /note="RAB2B, member RAS oncogene family"
                     /db_xref="GeneID:84932"
                     /db_xref="HGNC:HGNC:20246"
                     /db_xref="MIM:607466"
     exon            1..133
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..738
                     /gene="RAB2B"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-2B; RAS family, member RAB2B;
                     GTP-binding protein RAB2B"
                     /codon_start=1
                     /product="ras-related protein Rab-2B isoform 1"
                     /protein_id="NP_116235.2"
                     /db_xref="CCDS:CCDS9570.1"
                     /db_xref="GeneID:84932"
                     /db_xref="HGNC:HGNC:20246"
                     /db_xref="MIM:607466"
                     /translation="MTYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFG
                     ARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRETFNHLTSWLE
                     DARQHSSSNMVIMLIGNKSDLESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAF
                     INTAKEIYRKIQQGLFDVHNEANGIKIGPQQSISTSVGPSASQRNSRDIGSNSGCC"
     exon            134..205
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            206..273
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            274..356
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            357..449
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            450..561
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            562..630
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     exon            631..2914
                     /gene="RAB2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2892..2897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB2B"
                     /note="hexamer: AATATA"
     polyA_site      2914
                     /gene="RAB2B"
                     /note="major polyA site"
ORIGIN      
        1 gaagatcggt agattgagtg gctagagagg tcggaggtaa gtggctatag aagtcgggcg
       61 gacccggaac ccagaggacg cgacaccatg acttatgctt atctcttcaa gtatatcatc
      121 atcggagaca caggtgtggg gaagtcatgt ctcctcctgc agtttacaga taagcggttc
      181 cagcctgtcc acgacctcac aataggtgtg gagtttggag ctcgtatggt caacattgat
      241 ggaaaacaaa tcaaactgca aatctgggat acggctgggc aagaatcctt ccgttctatc
      301 acccgttcct actacagggg agcagctgga gcactgctgg tgtacgacat tacaaggcgt
      361 gaaaccttca accacctgac ctcatggtta gaggatgccc ggcagcactc tagttccaac
      421 atggttatca tgctcattgg gaataagagt gacctagagt cccgcaggga tgtgaagaga
      481 gaagaaggag aggcctttgc tagggagcat ggacttatat tcatggaaac ttcagccaaa
      541 acagcctgca atgttgaaga ggccttcatt aacacagcca aagaaatata taggaagatc
      601 cagcagggtt tatttgatgt ccacaatgag gcaaatggca tcaagattgg gccccaacag
      661 tcaatttcaa catcagtggg acccagtgcc tcccagcgga actctcgtga catagggtcc
      721 aactctggct gctgctgaac atctggcttg aacttttttt gtccttcctg gaatagcttc
      781 agatcaatag gcttaatgaa agaggtcttt cttgctttgg ctgagagcag cctcttttta
      841 aagtgtgatg ttttgccttt ccacctaaag accaggagag aatttgggcc cttactgacc
      901 tgtcctcctt cagggacatg agcattccct atagattagg gttcttctta tcctcctata
      961 caaatttctt aaattgttag gatcaaagtt gattatcaca gtagttaaaa aataatttca
     1021 tggcggggcg ccatggctca tgcctgtaat cctagcactt tgggaggcca aggtgggcag
     1081 atcacctgag gtcaagagtt cgagaccagc ctgaccaact tggagaaatg ccatctcaac
     1141 tgaaaataca aaattagctg ggtgtggtgg tgcatgcctg taatcccagg tactcgggag
     1201 gccaaggcag gagaatcgct tgaacccagg aggtgaaggt tacgctaagc caagatcacg
     1261 ccattgcact gcagcctggg caacaagagc aaaactctgt ctcaaataaa taaataattt
     1321 tttttttctt tttttttttt tttttttggg gggatggagt ctcactctgt ctccaggctg
     1381 gagtgcagtg gcatgatctt ggctcactgc aacctccact ttccaggttc aagcagttct
     1441 cctgcctcaa cctcccgagt agctgggact acaggcatgt gccaccacac ctggctcatt
     1501 tttgtatttt tagtagagac agggtttcac catgttggcc aggatggtct tgatctcttg
     1561 acctcgtgat ccgcccacct tggcctccca aagtgctgga ttacaggtgt gagccaccgt
     1621 gcctggccta aataaataat ttcgtaagca tatacaatcc acttcccact aagaattagg
     1681 gtcaaagaca ttctatttga acacttgcaa ttacctagat ctagttggcc tttggttgat
     1741 agatcctctg cctcggaatt tcattgagtt tttttcttcc ttgcctttgg gtgtctgctt
     1801 gccacttcct aagaattctt gtagaaggca gtttcctcta cttgcccaag agcactgagt
     1861 acttctctac tatcctatta ttagcttcta tctcttagtg taacttcaaa acttttaaga
     1921 gcagtgaagt tggtcaggga catgtggcca cttattatta cctaaagaaa acatttgttc
     1981 cctgttcatt ttattttagg ggccagatct aacattgtag tgtctttcac cagatagact
     2041 tctactgttt catcaaactc ccttcttaac tagacctaga ctttctactc caatcaggct
     2101 aatctactta ctgaatgtga catatttatt cctagttcca tacctttgca catgccctac
     2161 tctccactaa ttatacttaa aagtccaaaa attttttctt tagtaacaga cttaggtact
     2221 gctaagcagt tattaacaca atattcctta gttttcatat gttggttatt catatgtcta
     2281 tttatatgta tatttatttt tatgtatgtt actatgtaaa tatggtttgc agttgttttt
     2341 gtgtggaatc ttgtctttcc gtataagttg taagctcctt gagagcagga tccatgtcat
     2401 tcctttattt ttataaatta ttccccctat cattccttta cagtgcctag tgctactcat
     2461 tatgtgttca ttgaatttga ctgacatagt taaaaactta aggtttattt tagactttca
     2521 aggaaacaaa agactttaga gtcctctctc tgtaattctg ccccactcat ttgtttaccc
     2581 tgggttttat acagttctct tccttctccc ctcccacctt tccctggctt tttgcctcca
     2641 ttccatgagg catacagtaa ggctgcctgc tagtaagcag tcacataagt gggtacctat
     2701 ccagccattc tcttttcaga gcatataata ctatcttagc caaacttgcc tttgcttcac
     2761 tcatcatgca gccttctggg ttggttgcta tatatatctt ttttccttga tgtcccgttc
     2821 tcttccacag ccctgaggtc ttacgaattt ttctactttc tttttgctgt tgatgaattg
     2881 tttcattatt aaatatatgc atgtatcaaa gcta
//
